I am Jane Doe mainly follows the stories of a group of middle school girls from Boston, a 15-year-old from Seattle, and a 13-year-old girl from St. Louis. The group of " Jane Does " lodged suits against Backpage.com, a now-defunct classified advertising website, accusing the website of facilitating sex trafficking due to its business and editorial practices, as well as the design of the website itself. The suits particularly concerned Section 230 of the Communications Decency Act. I am Jane Doe also follows congressional actions against Backpage and online human trafficking. The film features interviews from Senators Rob Portman, John McCain, Claire McCaskill, and Heidi Heitkamp.