Have a deep view into what people are curious about.

🔗 Television 🔗 Media

TV-B-Gone is a universal remote control device for turning off a large majority—about 85%—of the available brands of television sets in 2015. It was created to allow people in a public place to turn off nearby television sets. Its inventor has referred to it as "an environmental management device". The device is part of a key-chain, and, like other remote devices, is battery-powered. Although it can require up to 72 seconds for the device to find the proper code for a particular television receiver, the most popular televisions turn off in the first few seconds.

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Europe 🔗 Ethnic groups

The Yenish (German: Jenische; French: Yéniche) are an itinerant group in Western Europe who live mostly in Germany, Austria, Switzerland, Luxembourg, Belgium, and parts of France, roughly centred on the Rhineland. A number of theories for the group's origins have been proposed, including that the Yenish descended from members of the marginalized and vagrant poor classes of society of the early modern period, before emerging as a distinct group by the early 19th century. Most of the Yenish became sedentary in the course of the mid-19th to 20th centuries.

🔗 Computing

QB64 (originally QB32) is a self-hosting BASIC compiler for Microsoft Windows, Linux and Mac OS X, designed to be compatible with Microsoft QBasic and QuickBASIC. QB64 is a C++ emitter, which is integrated with a C++ compiler to provide compilation via C++ code and GCC optimization.

QB64 implements most QBasic statements, and can run many QBasic programs, including Microsoft's QBasic Gorillas and Nibbles games. Furthermore, QB64 has been designed to contain an IDE resembling the QBASIC IDE. QB64 also extends the QBASIC programming language to include 64-bit data types, as well as better sound and graphics support. It can also emulate some DOS/x86 specific features such as INT 33h mouse access, and multiple timers.

Since version 2.0, QB64 now offers debugging abilities, with the new $DEBUG metacommand.

🔗 France 🔗 World Heritage Sites 🔗 Lighthouses

Cordouan lighthouse (French pronunciation: [kɔʁdwɑ̃]) is an active lighthouse located 7 kilometres (4.3 miles) at sea, near the mouth of the Gironde estuary in France. At a height of 67.5 metres (221 ft), it is the tenth-tallest "traditional lighthouse" in the world.

The Tour de Cordouan, the 'Patriarch of Lighthouses' is by far the oldest lighthouse in France, with construction starting in 1584 and finishing in 1611. Designed by leading Paris architect Louis de Foix, the lighthouse is something of a Renaissance masterpiece, drawing inspiration from Roman mausoleums, and the palaces, cathedrals, and forts of the Renaissance. Three stories were added in the 18th century.

Because of its outstanding Renaissance architecture and its testimony to the development of lighthouses, the Cordouan Lighthouse was listed as a historic monument in 1862, and recognized by UNESCO as a World Heritage Site in 2021.

🔗 Food and drink 🔗 Insects 🔗 Forestry

Shellac () is a resin secreted by the female lac bug on trees in the forests of India and Thailand. Chemically, it is mainly composed of aleuritic acid, jalaric acid, shellolic acid, and other natural waxes. It is processed and sold as dry flakes and dissolved in alcohol to make liquid shellac, which is used as a brush-on colorant, food glaze and wood finish. Shellac functions as a tough natural primer, sanding sealant, tannin-blocker, odour-blocker, stain, and high-gloss varnish. Shellac was once used in electrical applications as it possesses good insulation qualities and seals out moisture. Phonograph and 78 rpm gramophone records were made of shellac until they were replaced by vinyl long-playing records from 1948 onwards.

From the time shellac replaced oil and wax finishes in the 19th century, it was one of the dominant wood finishes in the western world until it was largely replaced by nitrocellulose lacquer in the 1920s and 1930s.

🔗 Aviation 🔗 Military history 🔗 Military history/Military aviation 🔗 Aviation/Aviation accident 🔗 Military history/Cold War 🔗 Military history/Russian, Soviet and CIS military history 🔗 Finland

Finnair Flight 915 (AY915) was a scheduled flight by Finnair from Tokyo, Japan, over the North Pole to Helsinki, Finland, on 23 December 1987. In 2014, Finnish media reported a claim by two of the flight’s pilots that the Soviet Union had fired a missile at the aircraft, which exploded less than 30 seconds before impact. The allegations came out only in September 2014, when Helsingin Sanomat, the leading Finnish daily newspaper, published an extensive article on the matter. The Finnish Broadcasting Corporation YLE reported on the article on the internet the same day.

When the matter came out, it caused outrage in Finland among those politicians and civil servants, to whom it should have been reported at the time, and it was widely publicised and commented upon in the Finnish media, amidst allegations of Finlandization.

The alleged incident has been compared to other similar incidents involving the Soviet Union, such as the Aero Kaleva in 1940, Aeroflot Flight 902 in 1962, Korean Air Lines Flight 902 in 1978, Korean Air Lines Flight 007 in 1983. Co-captain Kaukiainen said that the Finnair pilots decided to speak out on the matter after Malaysia Airlines Flight 17 had been shot down in Ukraine on 17 July 2014.

🔗 United Kingdom 🔗 Trains 🔗 Ireland

In British and Irish rail transport, a slip coach or slip carriage is passenger rolling stock that is uncoupled from an express train while the train is in motion, then slowed by a guard in the coach using the brakes, bringing it to a stop at the next station. The coach was thus said to be slipped from its train. This allowed passengers to alight at an intermediate station without the main train having to stop, thus improving the journey time of the main train. In an era when the railway companies were highly competitive, they strove to keep journey times as short as possible, avoiding intermediate stops wherever possible.

🔗 Climate change 🔗 China 🔗 Meteorology 🔗 Classical Greece and Rome 🔗 Greece 🔗 Rome 🔗 Ireland 🔗 Greece/Byzantine world 🔗 Peru

The extreme weather events of 535–536 were the most severe and protracted short-term episodes of cooling in the Northern Hemisphere in the last 2,000 years. The event is thought to have been caused by an extensive atmospheric dust veil, possibly resulting from a large volcanic eruption in the tropics or in Iceland. Its effects were widespread, causing unseasonable weather, crop failures, and famines worldwide.

🔗 Books 🔗 Urban studies and planning

The High Cost of Free Parking is an urban planning book by UCLA professor Donald Shoup dealing with the costs of free parking on society. It is structured as a criticism of the planning and regulation of parking and recommends that parking be built and allocated according to its fair market value. It incorporates elements of Shoup's Georgist philosophy.

The book was originally published in 2005 by the American Planning Association and the Planners Press. A revised edition was released in 2011 by Routledge.