Have a deep view into what people are curious about.

🔗 Biography 🔗 Mathematics 🔗 Germany 🔗 Physics 🔗 Women scientists 🔗 Biography/science and academia 🔗 Women's History 🔗 Women writers 🔗 Physics/Biographies 🔗 Toys

🔗 Medicine 🔗 Cats 🔗 Microbiology 🔗 Veterinary medicine

Toxoplasma gondii () is a parasitic protozoan (specifically an apicomplexan) that causes toxoplasmosis. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals,^: 1 but felids are the only known definitive hosts in which the parasite may undergo sexual reproduction.

In rodents, T. gondii alters behavior in ways that increase the rodents' chances of being preyed upon by felids. Support for this "manipulation hypothesis" stems from studies showing that T. gondii-infected rats have a decreased aversion to cat urine while infection in mice lowers general anxiety, increases explorative behaviors and increases a loss of aversion to predators in general. Because cats are one of the only hosts within which T. gondii can sexually reproduce, such behavioral manipulations are thought to be evolutionary adaptations that increase the parasite's reproductive success since rodents that do not avoid cat habitations will more likely become cat prey. The primary mechanisms of T. gondii–induced behavioral changes in rodents occur through epigenetic remodeling in neurons that govern the relevant behaviors (e.g. hypomethylation of arginine vasopressin-related genes in the medial amygdala, which greatly decrease predator aversion).

In humans, particularly infants and those with weakened immunity, T. gondii infection is generally asymptomatic but may lead to a serious case of toxoplasmosis. T. gondii can initially cause mild, flu-like symptoms in the first few weeks following exposure, but otherwise, healthy human adults are asymptomatic. This asymptomatic state of infection is referred to as a latent infection, and it has been associated with numerous subtle behavioral, psychiatric, and personality alterations in humans. Behavioral changes observed between infected and non-infected humans include a decreased aversion to cat urine (but with divergent trajectories by gender) and an increased risk of schizophrenia. Preliminary evidence has suggested that T. gondii infection may induce some of the same alterations in the human brain as those observed in rodents. Many of these associations have been strongly debated and newer studies have found them to be weak, concluding:

On the whole, there was little evidence that T. gondii was related to increased risk of psychiatric disorder, poor impulse control, personality aberrations, or neurocognitive impairment.

T. gondii is one of the most common parasites in developed countries; serological studies estimate that up to 50% of the global population has been exposed to, and may be chronically infected with, T. gondii; although infection rates differ significantly from country to country. Estimates have shown the highest IgG seroprevalence to be in Ethiopia, at 64.2%, as of 2018.

🔗 Novels 🔗 Philosophy 🔗 Philosophy/Philosophical literature 🔗 Novels/Science fiction 🔗 Anthropology 🔗 Anti-war

Cat's Cradle is a satirical postmodern novel, with science fiction elements, by American writer Kurt Vonnegut. Vonnegut's fourth novel, it was first published in 1963, exploring and satirizing issues of science, technology, the purpose of religion, and the arms race, often through the use of black humor. After turning down his original thesis in 1947, the University of Chicago awarded Vonnegut his master's degree in anthropology in 1971 for Cat's Cradle.

🔗 Computing 🔗 Computing/Software 🔗 Computing/Free and open-source software

netcat (often abbreviated to nc) is a computer networking utility for reading from and writing to network connections using TCP or UDP. The command is designed to be a dependable back-end that can be used directly or easily driven by other programs and scripts. At the same time, it is a feature-rich network debugging and investigation tool, since it can produce almost any kind of connection its user could need and has a number of built-in capabilities.

Its list of features includes port scanning, transferring files, and port listening, and it can be used as a backdoor.

🔗 Medicine 🔗 Chemicals 🔗 Medicine/Neurology 🔗 Pharmacology 🔗 Medicine/Psychiatry 🔗 Epilepsy

Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.

Benzodiazepines are depressants that enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation. These properties make benzodiazepines useful in treating anxiety, panic disorder, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as short, intermediate, or long-acting. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety.

Benzodiazepines are generally viewed as safe and effective for short-term use—about two to four weeks—although cognitive impairment and paradoxical effects such as aggression or behavioral disinhibition can occur. A minority of people have paradoxical reactions after taking benzodiazepines such as worsened agitation or panic. Benzodiazepines are associated with an increased risk of suicide due to aggression, impulsivity, and negative withdrawal effects. Long-term use is controversial because of concerns about decreasing effectiveness, physical dependence, benzodiazepine withdrawal syndrome, and an increased risk of dementia and cancer. The elderly are at an increased risk of both short- and long-term adverse effects, and as a result, all benzodiazepines are listed in the Beers List of inappropriate medications for older adults. There is controversy concerning the safety of benzodiazepines in pregnancy. While they are not major teratogens, uncertainty remains as to whether they cause cleft palate in a small number of babies and whether neurobehavioural effects occur as a result of prenatal exposure; they are known to cause withdrawal symptoms in the newborn.

Taken in overdose, benzodiazepines can cause dangerous deep unconsciousness, but they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. Combined with other central nervous system (CNS) depressants such as alcohol and opioids, the potential for toxicity and fatal overdose increases significantly. Benzodiazepines are commonly used recreationally and also often taken in combination with other addictive substances, and are controlled in most countries.

