Alex Bernier is a disillusioned priest and a member of the fictional Carolingian Order– an ancient sect that specializes in exorcisms and combatting demonic forces. The narrative begins with the mysterious death of Father Dominic– the head of the Carolingians, in Rome. Alex is dispatched by Cardinal Driscoll– a prominent Vatican official and papal candidate, to investigate the circumstances surrounding Dominic's demise. Before his departure, Alex is approached by Mara Williams– an artist who he previously attempted to exorcise. Mara reveals that she senses impending danger for Alex. It is disclosed that during the exorcism, Mara attempted to kill Alex, and was subsequently imprisoned in a mental institution. Despite that history between them, Alex permits Mara to accompany him to Rome after she assures him that she poses no threat. In Rome, Alex examines Dominic's corpse, and observes unusual markings, which he identifies as the work of a sin-eater– a figure that is capable of absolving sins outside of the Church's authority. Seeking assistance, Alex contacts his friend and fellow Carolingian priest, Thomas Garrett. The Vatican denies the existence of sin-eaters, and refuses to give Dominic a burial on consecrated ground, due to alleged excommunication. Defying orders, Alex conducts a clandestine funeral service for Dominic in the Carolingian cemetery. Cardinal Driscoll arrives in Rome, and presents Alex with an ancient dagger and a fragmentary parchment that contains an Aramaic incantation. Believing these to be tools to eliminate the sin-eater, Alex and Thomas pursue further information. Their search leads them to a clandestine figure known as the Black Pope, who operates an underground sect. The Black Pope instructs Alex to seek answers from dying people, and he orchestrated a scenario in which three men are hanged. One of the dying men provides a riddle that guides Alex to a meeting with the sin-eater. During their escape from the Black Pope's domain, Thomas is injured by demonic entities, and Alex brings him to a hospital. Alex then encounters the sin-eater, William Eden, at St. Peter's Basilica. Eden, weary after centuries of service, expresses a desire for Alex to succeed him. Intrigued but conflicted, Alex assists Eden in a sin-eating ritual but ultimately declines the offer, deciding to leave the priesthood to pursue a relationship with Mara. Unbeknownst to Alex, Eden visits Mara and inflicts fatal wounds, making it appear as a suicide attempt. Discovering her near death and beyond medical help, Alex performs the sin-eating ritual to ensure her passage to heaven. Realizing that Mara did not kill herself, Alex deduces Eden's manipulation, and resolves to confront him. Meanwhile, Thomas uncovers that the Black Pope is actually Cardinal Driscoll. Driscoll reveals the complete parchment, which outlines the true purpose of the dagger and incantation, which is not to kill the sin-eater, but to transfer his powers to a successor. Driscoll prevents Thomas from warning Alex of this revelation. Alex confronts Eden and, following the supposed instructions to eliminate him, stabs Eden with the dagger while reciting the incantation. Eden dies, and the sin-eating powers are inadvertently transferred to Alex. Thomas arrives too late to prevent the transfer, and informs Alex of Driscoll's deceit. It becomes apparent that Dominic, Eden, and Driscoll orchestrated events to manipulate Alex into becoming the new sin-eater: Eden sought release from his burden; Driscoll desired the papacy; and Dominic aimed to access forbidden knowledge. Alex exposes Driscoll's machinations to the Church, leading to the Cardinal's downfall. Facing ruin, Driscoll attempts suicide, and summons Alex to absolve his sins. Instead, Alex forces Driscoll to confront his own corruption, refusing to perform the ritual. Embracing his new role, Alex decides to use his abilities as a force for good, by offering salvation to people who he deems worthy, and denying it to people who are unrepentant.

Dieter and Margot Menliff, in an unhappy marriage, visit an old castle that Margot has just inherited. When they arrive, Dieter explores the basement, while Margot examines the rest of the castle. Dieter sees something in the cellar that causes him to drop his keys and flee. Margot has a vision in a dusty mirror. Halfway through the film, a second couple, Eva Ziehnagel and Gregor Grause, is introduced.

Trixie Zurbo is an eccentric woman who longs to quit her job as a security guard in a department store and become a private detective. She finally gets her wish when she takes a job in security at a casino. She accidentally becomes involved in a murderous plot and Trixie takes her first case; however, her unschooled command of the English language (malapropism) and comedy intervenes and the mess begins.

