Topic: Biology

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๐Ÿ”— Purple Earth Hypothesis

๐Ÿ”— Biology ๐Ÿ”— Astronomy ๐Ÿ”— Color ๐Ÿ”— Evolutionary biology

The Purple Earth Hypothesis (PEH) is an astrobiological hypothesis, first proposed by molecular biologist Shiladitya DasSarma in 2007, that the earliest photosynthetic life forms of Early Earth were based on the simpler molecule retinal rather than the more complex porphyrin-based chlorophyll, making the surface biosphere appear purplish rather than its current greenish color. It is estimated to have occurred between 3.5 and 2.4 billion years ago during the Archean eon, prior to the Great Oxygenation Event and Huronian glaciation.

Retinal-containing cell membranes exhibit a single light absorption peak centered in the energy-rich green-yellow region of the visible spectrum, but transmit and reflect red and blue light, resulting in a magenta color. Chlorophyll pigments, in contrast, absorb red and blue light, but little or no green light, which results in the characteristic green reflection of plants, green algae, cyanobacteria and other organisms with chlorophyllic organelles. The simplicity of retinal pigments in comparison to the more complex chlorophyll, their association with isoprenoid lipids in the cell membrane, as well as the discovery of archaeal membrane components in ancient sediments on the Early Earth are consistent with an early appearance of life forms with purple membranes prior to the turquoise of the Canfield ocean and later green photosynthetic organisms.

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๐Ÿ”— Dallol

๐Ÿ”— Volcanoes ๐Ÿ”— Biology ๐Ÿ”— Africa ๐Ÿ”— Geology ๐Ÿ”— Ethiopia

Dallol is a unique, terrestrial hydrothermal system around a cinder cone volcano in the Danakil Depression, northeast of the Erta Ale Range in Ethiopia. It is known for its unearthly colors and mineral patterns, and the very acidic fluids that discharge from its hydrothermal springs.

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๐Ÿ”— Axial twist theory

๐Ÿ”— Biology ๐Ÿ”— Physiology

The axial twist theory (a.k.a. axial twist hypothesis) is a proposed scientific theory to explain a range of unusual aspects of the body plan of vertebrates (including humans). It states that the rostral part of the head is "turned around" regarding the rest of the body. This end-part consists of the face (eyes, nose, and mouth) as well as part of the brain (cerebrum and thalamus). According to the theory, the vertebrate body has a left-handed chirality.

The axial twist theory competes with a number of other proposals that focus on more limited, specific aspects, most of which explain contralateral forebrain organization, the phenomenon that the left side of the brain mainly controls the right side of the body and vice versa. None of the proposed theories explaining this phenomenon, including axial twist theory, have gained general recognition. The genetic basis underlying the proposed developmental twist is not yet understood.

The axial twist theory would explain various anatomical phenomena, and addresses how and when the proposed twist between the end of the head and the rest of the body develops. It also addresses the possible evolutionary history. One prediction of the theory was the aurofacial asymmetry, which was then found empirically, albeit by one of the authors of the original theory.

Phenomena the theory can explain include:

  • Contralateral organization of the brain
  • Left-sided orientation of the heart
  • Asymmetric position of the gastrointestinal tract, the liver, and the pancreas
  • Optic chiasm
  • Chiasm of the trochlear nerve
  • Non-crossed olfactory tract
  • Aurofacial asymmetry
  • Yakovlevian torque
  • Asymmetry of the thoracal vertebra

According to the axial twist developmental model, the anterior part of the head turns against the rest of the body, except for the inner organs. Due to this twist, the forebrain and face are turned around such that left and right, but also anterior and posterior are flipped in the adult vertebrate.

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๐Ÿ”— Mirror life

๐Ÿ”— Biology ๐Ÿ”— Molecular and Cell Biology ๐Ÿ”— Chemistry ๐Ÿ”— Genetics

Mirror life (also called mirror-image life, chiral life, or enantiomeric life) is a hypothetical form of life with mirror-reflected molecular building blocks. The possibility of mirror life was first discussed by Louis Pasteur. Although this alternative life form has not been discovered in nature, efforts to build a mirror-image version of biology's molecular machinery are already underway.

