Paige Collins and her husband Leo come out of a movie theater on a snowy evening. On their way home, at a stop sign, Paige unbuckles her seatbelt to lean over and kiss Leo. At that very moment, a salt truck rams their car from behind and Paige crashes through the windshield. Both of them are rushed to a hospital. As Leo, in a voice-over, talks about how "moments of impact help in finding who we are," his relationship with Paige is explored – their courtship, engagement, and wedding at the Art Institute of Chicago, all interwoven with the present. Paige is put into an induced coma, and later regains consciousness to discover she has lost all of her memories. Paige's parents, Bill and Rita Thornton, learn about this and visit her, meeting Leo for the first time. Paige does not understand how Leo could be married to her, yet not have met her own parents. She finds it even stranger that he does not know either. Nor does Paige understand why she left law school, broke off an engagement with her previous fiancé, Jeremy, and lost contact with her family and friends. Needing evidence of her relationship with Leo, he plays her a voice message as proof. Paige is against the idea of moving back in with her parents, so decides to return to Leo, hoping it will help her regain her lost memories. She is welcomed home with a surprise party thrown by her friends, none of whom she can recall, so she feels overwhelmed. The next day, Paige ventures out to a café she regularly visited, but loses her way back. Paige calls Rita for help and returns to Leo. That evening, Bill and Rita invite the couple to dinner; later, Paige's sister Gwen and her fiancé invite them out to a bar. Leo comes to feel that he doesn't fit in with Paige's family. Paige later meets Jeremy again at the bar. Realizing that she is becoming infatuated with Jeremy, Leo persists in trying to help her regain her memory. Paige secretly meets Jeremy at his office, and asks him about their broken engagement. His answer is ambiguous; he is still clearly attracted to her. While Leo gives Paige a tour of her own studio, she suddenly lashes out at him. With Gwen's wedding approaching, Paige decides to stay with her parents. Leo asks Paige out on a date and spends the night with her, but the relationship is further strained when Bill attempts to persuade him to divorce her. When Jeremy begins taunting Leo, he eventually loses his temper and punches Jeremy. Paige rejoins law school and a heartbroken Leo reaches an epiphany that her memory may never return. At a Trader Joe's, Paige meets Diane, an old friend who is unaware of Paige's amnesia. It's revealed that Diane had an affair with Bill, thus explaining why Paige has been estranged from her family. When Paige angrily confronts Rita about this, she tells Paige that she decided to stay with her father for everything he had done right instead of leaving him for one transgression. Reuniting with Leo, Paige learns that he wanted to earn her love instead of driving her away from her family. While in class, Paige starts to take up sketching. Despite Bill's misgivings about quitting law school, Paige reassures him that she will always be his daughter no matter what. Paige continues her interest in art, eventually returning to sculpting and drawing. Jeremy confesses he broke up with his girlfriend in hopes of winning Paige back, but she turns him down, stating that she needs to know what life would be like without him. As the seasons change, Leo again reflects on "moments of impact," whose potential for change has ripple effects far beyond what can be predicted. Back in her room, Paige finds a menu card on which she had written her wedding vows. She later meets Leo at the cafe and, despite admitting the end of their relationship, they agree to have dinner together and walk off arm in arm.

