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Silphium (also known as silphion, laserwort, or laser) was a plant that was used in classical antiquity as a seasoning, perfume, as an aphrodisiac, or as a medicine. It also was used as a contraceptive by ancient Greeks and Romans. It was the essential item of trade from the ancient North African city of Cyrene, and was so critical to the Cyrenian economy that most of their coins bore a picture of the plant. The valuable product was the plant's resin (laser, laserpicium, or lasarpicium).

Silphium was an important species in prehistory, as evidenced by the Egyptians and Knossos Minoans developing a specific glyph to represent the silphium plant. It was used widely by most ancient Mediterranean cultures; the Romans who mentioned the plant in poems or songs, considered it "worth its weight in denarii" (silver coins), or even gold. Legend said that it was a gift from the god Apollo.

The exact identity of silphium is unclear. It is commonly believed to be a now-extinct plant of the genus Ferula, perhaps a variety of "giant fennel". The still-extant plants Margotia gummifera and Ferula tingitana have been suggested as other possibilities. Another plant, asafoetida, was used as a cheaper substitute for silphium, and had similar enough qualities that Romans, including the geographer Strabo, used the same word to describe both.

Hadacol was a patent medicine marketed as a vitamin supplement. Its principal attraction, however, was that it contained 12 percent alcohol (listed on the tonic bottle's label as a "preservative"), which made it quite popular in the dry counties of the southern United States. It was the product of four-term Louisiana State Senator Dudley J. LeBlanc, a Democrat from Erath in Vermilion Parish in southwestern Louisiana. He was not a medical doctor, nor a registered pharmacist, but had a strong talent for self-promotion. Time magazine once described him as "a stem-winding salesman who knows every razzle-dazzle switch in the pitchman's trade".

A mellified man, or a human mummy confection, was a legendary medicinal substance created by steeping a human cadaver in honey. The concoction is detailed in Chinese medical sources, most significantly the Bencao Gangmu of the 16th-century Chinese medical doctor and pharmacologist Li Shizhen. Relying on a second-hand account, Li reports a story that some elderly men in Arabia, nearing the end of their lives, would submit themselves to a process of mummification in honey to create a healing confection.

This process differed from a simple body donation because of the aspect of self-sacrifice; the mellification process would ideally start before death. The donor would stop eating any food other than honey, going as far as to bathe in the substance. Shortly, his feces (and even his sweat, according to legend) would consist of honey. When this diet finally proved fatal, the donor's body would be placed in a stone coffin filled with honey.

After a century or so, the contents would have turned into a sort of confection reputedly capable of healing broken limbs and other ailments. This confection would then be sold in street markets as a hard to find item with a hefty price.

This is a list of topics that have, at one point or another in their history, been characterized as pseudoscience by academics or researchers. Detailed discussion of these topics may be found on their main pages. These characterizations were made in the context of educating the public about questionable or potentially fraudulent or dangerous claims and practices—efforts to define the nature of science, or humorous parodies of poor scientific reasoning.

Criticism of pseudoscience, generally by the scientific community or skeptical organizations, involves critiques of the logical, methodological, or rhetorical bases of the topic in question. Though some of the listed topics continue to be investigated scientifically, others were only subject to scientific research in the past, and today are considered refuted but resurrected in a pseudoscientific fashion. Other ideas presented here are entirely non-scientific, but have in one way or another impinged on scientific domains or practices.

Many adherents or practitioners of the topics listed here dispute their characterization as pseudoscience. Each section here summarizes the alleged pseudoscientific aspects of that topic.

August Engelhardt (27 November 1875 – 6 May 1919) was a German author and founder of a sect of sun worshipers.

Life extension is the idea of extending the human lifespan, either modestly – through improvements in medicine – or dramatically by increasing the maximum lifespan beyond its generally settled limit of 125 years. The ability to achieve such dramatic changes, however, does not currently exist.

Some researchers in this area, and "life extensionists", "immortalists" or "longevists" (those who wish to achieve longer lives themselves), believe that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such products has not been proven to be effective or safe.

Coley's toxins (also called Coley's toxin, Coley's vaccine, Coley vaccine, Coley's fluid or mixed bacterial vaccine) is a mixture consisting of killed bacteria of species Streptococcus pyogenes and Serratia marcescens, named after William Coley, a surgical oncologist at the Hospital for Special Surgery who developed the mixture in the late 19th century as a treatment for cancer.

There is no evidence that Coley's toxins have any effectiveness in treating cancer, and use of them risks causing serious harm.