The diminutive Agent 00, the number 1 agent from the Secret Agency, is provided with a number of new hi-tech gadgets from his boss, and then sent to stop the mysterious warlord Mr. Giant, who has just kidnapped Dr. Kohler, a foreign scientist visiting Manila to offer his latest invention, the N-Bomb, to the government. Mr. Giant intends to use the lethal weapon to take over the world, but Agent 00 is ready to stop him. He can count on the help of Irma, a fellow agent who has infiltrated Mr. Giant's criminal organization, working for the drug traffickers that are headed by a gangster named Cobra. This leads to many battles between Agent 00 and the villain's henchmen. Once Irma's cover is blown, she is taken prisoner as a bait and sent to Mr. Kaiser, Mr. Giant's second-in-command, who keeps her in his lair. In order to find Kaiser, Agent 00 enlists the help of other Bond girl types, such as night club enthusiast Anna and criminal reporter Marilyn, romancing his way to their allegiance. After flushing out and killing criminal bosses of increasing importance, and all of their henchmen, Agent 00 reaches Kaiser, but by then Irma has been shipped to Hidden Island, Mr. Giant's super-secret lair. After finding the secret location of the island, Agent 00 uses a prototype size-compatible jet pack to get there, and calls for reinforcements. He confronts and kills Mr. Giant himself (who is revealed to be a dwarf himself, although taller than Agent 00), then along with the squad of agents from the Secret Agency, Agent 00 and Irma clean the island of all remaining henchmen. However, right after a freed Dr. Kohler has finally reached safety, Irma is shot and killed. In the final scene, Agent 00 is seen paying respect on her tomb.

Phil's wife Kim, the den mother of the local Cub Scout pack, gives a pinewood derby kit to each of the Cub Scouts. Although the boys are supposed to make their own cars from the kits, with appropriate adult supervision, the four dads obsessively take over the project, totally excluding the boys. As each man becomes more and more obsessed with building the fastest car, their wives eventually become so annoyed that they leave the house, taking their sons with them. Soon, "Big Jimmy" is the first to break secrecy to talk to Blaine, and the two of them then talk to Phil, showing him on the title page of the Pinewood Derby Bible that Ace Montana is the author. Not only that, but the car Ace built as an eight-year-old boy in California still holds the record for the fastest pinewood derby car on record. The three men decide to collaborate to build one car that will beat. To this end, they steal Ace's record holding car to reverse-engineer it, finding out that Ace's real name is Stacy Lynn, but are nearly caught in the act of returning it. The three men then succeed in building a fast car that will break the record, and Blaine and Jimmy decide that Phil should have the honor of having his son enter the car in the competition. At the Derby, the men and their wives are re-united. Kim tells Phil that their son Brady (Adam Hicks) has built his own car while staying with his grandfather, with advice from grandpa's neighbor, and she challenges him to "do the right thing". After some soul-searching, Phil passes up the car the three men built and allows Brady to register his car for the race – but "Big Jimmy" still wants to beat Ace, and takes the car for his son to enter. After several races, the competition comes down to six finalists, including Ace's, Brady's, and the car the three men built. In the final race their car is leading the pack but loses a wheel. Ace's car then takes the lead, but on the flat part of the track, Brady's car takes the lead and finishes first, setting a new pinewood derby record. Ace is shocked but makes a gesture of congratulating the Davises; still, the minute he leaves the room, he throws a temper tantrum. When Phil asks Brady who grandpa's neighbor was who gave him advice, Brady points out a man in the audience, who turns out to be the man in the instructional video Phil has been watching to help design his car.