Christopher Boyce, an expert in the sport of falconry and the son of a former FBI special agent, gets a job as a civilian defense contractor working in the so-called "Black Vault," a secure communication facility through which flows information on some of the most classified US operations in the world. Boyce becomes disillusioned with the US government through his new position, especially after reading a misrouted communiqué dealing with the CIA 's plan to depose the Prime Minister of Australia. Frustrated by this duplicity, Boyce decides to repay his government by passing classified secrets to the Soviets. Daulton Lee is Boyce's childhood friend, a drug addict and minor cocaine smuggler nicknamed "The Snowman", who has frustrated and alienated his family. Lee agrees to contact and deal with the KGB 's agents in Mexico on Boyce's behalf, motivated not by idealism but by what he perceives as an opportunity to make money with plans to settle in Costa Rica, a nation that at that time had no extradition treaty with the United States. As the pair become increasingly involved with espionage, Lee's ambition to create a major espionage business coupled with his excessive drug use begins to strain the two from each other. Alex, their Soviet handler, becomes increasingly reluctant to deal with Lee as the middleman because of Lee's periods of irrationality. Above all, Boyce wants to end the espionage so that he can resume a normal life with his girlfriend Lana and attend college. Boyce meets with Lee's KGB handler to explain the situation. Meanwhile, Lee is desperate to regain the Soviets' regard after realizing that the KGB no longer needs him as a courier. Lee is observed tossing a note over the fence at the Soviet embassy in Mexico City and is arrested by Mexican police and a US Foreign Service officer accompanies him to the police station. When the police search his pockets and find film from a Minox camera Boyce used to photograph documents along with a postcard used by the Soviets to show Lee the location of a drop zone, they produce pictures of the same location that was on the postcard, showing officers surrounding a dead policeman on the street. The Foreign Service officer explains that the Mexican police are trying to implicate him with the murder of the policeman. The police then take Lee away and interrogate him violently. Hours later, Lee reveals that he is a Soviet spy. Told by the Mexican police that he will be deported, Lee is offered a choice of where to be sent. Lee suggests Costa Rica, where he owns a house paid for with drug money, but the choice is merely between the Soviet Union and the United States. Lee reluctantly agrees to go back to America and is arrested as he walks across the border. Realizing that he too will soon be captured, Boyce releases his pet falcon, Fawkes, and then sits down to wait. Moments later, US Marshals and FBI agents surround him. In the closing scene, Lee and Boyce are seen being escorted to prison.

Tess McGill is a working-class woman from Staten Island who dreams of climbing the corporate ladder to an executive position. Having earned a business degree via night school, she works as a secretary at a stockbroker firm in lower Manhattan. There, Tess's boss and male co-workers treat her like a bimbo, despite benefiting from her intelligence and business instincts. After one humiliation too many from her scornful boss (he fixes her up with a rival executive, who only wants to do cocaine and have sex), Tess retaliates by posting on a VDT what she thinks of him and of what he's done. This greatly amuses Tess's colleagues, but also gets her fired. Shortly thereafter, Tess lands another job, this time as an administrative assistant to Katharine Parker, an associate partner at the mergers-and-acquisitions firm Petty Marsh. At first, Katharine seems supportive of Tess, encouraging her to share ideas. Eventually, however, she insists that Tess's proposed purchase of a radio network by Trask Industries would not work out. When Katharine breaks her leg skiing, she asks Tess to house-sit. While there, Tess discovers meeting notes which reveal Katharine's intention to pass off the Trask Industries idea as her own. Returning home, Tess finds her live-in boyfriend having sex with another woman. Tess dumps him. With Katharine still in the hospital, Tess uses her boss's connections and clothes to ramrod the Trask proposal. With help from her friend Cyn, Tess gives herself a makeover, borrowing Katharine's stylish clothes to look more professional. Tess schedules a meeting with Jack Trainer, a mergers-and-acquisitions associate from another company. The night before the meeting, she attends (on Katharine's behalf) a dinner hosted by Trainer's firm. Trainer is attracted to Tess, and approaches her at the bar. Yet Jack does not reveal his name, even after she asks directly whether he knows the man she's slated to meet with (himself). Trainer brings Tess to his apartment, after she passes out in a cab from a combination of Valium and alcohol. Tess leaves