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๐Ÿ”— Blue Field Entoptic Phenomenon

๐Ÿ”— Medicine ๐Ÿ”— Biology

The blue field entoptic phenomenon is an entoptic phenomenon characterized by the appearance of tiny bright dots (nicknamed blue-sky sprites) moving quickly along undulating pathways in the visual field, especially when looking into bright blue light such as the sky. The dots are short-lived, visible for about one second or less, and traveling short distances along seemingly random, undulating paths. Some of them seem to follow the same path as other dots before them. The dots may appear elongated along the path, like tiny worms. The dots' rate of travel appears to vary in synchrony with the heartbeat: they briefly accelerate at each beat. The dots appear in the central field of view, within 15 degrees from the fixation point. The left and right eye see different, seemingly random, dot patterns; a person viewing through both eyes sees a combination of both left and right visual field disturbances. While seeing the phenomenon, lightly pressing inward on the sides of the eyeballs at the lateral canthus causes the movement to stop being fluid and the dots to move only when the heart beats.

Most people are able to see this phenomenon in the sky, although it is relatively weak in most instances; many will not notice it until asked to pay attention. The dots are highly conspicuous against any monochromatic blue background of a wavelength of around 430ย nm in place of the sky. The phenomenon is also known as Scheerer's phenomenon, after the German ophthalmologist Richard Scheerer, who first drew clinical attention to it in 1924.

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๐Ÿ”— Belyayev's Fox Experiment

๐Ÿ”— Biography ๐Ÿ”— Soviet Union ๐Ÿ”— Russia ๐Ÿ”— Biology ๐Ÿ”— Biography/science and academia ๐Ÿ”— Russia/science and education in Russia ๐Ÿ”— Genetics ๐Ÿ”— Russia/physical geography of Russia

Dmitry Konstantinovich Belyayev (Russian: ะ”ะผะธฬั‚ั€ะธะน ะšะพะฝัั‚ะฐะฝั‚ะธฬะฝะพะฒะธั‡ ะ‘ะตะปัฬะตะฒ, 17 July 1917 โ€“ 14 November 1985) was a Russian geneticist and academician who served as director of the Institute of Cytology and Genetics (IC&G) of the USSR Academy of Sciences, Novosibirsk, from 1959 to 1985. His decades-long effort to breed domesticated foxes was described by The New York Times as โ€œarguably the most extraordinary breeding experiment ever conducted.โ€ A 2010 article in Scientific American stated that Belyayev โ€œmay be the man most responsible for our understanding of the process by which wolves were domesticated into our canine companions.โ€

Beginning in the 1950s, in order to uncover the genetic basis of the distinctive behavioral and physiological attributes of domesticated animals, Belyayev and his team spent decades breeding the wild silver fox (Vulpes vulpes) and selecting for reproduction only those individuals in each generation that showed the least fear of humans. After several generations of controlled breeding, a majority of the silver foxes no longer showed any fear of humans and often wagged their tails and licked their human caretakers to show affection. They also began to display spotted coats, floppy ears, curled tails, as well as other physical attributes often found in domesticated animals, thus confirming Belyayevโ€™s hypothesis that both the behavioral and physical traits of domesticated animals could be traced to "a collection of genes that conferred a propensity to tamenessโ€”a genotype that the foxes perhaps shared with any species that could be domesticated".

Belyayevโ€™s experiments were the result of a politically motivated demotion, in response to defying the now discredited non-Mendellian theories of Lysenkoism, which were politically accepted in the Soviet Union at the time. Belyayev has since been vindicated in recent years by major scientific journals, and by the Soviet establishment as a pioneering figure in modern genetics.

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๐Ÿ”— HeLa, the oldest and most commonly used human cell line

๐Ÿ”— Viruses ๐Ÿ”— Biology ๐Ÿ”— Philosophy ๐Ÿ”— Philosophy/Contemporary philosophy ๐Ÿ”— History of Science ๐Ÿ”— Molecular and Cell Biology ๐Ÿ”— Philosophy/Ethics ๐Ÿ”— Genetics ๐Ÿ”— Evolutionary biology ๐Ÿ”— Science Policy ๐Ÿ”— Molecular Biology/Molecular and Cell Biology

HeLa (; also Hela or hela) is an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line. The line was derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific, which gives rise to its extensive use in scientific research.

The cells from Lacks's cancerous cervical tumor were taken without her knowledge or consent, which was common practice at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Scientists would spend more time trying to keep the cells alive than performing actual research on them. Cells from Lacks' tumor behaved differently. As was custom for Gey's lab assistant, she labeled the culture 'HeLa', the first two letters of the patient's first and last name; this became the name of the cell line.

These were the first human cells grown in a lab that were naturally "immortal", meaning that they do not die after a set number of cell divisions (i.e. cellular senescence). These cells could be used for conducting a multitude of medical experimentsโ€”if the cells died, they could simply be discarded and the experiment attempted again on fresh cells from the culture. This represented an enormous boon to medical and biological research, as previously stocks of living cells were limited and took significant effort to culture.

