Miles Monroe is a jazz musician and owner of the Happy Carrot health-food store in New York City's Greenwich Village. He walks into the hospital in 1973 for a routine ulcer operation that goes wrong, leaving him relegated to 200 years of anonymous cryopreservation. Two scientists in 2173 illegally revive him. They are members of an underground rebellion at odds with the police state the United States had become after the massive destruction caused when "a man named Albert Shanker got a hold of a nuclear warhead." It is ostensibly ruled by a dictator known only as "The Leader", and about to implement a secret plan known as the "Aries Project". The rebels hope to use Miles as a spy to infiltrate and derail it, as he is the only member of the dystopian society without a known biometric identity. The authorities grow suspicious and arrive in force to question the scientists, who are arrested and taken to have their brains "electronically simplified". Miles escapes by disguising himself as a robot, which is then randomly delivered to work in the home of idle socialite Luna Schlosser. When Luna decides to have her new butler's rather unattractive head replaced with something more "aesthetically pleasing", Miles reveals his true identity. Spooked at his disclosure and unsympathetic to the rebels, she threatens to turn him in to the authorities. In response, Miles kidnaps her and goes on the run, searching for the Aries Project. After much bickering, Miles and Luna fall in love. Miles is captured and brainwashed into becoming a complacent member of society, while Luna escapes and joins the rebellion. The rebels kidnap Miles and perform successful reverse-brainwashing. Miles falls into the routine of rebel life, but grows jealous when he catches Luna kissing the handsome, hunky rebel leader, Erno Windt, and she announces that she has come to believe in free love. Miles tries to win Luna back. Eventually, he and Luna infiltrate the Aries Project, wherein they quickly learn that the national Leader had been killed by a rebel bomb ten months previously. All that survives is his nose. Miles and Luna disguise themselves as doctors, resulting in a case of mistaken identity, causing them to be placed in charge of cloning the Leader from his sole remaining part. Miles steals the nose and deadends the government's cloning scheme by dropping the nose in the path of a road roller. The pair escape, and later debate their future together. Miles tells Luna that Erno will inevitably become as corrupt as the Leader, as that is how all revolutions end up. Miles and Luna confess their love for one another, but she claims that science has proven men and women cannot have meaningful relationships due to chemical incompatibilities. Miles dismisses this theory, declaring that he does not believe in science. Luna then points out that he does not believe in God or political systems either, and asks if there is anything he does believe in. He responds, "Sex and death—two things that come once in a lifetime. But at least after death, you're not nauseous." The two embrace and kiss.

Nils Dickman is a snow plow driver in the fictional town of Tyos, Norway, just elected citizen of the year. His life, however, is shattered by the death of his son Ingvar, found dead by overdose of heroin. The police do not investigate but Dickman is sure that his son wasn't a drug user. When he is about to kill himself he learns from Finn, his son's friend, that Ingvar was mistakenly killed by a gang of drug dealers who actually intended to kill Finn; Nils begins to hunt for his son's murderers. He finds Jappe, one of the killers, and kills him after extracting the name of his accomplice, Ronaldo. Ronaldo tells Nils the name of the drug carrier, Strike, before being killed too. After killing Strike, concealing the bodies of the three gangsters and destroying 15 kilos of cocaine, Nils goes in search of the boss of the gang. He contacts his brother Egil, a former criminal now going straight. Egil advises him to hire a hitman to assassinate the powerful chief of criminals, the vegan gangster nicknamed Greven (The Count). Nils hires the Danish-Japanese hitman Kineseren (The Chinaman). Greven, who has lost three men and a lot of money, blames his competitors, a Serbian mafia family, with whom there has always been a territorial agreement. He sends his henchmen to kidnap one of the gang. The man reveals nothing and Greven kills him, unaware that he is the son of the Serbians' chief, the fearsome Papa. Kineseren asks Greven for a payoff and tells him that he has been hired by a man called Dickman. Greven assumes this is ex-criminal Egil, and goes to him for explanations. Egil understands the situation and allows himself to be executed to save Nils. After multiple complications, there is a gunfight at Nils's workplace in which all the gangsters are killed except Nils and Papa, who drive away together, both satisfied for having their sons avenged.

