Early 19th century England is besieged by zombies; the Bennet sisters—Elizabeth, Jane, Kitty, Lydia, and Mary—have all been trained in the art of weaponry and martial arts in Qing Dynasty-era China at their father's behest so they can defend themselves. Mrs. Bennet only wants to see her daughters married off to wealthy suitors. The Bennets attend a country dance also attended by newcomers Colonel Darcy, his good friend the amiable Charles Bingley and Bingley's snobbish sister Caroline. There, the young and handsome Bingley falls for lovely, sweet natured Jane. Charles Bingley has inherited £ 100,000 (£ 6 million today) - attracting Mrs. Bennet's attention as a desirable suitor for her daughter. When zombies attack the ball, the Bennet sisters fight them off, and Colonel Darcy, a skilled zombie killer who was trained in Japanese martial arts - with property that pays him £10,000 annually (£ 600,000 today) - becomes attracted to Elizabeth after seeing her fighting skills, although his behavior is outwardly aloof. During the ball, Darcy is disgusted to overhear Mrs. Bennet's mercenary delight that Jane has attracted a rich man. On the way to the Bingleys' some days later, Jane is attacked by a zombie and catches a fever. Darcy orders her confined in fear that she may have been bitten, but her illness is not zombie-related, and she recovers. The Bennets are visited by a cousin, the overbearing Parson Collins, who, as the only surviving male heir in the family, will inherit the Bennet home upon Mr. Bennet's death. Collins proposes to Elizabeth but states that she must give up her life as a warrior, something she refuses to do. Elizabeth meets a charming soldier named George Wickham and arranges to meet him at another ball. She travels with him to a church that is filled with zombies who feed on pig brains instead of human brains, keeping their behaviour relatively normal. Wickham believes that humans can coexist with these new "civilized" zombies. He informs Elizabeth that Darcy convinced the Bingleys to leave the county to keep Bingley away from Jane and then asks her to elope with him, but she refuses. When Darcy proposes to Elizabeth, having fallen in love with her despite his apparent coldness, she expresses outrage at his actions concerning Jane and fights him. Darcy later writes Elizabeth a letter to apologize. He regrets that he separated Jane and Bingley, fearing that Jane only wanted to marry Bingley for his wealth. He also exposes Wickham's true nature. He and Wickham were childhood friends, but Wickham may have murdered Darcy's father, squandered his inheritance, and tried to elicit additional money from Darcy's estate. When that fails, Wickham tries to elope with Darcy's young sister, Georgiana, for her fortune. Elizabeth learns that Wickham has run off with Lydia and London has been overrun with zombies. Darcy saves Lydia and learns that Wickham is using the "civilized" zombies to create a zombie army, which has overrun London based on Wickham's plan to rule the country. He stops him by giving the zombies human brains, which turns them savage. While fighting, Darcy stabs Wickham's chest, revealing him to have been undead all along, like the other supposedly tame zombies. Elizabeth saves Darcy from being killed by Wickham, who escapes (though Elizabeth has chopped off his right arm). As the two ride across a bridge, the human army destroys it to keep the zombies from crossing over from London. Darcy is injured in the explosion, and Elizabeth tearfully admits her love for him. After Darcy recovers, he proposes to Elizabeth again, and this time, she accepts. The two have a joint wedding with Bingley and Jane. In a mid-credits scene, Wickham arrives with his zombie army, along with the four horsemen, to crash the wedding, leaving everyone's fate unknown.

