Have a deep view into what people are curious about.

🔗 Skepticism 🔗 Neuroscience 🔗 Physiology

The gut–brain axis is the two-way biochemical signaling that takes place between the gastrointestinal tract (GI tract) and the central nervous system (CNS). The term "gut–brain axis" is occasionally used to refer to the role of the gut microbiota in the interplay as well. The "microbiota–gut–brain (MGB or BGM) axis" explicitly includes the role of gut microbiota in the biochemical signaling events that take place between the GI tract and the CNS. Broadly defined, the gut–brain axis includes the central nervous system, neuroendocrine system, neuroimmune systems, the hypothalamic–pituitary–adrenal axis (HPA axis), sympathetic and parasympathetic arms of the autonomic nervous system, the enteric nervous system, vagus nerve, and the gut microbiota.

Chemicals released in the gut by the microbiome can vastly influence the development of the brain, starting from birth. A review from 2015 states that the microbiome influences the central nervous system by “regulating brain chemistry and influencing neuro-endocrine systems associated with stress response, anxiety and memory function”. The gut, sometimes referred to as the “second brain”, functions off of the same type of neural network as the central nervous system, suggesting why it plays a significant role in brain function and mental health.

The bidirectional communication is done by immune, endocrine, humoral and neural connections between the gastrointestinal tract and the central nervous system. More research suggests that the gut microorganisms influence the function of the brain by releasing the following chemicals: cytokines, neurotransmitters, neuropeptides, chemokines, endocrine messengers and microbial metabolites such as "short-chain fatty acids, branched chain amino acids, and peptidoglycans”. The intestinal microbiome can then divert these products to the brain via the blood, neuropod cells, nerves, endocrine cells and more to be determined. The products then arrive at important locations in the brain, impacting different metabolic processes. Studies have confirmed communication between the hippocampus, the prefrontal cortex and the amygdala (responsible for emotions and motivation), which acts as a key node in the gut-brain behavioral axis.

While IBS is the only disease confirmed to be directly influenced by the gut microbiome, many disorders (such as anxiety, autism, depression and schizophrenia) have been linked to the gut-brain axis as well. The impact of the axis, and the various ways in which one can influence it, remains a promising research field which could result in future treatments for psychiatric, age-related, neurodegenerative and neurodevelopmental disorders. For example, according to a study from 2017, “probiotics have the ability to restore normal microbial balance, and therefore have a potential role in the treatment and prevention of anxiety and depression”.

The first of the brain–gut interactions shown, was the cephalic phase of digestion, in the release of gastric and pancreatic secretions in response to sensory signals, such as the smell and sight of food. This was first demonstrated by Pavlov through Nobel prize winning research in 1904.

Scientific interest in the field had already led to review in the second half of the 20th century. It was promoted further by a 2004 primary research study showing that germ-free (GF) mice showed an exaggerated HPA axis response to stress compared to non-GF laboratory mice.

As of October 2016, most of the work done on the role of gut microbiota in the gut–brain axis had been conducted in animals, or on characterizing the various neuroactive compounds that gut microbiota can produce. Studies with humans – measuring variations in gut microbiota between people with various psychiatric and neurological conditions or when stressed, or measuring effects of various probiotics (dubbed "psychobiotics" in this context) – had generally been small and were just beginning to be generalized. Whether changes to the gut microbiota are a result of disease, a cause of disease, or both in any number of possible feedback loops in the gut–brain axis, remained unclear.

🔗 Computing 🔗 Computer science 🔗 Lists 🔗 Science Fiction

Computers have often been used as fictional objects in literature, movies and in other forms of media. Fictional computers tend to be considerably more sophisticated than anything yet devised in the real world.

This is a list of computers that have appeared in notable works of fiction. The work may be about the computer, or the computer may be an important element of the story. Only static computers are included. Robots and other fictional computers that are described as existing in a mobile or humanlike form are discussed in a separate list of fictional robots and androids.

🔗 Human rights 🔗 Canada 🔗 Law 🔗 Canada/Canadian law

Section 33 of the Canadian Charter of Rights and Freedoms is part of the Constitution of Canada. It is commonly known as the notwithstanding clause (French: clause dérogatoire or clause nonobstant), sometimes referred to as the override power, and it allows Parliament or provincial legislatures to temporarily override sections 2 and 7–15 of the Charter.

🔗 Switzerland 🔗 Countries

Switzerland, officially the Swiss Confederation, is a country situated in the confluence of Western, Central, and Southern Europe. It is a federal republic composed of 26 cantons, with federal authorities seated in Bern. Switzerland is a landlocked country bordered by Italy to the south, France to the west, Germany to the north, and Austria and Liechtenstein to the east. It is geographically divided among the Swiss Plateau, the Alps, and the Jura, spanning a total area of 41,285 km² (15,940 sq mi), and land area of 39,997 km² (15,443 sq mi). While the Alps occupy the greater part of the territory, the Swiss population of approximately 8.5 million is concentrated mostly on the plateau, where the largest cities are located, among them the two global cities and economic centres of Zürich and Geneva.

The establishment of the Old Swiss Confederacy dates to the late medieval period, resulting from a series of military successes against Austria and Burgundy. Swiss independence from the Holy Roman Empire was formally recognized in the Peace of Westphalia in 1648. The Federal Charter of 1291 is considered the founding document of Switzerland which is celebrated on Swiss National Day. Since the Reformation of the 16th century, Switzerland has maintained a strong policy of armed neutrality; it has not fought an international war since 1815 and did not join the United Nations until 2002. Nevertheless, it pursues an active foreign policy and is frequently involved in peace-building processes around the world. Switzerland is the birthplace of the Red Cross, one of the world's oldest and best known humanitarian organisations, and is home to numerous international organisations, including the second largest UN office. It is a founding member of the European Free Trade Association, but notably not part of the European Union, the European Economic Area or the Eurozone. However, it participates in the Schengen Area and the European Single Market through bilateral treaties.

