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🔗 Law

The small penis rule is an informal strategy used by authors to evade libel lawsuits. It was described in a New York Times article in 1998:

"For a fictional portrait to be actionable, it must be so accurate that a reader of the book would have no problem linking the two," said Mr. Friedman. Thus, he continued, libel lawyers have what is known as "the small penis rule". One way authors can protect themselves from libel suits is to say that a character has a small penis, Mr. Friedman said. "Now no male is going to come forward and say, 'That character with a very small penis, that's me!'"

The small penis rule was referenced in a 2006 dispute between Michael Crowley and Michael Crichton. Crowley alleged that after he wrote an unflattering review of Crichton's novel State of Fear, Crichton included a character named "Mick Crowley" in the novel Next. The character is a child rapist, described as being a Washington, D.C.-based journalist and Yale graduate with a small penis.

🔗 Constructed languages 🔗 Graphic design

Isotype (International System of Typographic Picture Education) is a method of showing social, technological, biological, and historical connections in pictorial form. It consists of a set of standardized and abstracted pictorial symbols to represent social-scientific data with specific guidelines on how to combine the identical figures using serial repetition. It was first known as the Vienna Method of Pictorial Statistics (Wiener Methode der Bildstatistik), due to its having been developed at the Gesellschafts- und Wirtschaftsmuseum in Wien (Social and Economic Museum of Vienna) between 1925 and 1934. The founding director of this museum, Otto Neurath, was the initiator and chief theorist of the Vienna Method. Gerd Arntz was the artist responsible for realising the graphics. The term Isotype was applied to the method around 1935, after its key practitioners were forced to leave Vienna by the rise of Austrian fascism.

🔗 Greece 🔗 Politics 🔗 Elections and Referendums

In governance, sortition (also known as selection by lot, allotment, demarchy, or Stochocracy) is the selection of political officials as a random sample from a larger pool of candidates. Filling individual posts or, more usually in its modern applications, to fill collegiate chambers. The system intends to ensure that all competent and interested parties have an equal chance of holding public office. It also minimizes factionalism, since there would be no point making promises to win over key constituencies if one was to be chosen by lot, while elections, by contrast, foster it. In ancient Athenian democracy, sortition was the traditional and primary method for appointing political officials, and its use was regarded as a principal characteristic of democracy.

Today, sortition is commonly used to select prospective jurors in common law-based legal systems and is sometimes used in forming citizen groups with political advisory power (citizens' juries or citizens' assemblies).

🔗 History of Science 🔗 Tree of Life

The species problem is the set of questions that arises when biologists attempt to define what a species is. Such a definition is called a species concept; there are at least 26 recognized species concepts. A species concept that works well for sexually reproducing organisms such as birds is useless for species that reproduce asexually, such as bacteria. The scientific study of the species problem has been called microtaxonomy.

One common, but sometimes difficult, question is how best to decide which species an organism belongs to, because reproductively isolated groups may not be readily recognizable, and cryptic species may be present. There is a continuum from reproductive isolation with no interbreeding, to panmixis, unlimited interbreeding. Populations can move forward or backwards along this continuum, at any point meeting the criteria for one or another species concept, and failing others.

Many of the debates on species touch on philosophical issues, such as nominalism and realism, and on issues of language and cognition.

The current meaning of the phrase "species problem" is quite different from what Charles Darwin and others meant by it during the 19th and early 20th centuries. For Darwin, the species problem was the question of how new species arose. Darwin was however one of the first people to question how well-defined species are, given that they constantly change.

🔗 Cryptography 🔗 Cryptography/Computer science

In cryptography, the socialist millionaire problem is one in which two millionaires want to determine if their wealth is equal without disclosing any information about their riches to each other. It is a variant of the Millionaire's Problem whereby two millionaires wish to compare their riches to determine who has the most wealth without disclosing any information about their riches to each other.

It is often used as a cryptographic protocol that allows two parties to verify the identity of the remote party through the use of a shared secret, avoiding a man-in-the-middle attack without the inconvenience of manually comparing public key fingerprints through an outside channel. In effect, a relatively weak password/passphrase in natural language can be used.