In 1996 Brooklyn, Molly Wright witnesses her parents being neuralyzed by agents of Men in Black after they see an alien in their home. Molly helps the alien escape, avoiding neuralyzation herself. Twenty-three years later, rejected from government agencies due to her "delusions" regarding alien life, Molly tracks down an alien landing and follows MIB agents to their headquarters in New York City. Caught entering the agency, Molly makes an impression on Agent O after revealing she had bypassed neuralyzation, arguing that her obsessive search for them makes her "perfect" for the job and she has no life outside her search for the agency. She is awarded probationary agent status as "Agent M" and assigned to the organization's London branch. There, M meets High T, head of the London branch, and Agent H. M learns that H and T fought off an invasion of the Hive, a parasitic race who invade planets by merging with the DNA of the conquered species, at the Eiffel Tower in 2016, using a wormhole included in the original migration to Earth. H has since become unconcerned with his duties and only keeping his job due to High T covering for him. M arranges for herself to be assigned to assist H in his meeting with alien royalty Vungus the Ugly, H's close friend. During their night out with Vungus, they are accosted by mysterious alien Twins able to manifest as pure energy. The Twins fatally injure Vungus, who gives M a strange crystal before he dies, claiming that H has changed since they last met and cannot be trusted. M points out that few people knew Vungus' location, and he was likely betrayed by one of the agents present when High T assigned H to guard him. Nervous at the possibility of a traitor within MIB, High T assigns Agents C and M to investigate while H is demoted to desk duty, with evidence suggesting that the Twins had DNA traces of the Hive. H convinces M to join him in following a lead to Marrakesh, where they recover "Pawny", the last survivor of a small group of aliens attacked by the Twins. Pawny pledges loyalty to M, and they are trapped by MIB agents coordinated by C, who recovered video footage of Vungus passing the crystal to M and believes she is the traitor. With the aid of alien contacts Nasr and Bassam, H escapes with M and Pawny on a rocket-powered bike, and they learn that Vungus' crystal is a weapon powered by a compressed blue giant. As they repair the damaged bike, Bassam steals the weapon and takes it to H's ex-girlfriend Riza Stavros, an alien arms dealer. Traveling to Riza's island fortress, the trio attempts to infiltrate the base, but is caught by Riza and her bodyguard Luca Brasi. Luca, the alien M rescued as a child, returns the favor by allowing them to leave with the weapon while he keeps Riza contained. The three are cornered by the Twins, who are killed by High T and a group of agents. Although the case appears concluded, H and M review the evidence and realize that the Twins' phrases suggest they required the weapon to use against the Hive, especially when the only evidence of Hive DNA was provided by High T. They discover High T has deleted the case file and not sent the weapon to evidence, and has gone to the Eiffel Tower with the weapon. C also realizes High T's deception and allows H and M to follow High T to the Eiffel Tower. As they travel to the reopened wormhole, M's questioning of H's memory of the Hive's defeat reveals he was neuralyzed when the Hive converted T into one of their own during the battle. The High T/Hive hybrid activates a wormhole to draw the Hive to Earth, but H draws out High T's true personality long enough for M, with the help of Pawny, to use the weapon at full capacity to destroy both the hybrid and the Hive infestation trying to reach Earth. With the truth of T's conversion exposed, Agent O joins H and M in Paris, where she grants M full agent status and appoints H probationary head of MIB's London branch.

In 50 BC, in an Abyssinian castle, Princess Nawa uses a pair of enchanted earrings to escape an arranged marriage by swapping bodies with a slave girl. When each woman wears one of the earrings, their bodies are magically swapped while their minds remain in place. In a modern-day suburban town in California, Jessica Spencer is the beautiful but mean-spirited "hot chick". Her closest friends are April, Keecia and Lulu. April is Jessica's best friend, and all four girls are cheerleaders. At school one day, Jessica makes fun of an overweight girl named Hildenburg and a Wiccan girl named Eden. After that, she and her friends visit the local mall, where Jessica gets her rival Bianca into trouble and finds the earrings in an African -themed store owned by Madame Mambuza. The earrings are not for sale, but Jessica steals them anyway. Shortly afterward, small-time, 30-year-old criminal Clive Maxtone robs a nearby gas station. When Jessica and her friends stop and mistake him for an employee, he services their car to avoid raising suspicion. She accidentally drops one of the earrings on the ground, the girls drive away, and Clive picks up the earring. In their respective homes that evening, Jessica and Clive put on their earrings. When they wake up