Switzerland occupies the crossroads of Germanic and Romance Europe, as reflected in its four main linguistic and cultural regions: German, French, Italian and Romansh. Although the majority of the population are German-speaking, Swiss national identity is rooted in a common historical background, shared values such as federalism and direct democracy, and Alpine symbolism. Due to its linguistic diversity, Switzerland is known by a variety of native names: Schweiz [ˈʃvaɪts] (German); Suisse [sɥis(ə)] (French); Svizzera [ˈzvittsera] (Italian); and Svizra [ˈʒviːtsrɐ, ˈʒviːtsʁɐ] (Romansh). On coins and stamps, the Latin name, Confoederatio Helvetica – frequently shortened to "Helvetia" – is used instead of the four national languages.

The sovereign state is one of the most developed countries in the world, with the highest nominal wealth per adult and the eighth-highest per capita gross domestic product. It ranks at or near the top in several international metrics, including economic competitiveness and human development. Zürich, Geneva and Basel have been ranked among the top ten cities in the world in terms of quality of life, with Zürich ranked second globally. In 2019, IMD placed Switzerland first in the world in attracting skilled workers. World Economic Forum ranks it the 5th most competitive country globally.

🔗 Technology 🔗 Philosophy 🔗 Robotics 🔗 Philosophy/Philosophy of mind

The AI effect is a phenomenon in which advances in artificial intelligence lead to a redefinition of what is considered intelligence, such that capabilities achieved by AI systems are no longer regarded as examples of "real" intelligence.

The concept has been used to describe both a cognitive tendency and a sociotechnical pattern, in which successful AI techniques are reclassified as routine computation or absorbed into other domains.

Historian Pamela McCorduck described this as a recurring feature of AI research, noting that once a problem is solved, it is no longer considered evidence of intelligence. Researcher Rodney Brooks similarly observed that once systems are understood, they are often regarded as "just computation".

🔗 Computing

In computer storage, Bélády's anomaly is the phenomenon in which increasing the number of page frames results in an increase in the number of page faults for certain memory access patterns. This phenomenon is commonly experienced when using the first-in first-out (FIFO) page replacement algorithm. In FIFO, the page fault may or may not increase as the page frames increase, but in Optimal and stack-based algorithms like LRU, as the page frames increase the page fault decreases. László Bélády demonstrated this in 1969.

In common computer memory management, information is loaded in specific-sized chunks. Each chunk is referred to as a page. Main memory can hold only a limited number of pages at a time. It requires a frame for each page it can load. A page fault occurs when a page is not found, and might need to be loaded from disk into memory.

When a page fault occurs and all frames are in use, one must be cleared to make room for the new page. A simple algorithm is FIFO: whichever page has been in the frames the longest is the one that is cleared. Until Bélády's anomaly was demonstrated, it was believed that an increase in the number of page frames would always result in the same number of or fewer page faults.

🔗 Aviation 🔗 Military history 🔗 Military history/Military aviation 🔗 Aviation/Aviation accident 🔗 Military history/Cold War 🔗 Military history/Russian, Soviet and CIS military history 🔗 Finland

Finnair Flight 915 (AY915) was a scheduled flight by Finnair from Tokyo, Japan, over the North Pole to Helsinki, Finland, on 23 December 1987. In 2014, Finnish media reported a claim by two of the flight’s pilots that the Soviet Union had fired a missile at the aircraft, which exploded less than 30 seconds before impact. The allegations came out only in September 2014, when Helsingin Sanomat, the leading Finnish daily newspaper, published an extensive article on the matter. The Finnish Broadcasting Corporation YLE reported on the article on the internet the same day.

When the matter came out, it caused outrage in Finland among those politicians and civil servants, to whom it should have been reported at the time, and it was widely publicised and commented upon in the Finnish media, amidst allegations of Finlandization.

The alleged incident has been compared to other similar incidents involving the Soviet Union, such as the Aero Kaleva in 1940, Aeroflot Flight 902 in 1962, Korean Air Lines Flight 902 in 1978, Korean Air Lines Flight 007 in 1983. Co-captain Kaukiainen said that the Finnair pilots decided to speak out on the matter after Malaysia Airlines Flight 17 had been shot down in Ukraine on 17 July 2014.

🔗 Biography 🔗 China/Chinese history 🔗 Italy 🔗 China

Katarina Vilioni (died 1342) was one of the first Europeans known to have resided in China. She was apparently a member of a Genoese trading family that lived in Yangzhou during the mid-14th century.

Vilioni is known through her tombstone, which was rediscovered at Yangzhou in 1951. It suggests that Vilioni died in 1342 and was the daughter of a man named Domenico Vilioni.

🔗 Comedy

This Man, according to a website created in 2008 by Italian marketer Andrea Natella named Ever Dream This Man?, was a person who was claimed to have been repeatedly seen in dreams by the whole world since 2006, but was never found in the real world. Natella created the site in 2008, but it was not until October 2009 that it gained attention from the press and online internet users. This Man's notoriety spawned several internet memes that spoofed flyers of the website, references in films and television shows like The X-Files, and a manga series based on the hoax by Weekly Shonen Magazine.

🔗 Medicine 🔗 Linguistics 🔗 Linguistics/Applied Linguistics

Semantic satiation is a psychological phenomenon in which repetition causes a word or phrase to temporarily lose meaning for the listener, who then perceives the speech as repeated meaningless sounds. Extended inspection or analysis (staring at the word or phrase for a lengthy period of time) in place of repetition also produces the same effect.