🔗 Russia 🔗 Dogs 🔗 Russia/science and education in Russia 🔗 Genetics 🔗 Russia/physical geography of Russia 🔗 Russia/economy of Russia

The Russian domesticated red fox is a form of the wild red fox (Vulpes vulpes) which has been domesticated to an extent, under laboratory conditions. They are the result of an experiment which was designed to demonstrate the power of selective breeding to transform species, as described by Charles Darwin in On the Origin of Species. The experiment was purposely designed to replicate the process that had produced dogs from wolves, by recording the changes in foxes, when in each generation only the most tame foxes were allowed to breed. In short order, the descendant foxes became tamer and more dog-like in their behavior.

The program was started in 1959 in the Soviet Union by zoologist Dmitry Belyayev and it has been in continuous operation since. Today, the experiment is under the supervision of Lyudmila Trut, in Russia, at the Institute of Cytology and Genetics in Novosibirsk.

🔗 Computing

Refal ("[of] Recursive functions' algorithmic language") "is functional programming language oriented toward symbolic computations", including "string processing, language translation, [and] artificial intelligence". It is one of the oldest members of this family, first conceived of in 1966 as a theoretical tool, with the first implementation appearing in 1968. Refal was intended to combine mathematical simplicity with practicality for writing large and sophisticated programs.

One of the first functional programming languages to do so, and unlike Lisp of its time, Refal is based on pattern matching. Its pattern matching works in conjunction with term rewriting.

The basic data structure of Lisp and Prolog is a linear list built by cons operation in a sequential manner, thus with O(n) access to list's nth element. Refal's lists are built and scanned from both ends, with pattern matching working for nested lists as well as the top-level one. In effect, the basic data structure of Refal is a tree rather than a list. This gives freedom and convenience in creating data structures while using only mathematically simple control mechanisms of pattern matching and substitution.

Refal also includes a feature called the freezer to support efficient partial evaluation.

Refal can be applied to the processing and transformation of tree structures, similarly to XSLT.

🔗 Electronics

Wire wrap was invented to wire telephone crossbar switches, and later adapted to construct electronic circuit boards. Electronic components mounted on an insulating board are interconnected by lengths of insulated wire run between their terminals, with the connections made by wrapping several turns of uninsulated sections of the wire around a component lead or a socket pin.

Wires can be wrapped by hand or by machine, and can be hand-modified afterwards. It was popular for large-scale manufacturing in the 1960s and early 1970s, and continues today to be used for short runs and prototypes. The method eliminates the design and fabrication of a printed circuit board. Wire wrapping is unusual among other prototyping technologies since it allows for complex assemblies to be produced by automated equipment, but then easily repaired or modified by hand.

Wire wrap construction can produce assemblies which are more reliable than printed circuits: connections are less prone to fail due to vibration or physical stresses on the base board, and the lack of solder precludes soldering faults such as corrosion, cold joints and dry joints. The connections themselves are firmer and have lower electrical resistance due to cold welding of the wire to the terminal post at the corners.

Wire wrap was used for assembly of high frequency prototypes and small production runs, including gigahertz microwave circuits and supercomputers. It is unique among automated prototyping techniques in that wire lengths can be exactly controlled, and twisted pairs or magnetically shielded twisted quads can be routed together.

Wire wrap construction became popular around 1960 in circuit board manufacturing, and use has now sharply declined. Surface-mount technology has made the technique much less useful than in previous decades. Solder-less breadboards and the decreasing cost of professionally made PCBs have nearly eliminated this technology.

🔗 Viruses 🔗 Biology 🔗 Philosophy 🔗 Philosophy/Contemporary philosophy 🔗 History of Science 🔗 Molecular and Cell Biology 🔗 Philosophy/Ethics 🔗 Genetics 🔗 Evolutionary biology 🔗 Science Policy 🔗 Molecular Biology/Molecular and Cell Biology

HeLa (; also Hela or hela) is an immortal cell line used in scientific research. It is the oldest and most commonly used human cell line. The line was derived from cervical cancer cells taken on February 8, 1951 from Henrietta Lacks, a patient who died of cancer on October 4, 1951. The cell line was found to be remarkably durable and prolific, which gives rise to its extensive use in scientific research.

The cells from Lacks's cancerous cervical tumor were taken without her knowledge or consent, which was common practice at the time. Cell biologist George Otto Gey found that they could be kept alive, and developed a cell line. Previously, cells cultured from other human cells would only survive for a few days. Scientists would spend more time trying to keep the cells alive than performing actual research on them. Cells from Lacks' tumor behaved differently. As was custom for Gey's lab assistant, she labeled the culture 'HeLa', the first two letters of the patient's first and last name; this became the name of the cell line.