early the next day, believing that they slept together. Arriving for her meeting with Trainer and his associates, she is surprised to recognize him from the previous night. They both feign non-recognition. After the meeting, Tess worries that her deal has failed, until Jack arrives at Tess's office. He assures her that they did not sleep together, and that he wants to move forward with her idea. Together, they prepare the financials for her merger proposal, which they present successfully to Trask. Tess and Jack celebrate by giving in to their attraction, and ending up in bed. Thereafter, Tess discovers that Jack has been involved with Katharine, but was planning to break up with her when she went skiing and got injured. Katharine returns home on the day of the merger meeting. While Tess is helping her get settled, Katharine brings up the Trask merger, claiming she was intent on taking it to Jack, and on eventually giving Tess credit for it. Katharine adds that Jack's strict ethical code has prevented him from looking at another's ideas without verifying the source, ever since he was accused of stealing himself. Jack arrives in response to a call from Katharine, who unsuccessfully tries to seduce him. Tess avoids running into Jack at Katharine's apartment, but accidentally leaves her notebook there before she departs for the meeting. Katharine discovers Tess's deception by finding the notebook, which includes Jack's phone numbers and the scheduled merger meeting. At the meeting, Tess brings up what Katharine told her about Jack's ethical code, and about his being accused of stealing. Jack insists that it was all a lie. Then Katharine crashes the meeting and outs Tess as her secretary. She accuses Tess of stealing the Trask merger idea. Unable to defend herself, Tess apologizes profusely and leaves. Tess returns to Petty Marsh a day later, intent on cleaning out her desk. Instead she encounters Jack, Katharine, Trask, and members of Trask's board. Jack sticks up for Tess, who points out a news item which presents a possible risk to the merger's success. In an elevator pitch she explains to Trask what inspired her plan for his radio acquisition. Trask confronts Katharine, who, when she is unable to explain where Tess's plan came from, is fired. Tess lands an entry-level job with Trask Industries. She also moves in with Jack. On her first day at Trask, Tess meets a colleague named Alice, whom she takes for her new supervisor. Alice explains that she is actually Tess's secretary. Tess makes it very clear that she considers Alice a colleague, thus proving herself very different from Katharine. At the first opportunity, Tess calls Cyn from her new office and tells her that she has made it.

25 years old Sibel lives with her father and sister in a remote village in the mountains of Turkey's Black Sea region. She is mute and communicates by using the ancient whistled language of their region. Despised by her fellow villagers, she relentlessly hunts down a wolf sneaking in the neighboring forest, sparking off fears and fantasies among the villagers. There she crosses path with an injured and vulnerable fugitive, who is the first one to see her differently.

In 1881, after his father's death, Louis Wain, the only male member and eldest of the Wain family, supports his five sisters and his mother as a part-time illustrator for The Illustrated London News under editor Sir William Ingram. Wain declines a full-time job to try composing music and playwriting; neither venture is successful. Louis hires Emily Richardson as governess for his sisters and they are attracted to each other, to the dismay of eldest sister Caroline. Louis takes the full-time position to keep Emily as governess. He takes the family and Emily to the theatre to see The Tempest, during which he has a recurring nightmare of drowning. Emily comforts him in the men's toilets, causing a scandal when a neighbour gossips about the incident. Caroline fires Emily that night but before she can leave, Louis professes his love and they begin a courtship. They marry in 1884, causing another scandal due to her being ten years his senior and of a lower class. Louis takes freelance artist work to continue supporting his mother and sisters. Emily is diagnosed with breast cancer. They take in a stray kitten - unusual for the time - which they name Peter. Louis' initially realistic paintings of Peter become more anthropomorphic as Emily's condition worsens. Financial pressure causes Sir William to cut Louis' workload, and he advises Louis spend the time with Emily. She encourages Louis to show his cat pictures to Sir William, who prints them to acclaim in the Christmas edition. Emily dies. Louis draws more cat pictures, creating whole cat societies. By 1891, Wain's cat pictures are enormously popular, featured on postcards and greeting cards, and changing the perception of cats as acceptable house pets. He hosts cat-themed events and is chairman of The National Cat Society. Unaware of the need to copyright his work, Wain does not profit