Topic: Rodents

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Milwaukee Protocol

Medicine Viruses Dogs Cats Neuroscience Microbiology Medicine/Neurology Rodents Medicine/Translation Veterinary medicine Medicine/Dermatology

Rabies is a viral disease that causes inflammation of the brain in humans and other mammals. Early symptoms can include fever and tingling at the site of exposure. These symptoms are followed by one or more of the following symptoms: violent movements, uncontrolled excitement, fear of water, an inability to move parts of the body, confusion, and loss of consciousness. Once symptoms appear, the result is nearly always death. The time period between contracting the disease and the start of symptoms is usually one to three months, but can vary from less than one week to more than one year. The time depends on the distance the virus must travel along peripheral nerves to reach the central nervous system.

Rabies is caused by lyssaviruses, including the rabies virus and Australian bat lyssavirus. It is spread when an infected animal bites or scratches a human or other animal. Saliva from an infected animal can also transmit rabies if the saliva comes into contact with the eyes, mouth, or nose. Globally, dogs are the most common animal involved. In countries where dogs commonly have the disease, more than 99% of rabies cases are the direct result of dog bites. In the Americas, bat bites are the most common source of rabies infections in humans, and less than 5% of cases are from dogs. Rodents are very rarely infected with rabies. The disease can be diagnosed only after the start of symptoms.

Animal control and vaccination programs have decreased the risk of rabies from dogs in a number of regions of the world. Immunizing people before they are exposed is recommended for those at high risk, including those who work with bats or who spend prolonged periods in areas of the world where rabies is common. In people who have been exposed to rabies, the rabies vaccine and sometimes rabies immunoglobulin are effective in preventing the disease if the person receives the treatment before the start of rabies symptoms. Washing bites and scratches for 15 minutes with soap and water, povidone-iodine, or detergent may reduce the number of viral particles and may be somewhat effective at preventing transmission. As of 2016, only fourteen people had survived a rabies infection after showing symptoms.

Rabies caused about 17,400 human deaths worldwide in 2015. More than 95% of human deaths from rabies occur in Africa and Asia. About 40% of deaths occur in children under the age of 15. Rabies is present in more than 150 countries and on all continents but Antarctica. More than 3 billion people live in regions of the world where rabies occurs. A number of countries, including Australia and Japan, as well as much of Western Europe, do not have rabies among dogs. Many Pacific islands do not have rabies at all. It is classified as a neglected tropical disease.

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Rat Park

Medicine Psychology Rodents

Rat Park was a series of studies into drug addiction conducted in the late 1970s and published between 1978 and 1981 by Canadian psychologist Bruce K. Alexander and his colleagues at Simon Fraser University in British Columbia, Canada.

Alexander's hypothesis was that drugs do not cause addiction, and that the apparent addiction to opiate drugs commonly observed in laboratory rats exposed to them is attributable to their living conditions, and not to any addictive property of the drug itself.

To test his hypothesis, Alexander built Rat Park, a large housing colony, 200 times the floor area of a standard laboratory cage. There were 16–20 rats of both sexes in residence, food, balls and wheels for play, and enough space for mating. The results of the experiment appeared to support his hypothesis.

The two major science journals, Science and Nature, rejected Alexander, Coambs, and Hadaway's first paper, which appeared instead in Psychopharmacology in 1978. The paper's publication initially attracted no response. Within a few years, Simon Fraser University withdrew Rat Park's funding.

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Ship's cat

Cats Ships Rodents

The ship's cat has been a common feature on many trading, exploration, and naval ships dating to ancient times. Cats have been carried on ships for many reasons, most importantly to control rodents. Vermin aboard a ship can cause damage to ropes, woodwork, and more recently, electrical wiring. Also, rodents threaten ships' stores, devour crews' foodstuff, and could cause economic damage to ships' cargo such as grain. They are also a source of disease, which is dangerous for ships that are at sea for long periods of time. Rat fleas are carriers of plague, and rats on ships were believed to be a primary vector of the Black Death.

Cats naturally attack and kill rodents, and their natural ability to adapt to new surroundings made them suitable for service on a ship. In addition, they offer companionship and a sense of home, security and camaraderie to sailors away from home.

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