Have a deep view into what people are curious about.

🔗 Philosophy 🔗 Sociology 🔗 Gender Studies

The master suppression techniques is a framework articulated in 1945 by the Norwegian psychologist and philosopher Ingjald Nissen. These techniques identified by Nissen are ways to indirectly suppress and humiliate opponents. In the late 1970s, the framework was popularized by Norwegian social psychologist Berit Ås, who reduced Nissen's original nine means to five, and claimed this was a technique mostly used in the workplace by men against women. Master suppression techniques are defined as strategies of social manipulation by which a dominant group maintains such a position in an (established or unexposed) hierarchy. They are very prominent in Scandinavian scholarly and public debate, where the expression is also used to refer to types of social manipulation not part of Ås's framework. Master suppression techniques are sometimes called domination techniques.

🔗 United States 🔗 Military history 🔗 Military history/North American military history 🔗 Military history/United States military history 🔗 Korea 🔗 Military history/Maritime warfare 🔗 Ships 🔗 Pritzker Military Library 🔗 Korea/North Korea 🔗 United States/Colorado

USS Pueblo (AGER-2) is a Banner-class environmental research ship, attached to Navy intelligence as a spy ship, which was attacked and captured by North Korean forces on 23 January 1968, in what is known today as the "Pueblo incident" or alternatively, as the "Pueblo crisis".

The seizure of the U.S. Navy ship and her 83 crew members, one of whom was killed in the attack, came less than a week after President Lyndon B. Johnson's State of the Union address to the United States Congress, a week before the start of the Tet Offensive in South Vietnam during the Vietnam War and three days after 31 men of North Korea's KPA Unit 124 had crossed the Korean Demilitarized Zone (DMZ) and killed 26 South Koreans in an attempt to attack the South Korean Blue House (executive mansion) in the capital Seoul. The taking of Pueblo and the abuse and torture of her crew during the subsequent 11-month prisoner drama became a major Cold War incident, raising tensions between western and eastern powers.

North Korea stated that Pueblo deliberately entered their territorial waters 7.6 nautical miles (14 km) away from Ryo Island, and that the logbook shows that they intruded several times. However, the United States maintains that the vessel was in international waters at the time of the incident and that any purported evidence supplied by North Korea to support its statements was fabricated. Pueblo, still held by North Korea today, officially remains a commissioned vessel of the United States Navy. Since early 2013, the ship has been moored along the Pothong River in Pyongyang and used there as a museum ship at the Victorious War Museum. Pueblo is the only ship of the U.S. Navy still on the commissioned roster currently being held captive.

🔗 California 🔗 California/San Francisco Bay Area 🔗 Food and drink

Caffè Mediterraneum, often referred to as Caffè Med or simply the Med, was a café located on Telegraph Avenue in Berkeley, California, US, near the University of California, Berkeley. The Med was a landmark of Telegraph Avenue history, "listed for years in European guidebooks as 'the gathering place for 1960s radicals who created People's Park'" and as of 2009 described in Fodor's guidebook as "a relic of 1960s-era café culture". It was located at 2475 Telegraph Avenue, between Dwight Way and Haste Street.

🔗 Medicine 🔗 Food and drink 🔗 Medicine/Toxicology 🔗 Pharmacology 🔗 Medicine/Society and Medicine

Some fruit juices and fruits can interact with numerous drugs, in many cases causing adverse effects. The effect was first discovered accidentally, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol.

The effect is most studied with grapefruit and grapefruit juice, but similar effects have been observed with certain other citrus fruits. One medical review advises patients to avoid all citrus juices until further research clarifies the risks. Effects have been observed with apple juice, but their clinical significance is not yet known.

One whole grapefruit, or a small glass (200 mL (6.8 US fl oz)) of grapefruit juice, can cause drug overdose toxicity. Fruit consumed three days before the medicine can still have an effect. The relative risks of different types of citrus fruit have not been systematically studied. Affected drugs typically have an auxiliary label saying “Do not take with grapefruit” on the container, and the interaction is elaborated upon in the package insert. People are also advised to ask their physician or pharmacist about drug interactions.

The effects are caused by furanocoumarins (and, to a lesser extent, flavonoids). These chemicals inhibit key drug metabolizing enzymes, such as cytochrome P450 3A4 (CYP3A4). CYP3A4 is a metabolizing enzyme for almost 50% of drugs, and is found in the liver and small intestinal epithelial cells. As a result, many drugs are affected. Inhibition of enzymes can have two different effects, depending on whether the drug is either

1. metabolized by the enzyme to an inactive metabolite, or
2. activated by the enzyme to an active metabolite.

In the first instance, inhibition of drug-metabolizing enzymes results in elevated concentrations of an active drug in the body, which may cause adverse effects. Conversely, if the medication is a prodrug, it needs to be metabolised to be converted to the active drug. Compromising its metabolism lowers concentrations of the active drug, reducing its therapeutic effect, and risking therapeutic failure.

Low drug concentrations can also be caused when the fruit suppresses drug absorption from the intestine.

