Have a deep view into what people are curious about.

🔗 Musical Instruments 🔗 Electronic music

The Trautonium is an electronic synthesizer invented in 1930 by Friedrich Trautwein in Berlin at the Musikhochschule's music and radio lab, the Rundfunkversuchstelle. Soon afterwards Oskar Sala joined him, continuing development until Sala's death in 2002.

🔗 Skepticism 🔗 Neuroscience 🔗 Physiology

The gut–brain axis is the two-way biochemical signaling that takes place between the gastrointestinal tract (GI tract) and the central nervous system (CNS). The term "gut–brain axis" is occasionally used to refer to the role of the gut microbiota in the interplay as well. The "microbiota–gut–brain (MGB or BGM) axis" explicitly includes the role of gut microbiota in the biochemical signaling events that take place between the GI tract and the CNS. Broadly defined, the gut–brain axis includes the central nervous system, neuroendocrine system, neuroimmune systems, the hypothalamic–pituitary–adrenal axis (HPA axis), sympathetic and parasympathetic arms of the autonomic nervous system, the enteric nervous system, vagus nerve, and the gut microbiota.

Chemicals released in the gut by the microbiome can vastly influence the development of the brain, starting from birth. A review from 2015 states that the microbiome influences the central nervous system by “regulating brain chemistry and influencing neuro-endocrine systems associated with stress response, anxiety and memory function”. The gut, sometimes referred to as the “second brain”, functions off of the same type of neural network as the central nervous system, suggesting why it plays a significant role in brain function and mental health.

The bidirectional communication is done by immune, endocrine, humoral and neural connections between the gastrointestinal tract and the central nervous system. More research suggests that the gut microorganisms influence the function of the brain by releasing the following chemicals: cytokines, neurotransmitters, neuropeptides, chemokines, endocrine messengers and microbial metabolites such as "short-chain fatty acids, branched chain amino acids, and peptidoglycans”. The intestinal microbiome can then divert these products to the brain via the blood, neuropod cells, nerves, endocrine cells and more to be determined. The products then arrive at important locations in the brain, impacting different metabolic processes. Studies have confirmed communication between the hippocampus, the prefrontal cortex and the amygdala (responsible for emotions and motivation), which acts as a key node in the gut-brain behavioral axis.

While IBS is the only disease confirmed to be directly influenced by the gut microbiome, many disorders (such as anxiety, autism, depression and schizophrenia) have been linked to the gut-brain axis as well. The impact of the axis, and the various ways in which one can influence it, remains a promising research field which could result in future treatments for psychiatric, age-related, neurodegenerative and neurodevelopmental disorders. For example, according to a study from 2017, “probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression”.

The first of the brain–gut interactions shown, was the cephalic phase of digestion, in the release of gastric and pancreatic secretions in response to sensory signals, such as the smell and sight of food. This was first demonstrated by Pavlov through Nobel prize winning research in 1904.

Scientific interest in the field had already led to review in the second half of the 20th century. It was promoted further by a 2004 primary research study showing that germ-free (GF) mice showed an exaggerated HPA axis response to stress compared to non-GF laboratory mice.

As of October 2016, most of the work done on the role of gut microbiota in the gut–brain axis had been conducted in animals, or on characterizing the various neuroactive compounds that gut microbiota can produce. Studies with humans – measuring variations in gut microbiota between people with various psychiatric and neurological conditions or when stressed, or measuring effects of various probiotics (dubbed "psychobiotics" in this context) – had generally been small and were just beginning to be generalized. Whether changes to the gut microbiota are a result of disease, a cause of disease, or both in any number of possible feedback loops in the gut–brain axis, remained unclear.

🔗 Extinction

An endling is the last known individual of a species or subspecies. Once the endling dies, the species becomes extinct. The word was coined in correspondence in the scientific journal Nature. Alternative names put forth for the last individual of its kind include ender and terminarch.

The word relict may also be used, but usually refers to a population, rather than an individual, that is the last of a species.

A milk watcher, milk saver, pot watcher, pot minder, milk guard, or boil over preventer is a cooking utensil placed at the bottom of a pot to prevent the foaming boil-over of liquids by collecting small bubbles of steam into one large bubble.

🔗 Computing 🔗 Perl

The WikiWikiWeb is the first-ever wiki, or user-editable website. It was launched on 25 March 1995 by its inventor, programmer Ward Cunningham, to accompany the Portland Pattern Repository website discussing software design patterns. The name WikiWikiWeb originally also applied to the wiki software that operated the website, written in the Perl programming language and later renamed to "WikiBase". The site is frequently referred to by its users as simply "Wiki", and a convention established among users of the early network of wiki sites that followed was that using the word with a capitalized W referred exclusively to the original site.

