Have a deep view into what people are curious about.

🔗 Medicine 🔗 Chemicals 🔗 Medicine/Neurology 🔗 Pharmacology 🔗 Medicine/Psychiatry 🔗 Epilepsy

Benzodiazepines (BZD, BDZ, BZs), colloquially called "benzos", are a class of depressant drugs whose core chemical structure is the fusion of a benzene ring and a diazepine ring. They are prescribed to treat conditions such as anxiety disorders, insomnia, and seizures. The first benzodiazepine, chlordiazepoxide (Librium), was discovered accidentally by Leo Sternbach in 1955 and was made available in 1960 by Hoffmann–La Roche, who soon followed with diazepam (Valium) in 1963. By 1977, benzodiazepines were the most prescribed medications globally; the introduction of selective serotonin reuptake inhibitors (SSRIs), among other factors, decreased rates of prescription, but they remain frequently used worldwide.

Benzodiazepines are depressants that enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABA_A receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), anticonvulsant, and muscle relaxant properties. High doses of many shorter-acting benzodiazepines may also cause anterograde amnesia and dissociation. These properties make benzodiazepines useful in treating anxiety, panic disorder, insomnia, agitation, seizures, muscle spasms, alcohol withdrawal and as a premedication for medical or dental procedures. Benzodiazepines are categorized as short, intermediate, or long-acting. Short- and intermediate-acting benzodiazepines are preferred for the treatment of insomnia; longer-acting benzodiazepines are recommended for the treatment of anxiety.

Benzodiazepines are generally viewed as safe and effective for short-term use—about two to four weeks—although cognitive impairment and paradoxical effects such as aggression or behavioral disinhibition can occur. A minority of people have paradoxical reactions after taking benzodiazepines such as worsened agitation or panic. Benzodiazepines are associated with an increased risk of suicide due to aggression, impulsivity, and negative withdrawal effects. Long-term use is controversial because of concerns about decreasing effectiveness, physical dependence, benzodiazepine withdrawal syndrome, and an increased risk of dementia and cancer. The elderly are at an increased risk of both short- and long-term adverse effects, and as a result, all benzodiazepines are listed in the Beers List of inappropriate medications for older adults. There is controversy concerning the safety of benzodiazepines in pregnancy. While they are not major teratogens, uncertainty remains as to whether they cause cleft palate in a small number of babies and whether neurobehavioural effects occur as a result of prenatal exposure; they are known to cause withdrawal symptoms in the newborn.

Taken in overdose, benzodiazepines can cause dangerous deep unconsciousness, but they are less toxic than their predecessors, the barbiturates, and death rarely results when a benzodiazepine is the only drug taken. Combined with other central nervous system (CNS) depressants such as alcohol and opioids, the potential for toxicity and fatal overdose increases significantly. Benzodiazepines are commonly used recreationally and also often taken in combination with other addictive substances, and are controlled in most countries.

🔗 Skepticism 🔗 Business 🔗 Psychology 🔗 Cognitive science

In the field of social psychology, illusory superiority is a condition of cognitive bias wherein a person overestimates their own qualities and abilities, in relation to the same qualities and abilities of other people. Illusory superiority is one of many positive illusions, relating to the self, that are evident in the study of intelligence, the effective performance of tasks and tests, and the possession of desirable personal characteristics and personality traits. Overestimation of abilities compared to an objective measure is known as the overconfidence effect.

The term illusory superiority was first used by the researchers Van Yperen and Buunk, in 1991. The phenomenon is also known as the above-average effect, the superiority bias, the leniency error, the sense of relative superiority, the primus inter pares effect, and the Lake Wobegon effect, named after the fictional town where all the children are above average. The Dunning-Kruger effect is a form of illusory superiority shown by people on a task where their level of skill is low.

A vast majority of the literature on illusory superiority originates from studies on participants in the United States. However, research that only investigates the effects in one specific population is severely limited as this may not be a true representation of human psychology. More recent research investigating self-esteem in other countries suggests that illusory superiority depends on culture. Some studies indicate that East Asians tend to underestimate their own abilities in order to improve themselves and get along with others.

🔗 Archaeology 🔗 Paranormal

A thunderstone is a flint tool or fossil turned up by farmer's plow that was thought to have fallen from the sky. They were often thought to be thunderbolts. It was not until travelers returned from far-away places where these implements were in use among primitive cultures that the origins of these objects became known. Even then, these travelers' tales received little popular credence.

🔗 Musical Instruments

The Siemens Synthesizer (or "Siemens Studio für Elektronische Musik") was developed in Germany in 1959 by the German electronics manufacturer Siemens, originally to compose live electronic music for its own promotional films.

From 1956 to 1967, it had a significant influence on the development of electronic music. Among others, Mauricio Kagel, Henri Pousseur, Herbert Brün and Ernst Krenek completed important electronic works there.

🔗 History 🔗 Biology 🔗 Politics 🔗 Anthropology 🔗 Sociology 🔗 Conservatism 🔗 Folklore

Invented traditions are cultural practices that are presented or perceived as traditional, arising from the people starting in the distant past, but which in fact are relatively recent and often even consciously invented by identifiable historical actors. The concept was highlighted in the 1983 book The Invention of Tradition, edited by Eric Hobsbawm and Terence Ranger. Hobsbawm's introduction argues that many "traditions" which "appear or claim to be old are often quite recent in origin and sometimes invented." This "invention" is distinguished from "starting" or "initiating" a tradition that does not then claim to be old. The phenomenon is particularly clear in the modern development of the nation and of nationalism, creating a national identity promoting national unity, and legitimising certain institutions or cultural practices.

