Have a deep view into what people are curious about.

🔗 Video games 🔗 Star Trek

Alto Trek is a computer game, developed by Gene Ball and Rick Rashid for the Xerox Alto while they were graduate students at the University of Rochester during the late 1970s. It is one of the first networked multiplayer games.

🔗 Biography 🔗 Iran 🔗 Biography/science and academia 🔗 Open Access

Amir Emad Mirmirani (Persian: امیرعماد میرمیرانی) known by the nickname Jadi, is a programmer, blogger and internet activist in the field of Free and open-source software and Linux in Iran. He was arrested in October 2022 during the Iranian protests following the death of Mahsa Amini.

🔗 Economics 🔗 Business 🔗 Sociology 🔗 Occupations

This is a category of jobs that have been rendered obsolete due to advances in technology and/or social conditions.

🔗 Mathematics

The medieval Cistercian numerals, or "ciphers" in nineteenth-century parlance, were developed by the Cistercian monastic order in the early thirteenth century at about the time that Arabic numerals were introduced to northwestern Europe. They are more compact than Arabic or Roman numerals, with a single glyph able to indicate any integer from 1 to 9,999.

Digits are based on a horizontal or vertical stave, with the position of the digit on the stave indicating its place value (units, tens, hundreds or thousands). These digits are compounded on a single stave to indicate more complex numbers. The Cistercians eventually abandoned the system in favor of the Arabic numerals, but marginal use outside the order continued until the early twentieth century.

🔗 Military history 🔗 Military history/Military science, technology, and theory 🔗 Ukraine 🔗 Military history/Medieval warfare

The Siege of Caffa was a 14th-century military encounter when Jani Beg of the Golden Horde sieged the city of Caffa, (today Feodosia) between two periods in the 1340s. The city of Caffa, a Genoese colony, was a vital trading hub located in Crimea. The city was then part of Gazaria, a group of seven ports located in Crimea and belonging to the maritime empire of the Republic of Genoa. The event is historically significant primarily because it is believed to be one of the earliest instances of biological warfare.

The siege of Caffa was characterized by intense military tactics from both sides. After several years of siege, the armies of the Horde were forced to withdraw. The siege is famous for a story recounted by Italian notary Gabriel de Mussis, which attributed the subsequent spread of the Black Death to plague-infested corpses having been launched over the walls at the end of the siege.

🔗 Skepticism 🔗 Neuroscience 🔗 Physiology

The gut–brain axis is the two-way biochemical signaling that takes place between the gastrointestinal tract (GI tract) and the central nervous system (CNS). The term "gut–brain axis" is occasionally used to refer to the role of the gut microbiota in the interplay as well. The "microbiota–gut–brain (MGB or BGM) axis" explicitly includes the role of gut microbiota in the biochemical signaling events that take place between the GI tract and the CNS. Broadly defined, the gut–brain axis includes the central nervous system, neuroendocrine system, neuroimmune systems, the hypothalamic–pituitary–adrenal axis (HPA axis), sympathetic and parasympathetic arms of the autonomic nervous system, the enteric nervous system, vagus nerve, and the gut microbiota.

Chemicals released in the gut by the microbiome can vastly influence the development of the brain, starting from birth. A review from 2015 states that the microbiome influences the central nervous system by “regulating brain chemistry and influencing neuro-endocrine systems associated with stress response, anxiety and memory function”. The gut, sometimes referred to as the “second brain”, functions off of the same type of neural network as the central nervous system, suggesting why it plays a significant role in brain function and mental health.

The bidirectional communication is done by immune, endocrine, humoral and neural connections between the gastrointestinal tract and the central nervous system. More research suggests that the gut microorganisms influence the function of the brain by releasing the following chemicals: cytokines, neurotransmitters, neuropeptides, chemokines, endocrine messengers and microbial metabolites such as "short-chain fatty acids, branched chain amino acids, and peptidoglycans”. The intestinal microbiome can then divert these products to the brain via the blood, neuropod cells, nerves, endocrine cells and more to be determined. The products then arrive at important locations in the brain, impacting different metabolic processes. Studies have confirmed communication between the hippocampus, the prefrontal cortex and the amygdala (responsible for emotions and motivation), which acts as a key node in the gut-brain behavioral axis.

