Nick Naylor is a Big Tobacco spokesman using "research" from an institution of which he is vice-president, a tobacco lobby called the "Academy of Tobacco Studies". It claims there is no link between tobacco and lung disease. Naylor and his friends, firearm lobbyist Bobby Jay Bliss and alcohol lobbyist Polly Bailey, meet for lunch every week and jokingly call themselves the "Merchants of Death" or "The MOD Squad". As anti-tobacco campaigns mount and numbers of young smokers decline, Naylor's boss, B.R., sends Naylor to Los Angeles to bargain for cigarette product placement in upcoming movies. Naylor takes along his young son, Joey, in hopes of bonding with him. The next day, Naylor is sent to meet with Lorne Lutch, the cancer -stricken man who once played the Marlboro Man in cigarette ads and is now campaigning against cigarettes. As his son watches, Naylor successfully convinces Lutch to take a suitcase of money for his silence by playing on Lutch's principles and need to provide for his family. Senator Ortolan Finistirre, one of Naylor's most vehement critics, promotes a bill to add a skull and crossbones POISON warning to cigarette packaging. As Naylor is about to appear before a U.S. Senate committee to fight the bill, he is kidnapped by a clandestine group and covered in nicotine patches. Awakening in a hospital, he learns he has survived due to his high nicotine tolerance from heavy smoking, but he is now hypersensitive to nicotine and can never smoke again. Meanwhile, Naylor is seduced by a young reporter named Heather Holloway into revealing secret information about his life and career. She makes it public via an exposé, criticizing his business activities and accusing him of training his son Joey to follow his amoral example. This results in negative PR for Naylor, which costs him his job. After he hides out in his home for a few days, Naylor is visited by Joey who uses some of the debating skills his father taught him, which reminds Naylor of his own principles. Naylor apologizes to his friends in the MOD Squad and is inspired to take a new tactic. Naylor laments to the press about Holloway's ethics of using his private conversations with him after sex and goads Finistirre into allowing him to testify before the Senate committee. During the hearing, Naylor surprises everyone by admitting to the dangers of smoking but argues that public awareness is already high enough without extra warnings. He emphasizes consumer choice and responsibility and claims that if tobacco companies are guilty of tobacco-related deaths, then perhaps Finistirre's state of Vermont, as a major cheese producer, is likewise guilty of cholesterol -related deaths. When Finistirre attempts to regain control by demanding what Naylor would do when his son was 18 and wanted to smoke, Naylor simply replies that if his son wants to smoke then he'd buy him his first pack. Although B.R. insists in a live interview that Naylor is still their chief spokesman, Naylor rejects the job on camera. It turns out to be a good move as Big Tobacco is settling claims of liability and the Academy of Tobacco Studies shuts down. Naylor also mentions Heather was humiliated upon being terminated by the paper for her article and has been reduced to a cub reporter handling weather on a local news station. Naylor supports his son's newfound interest in debating and opens a private lobbying firm. The MOD Squad continues to meet with new members who represent the fast-food, oil, and biohazard industries. Now Naylor runs an agency called Naylor Strategic Relations and consults for cellphone industry representatives concerned about claims that cellphones cause brain cancer. He narrates: " Michael Jordan plays ball. Charles Manson kills people. I talk. Everyone has a talent."