from reproductions and the family remains in debt. Sister Marie becomes mentally unwell and the family is evicted. Sir William provides a property at a reduced rate. Marie is institutionalised and Peter dies, causing Wain's own mental health to deteriorate. Newspaper magnate William Randolph Hearst sponsors Wain on a trip to New York in 1907, where Max Kase tells him people love his pictures. After some success in New York, in 1914 Caroline asks him to return to England. Marie and their mother die from influenza. Sir William dies of gout, and the family is evicted and moves into a smaller London flat. As Britain enters the First World War, Louis hits his head jumping off a bus and falls into coma, in which he sees a vision of 1999. He designs futuristic-themed cat toys. The toys are manufactured, but a German U-boat sinks the ship carrying the toys. Caroline dies in 1917, and Louis suffers a series of mental breakdowns. In 1924, his sisters commit him to the Springfield Mental Hospital. Mental institution inspector Dan Rider recognises Louis; he had drawn his dog's portrait. He campaigns, along with Wain's three remaining sisters, to raise money for a better facility for Louis that allows patients cats and outdoor access. The campaign gets an enormous response, as H.G. Wells and other prominent British figures assist. Louis is transferred to Bethlem Royal Hospital, where he has a cat companion. In 1930, he is admitted to Napsbury Hospital in London Colney. Louis takes his journal and a piece of Emily's scarf out to the painted countryside, where Emily had told him he would find her.

Sophie, a teenage girl, has a dream in which she sees a man raking leaves by a swimming pool. She suddenly starts floating up to the sky and cries out to the man for help, revealing that he is her father Paul, a professor of evolutionary biology at a local university. When Paul learns that a former colleague is writing an article on a topic he had discussed with her many years earlier, he seeks to confront her but instead begs her for some recognition. Paul's journalist ex-girlfriend Claire spots him with his wife Janet and tells him he appears in her dreams. With his permission, she writes an article about the experience. Soon, hundreds of strangers come forward to name Paul as the man they see in their dreams. Paul enjoys the media coverage this brings, but is frustrated by consistently being depicted in the dreams as passive and uninteresting. In interviews with some of his students, he learns that their dreams sometimes feature disasters occurring or the dreamers asking Paul for help, only for him to remain emotionless and unhelpful. Janet asks Paul why he does not appear in her dreams, and describes her fantasy of Paul rescuing her while wearing the oversized suit worn by David Byrne in the 1984 Talking Heads concert film Stop Making Sense. Later that evening, a mentally ill man who has seen Paul in his dreams breaks into their house with a knife, raising concerns about the risks of his fame. Paul meets with a PR firm in the hopes of securing a book deal, but they instead attempt to convince him to advertise Sprite on social media. Molly, a young assistant at the firm, tells Paul that she has erotic dreams about him; he attempts to re-enact them for her, but prematurely ejaculates and leaves her apartment in shame. Paul is enraged to learn that his former colleague has published a high-profile paper on the subject about which he was thinking of writing his book. His presence in people's dreams becomes violent and sadistic, and he becomes vilified, being placed on leave after students refuse to attend his classes. Bystanders are bothered by his presence in public, resulting in a brawl at a diner. After Janet's career is affected, she asks Paul to issue a public apology, but he angrily refuses. Paul has a nightmare in which he is hunted and killed by a version of himself wielding a crossbow and subsequently releases a self-pitying apology video. Humiliated, Janet throws him out of the house. Paul forces his way into his daughter's school play but accidentally injures a teacher in the process and is restrained, becoming further vilified. Some time later, Paul ceases to appear in people's dreams. His own dream experience is revealed to have led to the discovery of a shared subconsciousness, and dreams have become an advertising space through the use of technology. Janet is separated from Paul and is dating a co-worker. Paul travels to France for a book tour to promote his book Dream Scenario, which he learns has been retitled Je suis ton cauchemar (I Am Your Nightmare) without his consent. The book is pitifully thin in the translated volume and his signing event has been moved to the dingy basement of the bookstore. Nevertheless, fans line up for his signed copies. Paul uses "dream travel" technology to enter one of Janet's dreams and rescue her while wearing the oversized suit. As he floats away, much like Sophie did in her first dream, Paul declares that he wishes the dream were reality.