the next morning, each of them is trapped in the other's body. This is especially difficult for Jessica, who has a cheering competition and the senior prom coming up soon. After Jessica convinces her friends of who she is, they help her investigate the body swap. Hildenburg, Eden and Bianca are all innocent, Hildenburg and Eden join Jessica after she apologizes to them, and Eden finds a picture of the earrings on the internet. When the girls return to the African store, Madame Mambuza explains how the earrings work and tells the girls they must find the other earring soon or the change will become permanent at the next full moon. Meanwhile, Jessica is hired for two jobs while secretly living with April. At her own home, where she works as a gardener, her parents tell her about their marital problems and she helps them rekindle their sex life. At school, while cleaning the boys' locker room as a custodian, she eavesdrops on her boyfriend Billy, who truly loves her unconditionally, and April's boyfriend Jake, who has been cheating on her. Faced with Jake's infidelity, April begins to fall in love with Jessica (although she's still stuck in Clive's body), who agrees to take her to the prom. At the cheering competition, Jessica signals romantically to Billy while disguised as the school mascot, but when the head of her costume falls off, he becomes confused and leaves with Bianca. Jessica goes to the prom with April and they kiss. Jake sees this and is so upset, he spills his drink on his date. April confesses to being in love with Jessica, who tells April she is perfect and doesn't need anybody. Jessica tries to win Billy back, telling Billy it's her in Clive's body, but he is so shocked and confused that he runs off. During this time, Clive has been using Jessica's body to make money from men, including Billy, who gives him his money and car, believing he is Jessica. Clive then tries to run him over. On the evening of the prom, Hildenburg sees a video of Clive in Jessica's body robbing a man on the TV news, goes to the scene of the crime, and finds a business card for the strip club where Clive works as a pole dancer. She informs Jessica at the prom, and the girls go to the club. When they find Clive, Jessica steals his earring and puts it on herself along with the other one. With both earrings now on the same person, Jessica's and Clive's bodies return to their original owners. After Jessica makes up with Billy, the film ends with the school's graduation ceremony, followed by a scene in which Clive, still running from the law and still dressed in lingerie and handcuffs, is picked up by a bartender who believes, based on earlier events, that he is gay. The bartender turns around slowly with a sinister smile on his face to look at Clive and locks his car's doors. Clive screams in horror as the bartender drives away.

Gregorio and Ingrid Cortez are spies with two children, Carmen and Juni, whom they shield from their lives to protect them from inherent danger. They work for the Organization of Super Spies (OSS) doing office consultant work, but are suddenly called back to active field work to find missing agents. Gregorio suspects children's television host Fegan Floop has kidnapped them, mutating them into his "Fooglies" – creatures on his show, a program that Juni avidly watches. The children are left in the care of their uncle, Felix Gumm. Gregorio and Ingrid are captured by Floop's "Thumb-Thumbs" (robots whose arms, legs, and heads resemble oversized thumbs) and taken to his castle. Felix is alerted to the parents' capture, activates the fail-safe, and tells the children the truth about their parents, and that he is not their uncle, but an agent sent to watch over them. The house is attacked by Ninja Thumb-Thumbs, and Felix is captured while the children escape alone via a miniature submarine set to autopilot to a safe house. At the safe house, the children accept that their parents were spies and decide to rescue them. Inside Floop's castle, he introduces his latest creation, small child-shaped robots, to Mr. Lisp. They plan to replace the world leaders' children with these super-strong robots to control the world, but since the androids have no artificial intelligence yet, they are unable to function outside their regular programming. Lisp is furious, demanding usable androids. Floop, with his second-in-command Alexander Minion, interrogates Gregorio and Ingrid about 'The Third Brain'. Ingrid knows nothing of it, while Gregorio claims he had destroyed the brain years ago. After Floop leaves, Gregorio reveals to Ingrid that the Third Brain was a secret OSS project he had worked on: an AI brain with all the skills of the entire OSS. The project was scrapped for being too dangerous, and many scientists demolished the brains that they were working on, but Gregorio refused to destroy the final prototype. At the safe house, Carmen and Juni are visited by OSS agent Ms. Gradenko. Giving Carmen a bracelet as a sign of trust, she asks about the Third Brain, but Carmen is confused. Gradenko orders the house to be dismantled, and the siblings realize Gradenko is a traitor when they see ninja Thumb-Thumbs destroying