In a galaxy "very, very, very, very far away", the ruthless Spaceballs, led by President Skroob, have squandered their planet's atmosphere. Desperate for oxygen, Skroob hatches a plan to steal it from the neighboring planet Druidia by obtaining the code to its air shield, destroying Druidia in the process. On Druidia, the spoiled Princess Vespa flees an arranged marriage to the narcoleptic Prince Valium, having already rejected all other suitors in her search for true love. Meanwhile, mercenary Lone Starr and his half-man, half-dog companion Barf are contacted by crime boss Pizza the Hutt, who demands repayment of a one-million space buck debt. King Roland of Druidia offers Starr the same amount to rescue Vespa and her droid servant, Dot Matrix. Aboard their Winnebago RV spaceship Eagle 5, Starr and Barf rescue the pair just before they are captured by the Spaceball ship Spaceball One, commanded by Colonel Sandurz and Skroob's enforcer, Dark Helmet, who wields the mystical power of the Schwartz. However, Eagle 5 runs out of fuel, forcing Starr to crash-land on the desert moon of Vega. The four wander through the scorching landscape, with Starr and Vespa exchanging barbed remarks and mutual attraction. They cannot act on their feelings, however, as Vespa is duty-bound to marry a prince. They collapse from the heat, but are rescued by the Dink-Dinks, a group of robed, diminutive aliens, and taken to the hidden temple of Yogurt, a wise sage who breaks the fourth wall to advertise fictitious Spaceballs tie-in merchandise. Yogurt guides Starr in using the Schwartz and a ring to channel its power. He also deciphers Starr's medallion–found with him as an abandoned baby–but withholds its meaning. Meanwhile, Helmet, having tracked Vespa's location using an instant VHS of Spaceballs, uses the Schwartz to disguise himself as Roland to lure her out of Yogurt's temple for capture. Helmet extorts the shield code from Roland by threatening to reverse the plastic surgery on Vespa's nose. Starr and Barf infiltrate the Planet Spaceball prison, rescue Vespa and Dot, and escape in Eagle 5. With the shield code in hand, Spaceball One transforms into "Mega-Maid", a giant maid robot, and begins vacuuming Druidia's atmosphere. Starr reverses the vacuum by using the Schwartz, saving the planet, then pilots Eagle 5 into Mega-Maid's head, finds the self-destruct button, and battles Helmet in a Schwartz duel using ring-projected lightsaber -like beams. Helmet steals Starr's ring and drops it down a grate, but Starr hears a telepathic message from Yogurt that the Schwartz is in him, not the ring. Starr wields the Schwartz to reflect Helmet's energy blast with a mirror, sending him flying into the self-destruct button. As Eagle 5 escapes, Skroob, Helmet, and Sandurz are left behind when all the escape pods are launched, and Mega-Maid explodes. The trio crash-land in the ship's remains on a nearby planet populated by intelligent apes, who are horrified to witness their arrival. Lone Starr and Barf discover on the news that Pizza the Hutt has eaten himself to death, absolving them from their debt. The duo return Vespa and Dot to Roland, but take only a small portion of the reward money to cover their expenses. Later, Starr and Barf discover a final message from Yogurt that reveals Starr's medallion identifies him as a prince. Upon returning to Druidia just in time to stop Vespa's wedding to Valium, Starr reveals his royal lineage and he and Vespa are joyously married.

