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🔗 Philosophy 🔗 Philosophy/Philosophical literature 🔗 Books

Simulacra and Simulation (French: Simulacres et Simulation) is a 1981 philosophical treatise by Jean Baudrillard, in which the author seeks to examine the relationships between reality, symbols, and society, in particular the significations and symbolism of culture and media involved in constructing an understanding of shared existence.

Simulacra are copies that depict things that either had no original, or that no longer have an original. Simulation is the imitation of the operation of a real-world process or system over time.

🔗 Military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry

The Lazy Dog (sometimes called a Red Dot Bomb or Yellow Dog Bomb) is a type of small, unguided kinetic projectile used by the U.S. Air Force. It measured about 1.75 inches (44 mm) in length, 0.5 inches (13 mm) in diameter, and weighed about 0.7 ounces (20 g).

The weapons were designed to be dropped from an aircraft. They contained no explosive charge but as they fell they would develop significant kinetic energy making them lethal and able to easily penetrate soft cover such as jungle canopy, several inches of sand, or light armor. Lazy Dog munitions were simple and relatively cheap; they could be dropped in huge numbers in a single pass. Though their effects were often no less deadly than other projectiles, they did not leave unexploded ordnance (UXO) that could be active years after a conflict ended.

Lazy Dog projectiles were used primarily during the Korean and the Vietnam Wars.

🔗 Mathematics 🔗 France

Nicolas Bourbaki (French pronunciation: ​[nikɔla buʁbaki]) is the collective pseudonym of a group of mathematicians, predominantly French alumni of the École normale supérieure (ENS). Founded in 1934–1935, the Bourbaki group originally intended to prepare a new textbook in analysis. Over time the project became much more ambitious, growing into a large series of textbooks published under the Bourbaki name, meant to treat modern pure mathematics. The series is known collectively as the Éléments de mathématique (Elements of Mathematics), the group's central work. Topics treated in the series include set theory, abstract algebra, topology, analysis, Lie groups and Lie algebras.

Bourbaki was founded in response to the effects of the First World War which caused the death of a generation of French mathematicians; as a result, young university instructors were forced to use dated texts. While teaching at the University of Strasbourg, Henri Cartan complained to his colleague André Weil of the inadequacy of available course material, which prompted Weil to propose a meeting with others in Paris to collectively write a modern analysis textbook. The group's core founders were Cartan, Claude Chevalley, Jean Delsarte, Jean Dieudonné and Weil; others participated briefly during the group's early years, and membership has changed gradually over time. Although former members openly discuss their past involvement with the group, Bourbaki has a custom of keeping its current membership secret.

The group's namesake derives from the 19th century French general Charles-Denis Bourbaki, who had a career of successful military campaigns before suffering a dramatic loss in the Franco-Prussian War. The name was therefore familiar to early 20th century French students. Weil remembered an ENS student prank in which an upperclassman posed as a professor and presented a "theorem of Bourbaki"; the name was later adopted.

The Bourbaki group holds regular private conferences for the purpose of drafting and expanding the Éléments. Topics are assigned to subcommittees, drafts are debated, and unanimous agreement is required before a text is deemed fit for publication. Although slow and labor-intensive, the process results in a work which meets the group's standards for rigour and generality. The group is also associated with the Séminaire Bourbaki, a regular series of lectures presented by members and non-members of the group, also published and disseminated as written documents. Bourbaki maintains an office at the ENS.

Nicolas Bourbaki was influential in 20th century mathematics, particularly during the middle of the century when volumes of the Éléments appeared frequently. The group is noted among mathematicians for its rigorous presentation and for introducing the notion of a mathematical structure, an idea related to the broader, interdisciplinary concept of structuralism. Bourbaki's work informed the New Math, a trend in elementary math education during the 1960s. Although the group remains active, its influence is considered to have declined due to infrequent publication of new volumes of the Éléments. However the collective's most recent publication appeared in 2016, treating algebraic topology.

🔗 Computer science 🔗 Mathematics

In mathematical logic and computer science, homotopy type theory (HoTT ) refers to various lines of development of intuitionistic type theory, based on the interpretation of types as objects to which the intuition of (abstract) homotopy theory applies.

This includes, among other lines of work, the construction of homotopical and higher-categorical models for such type theories; the use of type theory as a logic (or internal language) for abstract homotopy theory and higher category theory; the development of mathematics within a type-theoretic foundation (including both previously existing mathematics and new mathematics that homotopical types make possible); and the formalization of each of these in computer proof assistants.

There is a large overlap between the work referred to as homotopy type theory, and as the univalent foundations project. Although neither is precisely delineated, and the terms are sometimes used interchangeably, the choice of usage also sometimes corresponds to differences in viewpoint and emphasis. As such, this article may not represent the views of all researchers in the fields equally. This kind of variability is unavoidable when a field is in rapid flux.