🔗 Visual arts

The Voyage of Life is a series of four paintings created by Thomas Cole in 1842, representing an allegory of the four stages of human life. The paintings, Childhood, Youth, Manhood, and Old Age, depict a voyager who travels in a boat on a river through the mid-19th-century American wilderness. In each painting the voyager rides the boat on the River of Life accompanied by a guardian angel. The landscape, each reflecting one of the four seasons of the year, plays a major role in conveying the story. With each installment the boat's direction of travel is reversed from the previous picture. In childhood, the infant glides from a dark cave into a rich, green landscape. As a youth, the boy takes control of the boat and aims for a shining castle in the sky. In manhood, the adult relies on prayer and religious faith to sustain him through rough waters and a threatening landscape. Finally, the man becomes old and the angel guides him to heaven across the waters of eternity.

🔗 Technology 🔗 Electronics 🔗 Engineering 🔗 Industrial design

Muntzing is the practice and technique of reducing the components inside an electronic appliance to the minimum required for it to sufficiently function in most operating conditions, reducing design margins above minimum requirements toward zero. The term is named after the man who invented it, Earl "Madman" Muntz, a car and electronics salesman, who was not formally educated or trained in any science or engineering discipline.

In the 1940s and 1950s, television receivers were relatively new to the consumer market, and were more complex pieces of equipment than the radios which were then in popular use. TVs often contained upwards of 30 vacuum tubes, as well as transformers, rheostats, and other electronics. The consequence of high cost was high sales pricing, limiting potential for high-volume sales. Muntz expressed suspicion of complexity in circuit designs, and determined through simple trial and error that he could remove a significant number of electronic components from a circuit design and still end up with a monochrome TV that worked sufficiently well in urban areas, close to transmission towers where the broadcast signal was strong. He carried a pair of wire clippers, and when he felt that one of his builders was overengineering a circuit, he would begin snipping out some of the electronics components. When the TV stopped functioning, he would have the technician reinsert the last removed part. He would repeat the snipping in other portions of the circuit until he was satisfied in his simplification efforts, and then leave the TV as it was without further testing in more adverse conditions for signal reception.

As a result, he reduced his costs and increased his profits at the expense of poorer performance at locations more distant from urban centers. He reasoned that population density was higher in and near the urban centers where the TVs would work, and lower further out where the TVs would not work, so the Muntz TVs were adequate for a very large fraction of his customers. And for those further out, where the Muntz TVs did not work, those could be returned at the customer's additional effort and expense, and not Muntz's. He focused less resources in the product, intentionally accepting bare minimum performance quality, and focused more resources on advertising and sales promotions.

🔗 Animal anatomy 🔗 Neuroscience 🔗 Anatomy 🔗 Anatomy/Neuroanatomy

The enteric nervous system (ENS) or intrinsic nervous system is one of the main divisions of the autonomic nervous system (ANS) and consists of a mesh-like system of neurons that governs the function of the gastrointestinal tract. It is capable of acting independently of the sympathetic and parasympathetic nervous systems, although it may be influenced by them. The ENS is also called the second brain.It is derived from neural crest cells.

The enteric nervous system is capable of operating independently of the brain and spinal cord, but does rely on innervation from the autonomic nervous system via the vagus nerve and prevertebral ganglia in healthy subjects. However, studies have shown that the system is operable with a severed vagus nerve. The neurons of the enteric nervous system control the motor functions of the system, in addition to the secretion of gastrointestinal enzymes. These neurons communicate through many neurotransmitters similar to the CNS, including acetylcholine, dopamine, and serotonin. The large presence of serotonin and dopamine in the gut are key areas of research for neurogastroenterologists.

🔗 Architecture 🔗 Urban studies and planning

A charrette (American pronunciation: ), often Anglicized to charette or charet and sometimes called a design charrette, is an intense period of design or planning activity.

The word charrette may refer to any collaborative session in which a group of designers draft a solution to a design problem.

While the structure of a charrette varies, depending on the design problem and the individuals in the group, charrettes often take place in multiple sessions in which the group divides into sub-groups. Each sub-group then presents its work to the full group as material for further dialogue. Such charrettes serve as a way of quickly generating a design solution while integrating the aptitudes and interests of a diverse group of people. The general idea of a charrette is to create an innovative atmosphere in which a diverse group of stakeholders can collaborate to "generate visions for the future".

🔗 California

Early on the morning of May 16, 1946, a U.S. Army B-17 Flying Fortress aircraft crashed into White's Hill (also known locally as "White Hill") near Fairfax, California. Two men were killed and six seriously injured. There were reports that the B-17 was carrying nuclear weapons materials for the Operation Crossroads tests at Bikini atoll, but these reports were not confirmed. However, due to the behavior and activities of the military authorities at the crash site and the reports of several credible witnesses, including several of the crewmembers, questions about the plane's cargo remain.