Fritz Knobel (a fictionalized version of real-life forger Konrad Kujau) supports himself by faking and selling Nazi memorabilia. He sells a portrait of Eva Braun and one volume of what he alleges to be Hitler's diaries (but which he actually wrote himself) to factory owner Karl Lenz. Lenz shows off the diary to his guests during a "birthday party for the Führer ", among whom is sleazy journalist Hermann Willié. Willié works for the magazine "HH Press"; the letters HH are a licence plate abbreviation for Hamburg where the real-life Stern magazine is located, but are also the common abbreviation for " Heil Hitler " among neo-Nazis. Knobel, in need of material to produce more diaries, turns to his own life for inspiration; after he meets Martha and she becomes his lover (he is already married to Biggi), Martha becomes the inspiration for the diary version of Eva Braun. Rumors about the diaries cause a major Nazi craze in high society, allowing former Nazi officials to flaunt their old ranks (e.g. Obergruppenführer). Willié becomes even more obsessed, buying Hermann Göring 's old yacht Carin II and starting an affair with his (fictional) grandniece Freya von Hepp, who is based on Hermann Göring's daughter Edda Göring. Towards the end, the plot has developed its own dynamics, putting more and more pressure on Knobel to deliver the remaining volumes while in constant fear that his forgery will be discovered. The volumes are convincing enough to fool the enthusiastic journalists, who are willing to overlook some oddities, especially a false monogram "FH" instead of "AH" on one of the volumes. They invent alternative facts to explain away the discrepancy (the term " Führerhauptquartier " instead of "Adolf Hitler" for instance). Later, Knobel manages to manipulate a forensic graphoanalysis to his advantage, but it seems only a matter of time until the truth is discovered. The constant fear, and the struggle against developing a too-close identification with the person he is writing about, eventually make Knobel collapse. Biggi and Martha take charge of the situation, forcing him to pull himself out of the forgery business just in time, while (similar to the end of World War II) the Nazi-enthusiasts fall – more or less hard according to their personal level of belief.

Clifford Peache lives in an upscale Chicago luxury hotel with his father, the hotel manager, and his grandmother. He is a new student at Fleer H.S., where he arrives each day in a hotel limousine. Clifford quickly becomes a target of abuse from a gang of bullies, led by Melvin Moody. They regularly extort money from students, allegedly to protect them from another student, Ricky Linderman. According to school legend, Linderman has killed several people, including his own little brother. Not believing the stories, Clifford consults a teacher who claims that the only violence she's aware of from Ricky's past occurred when his nine-year-old brother died accidentally while playing alone with a gun. Ricky was the first to find the body. Despite the rumors, Clifford approaches Ricky and asks him to be his bodyguard. He refuses, but the boys become friends after Ricky saves him from a beating by Moody and his gang. He has emotional issues over the death of his brother, and although he's slow to trust Clifford, Ricky shows him a cherished motorcycle that he has been rebuilding. Their friendship is strengthened when Clifford successfully helps Ricky search junkyards for a hard-to-find cylinder for the motorcycle's engine. Through Clifford's friendship, Ricky comes out of his shell, proving to a few classmates that he's not the killer the school rumors allege. As Clifford, Ricky, and a few other friends from school eat lunch in Lincoln Park, Moody and his gang approach. Moody has enlisted older bodybuilder Mike to be his bodyguard. He intimidates and physically abuses Ricky, who refuses to fight. Mike vandalizes his motorcycle before Moody pushes it into the lagoon. Ricky runs away, ashamed and angry. Ricky later appears at Clifford's hotel, asking for money before leaving again. Clifford follows him and they argue before Ricky finally reveals that it was he who accidentally shot his brother while playing with their father's gun, and lied about finding his brother after the fact. As a result, he is overwhelmed with guilt and remorse, leaving Clifford behind as he takes a subway train into the night. Later, Moody is back at the park to continue bullying Clifford and his friends. Ricky is also there retrieving his motorcycle from the lagoon. Moody notices, demanding the motorcycle, which Ricky silently refuses. Moody summons Mike, who starts to push and intimidate Ricky again. The two then engage in a long fistfight, which Ricky ultimately wins, knocking Mike out. Moody and Clifford then split off into their own fistfight, after Moody tried to unfairly intervene in the fight between Ricky and Mike. Ricky urges Clifford to fight him while coaching him. Clifford initially fights incompetently, taunted by the overconfident Moody, but finally lands several solid punches, the last of which knocks Moody down, breaking his nose. Moody sits on the ground, humiliated, shocked, bleeding and complaining, revealing himself to be a coward. Ricky retrieves his motorcycle, and jokingly asks Clifford to be his bodyguard as they leave with their friends.