In New York City, a stray lightning bolt strikes the 102- floor, 73- elevator Millennium Building. The three main express elevators begin acting strangely, resulting in a guard 's flashlight being crushed. The next day, a group of pregnant women are held up between floors 21 and 22; The elevator overheats rapidly, causing two women to give birth and hospitalizing the rest. Reporter Jennifer Evans is called to write a report on the incident. After an investigation by METEOR elevator company technicians Jeff McClellan and Mark Newman, they determine that nothing is wrong with the elevators, a large part being Jeff's inability to actually admit there is something wrong (he states throughout his scenes that the computer controlling the elevators has absolutely no defects). A short time later, a blind man and his guide dog disappear in the building. The two guards from the beginning of the film discover the dog's corpse hanging from its collar on a shaft support. The discovering guard's head is caught between the elevator doors. He is decapitated a short while later, his partner too horrified to help him. Once again, the METEOR executives find nothing wrong with the elevators. Evans interviews Newman, who sarcastically states "Nine people out of ten make it out of an elevator alive." Evans places this in her report, causing a large controversy over his statement by his boss, Mitchell, and the police. During the same day, a roller skater is sucked into an elevator in the parking garage and shot out from the 86th floor of the building to his death. The roller skater's death is explained to the media as suicide. Evans visits Newman and shows him a tape of the roller skater's death. She points out the time it normally takes for the elevator to go up 86 floors would take about 40 seconds to a minute. However, the elevator ascended the floors in less than two seconds, thus noting that there is definitely something wrong. When they try to show the tape to Jeff, he refuses to watch it and leaves abruptly. Instead, they go to Evans' office and look up a man named Gunther Steinberg, who had been experimenting with organic reproducing computer chips using dolphin brains. However, the project had gone disastrously wrong, and Steinberg was fired. Later the next morning, Milligan, who remains suspicious of the elevators throughout the film, discovers Jeff's corpse in an elevator shaft. When Jennifer and Mark arrive, they are shocked to hear that the police have concocted a story of Jeff being a terrorist behind the incidents, to assure the public that the threat is over. Later during the day, an elevator cab flies to the top floor at such a speed that the floor flies off and all the people in it are killed. This event reaches the President and is seen as an act of terrorism. A terrorism unit is assembled at the building to get any further terrorists out of the building. Meanwhile, Jennifer and Mark discover a recent suicide could be linked to the incidents, as his extremely superstitious widow believes his soul has returned to punish others. Jennifer and Mark enter the building to discover and stop the threat once and for all. During the entry, Jennifer is taken into custody posing as a METEOR executive. During her first attempt to prove this fraud, she receives a phone call from a friend to explain that while Steinberg's time working on the chips had been revoked, Steinberg continued to work on the project, except not with dolphin brains. Eventually, Mitchell abandons Steinberg for fear of his reputation being ruined. Mark manages to get into the Millennium Building and discovers a large bio-chip in the form of a brain in an elevator shaft. It is assumed that this brain is alive and controlling the elevators. He attempts to destroy it using a screwdriver, but this attempt fails when it sends a flaming elevator down to kill him. Mark barely escapes while the elevator kills a SWAT officer who was barely out of the elevator shaft before he was sliced in half from his waist down, with the upper half of his body sliding across the floor. Mark gets hold of a stinger missile launcher and is about to destroy the organ when Steinberg intervenes, threatening him. Jennifer appears, having escaped custody, and frees Mark. As Mark tries to destroy the organ a third time, the police enter, giving Steinberg the opportunity to hold Jennifer hostage. Jennifer manages to escape thanks to Steinberg being unable to recognize one of his superiors. Steinberg is grabbed by the elevator shaft cables and pulled in, along with Mark. At the last second, Jennifer kicks the stinger launcher to Mark, who proceeds to destroy the organ. Steinberg's mutilated corpse falls seconds later. Sometime later, Mark and Jennifer leave the hospital where they find themselves trapped in an elevator. However, it proves to be a ruse for Mark to make a romantic overture toward Jennifer.