Two Romanian orphaned young women, Voichița and Alina, visit a Romanian Orthodox convent during Lent, where Voichița tells Alina the altar includes an icon that grants wishes. Alina had been working in Germany, and the two girls were previously roommates at a children's home and had shared a physical relationship. The monastery is led by a 30-year-old Priest who speaks ill of declining faith in Western Europe, citing same-sex marriage, and forbids anyone outside of the faith from entering. He inquires about Alina to Voichița, who tells him Alina irregularly attends church and does not go to confession. They urge Alina to begin confessing. Alina hopes to sleep with Voichița, but Voichița tells her they must be cautious given it is Lent. Some time later after Alina has left the convent, Voichița retrieves her, but Voichița tells Alina she is now a nun, that she has chosen to be with God so she will never be alone, and her love of Alina is different from before. They return to the convent, but Alina asks Voichița that they escape together. After Voichița refuses, Alina attempts to jump down a well, but is restrained by the nuns and taken to the hospital. There, doctors restrain Alina to prevent her self-harm, after which they send her back to the convent to assist with recovery. There, the nuns read to Alina about sin. Alina begins a Black Fast, but when the Priest learns of this when Alina is not at the table, they see Alina is attempting to enter the altar to make a wish to the icon. The Priest admits the icon exists, but says entering the altar is a severe sin, and tells the nuns the Devil is in Alina and the convent. Alina remains tied down to a board with chains and towels. The nuns witness a worsening in her condition and take her back to the hospital. There, the hospital staff find Alina is dead on arrival, and observe the wounds on her wrists and ankles from the restraints. The staff tells the nuns this constitutes homicide and threatens to call the police and media. An officer investigates the convent. Seeing the board Alina was tied to, the officer interprets it as a cross. The officer also says forcible restraint leading to death is a homicide. The Priest denies criminal intent, saying the restraints were to prevent self-harm, and invoking the analogy of a parent's right to force children to take medicine, though the officer replies Alina was not a child and the Priest was not her guardian. The nuns also cite Alina's strength as mysterious, but Voichița says Alina studied martial arts. The police take the Priest and the nuns who tied up Alina away, with Voichița choosing to go with them.

Grant and Fiona are a retired married couple living in rural Brant County, Ontario. Fiona begins to lose her memory, and it becomes apparent she has Alzheimer's disease. Throughout the film, Grant's reflections on his marriage are woven with his reflections on his own infidelities, and influence his eventual decisions regarding Fiona's happiness. When she feels she is becoming a risk to herself, Fiona decides to check into a nursing home, where one of the rules is that a patient cannot have any visitors for the first 30 days, in order to "adjust". Despite being wary of this policy, Grant agrees at the insistence of his wife whom he loves. During the drive to the home, Fiona acknowledges Grant's past infidelity while he was a university professor. Despite the awkward situation, the couple makes love one last time before separating. When the 30-day period ends, Grant goes to visit his wife again, only to find she has forgotten him, and turned her affections to Aubrey, a mute man in a wheelchair who has become her " coping partner" in the facility. A caregiver at the facility befriends Grant and gives him some advice and support. While seeing his wife grow closer to Aubrey, Grant becomes an unhappy voyeur when visiting his wife at the nursing home. As time goes by and Fiona still does not remember him, Grant even wonders whether Fiona's dementia is an act, to punish him for his past indiscretions. After some time, Aubrey's wife Marian removes him from the home due to financial difficulties. This causes Fiona to sink into a deep depression, with her physical well-being also appearing to deteriorate. Grant is touched by this, and visits Marian in an effort to allow Fiona to see Aubrey again. He would rather see his wife happy with another man than miserable and alone. Marian initially refuses, but the meeting leads to a tentative relationship between her and Grant. As time passes, Grant continues to visit both Fiona and Marian. He eventually succeeds in taking Aubrey back to visit his wife. But in his "moment alone" before he brings Aubrey into Fiona's room, Fiona temporarily remembers him and the love she has for him. They embrace.