Joe, Al, and Willie are three senior citizens who share a small apartment in Queens, New York City. Their days are spent on a park bench, and Joe is desperate to break the monotony. One day Joe suggests that they go on a "stick-up". They have no experience as criminals, but after some reluctance, the two others agree. Al surreptitiously borrows three pistols from the gun collection of his nephew Pete, who lives with his wife Kathy and two children Colleen and Kevin a few miles away. The trio, disguised with novelty glasses, pulls off the heist, netting $35,000. The excitement is too much for Willie, who soon suffers a fatal heart attack. Joe and Al give $25,000 to Pete and his family, claiming it is the proceeds from Willie's life insurance policy. They decide to splurge the remaining $10,000 on a trip to Las Vegas. Al and Joe win over $70,000 playing craps, but the trip, which they make right after Willie's funeral, exhausts Al and he dies in his sleep. Joe informs Pete that his uncle has died, then tells him about the bank heist and the Las Vegas adventure. He gives Pete the remaining bank loot and the Vegas winnings and tells him to store the cash in his safe deposit box and never tell anyone about it. The next day, on his way to Al's funeral, Joe is arrested. He confesses to the robbery but refuses to say what happened to the money. Pete visits Joe in prison and suggests giving back at least the stolen portion of the money in the hope of a lighter sentence. Joe explains that he is an old man with no family and, now, no friends, and is resigned to his fate. He tells Pete to enjoy his "inheritance", but while heading back to his cell, cheekily suggests that he plans to break out.

Andy Stitzer is a shy 40-year-old introvert who works as a stock supervisor at the electronics store Smart Tech. He gave up trying to have sex after various failed attempts and lives alone in an apartment with a collection of action figures and video games. When a conversation at a poker game with his co-workers, David, Jay, and Cal, turns to past sexual exploits, they figure out that he secretly is still a virgin. Andy is mortified upon discovering the next day that everyone else at work has learned about the secret, including their boss Paula, who is attracted to him and later privately offers to take his virginity. He almost quits work in humiliation before David consoles him and recommends trying again to have sex. David, Jay, and Cal become determined to help Andy achieve this. They all give differing advice on how to interact with women. David invites him to join them for a speed dating event and unsuccessfully tries to reconnect with his ex-girlfriend Amy there. Jay drags Andy to various social events, books a painful chest waxing appointment, and sets him up with a prostitute, which all end with embarrassing results. Cal advises Andy to be confident and to ask women questions instead of talking about himself. He practices this on a bookstore clerk named Beth, who quickly becomes intrigued by him. David gives Andy his pornography collection, encouraging him to masturbate. Andy eventually gets a date with a customer named Trish Piedmont. At the end of their first date, they almost have sex, but are interrupted by her 16-year-old daughter, Marla. Trish suggests they postpone having sex, and Andy enthusiastically agrees; they decide to abstain until their 20th date. Their relationship flourishes over the following weeks. She encourages Andy's dream of starting a business and helps fund it by selling his collectibles. After Marla argues with Trish over wanting birth control, Andy takes her to a group information session at a sexual health clinic, where she is mocked for being a virgin. Andy admits his virginity to defend her, earning him Marla's respect. Meanwhile, David suffers an emotional breakdown at work over his obsession with Amy, and takes a vow of celibacy. The breakdown prompts Paula to assign Andy his sales duties for the day, and she later promotes him to floor manager for his high sales quota. As Cal takes on Andy's previous role, he hires a woman named Bernadette to work at the store, hoping to match her with David so he can move on from Amy. After Jay's girlfriend, Jill, breaks up with him due to his infidelity, he concedes to Andy that sex can ruin a relationship. Following a reconciliation with Jill, Jay invites Andy and the others to a nightclub celebrating her pregnancy. Trish tries to initiate sex with Andy on their 20th date and becomes upset when he resists. They argue, and Andy leaves to meet his friends at a nightclub. He gets drunk and leaves with Beth to have sex at her apartment. Cal gets David and Bernadette to hook up, while Marla convinces Trish to reconcile with Andy. At Beth's, Andy sobers up and decides to leave without having sex, just as his friends arrive and encourage him to go back to Trish. Andy returns to his apartment to find Trish waiting for him. She has seen David's porn collection; he tries to explain, but she flees in alarm and disgust, fearing Andy may be a sexual deviant. While pursuing her on his bike, Andy collides with her car, flying through the side of a billboard truck. She rushes to his side, and Andy finally confesses that he is a virgin. Trish is relieved and accepting, and they profess their love for each other. They eventually marry in a lavish ceremony with everyone in attendance, having generated roughly $500,000 from the sales of his action figures to pay for it, before having sex for the first time. The film ends with a musical sequence where all the characters sing and dance to " Aquarius ".

