Have a deep view into what people are curious about.

🔗 Cities

The world's most livable cities is an informal name given to any list of cities as they rank on an annual survey of living conditions. In addition to providing clean water, clean air, adequate food and shelter, a ‘livable’ city must also generate a sense of community and offer hospitable settings for all, especially young people, to develop social skills, a sense of autonomy and identity.

Regions with cities commonly ranked in the top 50 include Australia, New Zealand, Canada and Europe. Three examples of such surveys are Monocle's "Most Liveable Cities Index", the Economist Intelligence Unit's "Global Liveability Ranking", and "Mercer Quality of Living Survey". Numbeo has the largest statistics and survey data based on cities and countries. Deutsche Bank's Liveability Survey is another ranking of cities by quality of life.

🔗 Computer science 🔗 Economics 🔗 Engineering

In multi-objective optimization, the Pareto front (also called Pareto frontier or Pareto curve) is the set of all Pareto efficient solutions. The concept is widely used in engineering.^{: 111–148} It allows the designer to restrict attention to the set of efficient choices, and to make tradeoffs within this set, rather than considering the full range of every parameter.^{: 63–65 : 399–412}

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Computing

Personal knowledge management (PKM) is a process of collecting information that a person uses to gather, classify, store, search, retrieve and share knowledge in their daily activities (Grundspenkis 2007) and the way in which these processes support work activities (Wright 2005). It is a response to the idea that knowledge workers need to be responsible for their own growth and learning (Smedley 2009). It is a bottom-up approach to knowledge management (KM) (Pollard 2008).

🔗 Linguistics

Initial-stress derivation is a phonological process in English that moves stress to the first syllable of verbs when they are used as nouns or adjectives. (This is an example of a suprafix.) This process can be found in the case of several dozen verb-noun and verb-adjective pairs and is gradually becoming more standardized in some English dialects, but it is not present in all. The list of affected words differs from area to area, and often depends on whether a word is used metaphorically or not. At least 170 verb-noun or verb-adjective pairs exist. Some examples are:

• record.

as a verb, "Remember to recórd the show!".

as a noun, "I'll keep a récord of that request."

• permit.

as a verb, "I won't permít that."

as a noun, "We already have a pérmit."

🔗 Physics 🔗 Astronomy 🔗 Geology 🔗 Mythology 🔗 Iceland 🔗 Norse history and culture 🔗 Mythology/Norse mythology

The sunstone (Icelandic: sólarsteinn) is a type of mineral attested in several 13th–14th-century written sources in Iceland, one of which describes its use to locate the Sun in a completely overcast sky. Sunstones are also mentioned in the inventories of several churches and one monastery in 14th–15th-century Iceland and Germany.

A theory exists that the sunstone had polarizing attributes and was used as a navigational instrument by seafarers in the Viking Age. A stone found in 2002 off Alderney, in the wreck of a 16th-century warship, may lend evidence of the existence of sunstones as navigational devices.

🔗 Astronomy 🔗 Geology

The Eltanin impact is thought to be an asteroid impact in the eastern part of the South Pacific Ocean during the Pliocene-Pleistocene boundary around 2.51 ± 0.07  million years ago. The location was at the edge of the Bellingshausen Sea 1,500 km (950 mi) southwest of Chile. The asteroid was estimated to be about one to four km (0.6 to 2.5 mi) in diameter and the impact would have left a crater approximately 35 km (22 mi) across.

🔗 Architecture 🔗 Classical Greece and Rome

The Roman architectural revolution, also known as the concrete revolution, is the name sometimes given to the widespread use in Roman architecture of the previously little-used architectural forms of the arch, vault, and dome. For the first time in history, their potential was fully exploited in the construction of a wide range of civil engineering structures, public buildings, and military facilities. These included amphitheatres, aqueducts, baths, bridges, circuses, dams, roads, and temples.

A crucial factor in this development that saw a trend to monumental architecture was the invention of Roman concrete (also called opus caementicium), which led to the liberation of the shape from the dictate of the traditional materials of stone and brick.

For the first time in recorded history we find evidence of an interest in the shapes of the space contained strong enough to outweigh the functional logic of the masonry masses that contained it. There was nothing new in the employment of curvilinear or polygonal forms, as such...But in so far as such buildings incorporated curvilinear or polygonal rooms and corridors, the shapes of these were determined by the form of the building as a whole, not by any aesthetic principle.

The development of Roman architecture, however, did not remain limited to these new forms and materials. An unrelated process of architectural innovation continued unabated, which, although less conspicuous, proved their usefulness for solving structural problems and found their way permanently into Western architecture, such as the lintel arch, the independent corbel, and the metal-tie.

During the Age of Augustus, almost the entire city of Rome was rebuilt causing an influx of craftsman and architects from all across Europe. Emperor Augustus aimed to develop new ideas in the construction of his buildings that would forever defy the limits that were ever thought possible. The Mausoleum in Campus Martius was one of the major monuments built by Augustus during his reign that was made almost entirely of concrete using updated construction techniques. The concrete is used in concentric rings that support the structure of the building like walls. The Theatre of Marcellus was another concrete triumph completed during the Age of Augustus, dedicated to the nephew of the emperor. The brick-faced concrete structure construction started under Julius Caesar but was completed under Augustus. It was this building that shows the integration of new concrete building techniques of Augustus's architects as opposed to those of Caesar. The Theatre of Marcellus uses a variety of materials that aid in the growth of the concrete revolution using readily available volcanic stones such as Tuscolo tuff and Tufo Lionato as aggregates in pozzolanic concretes.

These newly concocted recipes for concrete provided durability to walls and barrelled vaults as well as a unique aesthetic appeal. The integrated stone and masonry design illustrate a refinement that came with the concrete revolution as a result of the new techniques and styles developed under Augustus. The craftsmanship of the Theatre Marcellus demonstrated a skilled employment as well as rigorous technical supervision.

🔗 Russia 🔗 Russia/mass media in Russia 🔗 Politics 🔗 Media 🔗 Russia/politics and law of Russia

The firehose of falsehood, or firehosing, is a propaganda technique in which a large number of messages are broadcast rapidly, repetitively, and continuously over multiple channels (such as news and social media) without regard for truth or consistency. Since 2014, when it was successfully used by Russia during its annexation of Crimea, this model has been adopted by other governments and political movements around the world.