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🔗 Technology 🔗 India 🔗 Metalworking

Wootz steel is a crucible steel characterized by a pattern of bands. These bands are formed by sheets of microscopic carbides within a tempered martensite or pearlite matrix in higher carbon steel, or by ferrite and pearlite banding in lower carbon steels. It was a pioneering steel alloy developed in Southern India (Tamilakam present day Tamil Nadu and Kerala) and Sri Lanka in the 6th century BC and exported globally. It was also known in the ancient world by many different names including ukku, Hindvi steel, Hinduwani steel, Teling steel and seric iron.

🔗 Business 🔗 Engineering 🔗 Japan 🔗 Japan/Science and technology 🔗 Japan/Business and economy

Poka-yoke (ポカヨケ, [poka yoke]) is a Japanese term that means "mistake-proofing" or "inadvertent error prevention". A poka-yoke is any mechanism in any process that helps an equipment operator avoid (yokeru) mistakes (poka). Its purpose is to eliminate product defects by preventing, correcting, or drawing attention to human errors as they occur. The concept was formalised, and the term adopted, by Shigeo Shingo as part of the Toyota Production System. It was originally described as baka-yoke, but as this means "fool-proofing" (or "idiot-proofing") the name was changed to the milder poka-yoke.

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Military history/Military science, technology, and theory 🔗 Military history/Weaponry 🔗 Physics 🔗 Chemistry

FOGBANK is a code name given to a material used in nuclear weapons such as the W76, W78 and W80.

FOGBANK's precise nature is classified; in the words of former Oak Ridge general manager Dennis Ruddy, "The material is classified. Its composition is classified. Its use in the weapon is classified, and the process itself is classified." Department of Energy Nuclear Explosive Safety documents simply describe it as a material "used in nuclear weapons and nuclear explosives" along with lithium hydride (LiH) and lithium deuteride (LiD), beryllium (Be), uranium hydride (UH₃), and plutonium hydride.

However National Nuclear Security Administration (NNSA) Administrator Tom D'Agostino disclosed the role of FOGBANK in the weapon: "There's another material in the—it's called interstage material, also known as fog bank", and arms experts believe that FOGBANK is an aerogel material which acts as an interstage material in a nuclear warhead; i.e., a material designed to become a superheated plasma following the detonation of the weapon's fission stage, the plasma then triggering the fusion-stage detonation.

🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Military history/Military science, technology, and theory 🔗 Physics 🔗 Military history/World War II 🔗 Physics/History

The Einstein–Szilárd letter was a letter written by Leó Szilárd and signed by Albert Einstein that was sent to the United States President Franklin D. Roosevelt on August 2, 1939. Written by Szilárd in consultation with fellow Hungarian physicists Edward Teller and Eugene Wigner, the letter warned that Germany might develop atomic bombs and suggested that the United States should start its own nuclear program. It prompted action by Roosevelt, which eventually resulted in the Manhattan Project developing the first atomic bombs.

🔗 Cryptography 🔗 Cryptography/Computer science

In cryptography, a zero-knowledge proof or zero-knowledge protocol is a method by which one party (the prover) can prove to another party (the verifier) that they know a value x, without conveying any information apart from the fact that they know the value x. The essence of zero-knowledge proofs is that it is trivial to prove that one possesses knowledge of certain information by simply revealing it; the challenge is to prove such possession without revealing the information itself or any additional information.

If proving a statement requires that the prover possesses some secret information, then the verifier will not be able to prove the statement to anyone else without possessing the secret information. The statement being proved must include the assertion that the prover has such knowledge, but not the knowledge itself. Otherwise, the statement would not be proved in zero-knowledge because it provides the verifier with additional information about the statement by the end of the protocol. A zero-knowledge proof of knowledge is a special case when the statement consists only of the fact that the prover possesses the secret information.

Interactive zero-knowledge proofs require interaction between the individual (or computer system) proving their knowledge and the individual validating the proof.

A protocol implementing zero-knowledge proofs of knowledge must necessarily require interactive input from the verifier. This interactive input is usually in the form of one or more challenges such that the responses from the prover will convince the verifier if and only if the statement is true, i.e., if the prover does possess the claimed knowledge. If this were not the case, the verifier could record the execution of the protocol and replay it to convince someone else that they possess the secret information. The new party's acceptance is either justified since the replayer does possess the information (which implies that the protocol leaked information, and thus, is not proved in zero-knowledge), or the acceptance is spurious, i.e., was accepted from someone who does not actually possess the information.

Some forms of non-interactive zero-knowledge proofs exist, but the validity of the proof relies on computational assumptions (typically the assumptions of an ideal cryptographic hash function).

🔗 Computing

In laptop computing, the XJACK is a type of extendable connector or antenna for a type II PC card, designed by the Megahertz subsidiary of 3Com. When not in use, the XJACK retracts into the PC card for storage.

The XJACK was originally used in modem and network cards, to attach a standard RJ11 or 8P8C plug directly to the PC card. They do not require a separate dongle, which could be lost or misplaced, and do not need to be removed from the laptop when travelling. An alternative approach is to use larger type III cards with a regular modular connector socket, but this approach requires more space.

Wi-Fi PC cards for accessing wireless networks have an external portion containing the antenna for improved reception (as compared with inside the laptop), but this portion of the card may be accidentally damaged while moving the laptop. 3Com manufactured wireless cards with retractable antenna portions, also under the XJACK name. Other companies have since manufactured wireless cards with retractable antennas.

🔗 Sports 🔗 Basketball

Height can significantly influence success in sports, depending on how the design of the sport is linked to factors that are height-biased due to physics and biology. The balance of the intricate array of links will determine the degree to which height plays a role in success, if any.

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