The stable growth of HeLa enabled a researcher at the University of Minnesota hospital to successfully grow polio virus, enabling the development of a vaccine, and by 1952, Jonas Salk developed a vaccine for polio using these cells. To test Salk's new vaccine, the cells were put into mass production in the first-ever cell production factory.

In 1953, HeLa cells were the first human cells successfully cloned and demand for the HeLa cells quickly grew in the nascent biomedical industry. Since the cells' first mass replications, they have been used by scientists in various types of investigations including disease research, gene mapping, effects of toxic substances on organisms, and radiation on humans. Additionally, HeLa cells have been used to test human sensitivity to tape, glue, cosmetics, and many other products.

Scientists have grown an estimated 50 million metricย tons of HeLa cells, and there are almost 11,000ย patents involving these cells.

The HeLa cell lines are also notorious for invading other cell cultures in laboratory settings. Some have estimated that HeLa cells have contaminated 10โ€“20% of all cell lines currently in use.

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๐Ÿ”— Thermal Grill Illusion

๐Ÿ”— Biology

The thermal grill illusion is a sensory illusion originally demonstrated in 1896 by the Swedish physician Torsten Thunberg. The illusion is created by an interlaced grill of warm (e.g., 40ยฐC/104ยฐF) and cool (20ยฐC/68ยฐF) bars. When someone presses a hand against the grill, they experience the illusion of burning heat. But if the person presses against only a cool bar, only coolness is experienced; if the person presses against only a warm bar, only warmth is experienced.

Researchers have used the illusion to demonstrate that burning pain sensation is in fact a mixture of both cold and heat pain and that it is only the inhibition of the cold pain "channel" that reveals the heat component.

The illusion is demonstrated by positioning the middle finger in cold water and the ring and index fingers in warm water. Due to shortcomings in the body map - multisensory representation of the body - and this particular sensory input configuration, the brain is tricked into thinking the middle finger is in the warm water and the index and ring fingers in cold water.

In an fMRI experiment of the illusion, researchers recently observed an activation of the thalamus not seen for control stimuli. Also, activity in a portion of the right mid/anterior insula correlated with the perceived unpleasantness of the illusion.

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๐Ÿ”— Panspermia

๐Ÿ”— Biology ๐Ÿ”— Skepticism ๐Ÿ”— Solar System

Panspermia (from Ancient Greek ฯ€แพถฮฝ (pan), meaning 'all', and ฯƒฯ€ฮญฯฮผฮฑ (sperma), meaning 'seed') is the hypothesis that life exists throughout the Universe, distributed by space dust, meteoroids, asteroids, comets, planetoids, and also by spacecraft carrying unintended contamination by microorganisms. Distribution may have occurred spanning galaxies, and so may not be restricted to the limited scale of solar systems.

Panspermia hypotheses propose (for example) that microscopic life-forms that can survive the effects of space (such as extremophiles) can become trapped in debris ejected into space after collisions between planets and small Solar System bodies that harbor life. Some organisms may travel dormant for an extended amount of time before colliding randomly with other planets or intermingling with protoplanetary disks. Under certain ideal impact circumstances (into a body of water, for example), and ideal conditions on a new planet's surfaces, it is possible that the surviving organisms could become active and begin to colonize their new environment. At least one report finds that endospores from a type of Bacillus bacteria found in Morocco can survive being heated to 420ย ยฐC (788ย ยฐF), making the argument for Panspermia even stronger. Panspermia studies concentrate not on how life began, but on methods that may distribute it in the Universe.

Pseudo-panspermia (sometimes called "soft panspermia" or "molecular panspermia") argues that the pre-biotic organic building-blocks of life originated in space, became incorporated in the solar nebula from which planets condensed, and were furtherโ€”and continuouslyโ€”distributed to planetary surfaces where life then emerged (abiogenesis). From the early 1970s, it started to become evident that interstellar dust included a large component of organic molecules. Interstellar molecules are formed by chemical reactions within very sparse interstellar or circumstellar clouds of dust and gas. The dust plays a critical role in shielding the molecules from the ionizing effect of ultraviolet radiation emitted by stars.

The chemistry leading to life may have begun shortly after the Big Bang, 13.8 billion years ago, during a habitable epoch when the Universe was only 10 to 17 million years old. Though the presence of life is confirmed only on the Earth, some scientists think that extraterrestrial life is not only plausible, but probable or inevitable. Probes and instruments have started examining other planets and moons in the Solar System and in other planetary systems for evidence of having once supported simple life, and projects such as SETI attempt to detect radio transmissions from possible extraterrestrial civilizations.

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