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🔗 Medicine 🔗 Medicine/Neurology

Type 3 diabetes is a proposed term to describe the interlinked association between type 1 and type 2 diabetes, and Alzheimer's disease. This term is used to look into potential triggers of Alzheimer's disease in people with diabetes.

The proposed progression from diabetes to Alzheimer's disease is inadequately understood; however there are a number of hypotheses describing potential links between the two diseases. The internal mechanism of Insulin resistance and other metabolic risk factors such as hyperglycaemia, caused by oxidative stress and lipid peroxidation are common processes thought to be contributors to the development of Alzheimer's disease in diabetics.

Diagnosis for this disease is different between patients with type 1 and type 2 diabetes. Type 1 diabetes is usually discovered in children and adolescence while type 2 diabetic patients are often diagnosed later in life. While Type 3 diabetes is not a diagnosis in itself, a diagnosis of suspected Alzheimer's disease can be established through observational signs and sometimes with neuroimaging techniques such as Magnetic Resonance Imaging (MRI) to observe abnormalities in diabetic patient's brain tissue.

The techniques used to prevent the disease in patients with diabetes are similar to individuals who do not show signs of the disease. The four pillars of Alzheimer's disease prevention is currently used as a guide for individuals of whom are at risk of developing Alzheimer's disease.

Research into the effectiveness of Glucagon-like Peptide 1 and Melatonin administration to manage the progression of Alzheimer's disease in diabetic patients is currently being conducted to decrease the rate at which Alzheimer's disease progresses.

Labelling Alzheimer's disease as Type 3 Diabetes is generally controversial, and this definition is not a known medical diagnosis. While insulin resistance is a risk factor for the development of Alzheimer's disease and some other dementias, causes of Alzheimer's disease are likely to be much more complex than being explained by insulin factors on their own, and indeed several patients with Alzheimer's disease have normal insulin metabolism.

🔗 Television 🔗 Science Fiction 🔗 Television/British television 🔗 Television/ITC productions

The Prisoner is a 1967 British television series about an unnamed British intelligence agent who is abducted and imprisoned in a mysterious coastal village, where his captors designate him as Number Six and try to find out why he abruptly resigned from his job. Patrick McGoohan played the lead role as Number Six. The series was created by McGoohan with possible contributions from George Markstein. Episode plots have elements of science fiction, allegory, and psychological drama, as well as spy fiction. It was produced by Everyman Films for distribution by Lew Grade's ITC Entertainment.

A single series of 17 episodes was filmed between September 1966 and January 1968, with exterior location filming in Portmeirion, Wales. Interior scenes were filmed at MGM-British Studios in Borehamwood, north of London. The series was first broadcast in Canada beginning on 5 September 1967, in the UK on 29 September 1967, and in the US on 1 June 1968. Although the show was sold as a thriller in the mould of the previous series starring McGoohan, Danger Man, its combination of 1960s countercultural themes and surrealistic setting had a far-reaching influence on science fiction and fantasy TV programming, and on narrative popular culture in general. Since its initial screening, the series has developed a cult following.

A six-part TV miniseries remake aired on the US cable channel AMC in November 2009. In 2016, Big Finish Productions reinterpreted the series as an audio drama.

🔗 Film 🔗 Film/American cinema 🔗 Comedy 🔗 Chicago

Windy City Heat is a made-for-TV reality film produced by Comedy Central. It first aired on October 12, 2003.

🔗 Biography 🔗 Australia 🔗 Crime 🔗 Australia/Australian crime 🔗 South Africa 🔗 Zimbabwe

Paul Calder Le Roux (born 24 December 1972) is a former programmer, former criminal cartel boss and informant to the US Drug Enforcement Administration (DEA).

In 1999, he created E4M, a free and open-source disk encryption software program for Microsoft Windows, and is sometimes credited for open-source TrueCrypt, which is based on E4M's code, though he denies involvement with TrueCrypt.

He was arrested on 26 September 2012 for conspiracy to import narcotics into the United States, and agreed to cooperate with authorities in exchange for a lesser sentence and immunity to any crimes he might admit to afterwards. He subsequently admitted to arranging or participating in seven murders, carried out as part of an extensive illegal business empire.

Le Roux was sentenced to 25 years in prison in June 2020.

🔗 Philosophy 🔗 Philosophy/Logic 🔗 Philosophy/Contemporary philosophy 🔗 Philosophy/Ancient philosophy 🔗 Philosophy/Philosophy of mind 🔗 Philosophy/Modern philosophy 🔗 Philosophy/Metaphysics 🔗 Philosophy/Analytic philosophy 🔗 Folklore

In the metaphysics of identity, the ship of Theseus is a thought experiment that raises the question of whether an object that has had all of its components replaced remains fundamentally the same object. The concept is one of the oldest in Western philosophy, having been discussed by the likes of Heraclitus and Plato by ca. 500-400 BC.

🔗 Spaceflight

NASA Extreme Environment Mission Operations, or NEEMO, is a NASA analog mission that sends groups of astronauts, engineers and scientists to live in Aquarius underwater laboratory, the world's only undersea research station, for up to three weeks at a time in preparation for future space exploration.

Aquarius is an underwater habitat 3.5 miles (5.6 km) off Key Largo, Florida, in the Florida Keys National Marine Sanctuary. It is deployed on the ocean floor next to deep coral reefs 62 feet (19 m) below the surface.