🔗 Biography 🔗 Physics 🔗 Philosophy 🔗 Biography/science and academia 🔗 Philosophy/Philosophy of science 🔗 Philosophy/Contemporary philosophy 🔗 History of Science 🔗 Philosophy/Philosophers 🔗 Physics/Biographies 🔗 Ireland 🔗 University of Oxford 🔗 University of Oxford/University of Oxford (colleges)

Erwin Rudolf Josef Alexander Schrödinger (UK: , US: ; German: [ˈɛɐ̯vɪn ˈʃʁøːdɪŋɐ]; 12 August 1887 – 4 January 1961), sometimes written as Schroedinger or Schrodinger, was a Nobel Prize–winning Austrian and naturalized Irish physicist who developed fundamental results in quantum theory. In particular, he is recognized for postulating the Schrödinger equation, an equation that provides a way to calculate the wave function of a system and how it changes dynamically in time. He coined the term "quantum entanglement", and was the earliest to discuss it, doing so in 1932.

In addition, he wrote many works on various aspects of physics: statistical mechanics and thermodynamics, physics of dielectrics, colour theory, electrodynamics, general relativity, and cosmology, and he made several attempts to construct a unified field theory. In his book What Is Life? Schrödinger addressed the problems of genetics, looking at the phenomenon of life from the point of view of physics. He also paid great attention to the philosophical aspects of science, ancient, and oriental philosophical concepts, ethics, and religion. He also wrote on philosophy and theoretical biology. In popular culture, he is best known for his "Schrödinger's cat" thought experiment.

Spending most of his life as an academic with positions at various universities, Schrödinger, along with Paul Dirac, won the Nobel Prize in Physics in 1933 for his work on quantum mechanics, the same year he left Germany due to his opposition to Nazism. In his personal life, he lived with both his wife and his mistress which may have led to problems causing him to leave his position at Oxford. Subsequently, until 1938, he had a position in Graz, Austria, until the Nazi takeover when he fled, finally finding a long-term arrangement in Dublin where he remained until retirement in 1955. He died in Vienna of tuberculosis when he was 73.

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Medicine 🔗 Economics 🔗 Books 🔗 Politics 🔗 Women writers 🔗 Medicine/Psychiatry

The Shock Doctrine: The Rise of Disaster Capitalism is a 2007 book by the Canadian author and social activist Naomi Klein. In the book, Klein argues that neoliberal free market policies (as advocated by the economist Milton Friedman) have risen to prominence in some developed countries because of a deliberate strategy of "shock therapy". This centers on the exploitation of national crises (disasters or upheavals) to establish controversial and questionable policies, while citizens are excessively distracted (emotionally and physically) to engage and develop an adequate response, and resist effectively. The book suggests that some man-made events, such as the Iraq War, were undertaken with the intention of pushing through such unpopular policies in their wake.

Some reviewers criticized the book for making what they viewed as simplifications of political phenomena, while others lauded it as a compelling and important work. The book served as the main source of a 2009 documentary feature film with the same title directed by Michael Winterbottom.

🔗 Birds 🔗 Mythology

The barnacle goose myth is a widely-reported historical misconception about the breeding habits of the barnacle goose (Branta leucopsis) and brant goose (Branta bernicla). One version of the myth is that these geese emerge fully formed from goose barnacles (Cirripedia). Other myths exist about how the barnacle goose supposedly emerges and grows from matter other than bird eggs.

The etymology of the term "barnacle" suggests Latin, Old English, and French roots. There are few references in pre-Christian books and manuscripts – some Roman or Greek. The main vector for the myth into modern times was monastic manuscripts and in particular the bestiary.

The myth owes its long-standing popularity to an early ignorance of the migration patterns of geese. Early medieval discussions of the nature of living organisms were often based on myths or genuine ignorance of what is now known about phenomena such as bird migration. It was not until the late 19th century that bird migration research showed that such geese migrate northwards to nest and breed in Greenland or northern Scandinavia.

🔗 Geology

The Chesapeake Bay impact crater was formed by a bolide that impacted the eastern shore of North America about 35.5 ± 0.3 million years ago, in the late Eocene epoch. It is one of the best-preserved "wet-target" impact craters in the world.

Continued slumping of sediments over the rubble of the crater has helped shape the Chesapeake Bay.

🔗 Architecture 🔗 Marketing & Advertising 🔗 Retailing 🔗 Shopping Centers

In shopping mall design, the Gruen transfer (also known as the Gruen effect) is the moment when consumers enter a shopping mall or store and, surrounded by an intentionally confusing layout, lose track of their original intentions, making consumers more susceptible to make impulse buys. It is named for Austrian architect Victor Gruen, who disavowed such manipulative techniques.