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🔗 Disaster management 🔗 Crime 🔗 Law 🔗 England

R v Dudley and Stephens (1884) 14 QBD 273 DC is a leading English criminal case which established a precedent throughout the common law world that necessity is not a defence to a charge of murder. It concerned survival cannibalism following a shipwreck and its purported justification on the basis of a custom of the sea. It marked the culmination of a long history of attempts by the law, in the face of public opinion sympathetic to castaways, to outlaw the custom and it became something of a cause célèbre in Victorian Britain.

Dudley and Stephens were shipwrecked along with two other men. When one of them, the cabin boy Richard Parker, fell into a coma, Dudley and Stephens decided to kill him for food.

🔗 Telecommunications

The Strowger switch is the first commercially successful electromechanical stepping switch telephone exchange system. It was developed by the Strowger Automatic Telephone Exchange Company founded in 1891 by Almon Brown Strowger. Because of its operational characteristics it is also known as a step-by-step (SXS) switch.

🔗 Trains 🔗 Trains/Operations

Signalling block systems enable the safe and efficient operation of railways by preventing collisions between trains. The basic principle is that a route is broken up into a series of sections or "blocks". Only one train may occupy a block at a time, and the blocks are sized to allow a train to stop within them. That ensures that a train always has time to stop before getting dangerously close to another train on the same line. The block system is referred to in the UK as the method of working, in the US as the method of operation, and in Australia as safeworking.

In most situations, a system of signals is used to control the passage of trains between the blocks. When a train enters a block, signals at both ends change to indicate that the block is occupied, typically using red lamps or indicator flags. When a train first enters a block, the rear of the same train has not yet left the previous block, so both blocks are marked as occupied. That ensures there is slightly less than one block length on either end of the train that is marked as occupied, so any other train approaching that section will have enough room to stop in time, even if the first train has stopped dead on the tracks. The previously-occupied block will only be marked unoccupied when the end of the train has entirely left it, leaving the entire block clear.

Block systems have the disadvantage that they limit the number of trains on a particular route to something fewer than the number of blocks. Since the route has a fixed length, increasing the number of trains requires the creation of more blocks, which means the blocks are shorter and trains have to operate at lower speeds in order to stop safely. As a result, the number and size of blocks are closely related to the overall route capacity, and cannot be changed easily because expensive alterations to the signals along the line would be required.

Block systems are used to control trains between stations and yards, but not normally within the yards, where some other method is used. Any block system is defined by its associated physical equipment and by the application of a relevant set of rules. Some systems involve the use of signals while others do not. Some systems are specifically designed for single track railways, on which there is a danger of both head-on and rear-end collision, as opposed to double track, on which the main danger is rear-end collisions.

🔗 Economics 🔗 Politics 🔗 Futures studies 🔗 Civil Rights Movement

"The Triple Revolution" was an open memorandum sent to U.S. President Lyndon B. Johnson and other government figures on March 22, 1964. Drafted under the auspices of the Center for the Study of Democratic Institutions, it was signed by an array of noted social activists, professors, and technologists who identified themselves as the Ad Hoc Committee on the Triple Revolution. The chief initiator of the proposal was W. H. "Ping" Ferry, at that time a vice-president of CSDI, basing it in large part on the ideas of the futurist Robert Theobald.

🔗 Chemicals 🔗 Food and drink 🔗 Pharmacology 🔗 Molecular Biology 🔗 Molecular Biology/Molecular and Cell Biology

Miraculin is a taste modifier, a glycoprotein extracted from the fruit of Synsepalum dulcificum. The berry, also known as the miracle fruit, was documented by explorer Chevalier des Marchais, who searched for many different fruits during a 1725 excursion to its native West Africa.

Miraculin itself does not taste sweet. When taste buds are exposed to miraculin, the protein binds to the sweetness receptors. This causes normally sour-tasting acidic foods, such as citrus, to be perceived as sweet. The effect can last for one or two hours.

🔗 Technology 🔗 Physics 🔗 Telecommunications 🔗 Radio 🔗 Electronics 🔗 Engineering

In antenna theory, a phased array usually means an electronically scanned array, a computer-controlled array of antennas which creates a beam of radio waves that can be electronically steered to point in different directions without moving the antennas. The general theory of an electromagnetic phased array also finds applications in ultrasonic and medical imaging application (phased array ultrasonics) and in optics optical phased array.

