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🔗 Medicine 🔗 Pharmacology

Sofosbuvir, sold under the brand name Sovaldi among others, is a medication used to treat hepatitis C. It is only recommended with some combination of ribavirin, peginterferon-alfa, simeprevir, ledipasvir, daclatasvir, or velpatasvir. Cure rates are 30 to 97% depending on the type of hepatitis C virus involved. Safety during pregnancy is unclear; some of the medications used in combination may result in harm to the baby. It is taken by mouth.

Common side effects include feeling tired, headache, nausea, and trouble sleeping. Side effects are generally more common in interferon-containing regimens. Sofosbuvir may reactivate hepatitis B in those who have been previously infected. In combination with ledipasvir, daclatasvir or simeprevir it is not recommended with amiodarone due to the risk of an abnormally slow heartbeat. Sofosbuvir is in the nucleotide analog family of medication and works by blocking the hepatitis C NS5B protein.

Sofosbuvir was discovered in 2007, and approved for medical use in the United States in 2013. It is on the World Health Organization's List of Essential Medicines, the safest and most effective medicines needed in a health system. As of 2016, a 12-week course of treatment costs about US$84,000 in the United States, US$53,000 in the United Kingdom, US$45,000 in Canada, and about US$500 in India. Over 60,000 people were treated with sofosbuvir in its first 30 weeks being sold in the United States.

🔗 Iran 🔗 Classical Greece and Rome 🔗 Dams 🔗 Bridges and Tunnels

The Band-e Kaisar (Persian: بند قیصر, "Caesar's dam"‎), Pol-e Kaisar ("Caesar's bridge"), Bridge of Valerian or Shadirwan was an ancient arch bridge in Shushtar, Iran, and the first in the country to combine it with a dam. Built by the Sassanids, using Roman prisoners of war as workforce, in the 3rd century AD on Sassanid order, it was also the most eastern example of Roman bridge design and Roman dam, lying deep in Persian territory. Its dual-purpose design exerted a profound influence on Iranian civil engineering and was instrumental in developing Sassanid water management techniques.

The approximately 500 m long overflow dam over the Karun, Iran's most effluent river, was the core structure of the Shushtar Historical Hydraulic System (سازه‌های آبی شوشتر) from which the city derived its agricultural productivity, and which has been designated by the UNESCO as Iran's 10th World Heritage Site in 2009. The arched superstructure carried across the important road between Pasargadae and the Sassanid capital Ctesiphon. Many times repaired in the Islamic period, the dam bridge remained in use until the late 19th century.

🔗 International relations 🔗 Death 🔗 Law 🔗 International relations/International law

A custom of the sea is a custom said to be practiced by the officers and crew of ships and boats in the open sea, as distinguished from maritime law, which is a distinct and coherent body of law governing maritime questions and offenses.

Among these customs was the practice of cannibalism among shipwrecked survivors, by the drawing of lots to decide who would be killed and eaten so that the others might survive.

🔗 Computing 🔗 Books

Hacker's Delight is a software algorithm book by Henry S. Warren, Jr. first published in 2002. It presents fast bit-level and low-level arithmetic algorithms for common tasks such as counting bits or improving speed of division by using multiplication.

🔗 United States 🔗 Law 🔗 Marketing & Advertising

Leonard v. Pepsico, Inc., 88 F. Supp. 2d 116, (S.D.N.Y. 1999), aff'd 210 F.3d 88 (2d Cir. 2000), more widely known as the Pepsi Points case, is an American contract law case regarding offer and acceptance. The case was brought in the United States District Court for the Southern District of New York in 1999; its judgment was written by Kimba Wood.

In 1996, PepsiCo began a promotional loyalty program, in which customers could earn Pepsi Points; these points could, in turn, be traded for physical items. A television commercial for the loyalty program displayed the commercial's protagonist flying a McDonnell Douglas AV-8B Harrier II vertical take off jet aircraft to school, valued at $37.4 million at the time, which could be redeemed for 7,000,000 Pepsi Points. The plaintiff, John Leonard, discovered a loophole in the promotion, allowing him to purchase Pepsi Points at 10¢ per point. Leonard promptly delivered a check for $700,008.50 to PepsiCo, attempting to purchase the jet. PepsiCo initially refuted Leonard's offer, citing the humorous nature of the offer in the advertisement. Leonard then sued PepsiCo, Inc. in an effort to enforce the offer and acceptance perceived by Leonard to be made in the advertisement. In her judgment, Wood sided with PepsiCo, noting the frivolous and improbable nature of landing a fighter jet in a school zone that was portrayed by the protagonist. PepsiCo would re-release the advertisement, valuing the jet at 700,000,000 Pepsi Points.

🔗 Internet 🔗 Marketing & Advertising

Domain tasting is the practice of temporarily registering a domain under the five-day Add Grace Period at the beginning of the registration of an ICANN-regulated second-level domain. During this period, a registration must be fully refunded by the domain name registry if cancelled. This was designed to address accidental registrations, but domain tasters use the Add Grace Period for illegal purposes.

🔗 United States 🔗 Telecommunications

Area code 710 is a special area code, reserved to the federal government of the United States in 1983. As of December 2006, it had only one working number, 710-NCS-GETS (710-627-4387), which requires a special access code to use.

See Government Emergency Telecommunications Service for more information on this service.

🔗 Sociology 🔗 Organizations 🔗 Media 🔗 Culture 🔗 Sociology/social movements 🔗 Toys

The Barbie Liberation Organization or BLO, sponsored by RTMark, were a group of artists and activists involved in culture jamming. They gained notoriety in 1993 after switching voice boxes in talking G.I. Joes and Barbie dolls. The BLO performed "surgery" on a reported 300–500 dolls from retail and returned them to shelves, an action they refer to as shopgiving. Thus, Teen Talk Barbie dolls would say phrases such as "Vengeance is mine", while G.I. Joe dolls would say phrases such as "The beach is the place for summer!"

🔗 Biography 🔗 Video games

Zachtronics LLC is an American indie video game studio, best known for their engineering puzzle games and programming games. Zachtronics was founded by Zach Barth in 2000, who serves as its lead designer. Some of their products include SpaceChem, Infinifactory, TIS-100, and Shenzhen I/O.

🔗 Spaceflight

A diffractive solar sail, or diffractive lightsail, is a type of solar sail which relies on diffraction instead of reflection for its propulsion. Current diffractive sail designs use thin metamaterial films, containing micrometer-size gratings based on polarization or subwavelength refractive structures, causing light to spread out (i.e. diffract) and thereby exert radiation pressure when it passes through them.