Searching for a way to address overpopulation and global warming, Norwegian scientist Dr. Jørgen Asbjørnsen develops "downsizing", an irreversible process that shrinks organic material. He becomes part of the first group of human test subjects and is encouraged that the process reduces people to a height of approximately 5 inches (13 cm), drastically decreasing their consumption and waste. When the findings are revealed at a conference five years later, there is a global sensation. Ten years later, Paul and Audrey Safranek, a financially struggling married couple in Omaha, see Dave and Carol Johnson, who have downsized, at Paul's high school reunion. Rather than the touted environmental benefits, Dave argues the real reason to downsize is that one's money goes much further when one is small. Paul and Audrey decide to undergo the procedure and move to Leisureland, New Mexico, one of the fancier communities for small individuals. In a Leisureland recovery room after the procedure, Paul receives a call from Audrey, who says she backed out at the last minute and, because they are now different sizes, is leaving him. Because of his reduced size Paul has no choice but to take up solitary occupancy of a sprawling and luxurious mansion, previously selected by the couple using their greatly enhanced capital. Leisureland is presented as an attractive but bland consumerist enclave for the newly rich and downsized, protected by high walls and a dome. A year later, Paul signs his divorce papers. Unable to afford the mansion Audrey chose, he relocates to an apartment and takes a job as a customer service representative at Lands' End. He had let his occupational therapy license lapse, not anticipating the need to work after being shrunk. He has started dating someone, but they break up, and Paul finds himself at a wild party thrown by his shady yet charming neighbor, Dusan. The next morning, Paul recognizes one of Dusan's house cleaners as Ngoc Lan Tran, a Vietnamese political activist who was jailed and downsized against her will, escaped in a television box, barely survived being shipped to the United States, and was brought to Leisureland a year ago to have her leg amputated. Wanting to assist Ngoc Lan with her prosthetic leg, Paul goes to her apartment in the slums just outside the walls of Leisureland where those who had no money when they downsized or downsized illegally who now work as the service workers of the community live. Paul had not thought about this part of the small economy, and is shocked by conditions in the slum. At her apartment, Ngoc Lan has Paul try to help her dying friend. When she finally lets him work on her prosthetic leg, he breaks it, so, until she can get a new one, he agrees to work for her cleaning service and also help her gather food from around the city to distribute throughout the slums. Dusan, upon learning what Paul is doing, attempts to release Paul from his obligation by taking him to deliver supplies to the original colony for small people, but Ngoc Lan unexpectedly decides to tag along, as she has a standing invitation to visit Dr. Asbjørnsen, who had heard about her ordeal. In a Norwegian fjord, Dr. Asbjørnsen and his wife board the boat piloted by Dusan's friend Joris Konrad. Dr. Asbjørnsen announces it has just been determined conclusively that, due to the positive feedback of Antarctic methane emissions, the human race will soon become extinct. Paul asks if downsizing can save humanity, but Dr. Asbjørnsen says the procedure came too late, as only three percent of the world has so far chosen to downsize. That night, Paul and Ngoc Lan have sex. At the colony, the travelers discover that, the next day, Dr. Asbjørnsen is enacting a contingency plan: he and the other colonists are going to enter a large underground vault, and their descendants will emerge when the surface environment stabilizes in about eight thousand years. Dusan and Joris are skeptical of the cult-like plan and say the extinction will not happen for hundreds of years, while Paul is excited to enter the vault and help with this effort to ensure the future of mankind. He asks Ngoc Lan to join him, but she refuses, saying the people in need of help will be those left above ground. As the door of the vault is closing, Paul changes his mind and steps outside. Back in Leisureland, Paul continues to work with Ngoc Lan to serve the people of the slums, deriving contentment from things like bringing dinner to an old man.

Ten years after defeating Hades' Kraken, Perseus, the demigod son of Zeus, now lives as a fisherman with his son Heleus, after the death of his wife Io. Zeus visits Perseus, warning him that, since humans stopped praying to them, the gods are losing their powers and becoming mortal. They can no longer sustain the walls of Tartarus which are holding back the imprisoned Titan Kronos with him. Perseus, valuing his family's safety, refuses to help. Zeus meets his brothers Hades and Poseidon and his son Ares in Tartarus. He asks Hades for help in rebuilding Tartarus' walls, but Hades rejects the offer and attacks Zeus, as does Ares. Poseidon is fatally injured in the ensuing fight. Hades and Ares imprison Zeus, stealing his thunderbolt. They plan to make a deal with Kronos: in exchange for remaining immortal, they will drain Zeus' divine power to revive Kronos. The walls of Tartarus break, unleashing monsters onto the world. After killing a two-headed Chimera in his village, Perseus decides to see Zeus. He instead finds a dying Poseidon who informs him of the situation and tells him to find his demigod son Agenor, who will lead him to Hephaestus, who knows the way into Tartarus. Poseidon then gives Perseus his trident and succumbs to his injuries. Perseus, Andromeda and Agenor set out to find Hephaestus on a hidden island. Agenor explains that Hephaestus created three weapons which Zeus, Hades, and Poseidon wield: Zeus' thunderbolt, Hades' pitchfork, and Poseidon's trident, which can jointly form the Spear of Trium, the only weapon that can defeat Kronos. After an encounter with three Cyclopes, the travelers eventually meet the now-mortal Hephaestus and reach the entrance of a labyrinth leading to Tartarus. Hephaestus sacrifices himself during an attack by Ares to enable Perseus, Andromeda, and Agenor to enter the labyrinth. Inside the labyrinth, a Minotaur attacks Perseus, who kills it. The group eventually enters Tartarus. Meanwhile, Zeus has been almost entirely drained of power as Kronos awakens. Zeus apologizes to Hades for banishing him to the underworld and asks his forgiveness, as he has forgiven Hades for his actions. Hades decides to help Zeus and stop Kronos in contrast to Ares. Perseus arrives and frees Zeus. Ares wounds Zeus with Hades' pitchfork, allowing Perseus to obtain it before he and the others escape Tartarus with Zeus. Aiming to retrieve Zeus' thunderbolt from Ares in order to defeat Kronos, Perseus challenges him to a duel. Meanwhile, Andromeda's army is overwhelmed by the Makhai. Hades revives Zeus and together they defeat the creatures. Kronos appears and begins to attack Andromeda's army. Zeus and Hades hold off Kronos while Perseus duels Ares, eventually killing him with the thunderbolt. Combining the gods' weapons into the Spear of Trium, Perseus destroys Kronos by traveling to his heart and throwing the spear into it. Zeus reconciles with Perseus and then dies of his wounds and Hades leaves, accepting mortality. Heleus tells his father that he wants to return to his life as a fisherman, but Perseus tells him they cannot, and encourages Heleus to be proud of himself, as he is the son of Perseus and the grandson of Zeus, with Perseus giving his sword to Heleus.

In 50 BC, in an Abyssinian castle, Princess Nawa uses a pair of enchanted earrings to escape an arranged marriage by swapping bodies with a slave girl. When each woman wears one of the earrings, their bodies are magically swapped while their minds remain in place. In a modern-day suburban town in California, Jessica Spencer is the beautiful but mean-spirited "hot chick". Her closest friends are April, Keecia and Lulu. April is Jessica's best friend, and all four girls are cheerleaders. At school one day, Jessica makes fun of an overweight girl named Hildenburg and a Wiccan girl named Eden. After that, she and her friends visit the local mall, where Jessica gets her rival Bianca into trouble and finds the earrings in an African -themed store owned by Madame Mambuza. The earrings are not for sale, but Jessica steals them anyway. Shortly afterward, small-time, 30-year-old criminal Clive Maxtone robs a nearby gas station. When Jessica and her friends stop and mistake him for an employee, he services their car to avoid raising suspicion. She accidentally drops one of the earrings on the ground, the girls drive away, and Clive picks up the earring. In their respective homes that evening, Jessica and Clive put on their earrings. When they wake up the next morning, each of them is trapped in the other's body. This is especially difficult for Jessica, who has a cheering competition and the senior prom coming up soon. After Jessica convinces her friends of who she is, they help her investigate the body swap. Hildenburg, Eden and Bianca are all innocent, Hildenburg and Eden join Jessica after she apologizes to them, and Eden finds a picture of the earrings on the internet. When the girls return to the African store, Madame Mambuza explains how the earrings work and tells the girls they must find the other earring soon or the change will become permanent at the next full moon. Meanwhile, Jessica is hired for two jobs while secretly living with April. At her own home, where she works as a gardener, her parents tell her about their marital problems and she helps them rekindle their sex life. At school, while cleaning the boys' locker room as a custodian, she eavesdrops on her boyfriend Billy, who truly loves her unconditionally, and April's boyfriend Jake, who has been cheating on her. Faced with Jake's infidelity, April begins to fall in love with Jessica (although she's still stuck in Clive's body), who agrees to take her to the prom. At the cheering competition, Jessica signals romantically to Billy while disguised as the school mascot, but when the head of her costume falls off, he becomes confused and leaves with Bianca. Jessica goes to the prom with April and they kiss. Jake sees this and is so upset, he spills his drink on his date. April confesses to being in love with Jessica, who tells April she is perfect and doesn't need anybody. Jessica tries to win Billy back, telling Billy it's her in Clive's body, but he is so shocked and confused that he runs off. During this time, Clive has been using Jessica's body to make money from men, including Billy, who gives him his money and car, believing he is Jessica. Clive then tries to run him over. On the evening of the prom, Hildenburg sees a video of Clive in Jessica's body robbing a man on the TV news, goes to the scene of the crime, and finds a business card for the strip club where Clive works as a pole dancer. She informs Jessica at the prom, and the girls go to the club. When they find Clive, Jessica steals his earring and puts it on herself along with the other one. With both earrings now on the same person, Jessica's and Clive's bodies return to their original owners. After Jessica makes up with Billy, the film ends with the school's graduation ceremony, followed by a scene in which Clive, still running from the law and still dressed in lingerie and handcuffs, is picked up by a bartender who believes, based on earlier events, that he is gay. The bartender turns around slowly with a sinister smile on his face to look at Clive and locks his car's doors. Clive screams in horror as the bartender drives away.