At the wedding of Angus and Laura in Somerset, the perpetually late best man Charles, his flatmate Scarlett, his aristocratic friend Fiona and her brother Tom, Gareth and his partner Matthew, and Charles's deaf brother David, all gather. All are unmarried. At the reception, Charles meets Carrie, an American woman working in England. They spend the night together. In the morning, Carrie, who is returning to the U.S., laments that they may have "missed a great opportunity". Three months later, at the London wedding of Bernard and Lydia, Tom is the best man. At the reception, Charles runs into Carrie, who has returned to the UK. With Carrie is Hamish, her older, wealthy Scottish fiancé. Meanwhile, a pretty young woman, Serena, is attracted to David. During the reception, Charles is humiliated by several ex-girlfriends, including the distraught Henrietta, who claims Charles is a " serial monogamist " fearful of commitment. Charles retreats to an empty hotel suite and notices Carrie and Hamish departing by taxi, though Carrie returns to the reception shortly after; she and Charles spend a second night together. A month later, Charles receives an invitation to Carrie and Hamish's wedding. Charles runs into Carrie while searching for a wedding gift. He then helps Carrie choose a wedding dress. After, Charles awkwardly confesses he loves her, which Carrie gently rebuffs. A month later, Charles and his friends attend Carrie and Hamish's wedding. Scarlett meets Chester, a Texan, at the reception. Henrietta introduces her new boyfriend to Charles. Fiona, aware of Charles's unhappiness over Carrie, admits she loves him. Charles, though sympathetic, does not reciprocate her feelings. During Hamish's speech, Gareth suffers a fatal heart attack. At Gareth's funeral, Matthew delivers a heartfelt farewell to his love by reciting W. H. Auden 's " Funeral Blues ". Carrie and Charles share a brief moment, while Charles and Tom then ponder that, despite their clique's pride in being single, Gareth and Matthew were like a married couple. They wonder whether seeking "one true love" is futile. Ten months later, it is Charles and Henrietta's wedding. While seating guests, Tom meets his distant cousin, Deirdre, whom he has not seen since childhood; they are immediately smitten with each other. Scarlett and Chester are overjoyed to meet again. Carrie arrives and tells Charles that she and Hamish have separated following a difficult marriage. Charles has an emotional crisis inside the church's back room. After David and Matthew counsel him, Charles decides to proceed with the ceremony. When the vicar asks whether anyone has a reason why the couple should not marry, David uses British Sign Language to say the groom has doubts and loves someone else. After Charles confirms this, a furious Henrietta punches him at the altar, knocking him out and ending the ceremony. Later at his flat, Charles and the group are discussing the fiasco when Carrie arrives to apologise for causing trouble. Charles again says he loves her and proposes a lifelong commitment without marriage, which Carrie accepts. As they kiss, a thunderbolt flashes across the sky. In an ending photo montage, Henrietta has married an Army officer; David married Serena; Scarlett has married Chester, the Texan; Tom married Deirdre; Matthew has found a new partner; Fiona is with Prince Charles; and Charles and Carrie have had their first child.