Michael Lander is a Goodyear Blimp pilot who flies over National Football League games for network television coverage. Secretly deranged by years of torture as a POW in the Vietnam War, he had a bitter court martial upon his return and a failed marriage. He longs to kill himself and to take with him as many as possible of the cheerful, carefree civilians he sees from his blimp each weekend. Lander is desperately in love with Dahlia Iyad, an operative from the Palestinian terrorist group Black September, who controls and manipulates him. They conspire together to launch a suicide attack using a bomb composed of plastique and a quarter-million steel flechettes. They plan to mount the bomb on the underside of the gondola of the Goodyear blimp and detonate it over the Miami Orange Bowl during Super Bowl X, killing over 80,000 spectators, including the President of the United States, in order to call attention to the plight of the Palestinians and to punish the United States for supporting Israel. During a raid on a Black September safehouse in Beirut, the Israeli counter-terrorist Mossad agent David Kabakov surprises Iyad while she is showering. His mission was to kill everyone in the unit; however, seeing her unarmed and naked, he spares her life and turns his attention to clearing the rest of the safehouse, and she escapes. When the raid is complete, Kabakov finds a recorded message which Iyad had planned to publish after the terrorist attack. The recording explains the motive for the terrorism, but does not include any specific information about the attack plan itself. Collaborating with FBI agent Sam Corley, Kabakov and his partner Robert Moshevsky try to learn the details of the plan. Meanwhile, in Long Beach, Black September bribes freighter captain Tekiaki Ogawa to transport the plastic explosives, disguised as statuettes. Ogawa puts the explosives aboard Iyad and Lander's motorboat, but the two terrorists are discovered by the Coast Guard and forced to flee. Ogawa is interrogated by Kabakov and Moshevsky, only for a bomb Lander had secretly planted to explode, killing Ogawa and hospitalizing Kabakov. Iyad disguises herself as a nurse to infiltrate the hospital and assassinate Kabakov, only for Moshevsky to discover her before she kills him and departs. Kabakov questions Muzi, a local businessman and uses a contact in the Egyptian government named Riaf to discover her identity, and Corley tracks Iyad and her superior Mohammed Fasil to a hotel in Miami. They attempt to capture them, but Iyad retreats, while Fasil is killed by Kabakov in a shootout. After searching Iyad's room, Kabakov realizes that they are targeting the Super Bowl. Corley and Kabakov form a security detail to search the crowd for any sign of suspicious activity. During the Super Bowl game, Kabakov figures out that Iyad and Lander have mounted the bomb on the Goodyear blimp. He and Corley commandeer a helicopter and set out in pursuit of the blimp, accompanied by a police helicopter. Loaded with the bomb, the blimp approaches the stadium. Lander pilots the blimp while Iyad exchanges deadly gunfire with policemen in the pursuing cars and helicopters. From his place in one helicopter, Kabakov sees Iyad's face, and they both recognize each other from the Black September raid in Beirut, where he spared her life. This time, Iyad hesitates, but Kabakov does not and he shoots and kills her. Lander has been mortally wounded, but he lives long enough to succeed in flying the blimp straight into the Super Bowl, causing mass chaos and destruction in the stadium. Just before dying, with the electronic detonator destroyed, Lander lights the backup fuse of the weapon. With the weapon just minutes away from detonation, Kabakov lowers himself from the helicopter to the blimp, and hooks it up with a cable to the helicopter, which hauls it out of the panicked stadium and over the ocean. Kabakov unhooks the cable from the blimp, and clings to the cable as the helicopter moves away to a safe distance. A few seconds later, the bomb detonates, destroying the blimp and firing the flechettes harmlessly into the sea.

