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🔗 Computing 🔗 Computing/Early computers

The IBM 7950, also known as Harvest, was a one-of-a-kind adjunct to the Stretch computer which was installed at the United States National Security Agency (NSA). Built by IBM, it was delivered in 1962 and operated until 1976, when it was decommissioned. Harvest was designed to be used for cryptanalysis.

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Computing 🔗 Computing/Software 🔗 Computing/Computer science

"The Complexity of Songs" is a journal article published by computer scientist Donald Knuth in 1977, as an in-joke about computational complexity theory. The article capitalizes on the tendency of popular songs to devolve from long and content-rich ballads to highly repetitive texts with little or no meaningful content. The article notes that a song of length N words may be produced remembering, e.g., only O(log N) words ("space complexity" of the song).

🔗 Psychology 🔗 Anthropology 🔗 Sociology

Dunbar's number is a suggested cognitive limit to the number of people with whom one can maintain stable social relationships—relationships in which an individual knows who each person is and how each person relates to every other person. This number was first proposed in the 1990s by British anthropologist Robin Dunbar, who found a correlation between primate brain size and average social group size. By using the average human brain size and extrapolating from the results of primates, he proposed that humans can comfortably maintain 150 stable relationships. Dunbar explained it informally as "the number of people you would not feel embarrassed about joining uninvited for a drink if you happened to bump into them in a bar".

Proponents assert that numbers larger than this generally require more restrictive rules, laws, and enforced norms to maintain a stable, cohesive group. It has been proposed to lie between 100 and 250, with a commonly used value of 150. Dunbar's number states the number of people one knows and keeps social contact with, and it does not include the number of people known personally with a ceased social relationship, nor people just generally known with a lack of persistent social relationship, a number which might be much higher and likely depends on long-term memory size.

Dunbar theorised that "this limit is a direct function of relative neocortex size, and that this in turn limits group size [...] the limit imposed by neocortical processing capacity is simply on the number of individuals with whom a stable inter-personal relationship can be maintained". On the periphery, the number also includes past colleagues, such as high school friends, with whom a person would want to reacquaint himself or herself if they met again.

🔗 Philosophy 🔗 Philosophy/Philosophy of science 🔗 Philosophy/Epistemology

Molyneux's problem is a thought experiment in philosophy concerning immediate recovery from blindness. It was first formulated by William Molyneux, and notably referred to in John Locke's An Essay Concerning Human Understanding (1689). The problem can be stated in brief, "if a man born blind can feel the differences between shapes such as spheres and cubes, could he, if given the ability to see, distinguish those objects by sight alone, in reference to the tactile schemata he already possessed?"

🔗 Religion 🔗 Ancient Near East 🔗 Books 🔗 Iraq 🔗 Mythology 🔗 Arab world

The "Debate between sheep and grain" or "Myth of cattle and grain" is a Sumerian creation myth, written on clay tablets in the mid to late 3rd millennium BCE.

🔗 Mathematics

In knot theory, Conway notation, invented by John Horton Conway, is a way of describing knots that makes many of their properties clear. It composes a knot using certain operations on tangles to construct it.

🔗 Apple Inc. 🔗 Video games 🔗 Computing

The Apple Pippin is a defunct open multimedia technology platform, designed by Apple Computer, and marketed as PiPP!N. According to Apple, Pippin was directed at the home market as "an integral part of the consumer audiovisual, stereo, and television environment."

Pippin is based on the Apple Macintosh platform, including the classic Mac OS architecture. Apple built a demonstration device based on Pippin called "Pippin Power Player," and used it to demonstrate the platform at trade shows and to the media, in order to attract potential software developers and hardware manufacturers. Apple licensed the Pippin technology to third-party companies. Bandai Company Ltd. developed the ATMARK and @WORLD models, and focused them on the gaming and entertainment business in Japan and the United States. Katz Media developed the KMP 2000, and focused it on vertical markets throughout Europe and Canada.

🔗 Medicine 🔗 Medicine/Society and Medicine 🔗 Cambodia 🔗 Medicine/Reproductive medicine

Lucky Iron Fish are fish-shaped cast iron ingots used to provide dietary supplementation of iron to individuals affected by iron-deficiency anaemia. The ingots are placed in a pot of boiling water to leach elemental iron into the water and food. They were developed in 2008 by Canadian health workers in Cambodia, and in 2012 a company, The Lucky Iron Fish Project, was formed to develop the iron fish on a larger scale, promote them among rural areas, and distribute them to non-governmental organization partners. Notably, recent research found that the iron ingot had no effect on anemia. It therefore recommended against its use in Cambodia and other countries with low levels of iron deficiency.

🔗 Visual arts

A pointing machine is a measuring tool used by stone sculptors and woodcarvers to accurately copy plaster, clay or wax sculpture models into wood or stone. In essence the device is a pointing needle that can be set to any position and then fixed. It further consists of brass or stainless steel rods and joints which can be placed into any position and then tightened. It is not actually a machine; its name is derived from the Italian macchinetta di punta. The invention of the tool has been ascribed to both the French sculptor and medallist Nicolas-Marie Gatteaux (1751–1832) and to the British sculptor John Bacon (1740–1799). It was later perfected by Canova. However, similar devices were used in ancient times, when the copying of Greek sculptures for the Roman market was a large industry.