Penniless and straight out of the University of Iowa, Joe F. moves to New York needing an apartment and a job. With the fortuitous death of Mrs. Grotowski, an artist named Walter Shit helps Joe to take over the last rent-controlled apartment in a building slated for demolition by convincing everyone that Mrs. Grotowski was Joe's mother. If Senator Dougherty can empty the building, he can make way for the prison he intends to build there, and uses thug Alberto Bianco and his nephews, Vlad and Jesus, to intimidate tenants. Joe discovers he has twenty to thirty thousand roommates, all of them talking, singing cockroaches who are grateful that a slob has moved in. Led by Ralph, the sentient, tune-savvy insects scare away the thugs in an act of enlightened self-interest that endears them to their human meal ticket. Tired of living on handouts from mom back in Iowa and after a series of dead-end jobs ruined by his well-intentioned six-legged roomies, Joe finds himself the unskilled drummer in Walter Shit's band. Hanging posters for SHIT, he encounters Senator Dougherty's daughter Lily, promoting her own project, a community garden to occupy the vacant site surrounding Joe's building. A gift to Lily while working on her garden is enough to woo her back to Joe's apartment. However, the cockroaches break a promise to keep out of his business and a panicked Lily flees, only to discover the garden she'd worked on has been burned to the ground. During a fight with his roommates over his spoiled romantic evening, the building suffers the same fate as the garden. A mutual truce between the hapless and now homeless roommates leads the cockroaches to "call in favors from every roach, rat and pigeon in New York City" to try to make amends to Joe. Overnight, the roaches scour New York to gather materials to convert the entire area into a garden and take care of all the necessary paperwork to ensure harmony reigns over all.

The crew of the newly commissioned USS Enterprise (NCC-1701-A) are enjoying shore leave after the starship's shakedown cruise, with Kirk, Spock, and McCoy camping at Yosemite National Park. Their leave is interrupted when the Enterprise is ordered by Starfleet Command to rescue a human, a Klingon, and a Romulan, all diplomats who have been taken hostage on Nimbus III, a planet set aside as a neutral location to advance dialogue among the Federation, Klingon Empire, and Romulan Star Empire. Learning of the Enterprise ' s mission, the ambitious Klingon Captain Klaa decides to pursue Kirk for personal glory. On Nimbus III, the Enterprise crew discovers that Sybok, a renegade Vulcan, is behind the hostage crisis, prompting Spock to admit that Sybok is his half-brother. After the Enterprise crew saves the hostages, Sybok reveals that the hostage-taking was a ruse to lure a starship, which he plans to use to travel to the mythical planet Sha Ka Ree. Sybok believes it lies behind the Great Barrier, a powerful energy field at the galaxy's center, and that God is located there. To take control of the ship, Sybok uses his ability to reveal and heal the innermost pain of a person through the Vulcan mind meld, thus gaining the loyalty of most of the crew. McCoy's pain is that he had helped fulfill his terminally ill father's request to die, only to find later that a cure could have saved his father's life, which has caused him years of guilt. Spock's pain is the knowledge that his father rejected him at birth for being "too human". Kirk refuses to let Sybok remove his pain, claiming that it is necessary to make him human. The Enterprise successfully breaches the Great Barrier, unaware they are being followed by Captain Klaa's warship, a Klingon bird-of-prey. They discover a lone barren planet, and Sybok, Kirk, Spock, and McCoy take a shuttlecraft down to the surface. It appears uninhabited, but after Sybok calls out, a glowing field appears which quickly morphs through many forms representing various religions before settling into the image of a bearded human face, to which Sybok explains that they have come for "your wisdom". The entity asks how they breached the barrier, and upon being told about the Enterprise, it declares that it will use the ship to carry its wisdom to every corner of the universe. A skeptical Kirk asks "What does God need with a starship?", and when the entity asks who he is, Kirk expresses doubt that the actual supreme being would not already know. Irritated, the entity attacks him and Spock, after which they discover it is a powerful and malicious being, imprisoned on Sha Ka Ree in the distant past, with the Great