Gambler Nathan Detroit seeks to organize an unlicensed craps game, but the police, led by Lieutenant Brannigan, are "putting on the heat." Nathan's usual locations are turning him away due to Brannigan's intimidating pressure. The Biltmore garage will allow Nathan to hold a game, but the owner requires a $1,000 security deposit, which Nathan does not have. Adding to his problems, Nathan's fiancée, Miss Adelaide, a nightclub singer, wants to get married after being engaged for fourteen years. She also wants him to go straight, but his only talent is organizing illegal gambling. Nathan spots an old acquaintance, Sky Masterson, a gambler willing to bet on virtually anything and for high amounts. To win the $1,000 security deposit, Nathan bets Sky that he cannot take a girl of Nathan's choosing to dinner in Havana, Cuba. Nathan then nominates Sergeant Sarah Brown, a sister at the Save a Soul Mission, which opposes gambling. Sky pretends to be a repentant gambler to meet Sarah. Sky proposes a bargain: He will recruit a dozen sinners into the Mission for her Thursday-night meeting if she will have dinner with him in Havana. With General Matilda Cartwright threatening to close the Mission's Broadway branch due to low attendance, Sarah agrees to the date. Meanwhile, confident that he will win the bet, Nathan gathers all the gamblers, including a visitor that Harry the Horse has invited: Big Jule, a mobster. When Lieutenant Brannigan appears, Benny Southstreet claims they are celebrating Nathan marrying Adelaide. Nathan is shocked, but is forced to play along. Later, he realizes he has lost his bet and must marry Adelaide. Over the course of their stay in Cuba, Sky and Sarah begin to fall in love. They return to Broadway at dawn and meet the Save a Soul Mission band, which has been parading all night on Sky's advice. Police sirens are heard, and the gamblers, led by Nathan Detroit, flee out through the back room of the empty Mission where they were holding a craps game. The police arrive too late to make any arrests, but Lieutenant Brannigan finds Sarah and the other Save a Soul members being absent unlikely to be a coincidence and suspects Sky. Sarah is equally suspicious that Sky had something to do with the crap game at the Mission, and takes her leave of him, refusing to accept his denials. Sky still has to make good on his arrangement with Sarah to provide sinners to the Mission. Sarah would rather forget the whole thing, but Uncle Arvide Abernathy warns Sky that "If you don't make that marker good, I'm going to buzz it all over town you're a welcher." Nathan has continued the crap game in a sewer. With his revolver visible in its shoulder holster, Big Jule, who has lost all his money, forces Nathan to play against him while he cheats, cleaning Nathan out. Sky enters, knocks Big Jule down, and removes his pistol. Sky, who has been stung and devastated by Sarah's rejection, lies to Nathan that he lost the bet about taking her to Havana and pays Nathan the $1,000. Nathan tells Big Jule he now has money to play him again, but Harry the Horse says that Big Jule cannot play without cheating because "he cannot make a pass to save his soul." Sky overhears this, and the phrasing inspires him to make a bet: He will roll the dice, and if he loses, he will give all the other gamblers $1,000 each; if he wins, they are all to attend a prayer meeting at the Mission. The Mission is near closing when the gamblers arrive, filling the room; Sky won the bet. They confess their sins, though with little repentance. Nicely-Nicely Johnson however, recalling a dream he had the night before, seems to have an authentic connection to the Mission's aim, and this satisfies everyone. When Nathan tells Sarah that Sky lost the Cuba bet, which she knows he won, she hurries off to make up with him. There is eventually a double wedding in Times Square, with Sky marrying Sarah, and Nathan marrying Adelaide, while Nicely plays bass drum in the Mission's marching band.