🔗 United States 🔗 Elections and Referendums

The Massachusetts "Right to Repair" Initiative, also known as Question 1, appeared on the Massachusetts 2012 general election ballot as an initiated state statute. The Right to Repair proposal was to require vehicle owners and independent repair facilities in Massachusetts to have access to the same vehicle diagnostic and repair information made available to the manufacturers' Massachusetts dealers and authorized repair facilities. The initiative passed with overwhelming voter support on November 6, 2012, with 86% for and 14% against. The measure, originally filed four times with the Massachusetts Attorney General, was filed by Arthur W. Kinsman, and was assigned initiative numbers 11-17.

2019 Ballot Initiative In early 2019 the Massachusetts Legislature submitted bills advocating change to close loopholes associated with wireless transmission of diagnostic information. Advocates supporting an update to the Massachusetts Right to Repair law have announced that the required signatures have been gathered to place Right to Repair on the November 3, 2020 ballot.

🔗 Physics 🔗 Weather 🔗 Weather/Weather 🔗 Weather/General meteorology

A Fata Morgana (Italian: [ˈfaːta morˈɡaːna]) is a complex form of superior mirage visible in a narrow band right above the horizon. The term Fata Morgana is the Italian translation of "Morgan the Fairy" (Morgan le Fay of Arthurian legend). These mirages are often seen in the Italian Strait of Messina, and were described as fairy castles in the air or false land conjured by her magic.

Fata Morgana mirages significantly distort the object or objects on which they are based, often such that the object is completely unrecognizable. A Fata Morgana may be seen on land or at sea, in polar regions, or in deserts. It may involve almost any kind of distant object, including boats, islands, and the coastline. Often, a Fata Morgana changes rapidly. The mirage comprises several inverted (upside down) and upright images stacked on top of one another. Fata Morgana mirages also show alternating compressed and stretched zones.

The optical phenomenon occurs because rays of light bend when they pass through air layers of different temperatures in a steep thermal inversion where an atmospheric duct has formed. In calm weather, a layer of significantly warmer air may rest over colder dense air, forming an atmospheric duct that acts like a refracting lens, producing a series of both inverted and erect images. A Fata Morgana requires a duct to be present; thermal inversion alone is not enough to produce this kind of mirage. While a thermal inversion often takes place without there being an atmospheric duct, an atmospheric duct cannot exist without there first being a thermal inversion.

🔗 Anthropology 🔗 Archaeology 🔗 Yorkshire

The Heslington Brain is a 2,600-year-old human brain found inside a skull buried in a pit in Heslington, Yorkshire, in England, by York Archaeological Trust in 2008. It is the oldest preserved brain ever found in Eurasia, and is believed to be the best-preserved ancient brain in the world. The skull was discovered during an archaeological dig commissioned by the University of York on the site of its new campus on the outskirts of the city of York. The area was found to have been the site of well-developed permanent habitation between 2,000–3,000 years before the present day.

A number of possibly ritualistic objects were found to have been deposited in several pits, including the skull, which had belonged to a man probably in his 30s. He had been hanged before being decapitated with a knife and his skull appears to have been buried immediately. The rest of the body was missing. Although it is not known why he was killed, it is possible that it may have been a human sacrifice or ritual murder.

The brain was found while the skull was being cleaned. It had survived despite the rest of the tissue on the skull having disappeared long ago. After being extracted at York Hospital, the brain was subjected to a range of medical and forensic examinations by York Archaeological Trust which found that it was remarkably intact, though it had shrunk to only about 20% of its original size. It showed few signs of decay, though most of its original material had been replaced by an as yet unidentified organic compound, due to chemical changes during burial.

According to the archaeologists and scientists who have examined it, the brain has a "resilient, tofu-like texture". It is not clear why the Heslington brain survived, although the presence of a wet, anoxic environment underground seems to have been an essential factor, and research is still ongoing to shed light on how the local soil conditions may have contributed to its preservation.

WikiReader was a project to deliver an offline, text-only version of Wikipedia on a mobile device. The project was sponsored by Openmoko and made by Pandigital, and its source code has been released.

The project debuted an offline portable reader for Wikipedia in October 2009. Updates in multiple languages were available online and a twice-yearly offline update service delivered via Micro SD card was also available at a cost of $29 per year. WikiReader versions of the English Wikipedia, Wikiquote, Wiktionary and Project Gutenberg can be installed together on a user-supplied 16 GB Micro SDHC memory card. Unlike Wikipedia itself, the device features parental controls.

The device can also run programs written in the Forth programming language; a simple calculator program is included.

In late 2014, the WikiReader website and project itself were shut down and abandoned for unknown reasons. Existing WikiReaders no longer receive updates to their database. Devices, professionally produced updates, and homegrown updates continue to be available from the secondary markets (e.g. eBay and Amazon), as well as from community efforts centered around the WikiReader subreddit.

🔗 Military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry 🔗 Lists 🔗 Military history/Intelligence 🔗 Military history/Military land vehicles

This page contains a list of military tactics.

The meaning of the phrase is context sensitive, and has varied over time, like the difference between "strategy" and "tactics".