Married couple Ed (Lee Williams) and Sarah (Pollyanna McIntosh) have decided that they want to get away from their busy, stressful lives in London and move somewhere more peaceful. They believe that they've found the perfect place in a bucolic farmhouse in Scotland; however, their real estate agent Flo (Joanne Mitchell) informs them that the land is the site of a gruesome battle between the English and the Scottish. Despite this knowledge and Flo's chilly story, Ed and Sarah choose to purchase the farmhouse and restore the property. Initially all seems well, but on their first night they hear strange sounds in the nearby area and discover that they are not at all welcome in the area. Later that night while Sarah is downstairs she witnesses the key coming out of the door, implying someone is entering. Quickly, she hides under a table as three men wearing pig masks enter. Sarah moves to a different room and attempts to climb out of the window, breaking a glass and cutting her hand. She later escapes the house and enters the woods. Sarah runs through the woods before finding a car in front of an old farmhouse that holds Ed hostage. Sarah beats in his captor's face and when a second man comes in, she knocks him down, but as more come, she cuts her Achilles heel. She and Ed escape the house. Ed tells her to hide while he distracts them so that she can make a run for the road. Ed knocks one to the ground and escapes, but is later caught in a bear trap. The captor Ed knocked down wanted to kill him, but another captor stops him, mentioning "a plan" they had for Ed and Sarah. Sarah runs into a boy who was at their house earlier and he takes her to the road. Sarah is seen limping as many men surround her. She demands to know where her husband is as they close in on her. The film ends with Sarah and Ed being found in a square in the middle of Manchester, alive. A group of people are having a barbecue at their Scottish home. One of them is the little boy who helped Sarah to the road. He is wearing a pig mask, like the captors, implying that the pig masked captors were the ones that owned the house and wanted the rich couple from London out of their home.

Ex-soldier Ryan Reeve wakes up in the back of a moving van next to a young tied-up boy, Alex, who is being held prisoner. Strangely, the boy seems to think Reeve is the kidnapper though he has no memory of ever having seen the boy before, and looking at his watch, he last remembered it being six months previously. After freeing the boy, making a run for it, and attempting to figure out what has happened to him, all he remembers is being at a facility treating his severe PTSD. As one of their pursuers catches up to them, suddenly he blacks out again and awakes in a room with a mysterious young man (same as before) named Harkin Langham, who seems to think he is someone else. When Langham discovers who he really is, he disables Reeve and knocks him out. Reeve then wakes up in a mysterious bedroom having sex with a beautiful young woman. She identifies herself as a prostitute named Dana, who seems to remember meeting and engaging in sexual activity with a much more violent and sociopathic version of Reeve. He tries to explain his predicament, but she remains skeptical. He asks her to come with him, but she says she cannot leave as she is the "property" of a Russian gangster named Sergio. Reeve offers to free her if she will help him solve the mystery that his life has become. The two manage to escape, but Reeve again loses consciousness when the mind control system reboots and again Langham catches up to him. He must work out what is happening in bursts of exactly nine minutes and forty-seven seconds, as the control and conscious awareness of his body are repeatedly being hijacked and shuffled through different scenarios by person/s unknown. He teams up with Dana as he battles a conspiracy in mind control known as "Anomaly" led by Langham. Langham, meanwhile, urges him to stop fighting it, as it has nothing to do with him, however, he is convinced otherwise.

When Alice arrives unannounced at her estranged brother Ethan's house in an attempt to reconcile, bizarre visions and the return of Ethan's strange girlfriend, Misty, begin to spark paranoia and suspicion. As the haunting visions become more peculiar, the two siblings desperately cling to reality, but are forced to face the mysterious circumstances.

