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🔗 Medicine 🔗 Viruses

Original antigenic sin, also known as antigenic imprinting or the Hoskins effect, refers to the propensity of the body's immune system to preferentially utilize immunological memory based on a previous infection when a second slightly different version of that foreign pathogen (e.g. a virus or bacterium) is encountered. This leaves the immune system "trapped" by the first response it has made to each antigen, and unable to mount potentially more effective responses during subsequent infections. Antibodies or T-cells induced during infections with the first variant of the pathogen are subject to a form of original antigenic sin, termed repertoire freeze.

The phenomenon of original antigenic sin has been described in relation to influenza virus, dengue fever, human immunodeficiency virus (HIV) and to several other viruses.

This phenomenon was first described in 1960 by Thomas Francis Jr. in the article "On the Doctrine of Original Antigenic Sin". It is named by analogy to the theological concept of original sin. According to Francis as cited by Richard Krause:

"The antibody of childhood is largely a response to dominant antigen of the virus causing the first type A influenza infection of the lifetime. [...] The imprint established by the original virus infection governs the antibody response thereafter. This we have called the Doctrine of the Original Antigenic Sin."

🔗 Linguistics

A synecdoche ( sin-NEK-tə-kee, from Greek συνεκδοχή, synekdochē, 'simultaneous understanding') is a figure of speech in which a term for a part of something refers to the whole of something or vice versa. A synecdoche is a class of metonymy, often by means of either mentioning a part for the whole or conversely the whole for one of its parts. Examples from common English expressions include "suits" (for "businessmen"), "boots" (for "soldiers") (pars pro toto), and "America" (for "the United States of America", totum pro parte).

The use of government buildings to refer to their occupants is metonymy and sometimes also synecdoche. "The Pentagon" for the United States Department of Defense can be considered synecdoche, as the building can be considered part of the department. Likewise, using "Number 10" to mean "the Office of the Prime Minister" (of the United Kingdom) is a synecdoche.

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This is a list of common misconceptions. Each entry is formatted as a correction; the misconceptions themselves are implied rather than stated. These entries are meant to be concise, but more detail can be found in the main subject articles.

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Henry Alfred Kissinger (; German: [ˈkɪsɪŋɐ]; born Heinz Alfred Kissinger, May 27, 1923) is an American diplomat, political theorist, geopolitical consultant, and politician who served as United States Secretary of State and National Security Advisor under the presidential administrations of Richard Nixon and Gerald Ford. For his actions negotiating a ceasefire in Vietnam, Kissinger received the 1973 Nobel Peace Prize under controversial circumstances.

Kissinger was a Jewish refugee who fled Nazi Germany with his family in 1938. Upon arriving in the United States, he excelled academically and graduated from Harvard College in 1950, where he studied under William Yandell Elliott. He earned his M.A. and Ph.D. degrees at Harvard University in 1951 and 1954, respectively.

A practitioner of Realpolitik, Kissinger played a prominent role in United States foreign policy between 1969 and 1977, pioneering the policy of détente with the Soviet Union, orchestrating an opening of relations with the People's Republic of China, engaging in what became known as shuttle diplomacy in the Middle East to end the Yom Kippur War, and negotiating the Paris Peace Accords, which ended American involvement in the Vietnam War. Kissinger has also been associated with such controversial policies as the U.S. bombing of Cambodia during the Vietnam War, U.S. involvement in the 1973 Chilean military coup, a "green light" to Argentina's military junta for their Dirty War, and U.S. support for Pakistan during the Bangladesh Liberation War despite a genocide being perpetrated by Pakistan. After leaving government, he formed Kissinger Associates, an international geopolitical consulting firm. Kissinger has written over a dozen books on diplomatic history and international relations.