A 15-year-old drifter named Gary asks Joe Ransom, the even-tempered tattooed chain-smoking boss of a Texan tree-poisoning crew, for a job, and impresses him with his industriousness. The next day, Gary brings his alcoholic father, Wade, to work, but Wade's poor attitude and laziness get them fired. Joe witnesses Wade beat Gary and take his money. Gary later goes to Joe's house to ask for his job back, swearing he'll make up for his father's behavior. Joe agrees, and Gary begins working for him, hiding his money from Wade. Willie Russell, a criminal with whom Joe has a long-standing feud, shoots and wounds Joe as he leaves a friend's house. Later, Gary meets Willie and asks for a ride home; when Willie makes lewd comments about Gary's younger sister, Dorothy, Gary beats him up. Later, Wade beats to death a homeless man, stealing his liquor. Willie confronts Joe at a bar and asks where Gary lives in order to seek revenge. Joe does not answer and, when Willie presses him, beats him up. Joe tells the bartender to call the police before fleeing to a brothel but leaves after getting spooked by a guard dog. He goes home, getting his dog Faith and returns to the brothel, setting it on the guard dog, and has a prostitute give him oral sex. He leaves with his dog, who has killed the guard dog. Two police officers stop him at gunpoint, and Joe challenges them to a fight. Joe is arrested but released. Wade asks Gary for money, but Gary denies having any. Wade finds food in the cupboard and questions how he can afford food. They get into an argument that ends with Wade pulling a knife. He leaves but threatens to return and find Gary's money. Gary visits Joe, who tells him that he served 29 months for assaulting police officers. Gary agrees to help Joe look for his missing dog. After spending hours together and bonding, they find the dog and Joe gives Gary his lighter as a keepsake. Joe finds Wade walking and offers him a ride. They do not get far before Wade insults Gary and accuses Joe of not paying him. Joe grabs him by the collar and threatens to hurt him if anything happens to Gary. Later on, Gary tells Joe that he has enough money to buy his truck, and Joe takes him to the dealership where he has bought a new one. Joe tells Gary to keep the money he was going to use to buy Joe's truck and use it to obtain insurance. When he questions what insurance is, Joe promises to help him with it. As Joe drives home, a patrol cop stops him and tries to make him take a breathalyzer, but Joe refuses and drives away. After an altercation, Joe beats up the officer. A senior officer, a friend of Joe's and a fellow ex-con, visit Joe and says the patrol cop had it coming but warns him to keep his nose clean. Gary arrives at Joe's house, his face bruised, and asks to borrow his truck. Gary reveals that Wade beat him up, stole his truck, and left with Dorothy, intent on pimping her out to Willie and his goon. They go after Wade. Meanwhile, Willie pays Wade $60, and prepares to rape Dorothy first. Joe arrives and subdues Willie, and Gary leaves with Dorothy for help. Willie begs an unmoved Joe for his life, but as Joe prepares to kill him, one of Willie's thugs shoots him in the side and accidentally shoots Willie as well. Joe kills the thug then finishes Willie off before limping towards Wade, who is standing on a nearby bridge. He tries to shoot him, but misses. He attempts to shoot Wade again, but finds he is out of bullets. Wade asks Joe if he is his friend, and when Joe doesn't answer, leaps to his death. Joe then collapses and looks at the gaping wound in his side. Gary arrives with the sheriff and embraces Joe as he dies. He looks down and sees his father's body. Later, it is shown that an untold amount of time has passed. Gary is seen driving Joe's car with Joe's dog. He arrives at a job interview to replant the woods Joe and his crew had originally torn down.