Barrier put in place to keep it from escaping. Realizing his earlier naiveté, Sybok apologizes and attempts to distract the entity by physically attacking it, allowing the others the opportunity to escape. Kirk orders the Enterprise to fire a photon torpedo at the entity, but only Sybok is killed by the strike. Spock and McCoy beam back to the ship moments before the Klingon ship unexpectedly attacks and damages the Enterprise, stranding Kirk on the planet with the weakened and enraged entity. As Kirk attempts to escape from the entity, the Klingon Bird of Prey arrives and destroys the entity with a volley of disruptor fire. Kirk is beamed aboard the Klingon ship, where Spock is unexpectedly waiting. As Spock explains, he convinced the Klingon General Korrd (one of Sybok's hostages who had become a loyal follower) to order Captain Klaa to stand down and apologize for his actions, which Klaa grudgingly does. After returning to Earth, Kirk, Spock, and McCoy resume their camping trip at Yosemite.

Dawn O'Keefe is a teenage spokesperson for a Christian abstinence group, "The Promise". She frequently overhears her stepbrother Brad and his girlfriend Melanie arguing about his refusal to engage in vaginal intercourse, insisting on only having anal sex. One afternoon at a group meeting, Dawn is introduced to Tobey. Dawn, her friends Gwen and Phil, and Tobey begin going out as a group. Though Dawn and Tobey are attracted to each other, they initially agree they should not spend time alone together. However, they later give in and meet at a local swimming hole. After their swim, they enter a cave to get warm and begin kissing. Dawn becomes uncomfortable and tries to persuade Tobey to go back outside, but he becomes aggressive. When Dawn tries to push him off, he shakes her, smacking her head on the ground and dazing her. As Tobey attempts to rape her, but her vagina 'cuts' Toby's penis as it enters vagina, causing him to bleed and fall down the waters and die. A horrified Dawn flees the scene. After a Promise meeting, Dawn runs into her classmate Ryan at a dance. He drops her off at her home and asks her out on a date, but she declines. Dawn returns to the swimming hole and screams in horror when she sees a crab crawling on Tobey's severed penis. She drops her purity ring off a cliff. She then researches vagina dentata and realizes she may have it. She visits a gynecologist, Dr. Godfrey, but he assaults her during the examination, reaching up inside her without a glove. She panics and her vagina bites off four fingers on his right hand. On her way home, she sees several police vehicles passing her, as well as a car that resembles Tobey's. That evening, she returns to the pool to investigate. When she arrives, the police are bringing up Tobey's body. Dawn returns home to find her ailing mother, Kim, unconscious on the floor while Brad and Melanie are in his room having sex. Kim is taken to the hospital. Hysterical, Dawn goes to Ryan seeking help. Ryan gives her a sedative and stimulates her with a vibrator. Though initially afraid she will hurt him, she finds that when she is relaxed and consenting, her "teeth" do not engage. The following morning, they have sex again, but during intercourse, Ryan's friend calls. Ryan smugly boasts that he had made a bet with the friend that he could goad Dawn into sex. In her anger, her vagina bites off his penis and she leaves as he screams in agony. Dawn's stepfather Bill attempts to throw Brad out of the house, but Brad sets his pet Rottweiler on Bill, confessing his love for Dawn. Dawn meets Bill and Melanie at the hospital after her mother has died. Seeing her stepfather injured and hearing from Melanie how Brad told her to ignore her mother's cries for help, Dawn becomes emboldened by her power and goes home to seek revenge. She applies make-up and goes to Brad's room to seduce him. In the midst of the act, Brad recalls that when they were children, Dawn bit his finger, but it was not her mouth that bit him. As he realizes this, Dawn's vagina bites off his penis. She drops it on the ground and although Brad calls his dog to attack her, the animal instead eats the penis, spitting out the pierced glans. Dawn leaves despite his pleas for her to stay. Dawn cycles away from home, but her bicycle tire sustains a puncture, prompting her to hitchhike. She accepts a lift from an old man but falls asleep and wakes up after nightfall outside a convenience store. When she tries to exit his car, he repeatedly locks the doors while licking his lips. Dawn hesitates, then turns to the old man with a mischievous smile.

