Have a deep view into what people are curious about.

🔗 Medicine 🔗 Chemicals 🔗 Medicine/Neurology 🔗 Pharmacology 🔗 Medicine/Psychiatry 🔗 Epilepsy

Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.

Benzodiazepines are depressants that enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation. These properties make benzodiazepines useful in treating anxiety, panic disorder, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as short, intermediate, or long-acting. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety.

Benzodiazepines are generally viewed as safe and effective for short-term use—about two to four weeks—although cognitive impairment and paradoxical effects such as aggression or behavioral disinhibition can occur. A minority of people have paradoxical reactions after taking benzodiazepines such as worsened agitation or panic. Benzodiazepines are associated with an increased risk of suicide due to aggression, impulsivity, and negative withdrawal effects. Long-term use is controversial because of concerns about decreasing effectiveness, physical dependence, benzodiazepine withdrawal syndrome, and an increased risk of dementia and cancer. The elderly are at an increased risk of both short- and long-term adverse effects, and as a result, all benzodiazepines are listed in the Beers List of inappropriate medications for older adults. There is controversy concerning the safety of benzodiazepines in pregnancy. While they are not major teratogens, uncertainty remains as to whether they cause cleft palate in a small number of babies and whether neurobehavioural effects occur as a result of prenatal exposure; they are known to cause withdrawal symptoms in the newborn.

Taken in overdose, benzodiazepines can cause dangerous deep unconsciousness, but they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. Combined with other central nervous system (CNS) depressants such as alcohol and opioids, the potential for toxicity and fatal overdose increases significantly. Benzodiazepines are commonly used recreationally and also often taken in combination with other addictive substances, and are controlled in most countries.

🔗 California 🔗 California/San Francisco Bay Area

The Centennial Light is the world's longest-lasting light bulb, burning since 1901, and almost never switched off. It is at 4550 East Avenue, Livermore, California, and maintained by the Livermore-Pleasanton Fire Department. Due to its longevity, the bulb has been noted by The Guinness Book of World Records, Ripley's Believe It or Not!, and General Electric.

🔗 Biology 🔗 Physiology

The axial twist theory (a.k.a. axial twist hypothesis) is a proposed scientific theory to explain a range of unusual aspects of the body plan of vertebrates (including humans). It states that the rostral part of the head is "turned around" regarding the rest of the body. This end-part consists of the face (eyes, nose, and mouth) as well as part of the brain (cerebrum and thalamus). According to the theory, the vertebrate body has a left-handed chirality.

The axial twist theory competes with a number of other proposals that focus on more limited, specific aspects, most of which explain contralateral forebrain organization, the phenomenon that the left side of the brain mainly controls the right side of the body and vice versa. None of the proposed theories explaining this phenomenon, including axial twist theory, have gained general recognition. The genetic basis underlying the proposed developmental twist is not yet understood.

The axial twist theory would explain various anatomical phenomena, and addresses how and when the proposed twist between the end of the head and the rest of the body develops. It also addresses the possible evolutionary history. One prediction of the theory was the aurofacial asymmetry, which was then found empirically, albeit by one of the authors of the original theory.

Phenomena the theory can explain include:

• Contralateral organization of the brain
• Left-sided orientation of the heart
• Asymmetric position of the gastrointestinal tract, the liver, and the pancreas
• Optic chiasm
• Chiasm of the trochlear nerve
• Non-crossed olfactory tract
• Aurofacial asymmetry
• Yakovlevian torque
• Asymmetry of the thoracal vertebra

According to the axial twist developmental model, the anterior part of the head turns against the rest of the body, except for the inner organs. Due to this twist, the forebrain and face are turned around such that left and right, but also anterior and posterior are flipped in the adult vertebrate.

🔗 Soviet Union 🔗 Russia 🔗 Russia/mass media in Russia 🔗 Television 🔗 Russia/history of Russia

Lenin was a mushroom (Russian: Ленин — гриб) was a highly influential televised hoax by Soviet musician Sergey Kuryokhin and reporter Sergey Sholokhov. It was first broadcast on 17 May 1991 on Leningrad Television.

The hoax took the form of an interview on the television program Pyatoe Koleso (The Fifth Wheel). In the interview, Kuryokhin, impersonating a historian, narrated his findings that Vladimir Lenin consumed large quantities of psychedelic mushrooms and eventually became a mushroom himself. Kuryokhin arrived at his conclusion through a long series of logical fallacies and appeals to the authority of various "sources" (such as Carlos Castaneda, the Massachusetts Institute of Technology, and Konstantin Tsiolkovsky), creating the illusion of a reasoned and plausible logical chain.

The timing of the hoax played a large role in its success, coming as it did during the Glasnost period when the ebbing of censorship in the Soviet Union led to many revelations about the country's history, often presented in sensational form. Furthermore, Soviet television had, up to that point, been regarded by its audience as conservative in style and content. As a result, a large number of Soviet citizens (one estimate puts the number at 11,250,000 audience members) took the deadpan "interview" at face value, in spite of the absurd claims presented.