🔗 Plants 🔗 Ireland

The Hungry Tree is a tree in the grounds of the King's Inns in Dublin, Republic of Ireland. An otherwise unremarkable specimen of the London plane, it has become known for having partially consumed a nearby park bench. It has become a tourist attraction and is frequently photographed. The Hungry Tree was the subject of a campaign by Green Party politician Ciarán Cuffe to ensure its preservation.

🔗 Architecture 🔗 Urban studies and planning

A charrette (American pronunciation: ), often Anglicized to charette or charet and sometimes called a design charrette, is an intense period of design or planning activity.

The word charrette may refer to any collaborative session in which a group of designers draft a solution to a design problem.

While the structure of a charrette varies, depending on the design problem and the individuals in the group, charrettes often take place in multiple sessions in which the group divides into sub-groups. Each sub-group then presents its work to the full group as material for further dialogue. Such charrettes serve as a way of quickly generating a design solution while integrating the aptitudes and interests of a diverse group of people. The general idea of a charrette is to create an innovative atmosphere in which a diverse group of stakeholders can collaborate to "generate visions for the future".

🔗 Food and drink 🔗 Plants

Pepper X is a cultivar of Capsicum chili pepper bred by Ed Currie, creator of the Carolina Reaper. As of 2023, it is the world's hottest pepper.

🔗 Human rights 🔗 Medicine 🔗 History of Science 🔗 Alabama 🔗 Science Policy 🔗 Nursing

The Tuskegee Study of Untreated Syphilis in the Negro Male (informally referred to as the Tuskegee Experiment or Tuskegee Syphilis Study) was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.

The Public Health Service started the study in 1932 in collaboration with Tuskegee University (then the Tuskegee Institute), a historically Black college in Alabama. In the study, investigators enrolled a total of 600 impoverished African-American sharecroppers from Macon County, Alabama. Of these men, 399 had latent syphilis, with a control group of 201 men who were not infected. As an incentive for participation in the study, the men were promised free medical care. While the men were provided with both medical and mental care that they otherwise would not have received, they were deceived by the PHS, who never informed them of their syphilis diagnosis and provided disguised placebos, ineffective methods, and diagnostic procedures as treatment for "bad blood".

The men were initially told that the experiment was only going to last six months, but it was extended to 40 years. After funding for treatment was lost, the study was continued without informing the men that they would never be treated. None of the infected men were treated with penicillin despite the fact that, by 1947, the antibiotic was widely available and had become the standard treatment for syphilis.

The study continued, under numerous Public Health Service supervisors, until 1972, when a leak to the press resulted in its termination on November 16 of that year. By then, 28 patients had died directly from syphilis, 100 died from complications related to syphilis, 40 of the patients' wives were infected with syphilis, and 19 children were born with congenital syphilis.

The 40-year Tuskegee Study was a major violation of ethical standards and has been cited as "arguably the most infamous biomedical research study in U.S. history." Its revelation led to the 1979 Belmont Report and to the establishment of the Office for Human Research Protections (OHRP) and federal laws and regulations requiring institutional review boards for the protection of human subjects in studies. The OHRP manages this responsibility within the United States Department of Health and Human Services (HHS). Its revelation has also been an important cause of distrust in medical science and the US government amongst African Americans.

On May 16, 1997, President Bill Clinton formally apologized on behalf of the United States to victims of the study, calling it shameful and racist. "What was done cannot be undone, but we can end the silence," he said. "We can stop turning our heads away. We can look at you in the eye, and finally say, on behalf of the American people, what the United States government did was shameful and I am sorry."

🔗 Literature 🔗 Psychology

Oblique Strategies (subtitled Over One Hundred Worthwhile Dilemmas) is a card-based method for promoting creativity jointly created by Brian Eno and Peter Schmidt, first published in 1975. Physically, it takes the form of a deck of 7-by-9-centimetre (2.8 in × 3.5 in) printed cards in a black box. Each card offers a challenging constraint intended to help artists (particularly musicians) break creative blocks by encouraging lateral thinking.

🔗 Caves

Snottite, also snoticle, is a microbial mat of single-celled extremophilic bacteria which hang from the walls and ceilings of caves and are similar to small stalactites, but have the consistency of nasal mucus. In the Frasassi Caves in Italy, over 70% of cells in Snottite have been identified as Acidithiobacillus thiooxidans, with smaller populations including an archaeon in the uncultivated 'G-plasma' clade of Thermoplasmatales (>15%) and a bacterium in the Acidimicrobiaceae family (>5%).

The bacteria derive their energy from chemosynthesis of volcanic sulfur compounds including H₂S and warm-water solution dripping down from above, producing sulfuric acid. Because of this, their waste products are highly acidic (approaching pH=0), with similar properties to battery acid. Researchers at the University of Texas have suggested that this sulfuric acid may be a more significant cause of cave formation than the usual explanation offered of the carbonic acid formed from carbon dioxide dissolved in water.

Snottites were brought to attention by researchers Diana Northup and Penny Boston studying them (and other organisms) in a toxic sulfur cave called Cueva de Villa Luz (Cave of the Lighted House), in Tabasco, Mexico. Snottites were first discovered in this cave by Jim Pisarowicz in 1986, who also coined the term.

The BBC series Wonders of the Solar System saw Professor Brian Cox examining snottites and positing that if there is life on Mars, it may be similarly primitive and hidden beneath the surface of the Red Planet.