the escape submarine. With Gradenko's intentions revealed, Juni accidentally exposes the Third Brain, and a chase ensues. Carmen gets the brain, and she and Juni escape. She realizes too late that the bracelet from Gradenko has a tracking device, and she and Juni are attacked by their robot counterparts, who steal the Third Brain and fly away. Meanwhile, back at the castle, Gregorio tells Ingrid that Minion used to work for the OSS, but was fired after he reported him tampering with the Third Brain project. With it, Floop can achieve his goal, but he wishes to continue his children's TV show. Minion has different plans and takes over, locking Floop inside his "virtual room", the chamber where he films his television series. Carmen and Juni receive reluctant help from Gregorio's estranged brother Isador "Machete" Cortez when they show up at his spy shop. He refuses to accompany them, so they steal some gear and take his spy jet to fly to Floop's castle. After a few mishaps, Carmen and Juni eject themselves from the plane before it crashes into the castle, and they enter via the underwater entrance. While the children infiltrate the castle, Juni rescues Floop, who helps him and Carmen release their parents. Together, they trap Minion in Floop's Fooglies machine, mutating him into a Fooglie. Confronting Lisp and Gradenko, the family is beset by all 500 robot children. Suddenly, Machete busts through the window, reconciling with Gregorio and joining the family to fight. However, at the last moment, Floop reprograms the robots to change sides. The 500 superhuman robots quickly overpower Minion, Lisp, and Gradenko. With advice from Juni, Floop introduces the robot versions of Carmen and Juni on his show. At home, some time later, the family's breakfast is interrupted by Devlin, the head of the OSS, with a mission for Carmen and Juni. The children tell him they will only accept if all the Cortezes can work on the mission together as a family.

When a mission to retrieve a stolen suitcase bomb goes awry, CIA agent Kevin Pope is killed. Pope was working undercover as an antiquities dealer under the name Michael Turner. The CIA, which is desperate to complete the mission, discovers that Agent Pope had a twin brother, Jake Hayes, from whom he was separated at birth; their mother died giving birth and Hayes suffered from a severe lung infection that prompted the doctors to separate them because they felt that Hayes was unlikely to live for very long. Hayes hustles chess games, scalps tickets, and works at small clubs in Jersey City, New Jersey, to make ends meet. Meanwhile, Hayes's girlfriend, Julie grows tired of waiting for him to grow up and decides to move to Seattle, Washington. After the CIA successfully persuades Hayes to participate and begins to train Hayes for a mission that is to take place in Prague, Czech Republic, they are initially dismayed by his lack of refinement. Agent Gaylord Oakes confronts Hayes, telling him he does not trust him. When Hayes begins paying attention, the CIA sets him up in his brother's old apartment in Manhattan to test him and try to bait the men who killed his brother. Hayes is attacked, but escapes unharmed. Looking for a way out, Hayes goes to his foster mother only to be found by Oakes, who persuades him to finish the mission. After arriving in Prague, Hayes – posing as his dead brother – meets with the men selling the suitcase bomb. The seller, Adrik Vas is an ex-Russian Army Colonel with ties to the Russian Mafia. When they return to their hotel, Hayes is greeted by his brother's ex-girlfriend Nicole. Believing Hayes is his brother, she dines with him and returns to his hotel, where the couple is ambushed by rival buyers. Nicole figures out that Hayes is not his brother and returns to her assignment covering the Balkans for CNN. Hayes and Oakes meet with Vas and are able to steal the arming codes. Just as they close the deal, Vas' men double cross them with the rival buyer. When the rival dealers, who are part of a multi-national terrorist organization, learn they cannot detonate the bomb because of the missing codes, they kidnap Julie. Hayes gives himself up trying to save his girlfriend, and the terrorists get the codes back and arm the bomb. After interrogating one of the captured terrorists, they track the bomb to Grand Central Station. With the clock ticking, they locate the bomb and the terrorist leader Dragan Ađanić, who has started the countdown. Oakes rescues Hayes by killing two terrorists. As Hayes starts to enter the codes to disarm the bomb, Ađanić holds Julie hostage. To distract Ađanić, Hayes pretends to shoot Oakes, and they kill Ađanić by shooting him repeatedly. Hayes is able to disarm the bomb just prior to detonation. Hayes visits his brother's grave. Later, Oakes approaches Hayes at his wedding to Julie and warns him that a dangerous criminal has escaped from prison and is seeking revenge on Kevin Pope, but since Kevin is dead and Hayes was impersonating him, the criminal thinks Hayes is Kevin. Hayes begins to panic and demands that Oakes protect him, but Oakes laughs as he reveals that it was only a joke and he really just came for the wedding.