In a post-apocalyptic realm called Anmaere, an annual drive ships wild horses from a rundown city called Whithren to another, far-off city, Levithen. Many denizens of Whithren hope to board the boat with the horses and travel to Levithen, which they believe holds a more promising future for them.

John, now going by the surname Young, teaches comparative religion at a community college in Chico, California. He is well-liked by students and married to fellow faculty member Carolyn Kittriss. For the first time in his life, John shows signs of ageing and a cut during a hunting trip indicates that his regenerative abilities are diminishing. When Isabel, an enthusiastic student, is allowed to borrow books from John's collection, she discovers one authored by Dr. Jenkins and signed for John Oldman. Curious, Isabel learns about another, controversial book he authored, an account of the 14,000-year-old John Oldman. Drawing parallels between Oldman and their teacher, she shares the discovery with her classmates Tara, Liko and Philip. They are open to the possibility that they are the same person, although Philip's faith is challenged with the book's claim that John was Jesus Christ (another possibility is that he may have been the Teacher of Righteousness). Their suspicions are confirmed when they obtain the book and see the only photo of Oldman, who is described as averse to being photographed to facilitate forging new identities. Isabel attempts to contact Dr. Jenkins by email, but he rudely rejects her, assuming she is yet another person seeking to ridicule him. Undeterred, Isabel, Tara and Liko trespass into the Young household, discovering several books authored by John under various surnames. They also find a painting believed to be by Vincent van Gogh, which Isabel's cousin, an art major, considers possibly authentic supporting the book's claim that John had known van Gogh personally. The group later contacts a retired university professor who recalls meeting John during the 1950s. Isabel leaves a voice message for Jenkins, but this time he is interested when she mentions John Young and agrees to meet them on the condition that they first provide a clear photo of John's face. After unsuccessful attempts to take a picture in class, they go into his house at night and photograph him while he is asleep. Jenkins, although somewhat hesitant as the purported John appears aged, agrees. Shortly afterward, Tara visits John in his office. He becomes concerned when she cryptically claims to know his true identity. In tears, Tara explains that she has always felt lonely as well. When John attempts to comfort her, she makes a sexual advance, which he rejects, asking her to leave. Isabel scolds Tara when she confesses the incident, fearing that John may leave before Jenkins arrives. John is indeed preparing for departure, and his refusal to offer an explanation leads to an argument with his wife. That evening, the four confront John about the book's veracity. He admits to being Oldman but insists that the story was a fabrication and expresses regret that Jenkins damaged his own reputation by publishing it. To stop him, John is tased and restrained in his basement, assigning Philip to watch him while the others attempt to retrieve Jenkins, whose car has broken down nearby. Upon regaining consciousness, John warns Philip that their actions are criminal but offers not to report them if he is released. Philip, however, persists in questioning John about Jesus. After a few evasions, John finally admits to having been Jesus, explaining that he has avoided garnering attention since witnessing the distortion of his moral teachings. Although Philip initially welcomes the idea that John is divine despite telling the truth, the situation becomes tense when John expresses that all religious paths lead to salvation. Recounting the Book of Revelation, Philip renounces John as the seven-headed beast and stabs him. When Jenkins, Isabel, Liko and Tara arrive, they are shocked to find blood stains throughout the house, with both John and Philip missing. Weeks later, John has been hiding in the wilderness, and he arranges to meet with Harry. They speculate that his aging might result from the Holocene itself ending to herald the Anthropocene. John accepts Harry's invitation to live with his family. Back in his home, Jenkins is visited by an FBI agent who knows about John's many identities and extraordinary age, adding that he is a suspect in many violent crimes, including Philip's disappearance. When he asks Jenkins whether he believes an immortal serial killer is possible, Jenkins replies that anything is.