The film follows the lives of a small family living in the Chernobyl Exclusion Zone, a desolate and radioactive area abandoned after the 1986 nuclear disaster. The family is led by Baba Prisya, an elderly woman who believes in the supernatural and claims to communicate with rusalkas (water spirits from Slavic folklore). She lives with her daughter Slava, who is in poor health and has been abandoned by her husband, and her grandson Vovchyk, a young man who is shy and fearful of the outside world. Their secluded life is suddenly disrupted one day when Baba Prisya experiences a mystical vision. She is warned by an unknown entity about an impending personal catastrophe that will soon affect her and her family. Believing the warning to be true, Baba Prisya takes it as her mission to prevent the disaster, but her family is skeptical of her visions and beliefs. One day, Vovchyk ventures out into the surrounding wilderness to gather objects from the Exclusion Zone, against his grandmother’s warnings. During this trip, he encounters Vasya, a local policeman, who brings food and supplies to the family. Vasya, who believes the area is dangerous due to the radiation and the presence of bandits, advises the family to leave the zone. Baba Prisy refuses to leave, however, convinced that the radiation is a myth and that the real threat is something much more sinister. As Baba Prisya’s visions intensify, she becomes more obsessed with preventing the foretold catastrophe. She becomes increasingly erratic, convinced that the disaster is tied to extraterrestrial forces that have infiltrated the government. According to her beliefs, the Chernobyl disaster was orchestrated to drive people out of the area and pave the way for a base to communicate with these otherworldly beings. She insists that the government’s evacuation was a cover-up and that the radiation is a distraction from the true danger. The family’s tensions rise as Baba Prisya takes more drastic steps to prevent the catastrophe, including performing strange rituals and consuming a rare mushroom she believes will open a "gateway" to reveal hidden truths. This leads to surreal, nightmarish sequences, where reality and Baba Prisya’s delusions begin to blur. At one point, the family experiences vivid hallucinations, further complicating their understanding of what is real. As the family struggles to understand the meaning of Baba Prisya’s warnings, it becomes clear that her connection to the supernatural may have been stronger than they had thought. In the final act, the mystical warning comes to fruition when an unforeseen disaster strikes the family, leading to tragic consequences. The film ends on an ambiguous note, leaving viewers to question whether Baba Prisya’s beliefs were valid, or if the events were merely the product of her deteriorating mental state.

In 2004 Houston, Jack Harris leaves home with several million dollars in a duffel bag, to pay Russian mobsters. Harris is worried about the safety of his wife Diana and their children. Flashback to 1997 in Los Angeles, where Jack helps a sick friend managing a nightclub. Nearby, Wayne Beering and Buck Dolby are best friends renting together. The drug-addicted friends are watching porn movie reels when Wayne asks why there is no porn on the internet. Buck, a former NASA scientist, takes 15 minutes to create a program to allow online credit card transactions to charge people for looking at dirty pictures on their website. They quickly earn thousands of dollars. Needing more porn content they approach Nikita Sokoloff, a Russian mob boss who owns a local strip club; Sokoloff agrees to 25% of their business in return for letting them photograph and film his strippers. Within a month Buck and Wayne's website is hugely successful. They party in Las Vegas while neglecting payments to Sokoloff. Jack has made the LA nightclub a success and attracts the attention of Jerry Haggerty, a crooked lawyer hired by Wayne and Buck to sort out their problem with Sokoloff. Jack meets the friends and becomes a partner in the business, paying Haggerty $200,000 to get out, knowing Haggerty is under federal indictment and thus a threat to the business. Sokoloff's nephew comes to collect his $400,000 profit, but when he threatens to kill Jack's family, one of Jack's body guards punches him so hard that he falls dead. Jack and his partners dump the body in the ocean and fabricate a story that Sokoloff's nephew took the money and ran. Sokoloff is skeptical, but agrees to let it pass in return for an increase to 50% of the partnership. Jack expands the business by dropping their porn site and focusing on the online credit card billing services. They create a billing company called "24/7 billing.com", becoming the