These were the first human cells grown in a lab that were naturally "immortal", meaning that they do not die after a set number of cell divisions (i.e. cellular senescence). These cells could be used for conducting a multitude of medical experiments—if the cells died, they could simply be discarded and the experiment attempted again on fresh cells from the culture. This represented an enormous boon to medical and biological research, as previously stocks of living cells were limited and took significant effort to culture.

The stable growth of HeLa enabled a researcher at the University of Minnesota hospital to successfully grow polio virus, enabling the development of a vaccine, and by 1952, Jonas Salk developed a vaccine for polio using these cells. To test Salk's new vaccine, the cells were put into mass production in the first-ever cell production factory.

In 1953, HeLa cells were the first human cells successfully cloned and demand for the HeLa cells quickly grew in the nascent biomedical industry. Since the cells' first mass replications, they have been used by scientists in various types of investigations including disease research, gene mapping, effects of toxic substances on organisms, and radiation on humans. Additionally, HeLa cells have been used to test human sensitivity to tape, glue, cosmetics, and many other products.

Scientists have grown an estimated 50 million metric tons of HeLa cells, and there are almost 11,000 patents involving these cells.

The HeLa cell lines are also notorious for invading other cell cultures in laboratory settings. Some have estimated that HeLa cells have contaminated 10–20% of all cell lines currently in use.

🔗 Trains 🔗 Bridges and Tunnels

The Gotthard Base Tunnel (GBT; German: Gotthard-Basistunnel, Italian: Galleria di base del San Gottardo, Romansh: Tunnel da basa dal Son Gottard) is a railway tunnel through the Alps in Switzerland. It opened on 1 June 2016, and full service began on 11 December 2016. With a route length of 57.09 km (35.5 mi), it is the world's longest railway and deepest traffic tunnel and the first flat, low-level route through the Alps. It lies at the heart of the Gotthard axis and constitutes the third tunnel connecting the cantons of Uri and Ticino, after the Gotthard Tunnel and the Gotthard Road Tunnel.

The link consists of two single-track tunnels connecting Erstfeld (Uri) with Bodio (Ticino) and passing below Sedrun (Graubünden). It is part of the New Railway Link through the Alps (NRLA) project, which also includes the Ceneri Base Tunnel further south (scheduled to open late 2020) and the Lötschberg Base Tunnel on the other main north–south axis. It is referred to as a "base tunnel" since it bypasses most of the existing Gotthard railway line, a winding mountain route opened in 1882 across the Saint-Gotthard Massif, which was operating at its capacity before the opening of the GBT. The new base tunnel establishes a direct route usable by high-speed rail and heavy freight trains.

The main purpose of the Gotthard Base Tunnel is to increase local transport capacity through the Alpine barrier, especially for freight, notably on the Rotterdam–Basel–Genoa corridor, and more specifically to shift freight volumes from trucks to freight trains. This both significantly reduces the danger of fatal road crashes involving trucks, and reduces the environmental damage caused by heavy trucks. The tunnel provides a faster connection between the canton of Ticino and the rest of Switzerland, as well as between northern and southern Europe, cutting the Basel/Zürich–Lugano–Milan journey time for passenger trains by one hour (and from Lucerne to Bellinzona by 45 minutes).

After 64 percent of Swiss voters accepted the NRLA project in a 1992 referendum, first preparatory and exploratory work began in 1996. The official start of construction began on 4 November 1999 at Amsteg. Drilling operations in the eastern tunnel were completed on 15 October 2010 in a breakthrough ceremony broadcast live on Swiss TV, and in the western tunnel on 23 March 2011. The tunnel's constructor, AlpTransit Gotthard AG, originally planned to hand over the tunnel to Swiss Federal Railways (SBB CFF FFS) in operating condition in December 2016 but, on 4 February 2014, the handover date was changed to 5 June 2016 with the start of an 850-day opening countdown calendar on the AlpTransit homepage. As of 1998, the total projected cost of the project was CHF 6.323 billion; as of December 2015, the final cost is projected as CHF 9.560 billion. Nine people died during construction.