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🔗 Medicine

In medicine, the hygiene hypothesis states that early childhood exposure to particular microorganisms (such as the gut flora and helminth parasites) protects against allergies by properly tuning the immune system. In particular, a lack of such exposure is thought to lead to poor immune tolerance. The time period for exposure begins before birth and ends at school age.

While early versions of the hypothesis referred to microorganism exposure in general, later versions apply to a specific set of microbes that have co-evolved with humans. The updates have been given various names, including the microbiome depletion hypothesis, the microflora hypothesis, and the "old friends" hypothesis. There is a significant amount of evidence supporting the idea that lack of exposure to these microbes is linked to allergies or other conditions, although it is still rejected by many scientists.

The term "hygiene hypothesis" has been described as a misnomer because people incorrectly interpret it as referring to their own cleanliness. Having worse personal hygiene, such as not washing hands before eating, only increases the risk of infection without affecting the risk of allergies or immune disorders. Hygiene is essential for protecting vulnerable populations such as the elderly from infections, preventing the spread of antibiotic resistance, and combating emerging infectious diseases such as Ebola. The hygiene hypothesis does not suggest that having more infections during childhood would be an overall benefit.

🔗 Medicine 🔗 Skepticism 🔗 Anthropology 🔗 Medicine/Psychiatry

In medicine and medical anthropology, a culture-bound syndrome, culture-specific syndrome, or folk illness is a combination of psychiatric and somatic symptoms that are considered to be a recognizable disease only within a specific society or culture. There are no objective biochemical or structural alterations of body organs or functions, and the disease is not recognized in other cultures. The term culture-bound syndrome was included in the fourth version of the Diagnostic and Statistical Manual of Mental Disorders (American Psychiatric Association, 1994) which also includes a list of the most common culture-bound conditions (DSM-IV: Appendix I). Counterpart within the framework of ICD-10 (Chapter V) are the culture-specific disorders defined in Annex 2 of the Diagnostic criteria for research.

More broadly, an endemic that can be attributed to certain behavior patterns within a specific culture by suggestion may be referred to as a potential behavioral epidemic. As in the cases of drug use, or alcohol and smoking abuses, transmission can be determined by communal reinforcement and person-to-person interactions. On etiological grounds, it can be difficult to distinguish the causal contribution of culture upon disease from other environmental factors such as toxicity.

🔗 Medicine 🔗 Cats 🔗 Microbiology 🔗 Veterinary medicine

Toxoplasma gondii () is a parasitic protozoan (specifically an apicomplexan) that causes toxoplasmosis. Found worldwide, T. gondii is capable of infecting virtually all warm-blooded animals,^: 1 but felids are the only known definitive hosts in which the parasite may undergo sexual reproduction.

In rodents, T. gondii alters behavior in ways that increase the rodents' chances of being preyed upon by felids. Support for this "manipulation hypothesis" stems from studies showing that T. gondii-infected rats have a decreased aversion to cat urine while infection in mice lowers general anxiety, increases explorative behaviors and increases a loss of aversion to predators in general. Because cats are one of the only hosts within which T. gondii can sexually reproduce, such behavioral manipulations are thought to be evolutionary adaptations that increase the parasite's reproductive success since rodents that do not avoid cat habitations will more likely become cat prey. The primary mechanisms of T. gondii–induced behavioral changes in rodents occur through epigenetic remodeling in neurons that govern the relevant behaviors (e.g. hypomethylation of arginine vasopressin-related genes in the medial amygdala, which greatly decrease predator aversion).

In humans, particularly infants and those with weakened immunity, T. gondii infection is generally asymptomatic but may lead to a serious case of toxoplasmosis. T. gondii can initially cause mild, flu-like symptoms in the first few weeks following exposure, but otherwise, healthy human adults are asymptomatic. This asymptomatic state of infection is referred to as a latent infection, and it has been associated with numerous subtle behavioral, psychiatric, and personality alterations in humans. Behavioral changes observed between infected and non-infected humans include a decreased aversion to cat urine (but with divergent trajectories by gender) and an increased risk of schizophrenia. Preliminary evidence has suggested that T. gondii infection may induce some of the same alterations in the human brain as those observed in rodents. Many of these associations have been strongly debated and newer studies have found them to be weak, concluding:

On the whole, there was little evidence that T. gondii was related to increased risk of psychiatric disorder, poor impulse control, personality aberrations, or neurocognitive impairment.

