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🔗 Biography 🔗 Military history 🔗 Politics 🔗 Military history/Military biography 🔗 Biography/military biography 🔗 Military history/Cold War 🔗 Biography/politics and government 🔗 Military history/South American military history 🔗 Uruguay

José Alberto "Pepe" Mujica Cordano (Spanish: [xoˈse muˈxika]; born 20 May 1935) is a Uruguayan politician and farmer who served as the 40th President of Uruguay from 2010 to 2015. A former guerrilla with the Tupamaros, he was tortured and imprisoned for 14 years during the military dictatorship in the 1970s and 1980s. A member of the Broad Front coalition of left-wing parties, Mujica was Minister of Livestock, Agriculture, and Fisheries from 2005 to 2008 and a Senator afterwards. As the candidate of the Broad Front, he won the 2009 presidential election and took office as President on 1 March 2010.

He has been described as "the world's humblest head of state" due to his austere lifestyle and his donation of around 90 percent of his $12,000 monthly salary to charities that benefit poor people and small entrepreneurs. An outspoken critic of capitalism’s focus on stockpiling material possessions which do not contribute to human happiness, Pepe is often seen riding his 60-year-old bicycle. The Times Higher Education called him the "philosopher president" in 2015, a play on words of Plato's conception of the philosopher king.

🔗 China 🔗 Maps

Mao Kun map, usually referred to in modern Chinese sources as Zheng He's Navigation Map (simplified Chinese: 郑和航海图; traditional Chinese: 鄭和航海圖; pinyin: Zhèng Hé hánghǎi tú), is a set of navigation charts published in the Ming dynasty military treatise Wubei Zhi. The book was compiled by Mao Yuanyi in 1621 and published in 1628; the name of the map refers to his grandfather Mao Kun (Chinese: 茅坤; pinyin: Máo Kūn) from whose library the map is likely to have originated. The map is often regarded as a surviving document from the expeditions of Zheng He in addition to accounts written by Zheng's officers, such as Yingya Shenglan by Ma Huan, Xingcha Shenglan by Fei Xin, and Xiyang Fanguo Zhi by Gong Zhen. It is the earliest Chinese map to give an adequate representation of Southern Asia, Persia, Arabia and East Africa.

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 Psychoactive and Recreational Drugs

The Marsh Chapel Experiment, also called the "Good Friday Experiment", was a 1962 experiment conducted on Good Friday at Boston University's Marsh Chapel. Walter N. Pahnke, a graduate student in theology at Harvard Divinity School, designed the experiment under the supervision of Timothy Leary, Richard Alpert, and the Harvard Psilocybin Project. Pahnke's experiment investigated whether psilocybin (the active principle in psilocybin mushrooms) would act as a reliable entheogen in religiously predisposed subjects.

🔗 Germany 🔗 Astronomy 🔗 Archaeology 🔗 Visual arts

The Nebra sky disk is a bronze disk of around 30 centimeters (11 ³⁄₄ in) diameter and a weight of 2.2 kilograms (4.9 lb), having a blue-green patina and inlaid with gold symbols. These symbols are interpreted generally as the Sun or full moon, a lunar crescent, and stars (including a cluster of seven interpreted as the Pleiades). Two golden arcs along the sides, interpreted to mark the angle between the solstices, were added later. A final addition was another arc at the bottom surrounded with multiple strokes (of uncertain meaning, variously interpreted as a Solar Barge with numerous oars, the Milky Way, or a rainbow).

The disk is attributed to a site in present-day Germany near Nebra, Saxony-Anhalt, and dated by Archaeological association to c. 1600 BC. Researchers suggest the disk is an artifact of the Bronze Age Unetice culture.

The style in which the disk is executed was unlike any artistic style then known from the period, with the result that the object was initially suspected of being a forgery, but is now widely accepted as authentic.

The Nebra sky disk features the oldest concrete depiction of the cosmos yet known from anywhere in the world. In June 2013 it was included in the UNESCO Memory of the World Register and termed "one of the most important archaeological finds of the twentieth century."

🔗 Numbers 🔗 Linguistics 🔗 Malaysia

The long and short scales are two of several naming systems for integer powers of ten which use some of the same terms for different magnitudes.

For whole numbers smaller than 1,000,000,000 (10⁹), such as one thousand or one million, the two scales are identical. For larger numbers, starting with 10⁹, the two systems differ. For identical names, the long scale proceeds by powers of one million, whereas the short scale proceeds by powers of one thousand. For example, one billion is one thousand millions in the short scale, while it is one million millions in the long scale. The long scale system introduces new terms for the intervening values, typically replacing the word ending -ion with -iard.

🔗 Computer science

In computer science, higher-order abstract syntax (abbreviated HOAS) is a technique for the representation of abstract syntax trees for languages with variable binders.

🔗 Aviation 🔗 Aviation/aircraft

A ram air turbine (RAT) is a small wind turbine that is connected to a hydraulic pump, or electrical generator, installed in an aircraft and used as a power source. The RAT generates power from the airstream by ram pressure due to the speed of the aircraft.

🔗 Italy 🔗 Classical Greece and Rome 🔗 Athletics 🔗 Highways 🔗 Road transport 🔗 Highways/European Highways

The Appian Way (Latin and Italian: Via Appia) is one of the earliest and strategically most important Roman roads of the ancient republic. It connected Rome to Brindisi, in southeast Italy. Its importance is indicated by its common name, recorded by Statius, of Appia longarum... regina viarum ("the Appian Way, the queen of the long roads").

The road is named after Appius Claudius Caecus, the Roman censor who began and completed the first section as a military road to the south in 312 BC during the Samnite Wars.