In 1982, Sam Brenner and his friends Will Cooper and Ludlow "The Wonder Kid" Lamonsoff play at an amusement arcade together before Brenner participates in a video game championship, where he seemingly loses a Donkey Kong match to Eddie "The Fireblaster" Plant. Videotaped footage of the event is put in a time capsule that gets launched into outer space. In the present, Brenner, now an electronics installer, is summoned alongside lieutenant colonel Violet van Patten to the White House, where Cooper, now President of the United States, shows surveillance footage of a besiegement at the Andersen Air Force Base in Guam. Brenner notes the attack's resemblance to the game Galaga, but Admiral James Porter of the United States Navy strongly advocates against its inference in the case. Brenner meets up with Lamonsoff, who reveals the attack was caused by an alien force that mistook the time capsule's footage as a declaration of war and are now challenging Earth to a best-of-three battle using technological recreations of the championship's games, claiming they have won the first match. Brenner and Lamonsoff inform Cooper of a coordinated aim at India, but he dismisses their concerns. After the aliens win the second match by demolishing the Taj Mahal as Arkanoid, Brenner and Lamonsoff train Navy SEALs to play the games while van Patten develops effective rayguns. Calling themselves the "Arcaders", the team heads to London, where the aliens attack Hyde Park as Centipede before being repelled by Brenner and Lamonsoff. Cooper, Lamonsoff and Brenner recruit a convicted Eddie to assist in New York City, where the Arcaders battle a giant Pac-Man in Mini Coopers representing the ghosts. After Brenner defeats Pac-Man, the Arcaders receive Q*bert as a trophy. During a celebration at the White House however, the aliens announce that one of the Arcaders has cheated, meaning Earth forfeits the challenge. Before being abducted by the aliens, van Patten's son Matty discovers Eddie cheated in the fight against Pac-Man using a code written on his glasses, which he also used in the 1982 video game championship. The aliens attack Washington, D.C. with an army of 1980s video game characters. With Cooper and a repentant Eddie's help, the Arcaders fight through the onslaught while Lamonsoff persuades Lady Lisa, a video game character whom he has a crush on, to join them. Brenner, Violet, Will and Q*bert are summoned to the aliens' mother ship for a final chance to save Earth by facing the aliens' leader as Donkey Kong. The group is placed on the game's starting level, with Donkey Kong and the captives at the top level. Struggling against the obstacles, Brenner loses hope until Matty reveals Eddie's cheating. Realizing he actually is the world's best Donkey Kong player, Brenner regains his spirit and defeats Donkey Kong, resulting in the aliens' forces, including Lisa, being neutralized. The Arcaders are hailed as heroes as Will negotiates a peace agreement with the aliens. Eddie apologizes to Brenner for cheating and acknowledges him as the best Donkey Kong player. Seeing Ludlow devastated over Lisa's termination, Q*bert cheers him up by shapeshifting into her. Brenner and van Patten begin a relationship, Eddie meets Serena Williams and Martha Stewart as he requested and the aliens return to their home planet.