An all-American family inherits a deceased uncle's house. John and Mary Hyatt, together with daughter Debbie and son Billy move in, but Waldemar, a vampire, and Yolanda, his wife, want desperately to get into the rundown house because it contains a book of evil. Billy finds the mysterious book. He reads of a curse hanging over the date of Saturday the 14th. As he turns the page, a monster is unleashed and with each turn, another disappears from the page and is materialized within or outside the home. The house is soon swarming with monsters. Strange things start happening: eyes appear in John's coffee, sandwiches are mysteriously eaten, the television tunes into The Twilight Zone only, dirt is found in Mary's bed, dishes get done by themselves, neighbors disappear. As this is happening, neither John or Mary suspect anything, completely oblivious to the spooky occurrences around them. Waldemar gets into the house by turning into a bat. Mary keeps hearing noises at night, which she thinks are made by owls, but are actually the sounds of Waldemar in bat form. John hires an exterminator to get rid of the bats. The exterminator turns out to be Van Helsing, who is also after the book of evil. John and Mary begin planning a housewarming party for Saturday the 14th. Guests arrive, but they cannot leave. When they try, a thunderstorm appears outside the door. As the night unfolds, the monsters begin to kill the guests one by one. Eventually a duel between Van Helsing and Waldemar and Yolanda erupts, where it is discovered that Van Helsing wants the book in order to rule the world and Waldemar and Yolanda were only trying to stop him from getting his hands on it. Good triumphs over evil, as Van Helsing and the monsters are defeated. The Hyatts end up in an upscale new home, while Waldemar and Yolanda keep the original house as their own.

University of Central Arkansas student Chloe Steele has flown home from college to New York to surprise her father, pilot Rayford Steele, for his birthday party. However, her mother, Irene, informs her that her father cannot make it. While at the airport waiting for him, Chloe meets investigative reporter Cameron "Buck" Williams. Rayford shows up on his way to a flight and apologizes to Chloe for missing his birthday party, insisting he was called in to pilot a flight to London at the last minute. He also assures Chloe that things are fine between himself and his wife, who recently had become a proselytising Christian, much to Chloe's annoyance. Chloe suspects things are not fine between her parents; she had seen him flirting with flight attendant Hattie Durham and notices he has removed his wedding ring. Her suspicions are soon confirmed when an airport worker hands Chloe a pair of tickets for a concert in London that Rayford had ordered, proving that he'd planned the trip in advance. Chloe brushes off another of her mother's preachings and takes her brother to the mall. As she hugs him, he vanishes, into thin air, leaving his clothes behind. The same has happened to numerous others at the mall. Mayhem breaks loose as shoppers begin looting the stores. A driverless car plows through the mall windows, and a small plane without a pilot crashes into the parking lot. Chloe sees television reports of children and some adults disappearing, as worldwide panic sets in. On Rayford's flight, the same strange event has occurred; several people, including his co-pilot Chris Smith, Kimmy, one of the flight attendants, and all the children on board, have simply disappeared. The remaining passengers panic and demand answers. Rayford does his best to reassure the passengers he will pass on information once he has any. He has difficulty getting radio or satellite phone contact with anyone on the ground, until he is finally informed that people have disappeared everywhere and the world is in uproar. Soon a pilot-less jet approaches directly into their flight path resulting in a midair collision, which damages Rayford's fuel line. He decides his only option is to return to New York and hope his fuel holds out. On the ground, Chloe hears her father's mayday call on her cell phone and assumes his plane has crashed. She later finds her mother's jewelry left behind in the still-running shower, as she has also disappeared. Chloe makes her way to her mother's church, where family pastor Bruce Barnes explains that God has taken his believers to heaven and the rest have to face the end of days. The pastor explains he was not taken because he did not really believe what he had preached. Rayford comes to the same conclusion after finding evidence of religious belief in his copilot and stewardess' personal effects. He tells Hattie about his wife. She is upset as she hadn't known he was married, but Rayford convinces her to be brave and to help calm the passengers down until they can safely land. Chloe climbs to the top of a bridge, intending to commit suicide, but gets a call from Buck, who is in the cockpit with Rayford. Rayford explains to Chloe that all the New York-area airports are closed and the streets full, and he is low on fuel and has nowhere to land. Chloe finds an abandoned truck and uses it to clear away the equipment from a road under construction in order to create a makeshift runway. She uses her compass app and tells Rayford the coordinates of the landing site. Rayford is able to glide to a rough landing, saving the passengers, who leave the plane only to see the world aflame. As the film ends, Buck observes that it looks like the end of the world, while Chloe responds that it is just the beginning.