In 2044, computer hackers destroy the research records of Ambro, the largest and most powerful drug company. Before he can be caught, the lead hacker injects himself with a drug and disappears. Twenty years earlier, Frank Grieves, a former addict and current police officer, discovers a body at Ambro's corporate headquarters. Perplexed as to why his DNA scanner can not identify the body, Grieves becomes obsessed with solving the mystery. The only clue he has is the word " Morlock " hidden on the body. Grieves' superior, Nolan, does not approve of his investigation and instead orders him to work on busting the few remaining street dealers, who operate a shrinking black market since the legalisation of all narcotics. When Grieves continues his investigation, Ambro puts pressure on the police to rein him in. Eddie Rankin, Grieves' friend and a medical examiner, tells him that an unidentified drug was found in the man's body. Before Grieves or Rankin can examine it further, Ambro has the body destroyed. Against orders, Grieves returns to the site of the crime in search of more clues, where he recovers a young woman, Eva Gray, who has apparently been targeted for assassination by unknown forces. Grieves saves her life, only to find that Gray's assailant has disappeared into thin air. Grieves attempts to find a place to hide Gray, but his estranged wife, Angie, refuses to help. Gray, who is also unidentifiable, escapes his custody when he is distracted. When pushed, Rankin reveals he knows a scientist, Yuri Sidorov, who may be able to identify the unknown drug. After paying off Rankin's debt to Sidorov, the scientist tells him to return in twenty-four hours. After experiencing further obstruction from Ambro's security and his superiors, Grieves returns early to demand answers from Sidorov. There, he finds Gray, who, after Grieves threatens to harm Sidorov, reveals that she is a time-traveller from 2044. Because she is yet to be born, she has no record in Grieves' DNA database. Grieves dismisses this as the ravings of a junkie and demands to know what Ambro has planned, which he believes may be an experimental drug codenamed "Morlock". Although taken aback that he knows of the word, Gray sticks to her story. Ambro attacks Grieves as he transports Gray. Suddenly, reinforcements appear out of nowhere, disable Ambro's security forces, and disappear with Gray after injecting her with a drug. After Ambro goons attempt to kidnap his son, Grieves realises that the body he found earlier is the adult version of his 9-year-old son, Ben. "Morlock" is a code word based on The Time Machine, a book that Grieves gave to Ben. Now believing Gray's story, Grieves seeks help from Rankin, who refuses to become further involved. After Grieves leaves, Ambro orders the police to kill Rankin and kidnap Sidorov. Grieves has his family flee the city, and, after confronting Nolan, Grieves is also captured. Todd Ambro explains that they need Ben, as he will perfect their time-travelling drug, which is currently flawed in a way that prevents people from staying long in their destination unless they are dead. Ambro demonstrates by killing Sidorov and sending his body elsewhere in time. Desperate to protect his company's future, Ambro demands the police torture Ben's location from Grieves. After the others leave, Nolan sets Grieves free, saying that he knows Ambro will kill him next as a security threat. Nolan proposes they work together to escape, but Grieves instead forces one of Ambro's scientists to inject him with the time-travelling drug. Suddenly in 2044, Grieves speaks to his now-adult son and reinforces how important his mission is. Back in 2024, Grieves once again discovers the body at Ambro's headquarters, but this time it is his own body, not his son's.

Returning home with his mother Vinn from a trip to Berlin, Michael Gant, the son of Defense Intelligence Agency (DIA) director Robert Gant, is kidnapped and his security detail is nearly wiped out by the attacker, ex-DIA agent Sever. FBI agent Jeremiah Ecks left the agency after his wife Rayne was killed in a car bombing. His old boss, Julio Martin, asks him to investigate the Gant case. He claims that Vinn is still alive and he will give Ecks the information on her whereabouts if he helps take down Sever. Ecks agrees and discovers Sever is an orphaned Chinese girl the DIA adopted to train as a covert operative and assassin with " no fear, no conscience, and no morality. " Meanwhile, Robert Gant executes the only survivor of his son's security detail. He then orders his elite agents, led by A. J. Ross, to pursue Sever and rescue Michael. Ecks joins Martin and RCMP agent Harry Lee in Vancouver, where Sever is hiding out. Ecks learns that Gant stole an experimental weapon codenamed Softkill, a nanorobot which operates in the human circulatory system and can cause heart attacks at will. Gant had implanted Softkill in Michael in order to smuggle it into the United States. Ross and his men surround Sever in a shopping plaza, but she wipes out Ross's forces in a lengthy gun battle. Sever shoots Martin, and Ecks pursues Sever, climaxing with a fight that's cut off when Ross starts shooting at them with an M60 machine gun, giving Sever a chance to escape. Ecks is arrested by the Vancouver Police Department under the pretense that he shot Martin. While being transported to jail, his convoy is attacked by Sever, who frees Ecks. After a lengthy car chase, Sever throws a piece of paper at Ecks and tells him to ask Gant about his wife. Ecks meets Rayne at an aquarium and it's revealed that her "death" was orchestrated by Gant. Rayne ended up believing Ecks had died while he believed that she had. Rayne then married Gant under the name Vinn. It ends up that Gant had Sever's family killed; it was initially believed that kidnapping Michael was Sever's revenge. However, Rayne reveals that Michael is actually Ecks' son, and Sever's kidnapping was for his protection. Ecks, Rayne, and Sever go to Sever's underground bunker in an abandoned trainyard, where Rayne is reunited with Michael. Gant and Ross arrive with an army of heavily armed DIA agents, and a pitched battle ensues. Ecks and Sever eventually gain the upper hand and Sever kills Ross in a fight in the bunker. Gant tries to retrieve the Softkill in Michael's arm but is surprised to find it's not there. Sever kills Gant using a Softkill-loaded bullet and escapes as the police arrive. The film concludes with Ecks and Sever looking over the sea and Ecks thanking Sever for reuniting him with his family.