NASA has used it since 2001 for a series of space exploration simulation missions, usually lasting 7 to 14 days, with space research mainly conducted by international astronauts. The mission had cost about 500 million U.S. dollars. The crew members are called aquanauts (as they live underwater at depth pressure for a period equal to or greater than 24 continuous hours without returning to the surface), and they perform EVAs in the underwater environment. A technique known as saturation diving allows the aquanauts to live and work underwater for days or weeks at a time. After twenty four hours underwater at any depth, the human body becomes saturated with dissolved gas. With saturation diving, divers can accurately predict exactly how much time they need to decompress before returning to the surface. This information limits the risk of decompression sickness. By living in the Aquarius habitat and working at the same depth on the ocean floor, NEEMO crews are able to remain underwater for the duration of their mission.

For NASA, the Aquarius habitat and its surroundings provide a convincing analog for space exploration. Much like space, the undersea world is a hostile, alien place for humans to live. NEEMO crew members experience some of the same challenges there that they would on a distant asteroid, planet (i.e. Mars) or Moon. During NEEMO missions, the aquanauts are able to simulate living on a spacecraft and test spacewalk techniques for future space missions. Working in space and underwater environments requires extensive planning and sophisticated equipment. The underwater condition has the additional benefit of allowing NASA to "weight" the aquanauts to simulate different gravity environments.

Until 2012, Aquarius was owned by the National Oceanic and Atmospheric Administration (NOAA) and operated by the National Undersea Research Center (NURC) at the University of North Carolina–Wilmington as a marine biology study base.

Since 2013, Aquarius is owned by Florida International University (FIU). As part of the FIU Marine Education and Research Initiative, the Medina Aquarius Program is dedicated to the study and preservation of marine ecosystems worldwide and is enhancing the scope and impact of FIU on research, educational outreach, technology development, and professional training. At the heart of the program is the Aquarius Reef Base.

🔗 Death 🔗 Law 🔗 Romania

The trial of Nicolae and Elena Ceaușescu was held on 25 December 1989 by an Exceptional Military Tribunal, a drumhead court-martial created at the request of a newly formed group called the National Salvation Front. Its outcome was pre-determined, and it resulted in guilty verdicts and death sentences for former Romanian President and Romanian Communist Party General Secretary, Nicolae Ceaușescu, and his wife, Elena Ceaușescu.

The main charge was genocide— namely, murdering "over 60,000 people" during the revolution in Timișoara. Other sources put the death toll between 689 and 1,200. Nevertheless, the charges did not affect the trial. General Victor Stănculescu had brought with him a specially selected team of paratroopers from a crack regiment, handpicked earlier in the morning to act as a firing squad. Before the legal proceedings began, Stănculescu had already selected the spot where the execution would take place: along one side of the wall in the barracks' square.

Nicolae Ceaușescu refused to recognize the tribunal, arguing its lack of constitutional basis and claiming that the revolutionary authorities were part of a Soviet plot.

🔗 Novels 🔗 Novels/Science fiction 🔗 Science Fiction 🔗 Media franchises

Dune is a science fiction media franchise that originated with the 1965 novel Dune by Frank Herbert and has continued to add new publications up to 2017. Dune is frequently cited as the best-selling science fiction novel in history. It won the 1966 Hugo Award and the inaugural Nebula Award for Best Novel, and was later adapted into a 1984 film and a 2000 television miniseries. Herbert wrote five sequels, and the first two were presented as a miniseries in 2003. The Dune universe has also inspired some traditional games and a series of video games. Since 2009, the names of planets from the Dune novels have been adopted for the real-world nomenclature of plains and other features on Saturn's moon Titan.

Frank Herbert died in 1986. Beginning in 1999, his son Brian Herbert and science fiction author Kevin J. Anderson published a number of prequel novels, as well as two which complete the original Dune series (Hunters of Dune in 2006 and Sandworms of Dune in 2007), partially based on Frank Herbert's notes discovered a decade after his death.

The political, scientific, and social fictional setting of Herbert's novels and derivative works is known as the Dune universe, or Duniverse. Set tens of thousands of years in the future, the saga chronicles a civilization which has banned all forms of computers, or "thinking machines", but has also developed advanced technology and mental and physical abilities. Vital to this empire is the harsh desert planet Arrakis, only known source of the spice melange, the most valuable substance in the universe.

Due to the similarities between some of Herbert's terms and ideas and actual words and concepts in the Arabic language, as well as the series' "Islamic undertones" and themes, a Middle Eastern influence on Herbert's works has been noted repeatedly.

🔗 History 🔗 Middle Ages 🔗 Middle Ages/History

The Nine Worthies are nine historical, scriptural, and legendary personages who personify the ideals of chivalry established in the Middle Ages, whose lives were deemed a valuable study for aspirants to chivalric status. All were commonly referred to as 'Princes', regardless of their historical titles. In French they are called Les Neuf Preux or "Nine Valiants", giving a more specific idea of the moral virtues they exemplified: those of soldierly courage and generalship. In Italy they are i Nove Prodi.

The Nine Worthies include three pagans (Hector, Alexander the Great and Julius Caesar), three Jews (Joshua, David and Judas Maccabeus) and three Christians (King Arthur, Charlemagne and Godfrey of Bouillon).

🔗 Canada 🔗 Architecture 🔗 Canada/British Columbia 🔗 Canada/Vancouver

The Vancouver Special is an architectural style of residential houses developed in Metro Vancouver, Canada. The style was popular in the 1960s to 1980s due to ability to maximize floor space with relatively cheap construction costs.