Dr. Bill Harford and his wife Alice live in New York City with their daughter, Helena. At a Christmas party hosted by Bill's patient, Victor Ziegler, Bill reconnects with his former medical school classmate, Nick Nightingale, now a professional pianist. Meanwhile, an older Hungarian guest attempts to seduce Alice, while two young models try to seduce Bill. Victor interrupts Bill's flirtation to handle an emergency involving Mandy, a young woman who overdosed during sex with him. Bill helps stabilize Mandy. The following night, Bill and Alice smoke marijuana and discuss their unfulfilled desires. Bill dismisses the idea of Alice being unfaithful, believing women to be naturally loyal. However, Alice shocks him by confessing to fantasizing about a naval officer she observed while on vacation, even considering leaving Bill and Helena for him. Disturbed, Bill is called to a patient's home, where the patient's daughter, Marion, confesses her love and tries to seduce him. Bill resists and leaves. Wandering the city, Bill meets a prostitute named Domino. Before anything happens, Alice calls, prompting Bill to leave after paying Domino without proceeding further. Later, Bill encounters Nick at a jazz club. Nick tells Bill about a secretive late-night gig where he will play piano blindfolded, and reveals the password to gain entry. Intrigued, Bill visits a costume store, formerly owned by one of his patients but now run by Mr. Milich, to rent an outfit. During the visit, Milich discovers his teenage daughter with two older men and locks the men in a room, threatening to call the police. Bill arrives at the mansion, provides the password, and witnesses a bizarre sexual ritual. A masked woman warns him that he is in danger. He is taken to a gathering where the master of ceremonies demands a second password. Bill claims to have forgotten the second password, at which the master of ceremonies exposes him as an outsider. Before the master of ceremonies forces Bill to remove his clothes, the masked woman intervenes, offering herself to save him. Bill is let go with a stern warning to remain silent. Shaken, Bill returns home to find Alice laughing in her sleep. She tearfully recounts a dream of having sex with the naval officer and many other men while mocking Bill. The next day, Bill visits Nick's hotel, but the clerk claims Nick was taken away by two threatening men. Returning the costume, Bill notices the mask is missing and learns that Milich now profits from prostituting his daughter, offering her services to Bill. Consumed by jealousy and doubt, Bill revisits the mansion but receives an envelope warning him to stay away. That evening, he tries calling Marion but hangs up when her fiancé answers. He then visits Domino's apartment, only to find her roommate, Sally, who informs him that Domino has tested HIV-positive. As Bill leaves, a mysterious figure follows him. Later, at the morgue, he identifies Mandy as the masked woman from the orgy after reading about her death from an overdose. Victor summons Bill and admits to being at the orgy. He explains that there was no second password and that Bill's exposure was deliberate. Victor insists the secret society only seeks to intimidate him into silence but warns they are dangerous. He claims Nick has returned safely to Seattle and attributes Mandy's death to her drug addiction, dismissing foul play. Returning home, Bill finds the missing mask placed on his pillow. Breaking down in tears, he confesses everything to Alice. The next day, the couple takes Helena shopping for Christmas. Bill apologizes to Alice, who suggests they take action to repair their relationship. When he asks what she means, Alice responds with a single word: "Fuck."

In 1913 Houston, eight-year-old Howard Hughes 's mother gives him a bath and teaches him to spell "quarantine", warning him about the recent cholera outbreak. Fourteen years later, in 1927, he begins to direct his film Hell's Angels, and hires Noah Dietrich to manage the day-to-day operations of his business empire. After the release of The Jazz Singer, the first partially talking film, Hughes becomes obsessed with shooting his film realistically, and decides to convert the movie to a sound film. Despite the film being a hit, Hughes remains unsatisfied with the result and orders it to be recut after its Hollywood premiere. He becomes romantically involved with actress Katharine Hepburn, who helps to ease the symptoms of his worsening obsessive–compulsive disorder (OCD) and germaphobia. In 1935, Hughes test-flies the H-1 Racer, pushing it to a new speed record despite having to crash-land into a beet field when the aircraft runs out of fuel. Three years later, he flies around the world in four days, breaking the world record. He subsequently purchases majority interest in Transcontinental & Western Air (TWA). Juan Trippe, company rival and chairman of Pan Am, asks his crony, Senator Ralph Owen Brewster, to introduce the Community Airline Bill, which would give Pan Am exclusivity on international air travel. Hepburn grows tired of Hughes's eccentricity and workaholism, and leaves him for fellow actor Spencer Tracy. Hughes quickly finds a new love interest with 15-year-old Faith Domergue, and later actress Ava Gardner. However, he still has feelings for Hepburn, and bribes a reporter to keep reports about her affair with the married Tracy out of the press. In the mid-1940s, Hughes contracts two projects with the Army Air Forces, one for a spy aircraft, and another for a troop transport unit