After being homeschooled her entire life and having spent the last twelve years in Africa, 16-year-old Cady Heron begins her first day at North Shore High School. She has trouble making friends and is put down by the teachers on her first day, although she does befriend outcasts Janis Ian and Damian Leigh, who explain the school's various cliques to her, warning her about the "Plastics", a trio of wealthy and mean girls consisting of ruthless queen bee Regina George, insecure gossiper Gretchen Wieners, and bubbly airhead Karen Smith. Regina, Gretchen, and Karen take a shine to Cady and unexpectedly invite her to join the Plastics. Upon realizing this, Janis hatches a plan to infiltrate the group and destroy Regina's reputation. Cady becomes infatuated with her classmate Aaron Samuels. Karen and Gretchen warn her that, as Regina's ex-boyfriend, he is off-limits, though Regina assures Cady she does not care if Cady and Aaron date. Despite Janis's insistence that Regina is "evil", Cady comes to enjoy hanging out with the group, including writing insulting remarks about their classmates and teachers in a scrapbook called the "Burn Book." However, at a Halloween house party, instead of talking to Aaron on Cady's behalf, Regina kisses him in front of her and resumes their relationship. Feeling betrayed, an enraged Cady fully commits to Janis's plan. Over the following months, Cady, with Janis and Damian's help, manages to trick Gretchen into revealing her secrets, break up Regina's relationship with Aaron (and spend time with him by pretending to need math tutoring), and cause her to gain weight by giving her high-calorie snack "Kalteen Bars" under the pretense that they are diet food. After violating the Plastics' dress code rules by wearing sweatpants on Monday, due to her weight gain, Regina is kicked out of the group, as Cady becomes the new "queen bee". While Cady's parents are out of town, she throws a house party, and drunkenly admits to Aaron that she does not actually need math tutoring, and he renounces her for being as manipulative as Regina. Janis and Damian angrily confront Cady for throwing a party instead of attending the former's art show and declare that she has become as plastic as she pretended to be. Meanwhile, Regina becomes enraged when she discovers Cady's sabotage, and inserts fake slander of herself into the Burn Book, hoping to frame the latter and the other Plastics. Regina spreads the contents of the book throughout the hallways, inciting chaos. Principal Duvall and math teacher Ms. Norbury gather the female junior students in the gym to talk through their social issues. During this, Janis reveals her plan to destroy Regina to her face and openly mocks her, much to the students' excitement. Regina furiously storms out, pursued by an apologetic Cady. While ranting at Cady, Regina is hit by a school bus, fracturing her spine. Rumors circulate that Cady intentionally pushed Regina in front of the bus. After realizing a comment she wrote in the Burn Book has framed Ms. Norbury as a drug dealer, which has caused the police to come to the school and interrogate her math class, Cady decides to take full responsibility for the book. Regina, Gretchen, and Karen are spared punishment, but Cady becomes a social pariah, resulting in being grounded by her parents. To earn extra credit, Cady joins the school Mathletes, moderated by Ms. Norbury and led by fellow student Kevin Gnapoor. At the state finals, she correctly answers the tiebreaker question, winning the championship. The team arrives at the Spring Fling dance, where Cady is unexpectedly elected queen. She breaks the plastic tiara and distributes the pieces to others in the crowd, makes peace with Janis, Damian, and the Plastics, and shares a slow dance and a kiss with Aaron. The Plastics disband by the time senior year begins. A fully recovered Regina joins the school's lacrosse team to channel her anger positively, Gretchen joins the "Cool Asians" clique, and Karen becomes the school's weather girl. Cady begins dating Aaron and continues to hang out with Janis and Damian, with the former starting to date Kevin. While reflecting on herself on the relative social peace that has taken over North Shore High, Cady notices a new popular clique in the freshman class and wonders how long the "Junior Plastics" will last, jokingly imagining them being hit by a school bus.

