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🔗 Computing

In computer programming, homoiconicity (from the Greek words homo- meaning "the same" and icon meaning "representation") is a property of some programming languages. A language is homoiconic if a program written in it can be manipulated as data using the language, and thus the program's internal representation can be inferred just by reading the program itself. For example, a Lisp program is written as a regular Lisp list, and can be manipulated by other Lisp code. In homoiconic languages, all code can be accessed and transformed as data, using the same representation. This property is often summarized by saying that the language treats "code as data".

In a homoiconic language, the primary representation of programs is also a data structure in a primitive type of the language itself. This makes metaprogramming easier than in a language without this property: reflection in the language (examining the program's entities at runtime) depends on a single, homogeneous structure, and it does not have to handle several different structures that would appear in a complex syntax.

As noted above, a commonly cited example is Lisp, which was created to allow for easy list manipulations and where the structure is given by S-expressions that take the form of nested lists. Lisp programs are written in the form of lists; the result is that the program can access its own functions and procedures while running, and programmatically alter itself on the fly. Homoiconic languages typically include full support of syntactic macros, allowing the programmer to express transformations of programs in a concise way. Examples are the programming languages Clojure (a contemporary dialect of Lisp), Rebol (also its successor Red), Refal, Prolog, and more recently Julia.

🔗 Companies

PBworks (formerly PBwiki) is a commercial real-time collaborative editing (RTCE) system created by David Weekly, with Ramit Sethi and Nathan Schmidt, who joined shortly thereafter as co-founders. Based in San Mateo, California, United States, the company operates on a freemium basis, offering basic features free of charge and more advanced features for a fee.

PBworks' investors include Mohr Davidow Ventures and the Seraph Group, as well as angel investors Ron Conway and Chris Yeh.

🔗 Lists 🔗 Anthroponymy

This list of eponymous laws provides links to articles on laws, principles, adages, and other succinct observations or predictions named after a person. In some cases the person named has coined the law – such as Parkinson's law. In others, the work or publications of the individual have led to the law being so named – as is the case with Moore's law. There are also laws ascribed to individuals by others, such as Murphy's law; or given eponymous names despite the absence of the named person.

🔗 Biography 🔗 Systems 🔗 Biography/arts and entertainment

John Gall (September 18, 1925 – December 15, 2014) was an American author and retired pediatrician. Gall is known for his 1975 book General systemantics: an essay on how systems work, and especially how they fail..., a critique of systems theory. One of the statements from this book has become known as Gall's law.

🔗 British Museum 🔗 Radio 🔗 BBC 🔗 Radio/UK Radio

A History of the World in 100 Objects was a joint project of BBC Radio 4 and the British Museum, comprising a 100-part radio series written and presented by British Museum director Neil MacGregor. In 15-minute presentations broadcast on weekdays on Radio 4, MacGregor used objects of ancient art, industry, technology and arms, all of which are in the British Museum's collections, as an introduction to parts of human history. The series, four years in planning, began on 18 January 2010 and was broadcast over 20 weeks. A book to accompany the series, A History of the World in 100 Objects by Neil MacGregor, was published by Allen Lane on 28 October 2010. The entire series is also available for download along with an audio version of the book for purchase. The British Museum won the 2011 Art Fund Prize for its role in hosting the project.

In 2016, a touring exhibition of several items depicted on the radio program, also titled A History of the World in 100 Objects, travelled to various destinations, including Abu Dhabi (Manarat Al Saadiyat), Taiwan (National Palace Museum in Taipei), Japan (Tokyo Metropolitan Art Museum in Tokyo, Kyushu National Museum in Daizafu, and Kobe City Museum in Kobe), Australia (Western Australian Museum in Perth and National Museum of Australia in Canberra), and China (National Museum of China in Beijing and Shanghai Museum in Shanghai).

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 Economics 🔗 Sociology

Commons-based peer production (CBPP) is a term coined by Harvard Law School professor Yochai Benkler. It describes a model of socio-economic production in which large numbers of people work cooperatively; usually over the Internet. Commons-based projects generally have less rigid hierarchical structures than those under more traditional business models. Often—but not always—commons-based projects are designed without a need for financial compensation for contributors. For example, sharing of STL (file format) design files for objects freely on the internet enables anyone with a 3-D printer to digitally replicate the object saving the prosumer significant money.

The term is often used interchangeably with the term social production.

🔗 United States 🔗 Spaceflight 🔗 United States/Military history - U.S. military history 🔗 Physics

Project Longshot was a conceptual interstellar spacecraft design. It would have been an unmanned probe, intended to fly to and enter orbit around Alpha Centauri B powered by nuclear pulse propulsion.

🔗 California 🔗 Companies 🔗 Technology 🔗 Private Equity 🔗 California/San Francisco Bay Area

Y Combinator is an American seed accelerator launched in March 2005 and has been used to launch over 2,000 companies including Stripe, Airbnb, Cruise Automation, DoorDash, Coinbase, Instacart, and Dropbox. The combined valuation of the top YC companies was over $155 billion as of October, 2019.

🔗 Biography 🔗 California 🔗 California/San Francisco Bay Area 🔗 Apple Inc. 🔗 Biography/science and academia 🔗 LGBT studies

Ronald Wayne (born May 17, 1934) is a retired American electronics industry businessman. He co-founded Apple Computer Company (now Apple Inc.) as a partnership with Steve Wozniak and Steve Jobs, providing administrative oversight and documentation for the new venture. Twelve days later, he sold his 10% share of the new company back to Jobs and Wozniak for US$800, and one year later accepted a final US$1,500 to forfeit any potential future claims against the newly legally incorporated Apple, totaling $2,300.