In a simple array antenna, the radio frequency current from the transmitter is fed to multiple individual antenna elements with the proper phase relationship so that the radio waves from the separate elements combine (superpose) to form beams, to increase power radiated in desired directions and suppress radiation in undesired directions. In a phased array, the power from the transmitter is fed to the radiating elements through devices called phase shifters, controlled by a computer system, which can alter the phase or signal delay electronically, thus steering the beam of radio waves to a different direction. Since the size of an antenna array must extend many wavelengths to achieve the high gain needed for narrow beamwidth, phased arrays are mainly practical at the high frequency end of the radio spectrum, in the UHF and microwave bands, in which the operating wavelengths are conveniently small.

Phased arrays were originally conceived for use in military radar systems, to steer a beam of radio waves quickly across the sky to detect planes and missiles. These systems are now widely used and have spread to civilian applications such as 5G MIMO for cell phones. The phased array principle is also used in acoustics, and phased arrays of acoustic transducers are used in medical ultrasound imaging scanners (phased array ultrasonics), oil and gas prospecting (reflection seismology), and military sonar systems.

The term "phased array" is also used to a lesser extent for unsteered array antennas in which the phase of the feed power and thus the radiation pattern of the antenna array is fixed. For example, AM broadcast radio antennas consisting of multiple mast radiators fed so as to create a specific radiation pattern are also called "phased arrays".

🔗 Metalworking 🔗 Materials

Low-background steel is any steel produced prior to the detonation of the first nuclear bombs in the 1940s and 1950s. With the Trinity test and the nuclear bombings of Hiroshima and Nagasaki in 1945, and then subsequent nuclear weapons testing during the early years of the Cold War, background radiation levels increased across the world. Modern steel is contaminated with radionuclides because its production uses atmospheric air. Low-background steel is so-called because it does not suffer from such nuclear contamination. This steel is used in devices that require the highest sensitivity for detecting radionuclides.

The primary source of low-background steel is ships that were constructed before the Trinity test, most famously the scuttled German World War I warships in Scapa Flow.

🔗 Pharmacology

Eroom's law is the observation that drug discovery is becoming slower and more expensive over time, despite improvements in technology (such as high-throughput screening, biotechnology, combinatorial chemistry, and computational drug design), a trend first observed in the 1980s. The cost of developing a new drug roughly doubles every nine years (inflation-adjusted). In order to highlight the contrast with the exponential advancements of other forms of technology (such as transistors) over time, the law was deliberately spelled as Moore's law spelled backwards.

The article proposing and naming the law attributes it to four main causes.

• the 'better than the Beatles' problem: the sense that new drugs only have modest incremental benefit over drugs already widely considered as successful, such as Lipitor, and treatment effects on top of already effective treatments are smaller than treatment effects versus placebo. The smaller size of these treatment effects mandates an increase in clinical trial sizes to show the same level of efficacy. This problem was phrased as "better than the Beatles" to highlight the fact that it would be difficult to come up with new successful pop songs if all new songs had to be better than the Beatles.
• the 'cautious regulator' problem: the progressive lowering of risk tolerance seen by drug regulatory agencies that makes R&D both costlier and harder. After older drugs (such as Thalidomide or Vioxx) are removed from the market due to safety reasons, the bar on safety for new drugs is increased.
• the 'throw money at it' tendency: the tendency to add human resources and other resources to R&D, which may lead to project overrun.
• the 'basic research–brute force' bias: the tendency to overestimate the ability of advances in basic research and brute force screening methods to show a molecule as safe and effective in clinical trials. From the 1960s to the 1990s (and later), drug discovery has shifted from whole-animal classical pharmacology testing methods (phenotypic screening) to reverse pharmacology target-approaches that result in the discovery of drugs that may tightly bind with high-affinity to target proteins, but which still often fail in clinical trials due to an under-appreciation of the complexity of the whole organism. Furthermore, drug discovery techniques have shifted from small-molecule and iterative low-throughput search strategies to target-based high-throughput screening (HTS) of large compound libraries. But despite being faster and cheaper, HTS approaches may be less productive.

While some suspect a lack of "low-hanging fruit" as a significant contribution to Eroom's law, this may be less important than the four main causes, as there are still many decades' worth of new potential drug targets relative to the number of targets which already have been exploited, even if the industry exploits 4 to 5 new targets per year. There is also space to explore selectively non-selective drugs (or "dirty drugs") that interact with several molecular targets, and which may be particularly effective as central nervous system (CNS) therapeutics, even though few of them have been introduced in the last few decades.

🔗 Astronomy 🔗 Sweden 🔗 Solar System 🔗 Astronomy/Solar System

The Sweden Solar System is the world's largest permanent scale model of the Solar System. The Sun is represented by the Ericsson Globe in Stockholm, the largest hemispherical building in the world. The inner planets can also be found in Stockholm but the outer planets are situated northward in other cities along the Baltic Sea. The system was started by Nils Brenning and Gösta Gahm and is on the scale of 1:20 million.