Kate Dibiasky, a doctoral candidate in astronomy at Michigan State University, discovers a previously unknown comet. Her adviser, Dr. Randall Mindy, confirms that it will collide with Earth in approximately six months and is large enough to cause a global extinction event. NASA verifies the findings, and Dr. Teddy Oglethorpe, head of their Planetary Defense Coordination Office, accompanies Dibiasky and Mindy to present their findings to the White House. However, they are met with apathy from President Janie Orlean and her Chief of Staff Jason Orlean, who is also her son. Oglethorpe encourages Dibiasky and Mindy to leak the news to the media, which they then do on The Daily Rip, a popular morning talk show. When hosts Jack Bremmer and Brie Evantee treat the topic flippantly, Dibiasky loses her temper and angrily rants about the threat before leaving. Mindy receives public approval for his looks, while Dibiasky becomes the subject of negative memes for her on-air behavior. Public reaction is muted, and the announcement is downplayed by NASA Director Jocelyn Calder, a top donor to Orlean with no background in astronomy. When Orlean's sexual relations with Supreme Court nominee Sheriff Conlon become news, the president tries to divert public attention to the looming threat of the comet, announcing a project to use nuclear weapons to strike and divert the comet. The mission successfully launches, but Orlean abruptly aborts it when Peter Isherwell, the billionaire CEO of BASH Cellular and another top donor, discovers that the comet contains trillions of dollars' worth of rare-earth elements. The White House agrees to commercially exploit the comet by fragmenting and recovering it from the ocean, using technology proposed by BASH in a scheme that has not undergone peer review. Orlean sidelines Dibiasky and Oglethorpe while hiring Mindy as the National Science Advisor. Dibiasky attempts to mobilize public opposition to the scheme but gives up under threat from Orlean's administration. Mindy becomes a prominent voice advocating for the comet's commercial opportunities and begins an affair with Evantee. World opinion is divided among people who believe the comet is a severe threat, those who decry alarmism and believe that mining a destroyed comet will create jobs, and those who deny that the comet even exists. When Dibiasky returns home to Illinois, her parents kick her out of the house and she begins a relationship with a young man named Yule, a skateboarder, shoplifter, and Evangelical she meets at her retail job. Mindy's wife comes to Washington to confront him about his infidelity, but returns to Michigan without him. Mindy questions whether Isherwell's technology will be able to break apart the comet, angering the billionaire. Becoming frustrated with the administration, Mindy finally breaks down and rants on The Daily Rip, criticizing Orlean for downplaying the impending apocalypse and questioning humanity's indifference. Cut off from the administration, Mindy reconciles with Dibiasky as the comet becomes visible from Earth. Mindy, Dibiasky, and Oglethorpe organize a protest campaign on social media, telling people to "Just Look Up" and call on other countries to conduct comet interception operations. Simultaneously, Orlean starts an anti-campaign telling people "Don't Look Up". Oglethorpe informs Mindy and Dibiasky that Orlean and BASH cut Russia, India, and China out of the rights for the comet-mining deal, so those countries prepared their own joint deflection mission—only for their spacecraft to explode on takeoff, ending the possibility of a successful deflection. As the comet becomes larger in the sky, Orlean's supporters start turning on her administration. BASH's launches aimed at breaking the comet apart go awry, and everyone, beginning with Isherwell and Orlean in the flight control center, soon realizes that humanity is doomed. Isherwell, Orlean, and other elites board a sleeper spaceship designed to find an Earth-like planet; unthinkingly, Orlean leaves her son Jason behind. Orlean offers Mindy two places on the ship, but he declines, choosing to spend a final evening with his wife and children, and friends Oglethorpe, Dibiasky, and Yule. As expected, the comet strikes off the coast of Chile, causing a worldwide disaster and triggering an explosive extinction-level event, with globally catastrophic scenes being shown prior to the obliteration of the Mindy family gathering. In a mid-credits scene, Orlean, Isherwell and the surviving people who left Earth land on a lush alien planet 22,740 years later. Exiting naked and admiring the habitable world, Orlean is suddenly killed by a large, bird-like creature—a death predicted earlier by BASH's algorithms—and a further pack of the creatures surrounds and begins to converge on the planetary newcomers. In a post-credits scene on Earth, Jason emerges from the rubble, having survived the impact. He records himself, declaring himself the "last man on Earth", and asking any viewers still alive to "like and subscribe".

Mild-mannered Portuguese Brazilian billionaire cousins Bastiano and Antonio Coimbra de la Coronilla y Azevedo are in fear for their lives after several assassination attempts. Therefore, they have an agency find two look-alikes, stuntman Elliot Vance and the saxophone-playing small-time criminal Greg Wonder, to temporarily take their place and find out who is behind the assassination attempts. Elliot and Greg, both very tough and battle-ready as compared to the violence-averse Coimbra cousins, use their flamboyance and fighting skills to manage their way through all kinds of situations without too much trouble while getting closer to the mastermind behind it all. Additionally they quickly come to like the jet-set life. The resulting damage to their reputation provokes the Coimbras to return to Rio ahead of time. This puts them right into the sights of their enemies, alongside the cousins' look-alikes.