While IBS is the only disease confirmed to be directly influenced by the gut microbiome, many disorders (such as anxiety, autism, depression and schizophrenia) have been linked to the gut-brain axis as well. The impact of the axis, and the various ways in which one can influence it, remains a promising research field which could result in future treatments for psychiatric, age-related, neurodegenerative and neurodevelopmental disorders. For example, according to a study from 2017, “probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression”.

The first of the brain–gut interactions shown, was the cephalic phase of digestion, in the release of gastric and pancreatic secretions in response to sensory signals, such as the smell and sight of food. This was first demonstrated by Pavlov through Nobel prize winning research in 1904.

Scientific interest in the field had already led to review in the second half of the 20th century. It was promoted further by a 2004 primary research study showing that germ-free (GF) mice showed an exaggerated HPA axis response to stress compared to non-GF laboratory mice.

As of October 2016, most of the work done on the role of gut microbiota in the gut–brain axis had been conducted in animals, or on characterizing the various neuroactive compounds that gut microbiota can produce. Studies with humans – measuring variations in gut microbiota between people with various psychiatric and neurological conditions or when stressed, or measuring effects of various probiotics (dubbed "psychobiotics" in this context) – had generally been small and were just beginning to be generalized. Whether changes to the gut microbiota are a result of disease, a cause of disease, or both in any number of possible feedback loops in the gut–brain axis, remained unclear.

🔗 Economics 🔗 Education 🔗 Game theory 🔗 Games

A simulation game is "a game that contains a mixture of skill, chance, and strategy to simulate an aspect of reality, such as a stock exchange". Similarly, Finnish author Virpi Ruohomäki states that "a simulation game combines the features of a game (competition, cooperation, rules, participants, roles) with those of a simulation (incorporation of critical features of reality). A game is a simulation game if its rules refer to an empirical model of reality". A properly built simulation game used to teach or learn economics would closely follow the assumptions and rules of the theoretical models within this discipline.

🔗 Biography 🔗 Biography/science and academia 🔗 Israel

Abraham Lempel (Hebrew: אברהם למפל, 10 February 1936 – 4 February 2023) was an Israeli computer scientist and one of the fathers of the LZ family of lossless data compression algorithms.

🔗 Computer science 🔗 Disaster management 🔗 Philosophy 🔗 Cognitive science 🔗 Futures studies 🔗 Effective Altruism

Effective accelerationism, often abbreviated as "e/acc", is a 21st-century philosophical movement advocating an explicit pro-technology stance. Its proponents believe that artificial intelligence-driven progress is a great social equalizer which should be pushed forward. They see themselves as a counterweight to the cautious view that AI is highly unpredictable and needs to be regulated, often giving their opponents the derogatory labels of "doomers" or "decels" (short for deceleration).

Central to effective accelerationism is the belief that propelling technological progress at any cost is the only ethically justifiable course of action. The movement carries utopian undertones and argues that humans need to develop and build faster to ensure their survival and propagate consciousness throughout the universe.

Although effective accelerationism has been described as a fringe movement, it has gained mainstream visibility. A number of high-profile Silicon Valley figures, including investors Marc Andreessen and Garry Tan, explicitly endorsed the movement by adding "e/acc" to their public social media profiles. Yann LeCun and Andrew Ng are seen as further supporters, as they have argued for less restrictive AI regulation.

🔗 Environment 🔗 Biology 🔗 Physics 🔗 Guild of Copy Editors 🔗 Energy 🔗 Chemical and Bio Engineering

Artificial photosynthesis is a chemical process that biomimics the natural process of photosynthesis to convert sunlight, water, and carbon dioxide into carbohydrates and oxygen. The term artificial photosynthesis is commonly used to refer to any scheme for capturing and storing the energy from sunlight in the chemical bonds of a fuel (a solar fuel). Photocatalytic water splitting converts water into hydrogen and oxygen and is a major research topic of artificial photosynthesis. Light-driven carbon dioxide reduction is another process studied that replicates natural carbon fixation.

Research of this topic includes the design and assembly of devices for the direct production of solar fuels, photoelectrochemistry and its application in fuel cells, and the engineering of enzymes and photoautotrophic microorganisms for microbial biofuel and biohydrogen production from sunlight.