for use in World War II. In 1946, with the H-4 Hercules flying boat still in construction, Hughes finishes the XF-11 reconnaissance aircraft and takes it for a test flight. However, one of the engines fails midflight; he crashes in Beverly Hills and is severely injured, but miraculously survives. The army cancels its order for the H-4 Hercules, although Hughes still continues the development with his own money. Dietrich informs Hughes that he must choose between funding the airlines or his flying boat. Hughes orders Dietrich to mortgage the TWA assets so he can continue the development. By 1947, his OCD worsens and Hughes becomes increasingly paranoid, planting microphones and tapping Gardner's phone lines to keep track of her, until she kicks him out of her house. The FBI searches his home for incriminating evidence of war profiteering, searching through his possessions. Brewster privately offers to drop the charges if Hughes sells TWA to Trippe, but Hughes refuses. Hughes's OCD symptoms become extreme, and he retreats into an isolated " germ -free zone" for three months. Trippe has Brewster summon him for a Senate investigation, certain that Hughes will not show up. Gardner visits him and personally grooms and dresses him in preparation for the hearing. An invigorated Hughes defends himself against Brewster's charges and accuses the Senator of taking bribes from Trippe. He concludes by announcing that he has committed to completing the H-4 aircraft, and that he will leave the country if he cannot get it to fly. Brewster's bill is promptly defeated. After successfully flying the aircraft, Hughes speaks with Dietrich and his engineer Glenn Odekirk about a new jetliner for TWA. However, he begins hallucinating and has a panic attack. As Odekirk hides him in a restroom while Dietrich fetches a doctor, Hughes begins to have flashbacks of his childhood, his love for aviation and his ambition for success, compulsively repeating the phrase, "the way of the future".

Osage Nation elders bury a ceremonial pipe, mourning their descendants' assimilation into White American society. Wandering through their Oklahoma reservation during the annual "flower moon" phenomenon of fields of blooms, several Osage find oil gushing from the ground. The tribe becomes wealthy as it retains mineral rights. However, the law requires court-appointed white legal guardians to manage the money of full and half-blood members, assuming them "incompetent". In 1919, Ernest Burkhart returns from World War I to live with his brother Byron and uncle William King Hale on Hale's reservation ranch. Hale, a reserve deputy sheriff and cattle rancher, poses as a friendly benefactor to the Osage. Ernest and Byron commit armed robbery against the Osage. Ernest develops a romance with Mollie Kyle, an Osage whose family owns oil headrights. They marry in an Osage ceremony with Catholic elements and raise three children. Hale contracts the killing of multiple wealthy Osage, explaining that Ernest will inherit more headrights the more of Mollie's family dies. Mollie is diabetic, and her mother, Lizzie, is ill. After Mollie's sister Minnie dies of a mysterious illness, Hale orders Byron to kill another of Mollie's sisters, Anna. Lizzie and the Osage council blame the white residents and urge the tribe to fight back. The 1921 Tulsa race massacre causes further concern amongst the Osage that they could suffer similarly. Lizzie's ancestors welcome her to the afterlife as she dies. Hale has Ernest arrange the murder of Mollie's first husband, Henry Roan, but Ernest's hitman neglects to make the murder look like a suicide as instructed. Even so, the sheriff and judges are in Hale's pocket, so there are no investigations. An Osage Nation representative seeking to lobby Congress is murdered in Washington, D.C. Mollie hires private detective William J. Burns, but he is severely beaten by Ernest and Byron. Again at Hale's behest, Ernest arranges the bombing of the home of Mollie's last surviving sister, Reta, and her husband, Bill. As the last surviving member of her family, Mollie inherits their headrights. She travels to Washington and asks President Calvin Coolidge for help. Hale orders Ernest to poison Mollie's insulin to "slow her down". Mollie's condition worsens, and Ernest exhibits similar symptoms after also ingesting the poison. Bureau of Investigation Agent Thomas Bruce White Sr. and his assistants discover the truth. Hale tries to cover his tracks by murdering his hitmen, but White arrests Hale and Ernest. Two agents find Mollie near death and rush her to the hospital, where it is found that she has been repeatedly poisoned. She recovers. White persuades Ernest to confess and turn state's evidence against his uncle. Hale's attorney, W. S. Hamilton, tries to convince Ernest to claim he was tortured and recant. After his daughter dies of whooping cough, Ernest testifies, wanting to be around for his remaining family. Mollie leaves Ernest after he refuses to admit to poisoning her. A radio drama years later reveals the Shoun brothers were implicated in other "wasting deaths" but never prosecuted due to lack of evidence; Byron was tried as an accomplice to Anna's murder but served no prison time due to a hung jury; Hale and Ernest were sentenced to life imprisonment but later paroled despite Osage protests; and Mollie died of diabetes-related complications in 1937 at the age of 50, her obituary stating that she was buried with her parents, sisters, and daughter while making no mention of the Osage murders.

