Have a deep view into what people are curious about.

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 United States/U.S. Government 🔗 United States 🔗 International relations 🔗 Germany 🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Europe 🔗 Italy 🔗 Sociology 🔗 Organizations 🔗 Military history/German military history 🔗 Military history/French military history 🔗 Military history/Cold War 🔗 Cold War 🔗 Military history/Dutch military history 🔗 Rome 🔗 European history 🔗 Military history/Italian military history 🔗 Military history/European military history 🔗 Military history/British military history 🔗 Military history/Post-Cold War 🔗 NATO

Operation Gladio is the codename for clandestine "stay-behind" operations of armed resistance that were organized by the Western Union (WU), and subsequently by NATO and the CIA, in collaboration with several European intelligence agencies. The operation was designed for a potential Warsaw Pact invasion and conquest of Europe. Although Gladio specifically refers to the Italian branch of the NATO stay-behind organizations, "Operation Gladio" is used as an informal name for all of them. Stay-behind operations were prepared in many NATO member countries, and some neutral countries.

During the Cold War, some anti-communist armed groups engaged in the harassment of left-wing parties, torture, terrorist attacks, and massacres in countries such as Italy. The role of the CIA and other intelligence organisations in Gladio—the extent of its activities during the Cold War era and any responsibility for terrorist attacks perpetrated in Italy during the "Years of Lead" (late 1960s–early 1980s)—is the subject of debate.

In 1990, the European Parliament adopted a resolution alleging that military secret services in certain member states were involved in serious terrorism and crime, whether or not their superiors were aware. The resolution also urged investigations by the judiciaries of the countries in which those armies operated, so that their modus operandi and actual extension would be revealed. To date, only Italy, Switzerland and Belgium have had parliamentary inquiries into the matter.

The three inquiries reached differing conclusions as regarded different countries. Guido Salvini, a judge who worked in the Italian Massacres Commission, concluded that some right-wing terrorist organizations of the Years of Lead (La Fenice, National Vanguard and Ordine Nuovo) were the trench troops of a secret army, remotely controlled by exponents of the Italian state apparatus and linked to the CIA. Salvini said that the CIA encouraged them to commit atrocities. The Swiss inquiry found that British intelligence secretly cooperated with their army in an operation named P-26 and provided training in combat, communications, and sabotage. It also discovered that P-26 not only would organize resistance in case of a Soviet invasion, but would also become active should the left succeed in achieving a parliamentary majority. The Belgian inquiry could find no conclusive information on their army. No links between them and terrorist attacks were found, and the inquiry noted that the Belgian secret services refused to provide the identity of agents, which could have eliminated all doubts. A 2000 Italian parliamentary report from the left wing coalition Gruppo Democratici di Sinistra l'Ulivo reported that terrorist massacres and bombings had been organised or promoted or supported by men inside Italian state institutions who were linked to American intelligence. The report also said the United States was guilty of promoting the strategy of tension. Operation Gladio is also suspected to have been activated to counter existing left-wing parliamentary majorities in Europe.

The US State Department published a communiqué in January 2006 that stated claims the United States ordered, supported, or authorized terrorism by stay-behind units, and US-sponsored "false flag" operations are rehashed former Soviet disinformation based on documents that the Soviets forged.

The word gladio is the Italian form of gladius, a type of Roman shortsword.

🔗 Comedy

This Man, according to a website created in 2008 by Italian marketer Andrea Natella named Ever Dream This Man?, was a person who was claimed to have been repeatedly seen in dreams by the whole world since 2006, but was never found in the real world. Natella created the site in 2008, but it was not until October 2009 that it gained attention from the press and online internet users. This Man's notoriety spawned several internet memes that spoofed flyers of the website, references in films and television shows like The X-Files, and a manga series based on the hoax by Weekly Shonen Magazine.

🔗 Psychology 🔗 Websites 🔗 Websites/Computing 🔗 Sociology 🔗 Discrimination 🔗 Sociology/social movements 🔗 Conservatism 🔗 Gender Studies 🔗 Feminism 🔗 Men's Issues

The manosphere is a varied collection of websites, blogs, and online forums promoting masculinity, misogyny, and opposition to feminism. Communities within the manosphere include men's rights activists (MRAs), incels (involuntary celibates), Men Going Their Own Way (MGTOW), pick-up artists (PUA), and fathers' rights groups. While the specifics of each group's beliefs sometimes conflict, they are generally united in the belief that society is biased against men due to the influence of feminism, and that feminists promote misandry (hatred of men). Acceptance of these ideas is described as "taking the red pill", a metaphor borrowed from the film The Matrix.

The manosphere overlaps with the far-right and alt-right communities. It has also been associated with online harassment and has been implicated in radicalizing men into misogynist beliefs and the glorification of violence against women. Some sources have associated manosphere-based radicalization with mass shootings motivated by misogyny. The manosphere received significant media coverage following the 2014 Isla Vista killings in California, the 2015 Umpqua Community College shooting in Oregon, and the 2018 Toronto van attack, as well as the online harassment campaign against women in the video game industry known as GamerGate.

Major figures within the movement include various social media influencers, including Andrew Tate, Amrou "Myron Gaines" Fudl, Adin Ross, Roosh V, Carl Benjamin and Jordan Peterson.

