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🔗 Aviation 🔗 Norway 🔗 Arctic 🔗 Sweden

Andrée's Arctic balloon expedition of 1897 was an effort to reach the North Pole in which all three Swedish expedition members – S. A. Andrée, Knut Frænkel, and Nils Strindberg – perished. Andrée, the first Swedish balloonist, proposed a voyage by hydrogen balloon from Svalbard to either Russia or Canada, which was to pass, with luck, straight over the North Pole on the way. The scheme was received with patriotic enthusiasm in Sweden, a northern nation that had fallen behind in the race for the North Pole.

Andrée ignored many early signs of the dangers associated with his balloon plan. Being able to steer the balloon to some extent was essential for a safe journey, but there was much evidence that the drag-rope steering technique he had invented was ineffective. Worse, the polar balloon Örnen (Eagle) was delivered directly to Svalbard from its manufacturer in Paris without being tested. When measurements showed it to be leaking more than expected, Andrée failed to acknowledge the risk.

After Andrée, Strindberg, and Frænkel lifted off from Svalbard in July 1897, the balloon lost hydrogen quickly and crashed on the pack ice after only two days. The explorers were unhurt but faced a grueling trek back south across the drifting icescape. Inadequately clothed, equipped, and prepared, and shocked by the difficulty of the terrain, they did not make it to safety. As the Arctic winter closed in on them in October, the group ended up exhausted on the deserted Kvitøya (White Island) in Svalbard and died there. For 33 years the fate of the expedition remained one of the unsolved riddles of the Arctic. The chance discovery in 1930 of the expedition's last camp created a media sensation in Sweden, where the dead men had been mourned and idolized.

Andrée's motives and mindset have been the subject of extensive fictional and historical discussion, particularly inspired by his apparent foolhardiness. An early example is Per Olof Sundman's fictionalized bestseller novel of 1967, The Flight of the Eagle, which portrays Andrée as weak and cynical, at the mercy of his sponsors and the media. Modern writers have been generally critical of Andrée.

🔗 Computing 🔗 Computer science

In theoretical computer science, the π-calculus (or pi-calculus) is a process calculus. The π-calculus allows channel names to be communicated along the channels themselves, and in this way it is able to describe concurrent computations whose network configuration may change during the computation.

The π-calculus is simple, it has few terms and so is a small, yet expressive language (see #Syntax). Functional programs can be encoded into the π-calculus, and the encoding emphasises the dialogue nature of computation, drawing connections with game semantics. Extensions of the π-calculus, such as the spi calculus and applied π, have been successful in reasoning about cryptographic protocols. Beside the original use in describing concurrent systems, the π-calculus has also been used to reason about business processes and molecular biology.

🔗 Technology 🔗 Computing 🔗 Computer science

Reversible computing is a model of computing where the computational process to some extent is time-reversible. In a model of computation that uses deterministic transitions from one state of the abstract machine to another, a necessary condition for reversibility is that the relation of the mapping from (nonzero-probability) states to their successors must be one-to-one. Reversible computing is a form of unconventional computing.

🔗 Novels 🔗 Novels/19th century 🔗 Novels/Science fiction 🔗 New Zealand 🔗 Sociology

Erewhon: or, Over the Range () is a novel by English writer Samuel Butler, first published anonymously in 1872, set in a fictional country discovered and explored by the protagonist. The book is a satire on Victorian society.

The first few chapters of the novel dealing with the discovery of Erewhon are in fact based on Butler's own experiences in New Zealand, where, as a young man, he worked as a sheep farmer on Mesopotamia Station for about four years (1860–64), and explored parts of the interior of the South Island and wrote about in his A First Year in Canterbury Settlement (1863).

The novel is one of the first to explore ideas of artificial intelligence, as influenced by Darwin's recently published On the Origin of Species (1859) and the machines developed out of the Industrial Revolution (late 18th to early 19th centuries). Specifically, it concerns itself, in the three-chapter "Book of the Machines", with the potentially dangerous ideas of machine consciousness and self-replicating machines.

🔗 Economics 🔗 Psychology 🔗 Marketing & Advertising 🔗 Retailing

In decision making and psychology, decision fatigue refers to the deteriorating quality of decisions made by an individual after a long session of decision making. It is now understood as one of the causes of irrational trade-offs in decision making. Decision fatigue may also lead to consumers making poor choices with their purchases.

There is a paradox in that "people who lack choices seem to want them and often will fight for them", yet at the same time, "people find that making many choices can be [psychologically] aversive."

For example, major politicians and businessmen such as former United States President Barack Obama, Steve Jobs, and Mark Zuckerberg have been known to reduce their everyday clothing down to one or two outfits in order to limit the number of decisions they make in a day.

🔗 Linguistics

Initial-stress derivation is a phonological process in English that moves stress to the first syllable of verbs when they are used as nouns or adjectives. (This is an example of a suprafix.) This process can be found in the case of several dozen verb-noun and verb-adjective pairs and is gradually becoming more standardized in some English dialects, but it is not present in all. The list of affected words differs from area to area, and often depends on whether a word is used metaphorically or not. At least 170 verb-noun or verb-adjective pairs exist. Some examples are:

• record.

as a verb, "Remember to recórd the show!".

as a noun, "I'll keep a récord of that request."

• permit.

as a verb, "I won't permít that."

as a noun, "We already have a pérmit."

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Internet culture 🔗 Skepticism 🔗 Alternative Views 🔗 Paranormal

John Titor (May 5, 6 or 7, 1998) is a name used on several bulletin boards during 2000 and 2001 by a poster claiming to be an American military time traveler from 2036. Titor made numerous vague and specific predictions regarding calamitous events in 2004 and beyond, including a nuclear war, none of which came true. Subsequent closer examination of Titor's assertions provoked widespread skepticism. Inconsistencies in his explanations, the uniform inaccuracy of his predictions, and a private investigator's findings all led to the general impression that the entire episode was an elaborate hoax. A 2009 investigation concluded that Titor was likely the creation of Larry Haber, a Florida entertainment lawyer, along with his brother Morey, a computer scientist.

🔗 Biography 🔗 Lists 🔗 Christianity 🔗 Christianity/Jesus

This is a partial list of notable people who have been claimed, either by themselves or by their followers, in some way to be the reincarnation or incarnation of Jesus, or the Second Coming of Christ.