In 1815, French prisoner Jean Valjean is released from the Bagne of Toulon after a nineteen-year sentence for stealing bread and attempting to escape the sentence. His paroled status prevents him from finding work or accommodation, but he is sheltered by the kindly Bishop of Digne. Valjean attempts to steal his silverware and is captured, but the bishop claims he gave him the silver and tells him to use it to begin an honest life. Moved, Valjean breaks his parole and assumes a new identity, intending to redeem others. Eight years later, Valjean is a respected factory owner and mayor of Montreuil, Pas-de-Calais. He is startled when Javert, formerly a Toulon prison guard, arrives as his new chief of police. Witnessing Valjean rescue a worker trapped under a cart makes Javert suspect the former's true identity. Meanwhile, one of Valjean's workers, Fantine, is fired by the foreman when she is revealed to have an illegitimate daughter, Cosette, residing with the greedy Thénardier family, to whom Fantine sends her earnings. Out on the streets and increasingly ill, Fantine sells her hair, teeth and eventually her body to support Cosette. Javert arrests her after she physically attacks a sexually abusive client, but Valjean recognises her and takes her to the hospital, much to Javert's suspicion and anger. Learning that a man has been wrongly identified as him, Valjean reveals his identity to the court before returning to the dying Fantine, promising to care for Cosette. Javert arrives to arrest him but he escapes to the Thénardiers' inn. Valjean pays Fantine's debts, then flees from Javert with Cosette. Nine years later, Valjean has become a philanthropist to the poor in Paris. General Lamarque, the only government official sympathetic to the poor, dies, and the revolutionist group Friends of the ABC plot against the monarchy. Marius Pontmercy, a member of the Friends, falls in love with Cosette at first sight and asks his best friend Éponine, the Thénardiers' daughter, to find her. He and Cosette meet and confess their love; Éponine, herself in love with Marius, is heartbroken. Thénardier attempts to rob Valjean's house, but Éponine stops him. Fearing Javert is near, Valjean plans to flee to England with Cosette. Cosette, wanting to stay near Marius, is hesitant about the idea, but when Valjean ignores her pleas, she leaves Marius a letter, which Éponine hides from him. During Lamarque's funeral procession, the revolt begins and barricades are built across Paris. Javert poses as an ally to spy on the rebels, but the street urchin Gavroche exposes him as a policeman. During the first skirmish against the soldiers, Éponine takes a bullet for Marius and dies in his arms, giving him Cosette's letter and confessing her love, leaving Marius devastated and heartbroken over the death of his best friend. Marius's answer to Cosette is intercepted by Valjean, who joins the revolt to protect him. Valjean offers to execute the imprisoned Javert, but releases him instead, pretending he shot him. By dawn, the soldiers storm the barricade and kill everyone except Marius and Valjean, who escape into the sewers. Javert waits for him to exit, but seeing that Marius is close to death, he lets them go. Morally disturbed by the mercy of his nemesis and his own in return, Javert kills himself by throwing himself in the Seine. Marius recovers, traumatized by the death of his friends, especially Éponine. Marius and Cosette are reunited, but Valjean, concerned his past would threaten their happiness, makes plans to leave. He reveals his past to Marius, who promises to remain silent. At Marius and Cosette's wedding, the Thénardiers crash the reception to blackmail him; but instead, realizing that Valjean saved him from the barricade, Marius forces Thénardier to reveal where he is. Cosette and Marius find Valjean, who gives them letters of confession before dying peacefully. His spirit is guided by visions of Fantine and the Bishop to join Éponine, Gavroche, and the Friends of the ABC in the afterlife.