🔗 Computer science

In computer science, the maximum sum subarray problem, also known as the maximum segment sum problem, is the task of finding a contiguous subarray with the largest sum, within a given one-dimensional array A[1...n] of numbers. Formally, the task is to find indices ${\displaystyle i}$ and ${\displaystyle j}$ with ${\displaystyle 1\leq i\leq j\leq n}$, such that the sum

${\displaystyle \sum _{x=i}^{j}A[x]}$

is as large as possible. (Some formulations of the problem also allow the empty subarray to be considered; by convention, the sum of all values of the empty subarray is zero.) Each number in the input array A could be positive, negative, or zero.

For example, for the array of values [−2, 1, −3, 4, −1, 2, 1, −5, 4], the contiguous subarray with the largest sum is [4, −1, 2, 1], with sum 6.

Some properties of this problem are:

1. If the array contains all non-negative numbers, then the problem is trivial; a maximum subarray is the entire array.
2. If the array contains all non-positive numbers, then a solution is any subarray of size 1 containing the maximal value of the array (or the empty subarray, if it is permitted).
3. Several different sub-arrays may have the same maximum sum.

This problem can be solved using several different algorithmic techniques, including brute force, divide and conquer, dynamic programming, and reduction to shortest paths.

🔗 Russia 🔗 Crime 🔗 Death

The 2022 Russian businessmen mystery deaths are a series of unusual deaths of Russian-connected businessmen in 2022. Most of the deaths were officially declared to be suicides, but a number of commentators have suggested that the circumstances of the suicides appear to be suspicious and may have been staged.

🔗 Environment 🔗 Disaster management 🔗 Energy 🔗 Pennsylvania 🔗 Mining

The Centralia mine fire is a coal-seam fire that has been burning underneath the borough of Centralia, Pennsylvania, United States, since at least May 27, 1962. Its original cause is still a matter of debate. It is burning in underground coal mines at depths of up to 300 feet (90 m) over an 8-mile (13 km) stretch of 3,700 acres (15 km²). At its current rate, it could continue to burn for over 250 years. It has caused most of the town to be abandoned: the population dwindled from around 1,500 at the time the fire started to 7 in 2013, and most of the buildings have been levelled.

🔗 Architecture 🔗 Pennsylvania 🔗 Pittsburgh

A Pittsburgh toilet, or Pittsburgh potty, is a common fixture in pre-World War II houses built in Pittsburgh, Pennsylvania, United States and surrounding region. It consists of an ordinary flush toilet installed in the basement, with no surrounding walls. Most of these toilets are paired with a crude basement shower apparatus and large sink, which often doubles as a laundry basin. Also, because western Pennsylvania is a steep topographical zone, many basements have their own entryway, allowing homeowners to enter from their yard or garage, cleanse themselves in their basement, and then ascend their basement stairs refreshed. Its primary function was to serve as a cleanup station for steel mill workers to clean themselves after returning from work. The toilet fixtures would also limit the harm of sewage backups in hilly Pittsburgh, providing a lower, flushable outlet than the main part of the house.

🔗 Books

"Uncleftish Beholding" (1989) is a short text by Poul Anderson designed to illustrate what English might look like without its large number of loanwords from languages such as French, Greek, and Latin. Written in a form of "Anglish," the work explains atomic theory using Germanic words almost exclusively and coining new words when necessary; many of these new words have cognates in modern German, an important scientific language in its own right. The title phrase uncleftish beholding calques "atomic theory."

To illustrate, the text begins:

For most of its being, mankind did not know what things are made of, but could only guess. With the growth of worldken, we began to learn, and today we have a beholding of stuff and work that watching bears out, both in the workstead and in daily life.

It goes on to define firststuffs (chemical elements), such as waterstuff (hydrogen), sourstuff (oxygen), and ymirstuff (uranium), as well as bulkbits (molecules), bindings (compounds), and several other terms important to uncleftish worldken (atomic science). Wasserstoff and Sauerstoff are the modern German words for hydrogen and oxygen, and in Dutch the modern equivalents are waterstof and zuurstof. Sunstuff refers to helium, which derives from ἥλιος, the Ancient Greek word for "sun." Ymirstuff references Ymir, a giant in Norse mythology similar to Uranus in Greek mythology.

The vocabulary used in Uncleftish Beholding does not completely derive from Anglo-Saxon. Around, from Old French reond (Modern French rond), completely displaced Old English ymbe (cognate to German um) and left no "native" English word for this concept. The text also contains the French-derived words rest, ordinary and sort.

The text gained increased exposure and popularity after being circulated around the Internet, and has served as inspiration for some inventors of Germanic English conlangs. Douglas Hofstadter, in discussing the piece in his book Le Ton beau de Marot, jocularly refers to the use of only Germanic roots for scientific pieces as "Ander-Saxon."