Kissinger remains a controversial and polarizing figure in U.S. politics, both venerated by some as a highly effective U.S. Secretary of State and condemned by others for allegedly tolerating or supporting war crimes committed by allied nation states during his tenure. A 2015 survey of top international relations scholars, conducted by College of William & Mary, ranked Kissinger as the most effective U.S. secretary of state in the 50 years to 2015. A centenarian, Kissinger is the oldest living former U.S. Cabinet member and the last surviving member of Nixon's Cabinet. The previous oldest cabinet member was George Shultz, who died at the age of 100 in February 2021.

🔗 Computing 🔗 Time 🔗 Linux

Unix time (also known as Epoch time, POSIX time, seconds since the Epoch, or UNIX Epoch time) is a system for describing a point in time. It is the number of seconds that have elapsed since the Unix epoch, that is the time 00:00:00 UTC on 1 January 1970, minus leap seconds. Leap seconds are ignored, with a leap second having the same Unix time as the second before it, and every day is treated as if it contains exactly 86400 seconds. Due to this treatment, Unix time is not a true representation of UTC.

Unix time is widely used in operating systems and file formats. In Unix-like operating systems, date is a command which will print or set the current time; by default, it prints or sets the time in the system time zone, but with the -u flag, it prints or sets the time in UTC and, with the TZ environment variable set to refer to a particular time zone, prints or sets the time in that time zone.

🔗 Zoo 🔗 Primates

Ken Allen (February 13, 1971 – December 1, 2000) was a Bornean orangutan at the San Diego Zoo. He became one of the most popular animals in the history of the zoo because of his many successful escapes from his enclosures. He was nicknamed "the hairy Houdini".

Ken Allen was born in captivity at the San Diego Zoo in 1971. During the 1980s, Ken Allen gained worldwide attention for a series of three escapes from his enclosure, which had been thought to be escape-proof. During some of his escapes, his female companions would join him. Ken Allen's ability to outwit his keepers, as well as his docile demeanor during his escapes, resulted in fame. He had his own fan club, and was the subject of T-shirts and bumper stickers (most reading "Free Ken Allen"). A song, The Ballad of Ken Allen, was written about him.

Ken Allen developed prostate cancer and was euthanized on December 1, 2000. He was 29 years old.

🔗 Computing

A wetware computer is an organic computer (which can also be known as an artificial organic brain or a neurocomputer) composed of organic material such as living neurons. Wetware computers composed of neurons are different than conventional computers because they are thought to be capable in a way of "thinking for themselves", because of the dynamic nature of neurons. While wetware is still largely conceptual, there has been limited success with construction and prototyping, which has acted as a proof of the concept's realistic application to computing in the future. The most notable prototypes have stemmed from the research completed by biological engineer William Ditto during his time at the Georgia Institute of Technology. His work constructing a simple neurocomputer capable of basic addition from leech neurons in 1999 was a significant discovery for the concept. This research acted as a primary example driving interest in the creation of these artificially constructed, but still organic brains.

🔗 Law 🔗 Statistics

The Howland will forgery trial was a U.S. court case in 1868 to decide Henrietta Howland Robinson's contest of the will of Sylvia Ann Howland. It is famous for the forensic use of mathematics by Benjamin Peirce as an expert witness.

🔗 Physics 🔗 Chemistry 🔗 Geology 🔗 Rocks and minerals

A quasiperiodic crystal, or quasicrystal, is a structure that is ordered but not periodic. A quasicrystalline pattern can continuously fill all available space, but it lacks translational symmetry. While crystals, according to the classical crystallographic restriction theorem, can possess only two-, three-, four-, and six-fold rotational symmetries, the Bragg diffraction pattern of quasicrystals shows sharp peaks with other symmetry orders—for instance, five-fold.

Aperiodic tilings were discovered by mathematicians in the early 1960s, and, some twenty years later, they were found to apply to the study of natural quasicrystals. The discovery of these aperiodic forms in nature has produced a paradigm shift in the fields of crystallography. Quasicrystals had been investigated and observed earlier, but, until the 1980s, they were disregarded in favor of the prevailing views about the atomic structure of matter. In 2009, after a dedicated search, a mineralogical finding, icosahedrite, offered evidence for the existence of natural quasicrystals.