In January 1994, the U.S. Ohio -class submarine USS Montana has an encounter with an unidentified submerged object, and sinks near the Cayman Trough. With Soviet ships moving in to try to salvage the sub, and a hurricane moving over the area, the U.S. government sends a SEAL team to Deep Core, a privately owned, experimental underwater drilling platform near the Cayman Trough, to use it as a base of operations. The platform's designer, Dr. Lindsey Brigman, insists on going along with the SEAL team, even though her estranged husband, Virgil "Bud" Brigman, is the current foreman. During the initial investigation of Montana, a power cut in the team's submersibles leads to Lindsey seeing a strange light circling the sub, which she later calls a "non-terrestrial intelligence", or "NTI". Lt. Hiram Coffey, the SEAL team leader, is ordered to accelerate their mission, and takes one of the mini-subs, without Deep Core ' s permission, to recover a Trident missile warhead from Montana, just as the storm hits above, leaving the crew unable to disconnect from their surface support ship in time. The cable crane is torn from the ship and falls into the trench, dragging Deep Core to the edge before it stops. The rig is partially flooded, killing several crew members, and damaging its power systems. The crew waits out the storm so they can restore communications and be rescued. As they struggle against the cold, they find the NTIs have formed an animated column of water to explore the rig, which they equate to an alien version of a remotely operated vehicle. Though they treat it with curiosity, Coffey is agitated and cuts it in half by closing a pressure bulkhead on it, causing it to retreat. Realizing that Coffey is experiencing paranoia as a result of suffering from high-pressure nervous syndrome, the crew spies on him through an ROV, finding him, along with another SEAL, arming the warhead to attack the NTIs. To try to stop him, Bud fights Coffey, but Coffey escapes in a mini-sub with the primed warhead. Bud and Lindsey give chase in the other sub, damaging both. Coffey is able to launch the warhead into the trench, but his sub drifts over the edge and implodes from the pressure, killing him. Bud's mini-sub is inoperable and taking on water. With only one functional diving suit, Lindsey opts to drown and hopefully enter deep hypothermia when the ocean's cold water engulfs her, with hopes of being able to be resuscitated. Bud swims back to the platform with her body; there, he and the crew use a defibrillator and administer CPR, and they revive her. It is decided that they need to disarm the warhead, which is more than 2 miles (3.2 km) below them. One SEAL, Ensign Monk, helps Bud use an experimental diving suit equipped with a liquid breathing apparatus to survive to that depth, though he will only be able to communicate through a keypad on the suit. Bud begins his dive, assisted by Lindsey's voice to keep him coherent against the effects of the mounting pressure, and he reaches the warhead. Monk guides him in successfully disarming it. With little oxygen left in the system, Bud explains that he knew it was a one-way trip, and he tells Lindsey he loves her. As he waits for death, an NTI approaches Bud, takes his hand, and guides him to a massive alien city deep in the trench. Inside, the NTIs create an atmospheric pocket for Bud, allowing him to breathe normally. The NTIs then play back Bud's message to his wife and look at each other with understanding. On Deep Core, the crew is waiting for rescue when they see a message from Bud that he met some friends and warns them to hold on. The base shakes, and lights from the trench herald the arrival of the alien ship. It rises to the ocean's surface, with Deep Core and several of the surface ships run aground on its hull. The crew of Deep Core exits the platform, surprised they are not dead from the sudden decompression. They see Bud walking out of the alien ship, and Lindsey races to hug him.