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🔗 Arthropods

Neobuthus factorio is a species of scorpion from the family Buthidae found in Somalia.

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 Internet 🔗 Computing 🔗 Computing/Computer Security 🔗 Computing/Websites 🔗 Computing/Networking

Domain fronting is a technique for Internet censorship circumvention that uses different domain names in different communication layers of an HTTPS connection to discreetly connect to a different target domain than is discernable to third parties monitoring the requests and connections.

Due to quirks in security certificates, the redirect systems of the content delivery networks (CDNs) used as 'domain fronts', and the protection provided by HTTPS, censors are typically unable to differentiate circumvention ("domain-fronted") traffic from overt non-fronted traffic for any given domain name. As such they are forced to either allow all traffic to the domain front—including circumvention traffic—or block the domain front entirely, which may result in expensive collateral damage and has been likened to "blocking the rest of the Internet".

Domain fronting does not conform to HTTP standards that require the SNI extension and HTTP Host header to contain the same domain. Many large cloud service providers, including Amazon, Microsoft, and Google, actively prohibit domain fronting, which has limited it as a censorship bypass technique. Pressure from censors in Russia and China is thought to have contributed to these prohibitions, but domain fronting can also be used maliciously.

A newer variant of domain fronting, domain hiding, passes an encrypted request for one resource (say, a website), concealed behind an unencrypted (plaintext) request for another resource whose DNS records are stored in the same cloud. It has much the same effect. Refraction networking is an application of the broader principle.

🔗 United States 🔗 Donald Trump 🔗 Taiwan

The Trump–Tsai call was a telephone conversation between the U.S President-elect Donald Trump and the President of Taiwan Tsai Ing-wen which took place on December 2, 2016. This event marked the first time since 1979 that a U.S. president or President-elect had directly spoken with a ROC President. In the call, Tsai congratulated Trump for his victory in the presidential election. The two leaders spoke for around 10 minutes, focusing on politics, economy, and security in Asia-Pacific. Following the call, Trump publicized this on Twitter and Facebook and said thank you to "the President of Taiwan". After Trump's transition team confirmed the event, the Presidential Office of Taiwan released a statement about the content of the call.

Several prominent Republicans praised the call between the two leaders, saying that the United States needs no more pressure from the government of the People's Republic of China (commonly called "China"), which does not recognize the ROC government and claims Taiwan is part of its territory. Some commentators from U.S. media outlets said that the call humiliated Beijing as it seemed a violation of a diplomatic practice. Other media and comments criticized the One-China policy, saying that Trump's move was morally right and strategically correct for American interests. Wang Yi, the Foreign Minister of the People's Republic of China subsequently responded that this event is only a "small trick" played by Taiwan and will not change the One-China Policy. A spokesperson for the Presidential Office in Taipei expressed that there is no conflict between the Cross-Strait relations and the Taiwan–U.S. relations. The Obama administration stated that the U.S. would uphold the One-China Policy. Trump later responded by saying that the U.S. did not have to follow that policy.

🔗 Biology 🔗 Neuroscience 🔗 Physiology 🔗 Science

A microtome (from the Greek mikros, meaning "small", and temnein, meaning "to cut") is a cutting tool used to produce extremely thin slices of material known as sections, with the process being termed microsectioning. Important in science, microtomes are used in microscopy for the preparation of samples for observation under transmitted light or electron radiation.

Microtomes use steel, glass or diamond blades depending upon the specimen being sliced and the desired thickness of the sections being cut. Steel blades are used to prepare histological sections of animal or plant tissues for light microscopy. Glass knives are used to slice sections for light microscopy and to slice very thin sections for electron microscopy. Industrial grade diamond knives are used to slice hard materials such as bone, teeth and tough plant matter for both light microscopy and for electron microscopy. Gem-quality diamond knives are also used for slicing thin sections for electron microscopy.

Microtomy is a method for the preparation of thin sections for materials such as bones, minerals and teeth, and an alternative to electropolishing and ion milling. Microtome sections can be made thin enough to section a human hair across its breadth, with section thickness between 50 nm and 100 μm.