Roughly, an ordering is non-periodic if it lacks translational symmetry, which means that a shifted copy will never match exactly with its original. The more precise mathematical definition is that there is never translational symmetry in more than n – 1 linearly independent directions, where n is the dimension of the space filled, e.g., the three-dimensional tiling displayed in a quasicrystal may have translational symmetry in two directions. Symmetrical diffraction patterns result from the existence of an indefinitely large number of elements with a regular spacing, a property loosely described as long-range order. Experimentally, the aperiodicity is revealed in the unusual symmetry of the diffraction pattern, that is, symmetry of orders other than two, three, four, or six. In 1982 materials scientist Dan Shechtman observed that certain aluminium-manganese alloys produced the unusual diffractograms which today are seen as revelatory of quasicrystal structures. Due to fear of the scientific community's reaction, it took him two years to publish the results for which he was awarded the Nobel Prize in Chemistry in 2011. On 25 October 2018, Luca Bindi and Paul Steinhardt were awarded the Aspen Institute 2018 Prize for collaboration and scientific research between Italy and the United States.

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Benjamin Franklin (January 17, 1706 [O.S. January 6, 1705] – April 17, 1790) was an American polymath and one of the Founding Fathers of the United States. Franklin was a leading writer, printer, political philosopher, politician, Freemason, postmaster, scientist, inventor, humorist, civic activist, statesman, and diplomat. As a scientist, he was a major figure in the American Enlightenment and the history of physics for his discoveries and theories regarding electricity. As an inventor, he is known for the lightning rod, bifocals, and the Franklin stove, among other inventions. He founded many civic organizations, including the Library Company, Philadelphia's first fire department and the University of Pennsylvania.

Franklin earned the title of "The First American" for his early and indefatigable campaigning for colonial unity, initially as an author and spokesman in London for several colonies. As the first United States Ambassador to France, he exemplified the emerging American nation. Franklin was foundational in defining the American ethos as a marriage of the practical values of thrift, hard work, education, community spirit, self-governing institutions, and opposition to authoritarianism both political and religious, with the scientific and tolerant values of the Enlightenment. In the words of historian Henry Steele Commager, "In a Franklin could be merged the virtues of Puritanism without its defects, the illumination of the Enlightenment without its heat." To Walter Isaacson, this makes Franklin "the most accomplished American of his age and the most influential in inventing the type of society America would become."

Franklin became a successful newspaper editor and printer in Philadelphia, the leading city in the colonies, publishing the Pennsylvania Gazette at the age of 23. He became wealthy publishing this and Poor Richard's Almanack, which he authored under the pseudonym "Richard Saunders". After 1767, he was associated with the Pennsylvania Chronicle, a newspaper that was known for its revolutionary sentiments and criticisms of British policies.

He pioneered and was the first president of Academy and College of Philadelphia which opened in 1751 and later became the University of Pennsylvania. He organized and was the first secretary of the American Philosophical Society and was elected president in 1769. Franklin became a national hero in America as an agent for several colonies when he spearheaded an effort in London to have the Parliament of Great Britain repeal the unpopular Stamp Act. An accomplished diplomat, he was widely admired among the French as American minister to Paris and was a major figure in the development of positive Franco-American relations. His efforts proved vital for the American Revolution in securing shipments of crucial munitions from France.

He was promoted to deputy postmaster-general for the British colonies in 1753, having been Philadelphia postmaster for many years, and this enabled him to set up the first national communications network. During the revolution, he became the first United States Postmaster General. He was active in community affairs and colonial and state politics, as well as national and international affairs. From 1785 to 1788, he served as governor of Pennsylvania. He initially owned and dealt in slaves but, by the late 1750s, he began arguing against slavery and became an abolitionist.

His life and legacy of scientific and political achievement, and his status as one of America's most influential Founding Fathers, have seen Franklin honored more than two centuries after his death on coinage and the $100 bill, warships, and the names of many towns, counties, educational institutions, and corporations, as well as countless cultural references.