Have a deep view into what people are curious about.

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 Philosophy 🔗 Philosophy/Logic

Erotetics or erotetic logic is a part of logic, devoted to logical analysis of questions. It is sometimes called the logic of questions and answers.

🔗 Computing

Better Portable Graphics (BPG) is a file format for coding digital images, which was created by programmer Fabrice Bellard in 2014. He has proposed it as a replacement for the JPEG image format as the more compression-efficient alternative in terms of image quality or file size.

It is based on the intra-frame encoding of the High Efficiency Video Coding (HEVC) video compression standard. Tests on photographic images in July 2014 found that BPG produced smaller files for a given quality than JPEG, JPEG XR and WebP.

The format has been designed to be portable and work in low memory environments, and used in portable handheld and IoT devices, where those properties are particularly important. Current research works on designing and developing more energy-efficient BPG hardware which can then be integrated in portable devices such as digital cameras.

While there is no built-in native support for BPG in any mainstream browsers, websites can still deliver BPG images to all browsers by including a JavaScript library written by Bellard.

🔗 Literature

A chrestomathy ( kreh-STOM-ə-thee; from the Ancient Greek χρηστομάθεια khrēstomátheia 'desire of learning', from χρηστός khrēstós 'useful' + μανθάνω manthánō 'learn') is a collection of selected literary passages (usually from a single author); a selection of literary passages from a foreign language assembled for studying the language; or a text in various languages, used especially as an aid in learning a subject.

In philology or in the study of literature, it is a type of reader which presents a sequence of example texts, selected to demonstrate the development of language or literary style. It is different from an anthology because of its didactic purpose.

🔗 Japan 🔗 Japan/Culture 🔗 Textile Arts

Shibori (しぼり / 絞り) is a Japanese manual resist dyeing technique, which produces a number of different patterns on fabric.

🔗 Mathematics 🔗 Greece

Greek numerals, also known as Ionic, Ionian, Milesian, or Alexandrian numerals, are a system of writing numbers using the letters of the Greek alphabet. In modern Greece, they are still used for ordinal numbers and in contexts similar to those in which Roman numerals are still used elsewhere in the West. For ordinary cardinal numbers, however, Greece uses Arabic numerals.

🔗 Cycling 🔗 Motorcycling

Countersteering is used by single-track vehicle operators, such as cyclists and motorcyclists, to initiate a turn toward a given direction by momentarily steering counter to the desired direction ("steer left to turn right"). To negotiate a turn successfully, the combined center of mass of the rider and the single-track vehicle must first be leaned in the direction of the turn, and steering briefly in the opposite direction causes that lean. The rider's action of countersteering is sometimes referred to as "giving a steering command".^: 15

The scientific literature does not provide a clear and comprehensive definition of countersteering. In fact, "a proper distinction between steer torque and steer angle ... is not always made."

🔗 Science 🔗 Tree of Life

Lumpers and splitters are opposing factions in any discipline that has to place individual examples into rigorously defined categories. The lumper–splitter problem occurs when there is the desire to create classifications and assign examples to them, for example schools of literature, biological taxa and so on. A "lumper" is an individual who takes a gestalt view of a definition, and assigns examples broadly, assuming that differences are not as important as signature similarities. A "splitter" is an individual who takes precise definitions, and creates new categories to classify samples that differ in key ways.

🔗 Computing 🔗 Computer science

In computer science, program synthesis is the task to construct a program that provably satisfies a given high-level formal specification. In contrast to program verification, the program is to be constructed rather than given; however, both fields make use of formal proof techniques, and both comprise approaches of different degrees of automation. In contrast to automatic programming techniques, specifications in program synthesis are usually non-algorithmic statements in an appropriate logical calculus.

The primary application of program synthesis is to relieve the programmer of the burden of writing correct, efficient code that satisfies a specification. However, program synthesis also has applications to superoptimization and inference of loop invariants.

🔗 Physics 🔗 China 🔗 Astronomy 🔗 History of Science 🔗 Astronomy/Astronomical objects 🔗 Arab world

SN 1006 was a supernova that is likely the brightest observed stellar event in recorded history, reaching an estimated −7.5 visual magnitude, and exceeding roughly sixteen times the brightness of Venus. Appearing between April 30 and May 1, 1006 AD in the constellation of Lupus, this "guest star" was described by observers across the modern day countries of China, Japan, Iraq, Egypt, and the continent of Europe, and possibly recorded in North American petroglyphs. Some reports state it was clearly visible in the daytime. Modern astronomers now consider its distance from Earth to be about 7,200 light-years.