🔗 Novels 🔗 Radio 🔗 Novels/Science fiction 🔗 Novels/Short story

"The Machine Stops" is a science fiction short story (12,300 words) by E. M. Forster. After initial publication in The Oxford and Cambridge Review (November 1909), the story was republished in Forster's The Eternal Moment and Other Stories in 1928. After being voted one of the best novellas up to 1965, it was included that same year in the populist anthology Modern Short Stories. In 1973 it was also included in The Science Fiction Hall of Fame, Volume Two.

The story, set in a world where humanity lives underground and relies on a giant machine to provide its needs, predicted technologies similar to instant messaging and the Internet.

🔗 History of Science 🔗 Robotics

Leachim was an early example of Diphone synthetic speech and demonstrated how voice branching could be done quickly via computer discs to create understandable speech (i.e. verbal output). This method combined phonemes, words, and sentences to form verbal responsive messages when prompted by the computer. The device received attention on a world-wide basis because hundreds of articles were written about it.

🔗 Spaceflight 🔗 China

PAS-22, previously known as AsiaSat 3 and then HGS-1, was a geosynchronous communications satellite, which was salvaged from an unusable geosynchronous transfer orbit by means of the Moon's gravity.

🔗 Indigenous peoples of the Americas 🔗 Peru

Quipu (also spelled khipu) are recording devices fashioned from strings historically used by a number of cultures in the region of Andean South America. Knotted strings were used by many other cultures such as the ancient Chinese and native Hawaiians, but such practices should not be confused with the quipu, which refers only to the Andean device.

A quipu usually consisted of cotton or camelid fiber strings. The Inca people used them for collecting data and keeping records, monitoring tax obligations, properly collecting census records, calendrical information, and for military organization. The cords stored numeric and other values encoded as knots, often in a base ten positional system. A quipu could have only a few or thousands of cords. The configuration of the quipus has been "compared to string mops." Archaeological evidence has also shown the use of finely carved wood as a supplemental, and perhaps more sturdy, base to which the color-coded cords would be attached. A relatively small number have survived.

Objects that can be identified unambiguously as quipus first appear in the archaeological record in the first millennium AD. They subsequently played a key part in the administration of the Kingdom of Cusco and later Tawantinsuyu, the empire controlled by the Inca ethnic group, flourishing across the Andes from c. 1100 to 1532 AD. As the region was subsumed under the invading Spanish Empire, the quipu faded from use, to be replaced by European writing and numeral systems. However, in several villages, quipu continued to be important items for the local community, albeit for ritual rather than practical use. It is unclear as to where and how many intact quipus still exist, as many have been stored away in mausoleums.

Quipu is the Spanish spelling and the most common spelling in English. Khipu (pronounced [ˈkʰɪpʊ], plural: khipukuna) is the word for "knot" in Cusco Quechua. In most Quechua varieties, the term is kipu.

🔗 Video games 🔗 Video games/Nintendo

The video game crash of 1983 (known as the Atari shock in Japan) was a large-scale recession in the video game industry that occurred from 1983 to 1985, primarily in the United States. The crash was attributed to several factors, including market saturation in the number of game consoles and available games, and waning interest in console games in favor of personal computers. Revenues peaked at around $3.2 billion in 1983, then fell to around $100 million by 1985 (a drop of almost 97 percent). The crash abruptly ended what is retrospectively considered the second generation of console video gaming in North America.

Lasting about two years, the crash shook the then-booming industry, and led to the bankruptcy of several companies producing home computers and video game consoles in the region. Analysts of the time expressed doubts about the long-term viability of video game consoles and software.

The North American video game console industry eventually recovered a few years later, mostly due to the widespread success of the Nintendo Entertainment System (NES) in 1985; Nintendo designed the NES as the Western branding for its Famicom console originally released in 1983 in order to avoid the missteps which caused the 1983 crash and avoid the stigma which video games had at that time.