T. gondii is one of the most common parasites in developed countries; serological studies estimate that up to 50% of the global population has been exposed to, and may be chronically infected with, T. gondii; although infection rates differ significantly from country to country. Estimates have shown the highest IgG seroprevalence to be in Ethiopia, at 64.2%, as of 2018.

🔗 Biography 🔗 Medicine 🔗 Biography/science and academia 🔗 History of Science 🔗 Hungary 🔗 Medicine/Society and Medicine

Ignaz Philipp Semmelweis (German: [ˈɪɡnaːts ˈzɛml̩vaɪs]; Hungarian: Semmelweis Ignác Fülöp [ˈsɛmmɛlvɛjs ˈiɡnaːts ˈfyløp]; 1 July 1818 – 13 August 1865) was a Hungarian physician and scientist of German descent who was an early pioneer of antiseptic procedures and was described as the "saviour of mothers". Postpartum infection, also known as puerperal fever or childbed fever, consists of any bacterial infection of the reproductive tract following birth and in the 19th century was common and often fatal. Semmelweis discovered that the incidence of infection could be drastically reduced by requiring healthcare workers in obstetrical clinics to disinfect their hands. In 1847, he proposed hand washing with chlorinated lime solutions at Vienna General Hospital's First Obstetrical Clinic, where doctors' wards had thrice the mortality of midwives' wards. The maternal mortality rate dropped from 18% to less than 2%, and he published a book of his findings, Etiology, Concept and Prophylaxis of Childbed Fever, in 1861.

Despite his research, Semmelweis's observations conflicted with the established scientific and medical opinions of the time and his ideas were rejected by the medical community. He could offer no theoretical explanation for his findings of reduced mortality due to hand-washing, and some doctors were offended at the suggestion that they should wash their hands and mocked him for it. In 1865, the increasingly outspoken Semmelweis allegedly suffered a nervous breakdown and was committed to an asylum by his colleagues. In the asylum, he was beaten by the guards. He died 14 days later from a gangrenous wound on his right hand that may have been caused by the beating.

His findings earned widespread acceptance only years after his death, when Louis Pasteur confirmed the germ theory, giving Semmelweis' observations a theoretical explanation, and Joseph Lister, acting on Pasteur's research, practised and operated using hygienic methods with great success.

🔗 United States 🔗 Biography 🔗 Medicine 🔗 Biology 🔗 Biography/science and academia 🔗 India 🔗 Molecular and Cell Biology 🔗 Medicine/Medical genetics 🔗 United States/Asian Americans

Har Gobind Khorana (9 January 1922 – 9 November 2011) was an Indian-American biochemist. While on the faculty of the University of Wisconsin–Madison, he shared the 1968 Nobel Prize for Physiology or Medicine with Marshall W. Nirenberg and Robert W. Holley for research that showed the order of nucleotides in nucleic acids, which carry the genetic code of the cell and control the cell's synthesis of proteins. Khorana and Nirenberg were also awarded the Louisa Gross Horwitz Prize from Columbia University in the same year.

Born in British India, Khorana served on the faculties of three universities in North America. He became a naturalized citizen of the United States in 1966, and received the National Medal of Science in 1987.

🔗 Medicine 🔗 Athletics 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Sports 🔗 Horse racing

The poppy seed defence is a commonly cited reason to avoid any sanction for failing a drug test. The defence asserts that a suspect's positive result was a result of the person having consumed poppy seeds prior to taking the test. It has been recognised in medical and legal fields as a valid defence.

🔗 International relations 🔗 Disaster management 🔗 Medicine 🔗 Death

A pandemic (from Greek πᾶν pan "all" and δῆμος demos "people") is a disease epidemic that has spread across a large region, for instance multiple continents, or worldwide. A widespread endemic disease with a stable number of infected people is not a pandemic. Further, flu pandemics generally exclude recurrences of seasonal flu.

Throughout history, there have been a number of pandemics of diseases such as smallpox and tuberculosis. One of the most devastating pandemics was the Black Death (also known as The Plague), which killed an estimated 75–200 million people in the 14th century. Other notable pandemics include the 1918 influenza pandemic (Spanish flu) and the 2009 flu pandemic (H1N1). Current pandemics include HIV/AIDS and the 2019 coronavirus disease, which was declared a pandemic on 11 March 2020 by the World Health Organization (WHO).