titular Middle Men for other internet-based porn providers. The billing business is making hundreds of millions of dollars within a year. Jack becomes addicted to the money, sex and power of his new L.A. lifestyle, spends little time with his Houston family and starts a relationship with porn star Audrey Dawns. Haggerty, bitter that Jack cut him out of a multimillion dollar partnership, schemes to take over the company. He easily manipulates the foolish Wayne and Buck to work with Denny Z, providing billing services for Denny's numerous child pornography websites. Audrey's live stream porn site is watched by an international web of terrorists, which the US Government uses to track and arrest or kill the terrorists. The FBI asks for Jack and Audrey's help to expand their terrorist hunt, but Wayne and Buck fear that Jack is meeting with the FBI to turn them in for the murder of Sokoloff's nephew and the child porn. The two confide in Haggerty about killing Sokoloff's nephew, which Haggerty uses to incite Sokoloff to make a move on Jack. Jack's life is further complicated when Sokoloff's men kidnap his maid's son, who they believe is Jack's son. Jack gathers up several million dollars and goes to meet Sokoloff, as seen at the start of the film. Jack is told that the boy will be released if he signs a contract giving his partnership share to Wayne, Buck, Sokoloff, and Haggerty. Jack signs the agreement but backdates it to before Denny Z's child porn business was added. Sokoloff shoots Haggerty dead but lets Jack go as thanks for all the money he has made him. Jack's FBI friend charges Sokoloff, Wayne and Buck with providing billing services for child porn. They turn states evidence against Denny Z for a reduced sentence. Sokoloff flees the country and is alleged to be in Moscow. Jack and the maid's son return home, where Diane welcomes Jack back into their family.

During the Great Fire of Rome in AD 64, Emperor Nero "fiddles". Tigellinus informs Nero that he is suspected of starting the fire. Nero instead has the fire blamed on the Christians. In Rome, the Apostle Titus, Mercia, and Favius are apprehended by a mob for being Christians. Marcus Superbus, the prefect of Rome, arrives and disperses the mob, allowing the Christians to go free. News of Marcus's mercy towards the Christians spreads throughout Rome, including to Empress Poppaea. At a fountain, Marcus meets with Mercia again; there, Licinius reads Nero's edict to Marcus reminding him of his duty to arrest Christians. Later that night, Titus sends Stephan, a young Christian man, to tell other Christians of the secret meeting at the Cestian Bridge. Shortly after, Marcus arrives at Mercia's home wanting to take her for himself, but Mercia decides to stay. Stephan is arrested by Licinius under suspicion of being a Christian. In a dungeon, under torture Stephan reveals the location of the Christians' secret meeting. After learning of Stephan's arrest and torture, Marcus races to the meeting hoping to save Mercia. Along the way, he crashes into Poppaea's carriage. She demands Marcus stay, but he leaves her and promises to be with her in the morning. At the meeting, Roman soldiers surround the Christians, and Titus and some members of his congregation are struck dead by arrows. Marcus arrives at the meeting and saves Mercia, and takes her home, while the other Christians are arrested and imprisoned. The next morning, Poppaea scolds Marcus for his affections to Mercia. Elsewhere in the palace, Tigellinus informs Nero of Marcus's disobedience to his edict. Nero accuses Marcus of betrayal. Jealous of Mercia, Poppaea influences Nero to sign an order for Mercia's arrest. At a feast in Marcus's home, he introduces Mercia to Ancaria, who performs an exotic dance. Outside, Ancaria's performance is drowned out by the Christians' singing. Annoyed by the singing, Marcus sends his party away so he may be alone with Mercia. He tries to get Mercia to renounce her Christian faith so she may be with him, but she refuses. Shortly after, Licinius arrives to arrest Mercia, who is to be executed for treason amongst one hundred Christians in the arena. Marcus returns to Nero's palace and demands that the emperor spare Mercia, but Nero refuses. In the arena, the audience is entertained by several spectacles, including gladiator battles. When the time for the Christians' execution arrives, Mercia is told to stay behind by Poppaea's orders, as she is to be executed alone. In the arena, the Christians are mauled to death by lions. Following the execution, Marcus again asks for Mercia to renounce her faith and be his wife. Mercia refuses once more, but she states that she loves him. Refusing to live without her, Marcus accompanies Mercia, and they are both executed.