🔗 Medicine 🔗 China 🔗 Plants 🔗 Pharmacology 🔗 Psychoactive and Recreational Drugs

For over two millennia, texts in Chinese herbology and traditional Chinese medicine have recorded medicinal plants that are also hallucinogens and psychedelics. Some are familiar psychoactive plants in Western herbal medicine (e.g., Chinese: 莨菪; pinyin: làngdàng, i.e. Hyoscyamus niger), but several Chinese plants have not been noted as hallucinogens in modern works (e.g.,Chinese: 雲實; pinyin: yúnshí; lit. 'cloud seed', i.e. Caesalpinia decapetala). Chinese herbals are an important resource for the history of botany, for instance, Zhang Hua's c. 290 Bowuzhi is the earliest record of the psilocybin mushroom xiàojùn 笑菌 (lit. "laughing mushroom", i.e. Gymnopilus junonius).

🔗 Linguistics 🔗 Professional wrestling

In professional wrestling, kayfabe (also called work or worked) is the portrayal of staged events within the industry as "real" or "true", specifically the portrayal of competition, rivalries, and relationships between participants as being genuine and not of a staged or predetermined nature of any kind. The term kayfabe has evolved to also become a code word of sorts for maintaining this "reality" within the direct or indirect presence of the general public.

Kayfabe is often seen as the suspension of disbelief that is used to create the non-wrestling aspects of promotions, such as feuds, angles, and gimmicks in a manner similar to other forms of fictional entertainment. In relative terms, a wrestler breaking kayfabe during a show would be likened to an actor breaking character on-camera. Also, since wrestling is performed in front of a live audience, whose interaction with the show is crucial to its success, kayfabe can be compared to the fourth wall in acting, since hardly any conventional fourth wall exists to begin with. In general, everything in a professional wrestling show is to some extent scripted, or "kayfabe", even though at times it is portrayed as real-life.

Kayfabe was fiercely maintained for decades, but with the advent of the Internet wrestling community, and the sports entertainment movement, the pro wrestling industry has become less concerned with protecting so-called backstage secrets and typically maintains kayfabe only during the shows. Kayfabe is, however, occasionally broken during shows, usually when dealing with genuine injuries during a match or paying tribute to wrestlers.

🔗 Germany 🔗 Skepticism 🔗 Paranormal

An April 1561 broadsheet by Hans Glaser described a mass sighting of celestial phenomena or unidentified flying objects (UFO) above Nuremberg (then a Free Imperial City of the Holy Roman Empire). Ufologists have speculated that these phenomena may have been extraterrestrial spacecraft. Skeptics assert that the phenomenon was likely to have been another atmospheric phenomenon, such as a sun dog, although the print doesn't fit the usual classic description of the phenomena.

🔗 Time 🔗 Moon

A blue moon is an additional full moon that appears in a subdivision of a year: either the third of four full moons in a season, or a second full moon in a month of the common calendar.

The phrase in modern usage has nothing to do with the actual color of the Moon, although a visually blue Moon (the Moon appearing with a bluish tinge) may occur under certain atmospheric conditions – for instance, if volcanic eruptions or fires release particles in the atmosphere of just the right size to preferentially scatter red light.

🔗 Physics 🔗 History of Science

The ultraviolet catastrophe, also called the Rayleigh–Jeans catastrophe, was the prediction of late 19th century to early 20th century classical physics that an ideal black body at thermal equilibrium would emit an unbounded quantity of energy as wavelength decreased into the ultraviolet range.^: 6–7 The term "ultraviolet catastrophe" was first used in 1911 by Paul Ehrenfest, but the concept originated with the 1900 statistical derivation of the Rayleigh–Jeans law.

The phrase refers to the fact that the empirically derived Rayleigh–Jeans law, which accurately predicted experimental results at large wavelengths, failed to do so for short wavelengths. (See the image for further elaboration.) As the theory diverged from empirical observations when these frequencies reached the ultraviolet region of the electromagnetic spectrum, there was a problem. This problem was later found to be due to a property of quanta as proposed by Max Planck: There could be no fraction of a discrete energy package already carrying minimal energy.

Since the first use of this term, it has also been used for other predictions of a similar nature, as in quantum electrodynamics and such cases as ultraviolet divergence.

🔗 Computing 🔗 Computing/Computer hardware

Model M designates a group of computer keyboards designed and manufactured by IBM starting in 1984, and later by Lexmark International, Maxi Switch, and Unicomp. The keyboard's many variations have their own distinct characteristics, with the vast majority having a buckling-spring key design and swappable keycaps. Model M keyboards have been praised by computer enthusiasts and frequent typists due to their durability and consistency, and the tactile and auditory feedback they provide.

The Model M is also regarded as a timeless and durable piece of hardware. Although the computers and computer peripherals produced concurrently with the Model M are considered obsolete, many Model M keyboards are still in use due to their physical durability and the continued validity of their ANSI 101-key and ISO 102-key layouts, through the use of a PS/2 female to USB male adapter with a built-in level converter. Since their original popularity, new generations of writers and computer technicians have rediscovered their unique functionality and aesthetics. The Kentucky-based company Unicomp continues to manufacture and sell Model M keyboards.