Sholokhov has said that perhaps the most notable result of the show was an appeal by a group of party members to the Leningrad Regional Committee of the CPSU to clarify the veracity of Kuryokhin's claim. According to Sholokhov, in response to the request one of the top regional functionaries stated that "Lenin could not have been a mushroom" because "a mammal cannot be a plant." Modern taxonomy classifies mushrooms as fungi, a separate kingdom from plants.

The incident has served as a watershed moment in Soviet (and Russian) culture and has often been used as proof of the gullibility of the masses.

🔗 Politics 🔗 Socialism 🔗 Holidays 🔗 Organized Labour 🔗 Neopaganism

May Day is a public holiday in some regions, usually celebrated on 1 May or the first Monday of May. It is an ancient festival marking the first day of summer, and a current traditional spring holiday in many European cultures. Dances, singing, and cake are usually part of the festivities.

In 1889, May Day was chosen as the date for International Workers' Day by the socialists and communists of the Second International, as well as anarchists, labor activists, and leftists in general around the world, to commemorate the Haymarket affair in Chicago and the struggle for an eight-hour working day. International Workers' Day is also called "May Day", but it is a different celebration from the traditional May Day.

🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry 🔗 Physics 🔗 Chemistry

FOGBANK is a code name given to a material used in nuclear weapons such as the W76, W78 and W80.

FOGBANK's precise nature is classified; in the words of former Oak Ridge general manager Dennis Ruddy, "The material is classified. Its composition is classified. Its use in the weapon is classified, and the process itself is classified." Department of Energy Nuclear Explosive Safety documents simply describe it as a material "used in nuclear weapons and nuclear explosives" along with lithium hydride (LiH) and lithium deuteride (LiD), beryllium (Be), uranium hydride (UH₃), and plutonium hydride.

However National Nuclear Security Administration (NNSA) Administrator Tom D'Agostino disclosed the role of FOGBANK in the weapon: "There's another material in the—it's called interstage material, also known as fog bank", and arms experts believe that FOGBANK is an aerogel material which acts as an interstage material in a nuclear warhead; i.e., a material designed to become a superheated plasma following the detonation of the weapon's fission stage, the plasma then triggering the fusion-stage detonation.

🔗 Archaeology 🔗 Wiltshire

The Stonehenge Archer is the name given to a Bronze Age man whose body was discovered in the outer ditch of Stonehenge. Unlike most burials in the Stonehenge Landscape, his body was not in a barrow, although it did appear to have been deliberately and carefully buried in the ditch.

Examination of the skeleton indicated that the man was local to the area and aged about 30 when he died. Radiocarbon dating suggests that he died around 2300 BCE, making his death roughly contemporary with the Amesbury Archer and the Boscombe Bowmen buried 3 miles away in Amesbury.

He came to be known as an archer because of the stone wrist-guard and a number of flint arrowheads buried with him. In fact, several of the arrowheads' tips were located in the skeleton's bones, suggesting that the man had been killed by them.

His body was excavated in 1978 by Richard Atkinson and John G. Evans who had been re-examining an older trench in the ditch and bank of Stonehenge. His remains are now housed in the Salisbury Museum in Salisbury.

🔗 Cryptography 🔗 Cryptography/Computer science 🔗 Judaism

Atbash (Hebrew: אתבש‎; also transliterated Atbaš) is a monoalphabetic substitution cipher originally used to encrypt the Hebrew alphabet. It can be modified for use with any known writing system with a standard collating order.

🔗 Biography 🔗 Aviation 🔗 Soviet Union 🔗 Military history 🔗 Military history/Military biography 🔗 Aviation/aerospace biography 🔗 Cold War 🔗 Military history/Russian, Soviet and CIS military history 🔗 Aviation/Soviet aviation

Stanislav Yevgrafovich Petrov (Russian: Станисла́в Евгра́фович Петро́в; 7 September 1939 – 19 May 2017) was a lieutenant colonel of the Soviet Air Defence Forces who played a key role in the 1983 Soviet nuclear false alarm incident. On 26 September 1983, three weeks after the Soviet military had shot down Korean Air Lines Flight 007, Petrov was the duty officer at the command center for the Oko nuclear early-warning system when the system reported that a missile had been launched from the United States, followed by up to five more. Petrov judged the reports to be a false alarm, and his decision to disobey orders, against Soviet military protocol, is credited with having prevented an erroneous retaliatory nuclear attack on the United States and its NATO allies that could have resulted in large-scale nuclear war. Investigation later confirmed that the Soviet satellite warning system had indeed malfunctioned.

🔗 United States 🔗 Aviation 🔗 Military history 🔗 Military history/Military aviation 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Crime 🔗 Business 🔗 Politics 🔗 Military history/German military history 🔗 Military history/Dutch military history 🔗 Japan 🔗 Japan/Japanese military history 🔗 Military history/Asian military history 🔗 Military history/Japanese military history 🔗 Military history/Italian military history 🔗 Japan/Politics 🔗 Military history/European military history

The Lockheed bribery scandals encompassed a series of bribes and contributions made by officials of U.S. aerospace company Lockheed from the late 1950s to the 1970s in the process of negotiating the sale of aircraft.

The scandal caused considerable political controversy in West Germany, Italy, the Netherlands and Japan. In the U.S., the scandal nearly led to Lockheed's downfall, as it was already struggling due to the commercial failure of the L-1011 TriStar airliner.