A young man named Scat comes up with a new idea for a drink after he drops his drink and swears, calling it 'FUKK'. He goes to Addison Cola Company where he maneuvers a meeting with a formidable marketing executive, Six, by triggering the fire alarm. While mediocre, she tells him that she and her team will polish it before it is presented to the board. During the meeting, the board shows some resistance but Six informs them that Scat is willing to give up trademark provisions for a mere two million. Scat then realizes he has not reserved the trademark and scrambles to the Patent and Trademark Office only to find out that his roommate, Sneaky Pete, stole his idea and registered it earlier that morning. Success befalls Pete as 'FUKK' becomes the highest-selling energy drink in the nation. Embittered, Scat goes back to his ordinary life but is later recruited by Six to help her come up with a new ad campaign after she is booted off the 'FUKK' campaign and relegated to Addy Classics. Instructed to come up with a brilliant idea by Friday (only five days away), Scat moves in with Six and is unable to think of anything until moments before the deadline. After shaking a vending machine in frustration and Six telling him that twelve people have died by being crushed by vending machines, he comes up with the idea of 'Wouldn't you die for a Fukk' advertising a cartoon where people die by being crushed by vending machines because they want the drink so badly. The ad is accepted and aired but a young teenager dies by being crushed by a vending machine and the ad is now considered insensitive and taken off air. Scat and Six attend the funeral and when Scat makes a speech, Six points out that all the mourners are actors that she recognizes from ads. Scat quickly realizes that Sneaky Pete created this fake death to get their ad to fail, and he quickly pulls out the fake body from the coffin and holds it up for all to see. Scat is fired while believing that Six remains at the company. In reality, Six quit when Addison refused to keep Scat, now working at a shoe store. After a brief stint as a rickshaw driver, Scat is hired by a rival company, and Six is also poached. As Scat and Six are being hired Six drops a name tag from her work, possibly revealing a glimpse of her real name (appearing to be Elizabeth), before she quickly covers and retrieves the name tag. The two must come up with a new drink idea and after talking about their attraction for each other, Scat comes up with the 'Average KOK'. He presents this as a drink to the board and also thinks of a different drink just called 'KOK' that they give to celebrities. The normal 'KOK's are numbered up to 100 and each number represents a celebrity and the celebrity deems who can drink their numbered drink. After the frenzy for the drink that they can't have, Scat and the company decide to make the drink go public but not before the suicide of a teenager who killed himself after not being 'cool' enough to drink his lucky number 17's corresponding drink. After confirming that this time the death is real, Scat goes on TV to apologize but ends up pointing out that drink sales have never been higher even after the death and that people, like him, 'have a dream'.Scat walks along watching himself on the TV displays and Six finds him. Scat tells her his real name is 'Michael' and asks for her real name. They kiss, but Six insists that "Six" is her name. Scat says, "It's been a pleasure doing business with you, Six," and walks away.

In the year 2017, the United States has fragmented into post-apocalyptic wastelands with a few civilized areas. An ongoing economic crisis has led to the recycling of aging 20th-century mechanical and technological equipment. Society has also become averse to intimacy, as well as both increasingly hypersexualized and bureaucratic. Robotic technology has produced gynoids as substitutes for wives. The declining instances of actual sex among men and women is litigious, with one brothel having lawyers draft up contracts detailing the intended sexual rendezvous. Recycling executive Sam Treadwell owns a Cherry 2000 model as his wife. After she short circuits during sex on a wet kitchen floor, Sam is told by a repairman that she is damaged beyond repair, though her rare and valuable memory disk, which contains her entire personality, can be used in a new body if the same model can be found. A gynoid dealer tells Sam that the Cherry 2000 model is no longer produced and that the only remaining ones are in a defunct warehouse in "Zone 7", a particularly dangerous, lawless area. With Cherry's memory disk stored in a device that plays back Cherry's voice, Sam hires Edith "E" Johnson, a tough tracker, to guide him to the factory. They set off in Edith's heavily modified 1965 Ford Mustang. Entering Zone 7, they encounter Lester, a wasteland overlord with deranged subordinates. Edith and Sam take refuge in an underground reservoir occupied by Six-Fingered Jake, an elderly tracker who was Edith's mentor. When Lester's men attack, the three attempt to escape, but Sam is knocked unconscious and taken to a 1950s-styled motel/village. Ginger, one of Lester's gang, reveals herself as Sam's ex-girlfriend, previously known as Elaine. Lester decides to induct Sam into the group, and Sam, believing that Edith and Jake are dead, goes along for a while. When he witnesses the group sadistically murdering a tracker, Sam decides to escape and runs into Edith and Jake, still quite alive. Jake, who had earlier led Sam to believe that the Cherry 2000 memory disk had been lost, still has it and gives it to Edith while he stays behind to draw off Lester's gang. Sam, a veteran of earlier wars, shows that he is a capable fighter, and Edith begins to have feelings for him. Sam's own growing feelings toward Edith, though, are derailed when he hears Cherry's voice accidentally play on the audio device. Continuing to work their way to the gynoid warehouse, they arrive at a brothel/gas station owned by Snappy Tom, a friend of Jake's, where a dilapidated Aeronca Champion light airplane is stored. Edith repairs the plane using parts from the Mustang. Jake catches up with the group and reminisces with Snappy Tom, but Snappy's live-in girlfriend betrays their location to Lester over the radio and shoots Jake in the back. Edith and Sam manage to escape in the plane. Sam is almost ready to abandon the quest, but Edith is determined to complete her job as a tracker so Jake's death will not become meaningless. As they land, Zone 7 is revealed to be actually the abandoned ruins of Las Vegas and the gynoid "warehouse" is actually a casino. Sam finally finds a functional Cherry 2000 model and activates her with the memory disk; however, being programmed only for home life and sex, the robot is incapable of adapting to the current dangerous situation when Lester and his gang attack. In an extended battle, Sam, Edith, and Cherry climb aboard the airplane, but their combined weight prevents takeoff. Edith jumps out so that Sam and the robot can escape, but Sam realizes that Cherry cannot provide the human interaction that he and Edith have had and turns the plane around. Cherry, programmed to fulfill Sam's wishes, offers to bring him a Pepsi, so he sends her away as he and Edith fight off Lester's gang and take off in the plane. When Lester tries to lasso the plane, he gets caught in the rope and hangs himself from one of the ancient Las Vegas neon casino signs. Edith and Sam kiss as they fly away into the sunset.

Bob Munro, an executive at the large soda company Pure Vibe, struggles with the whims of his self-absorbed boss Todd Mallory. His family — materialistic wife Jamie and their teenage children, sharp-tongued Cassie and self-confident Carl — are also demanding, and he had promised them a vacation in Hawaii. During an event Todd hosted, Cassie's friend Gretchen insults Todd and stains his suit with a soda. Todd, who sought to acquire the Alpine Soda company in Boulder, Colorado, blames Bob for the incident and threatens to fire him if he does not promote the takeover. Todd's demand forces the Munros to cancel their vacation. Bob, concealing the real reason for not going to Hawaii, rents an RV and tells his family that they are traveling to the Rockies; he plans to make a detour in Colorado to secretly attend the meeting in Boulder. The trip is marked by numerous mishaps. Bob's inexperience in handling the large vehicle results in him colliding with various obstacles and damaging the parking brake. During a stopover in Nevada, he must fix an unsavory clog in the toilet tank. The family also fumigates the RV with stink bombs to drive out intrusive raccoons. During the trip, the Munros have several encounters with the Gornickes, a good-natured but exhausting family who live in their own RV, consisting of dad Travis, mobile sales rep and cosmetologist mom Mary Jo, and their three children, Earl, Moon, and Billy. As they approach Colorado, Carl tries playing basketball with some older boys, but Bob makes it awkward and embarrasses him. The two go for a walk in the woods and somehow bond over the future of Carl's heavyweight career. Later, the Munros reconnect as a family and enjoy the beauty of their surroundings. Nearing Boulder, Bob fakes an upset stomach and sends the rest of the family on a hike before meeting with the Alpine Soda owners. The meeting is promising, but on the way back, Bob gets stuck in a traffic jam, forcing him to take the RV through a treacherous four-wheel-drive trail; he returns to his family with a badly battered vehicle. Todd calls Bob and demands that he return the next day to repeat the presentation to the entire Alpine Soda staff. However, the RV's parking brake fails again and sends it rolling into a mountain lake. Bob is forced to confess the true purpose of the trip to his family, explaining that he fears losing his job and their standard of living. Taken aback, the family refuses to accompany him, leaving him to make his way to the meeting alone on a bike recovered from the RV. The Gornickes appear and pick up the Munros. Along the way, the two families bond; Bob spots them together from a distance on the road. Deciding his family is more important than his job, he catches up to them and reconciles with everyone. In return, the Gornickes drive him the rest of the way to the meeting. At the Alpine Soda headquarters, Bob begins to pitch the takeover to the staff; halfway through, he has an epiphany and encourages their independence, aware that Todd would ruin the brand. In retaliation, Todd fires Bob; Carl angrily throws to the ground and tackles him, making him a hero. Then Bob retorts that he quits anyway. On their way home in the sodden and battered RV, the Munros are stopped by a police officer on behalf of the Alpine Soda owners, who offer Bob a job overseeing their company's expansion. The RV's parking brake fails again, flattening the police car and the Alpine Soda company owners' car. During the credits, the two families are shown dancing and singing along to " Route 66 ".