After Andrée must abort a first attempt in August 1896 to reach the North Pole with the hydrogen balloon Örnen ("the eagle"), he returns from Spitsbergen to Stockholm to prepare for a new attempt the following year. In the wake of this failure, he faces criticism from both societal and scientific circles, openly expressed by expedition participant Nils Ekholm. Andrée dispels all doubts and tirelessly advances plans for another attempt. Ekholm is replaced by Knut Frænkel. The balloon is inspected in Paris at the workshop of Henri Lachambre, while the third expedition member, Nils Strindberg, becomes engaged to his girlfriend, Anna Charlier. In the summer of 1897, the polar explorers set off again for Spitsbergen, where after some waiting for favorable winds, they manage to launch. However, problems arise soon after, and the journey does not proceed as planned. After a while, the balloon becomes difficult to keep aloft, forcing them to land on the pack ice. The three men are compelled to undertake a grueling trek back over the ice with heavy sledges, which increasingly pushes them to their physical and mental limits. When they finally reach the uninhabited and inhospitable island of Kvitøya, they are nearly at the end of their strength. After Strindberg, exhausted, has died and been buried, Frænkel also loses his life due to an attack by a polar bear. Disillusioned, Andrée remains alone in the barren ice desert.

Occupational therapist Dian Fossey is inspired by anthropologist Louis Leakey to devote her life to the study of primates. She writes ceaselessly to Leakey for a job cataloging and studying the rare mountain gorillas of Africa. Following him to a lecture in Louisville, Kentucky in 1966, she convinces him of her conviction. They travel to the Congo, where Leakey and his foundation equip her to make contact with the gorillas, and introduce her to a local animal tracker, Sembagare. Settling deep in the jungle, Fossey and Sembagare locate a troop of gorillas, but are displaced by the events of the Congo Crisis and forcibly evicted from their research site by Congolese soldiers, who accuse Fossey of being a foreign spy. Fossey is resigned to returning to the United States, but Sembagare and her temporary host Rosamond Carr motivate her to stay in Africa. Fossey establishes new research efforts in the jungles of neighboring Rwanda, where rampant poaching become apparent when she discovers several traps near her new base at Karisoke. Nevertheless, Fossey and her colleagues make headway with the gorillas, taking account of their communication and social groups. Her work impresses Leakey and gains international attention. National Geographic, which funds her efforts, dispatches photographer Bob Campbell to highlight her research. Fossey, initially unreceptive, grows increasingly attached to Campbell after several photo sessions with the gorillas, and the two become lovers, in spite of Campbell's marriage. Campbell proposes to divorce his wife and marry Fossey but insists that she would have to spend time away from Karisoke and her gorillas, leading her to end their relationship. Fossey forms an emotional bond with a gorilla named Digit, and attempts to prevent the export of other gorillas by trader Van Vecten. Appalled by the poaching of the gorillas, Fossey complains to the Rwandan government and is dismissed, but a government minister promises to hire an anti-poaching squad. Fossey's frustrations reach a climax when Digit is beheaded by poachers. She leads numerous anti-poaching patrols, burns down the poachers' villages, and even stages a mock execution of one of the offenders, serving to alienate some of her research assistants and gaining her various enemies. Sembagare expresses concern at Fossey's opposition to the emergent industry of gorilla tourism, but she nonchalantly dismisses his worries. On Boxing Day, 1985, Fossey is murdered in the bedroom of her cabin by an assassin with a machete. At a funeral attended by Sembagare, Carr, and others, she is buried in the same cemetery where Digit and other gorillas had been laid to rest. Sembagare symbolically links the graves of Fossey and Digit with stones as a sign that their souls rest in peace together before leaving. An epilogue text explains that Fossey's actions helped save the gorillas from extinction, while her death remains a mystery.

The film begins with a reenactment of the gruesome act of cannibalism described by the prosecuting attorney during Alferd Packer's 1883 trial. During this sensationalized account, a haggard Packer repeatedly insists that was not how it happened. During a break in the trial, Packer is enticed by journalist Polly Pry to tell his side of the story, which he proceeds to do, via flashback beginning with his horse Lianne galloping in a field. In 1873, Packer was part of a group of miners in Bingham Canyon, Utah who hear of new prospects in Breckenridge. Together, the small group decide to travel together into Colorado Territory. Packer is appointed as the replacement for the original guide, since he claimed knowledge of the area. He and Lianne set off on what Packer estimates will be a three-week journey with a party of five miners: Shannon Wilson Bell, James Humphrey, Frank Miller, George Noon and Israel Swan. Four weeks later, while attempting to visit Provo for supplies they become convinced they are lost. They are given local warning them of impending doom awaiting them in the mountains. Finally arriving in Provo, they run into a group of three fur trappers bound for Saguache; O.D. Loutzenheiser, Preston Nutter, and their diminutive leader, Jean "Frenchy" Cabazon. The trappers despise the miners, whom they contemptuously call "diggers", yet seem to like Packer's Arabian horse, telling Packer that she's a "trapper horse". The next day, Packer wakes up to discover his horse Lianne is missing. The men attempt to cross the Green River near the Utah border. Eventually, after a disastrous crossing of the Colorado River the Packer party is spotted by two " Nihonjin " Indians. They are taken back to the tribe's encampment near Delta where the chief warns them of a winter storm, allowing them to wait it out with the tribe. Packer's party also find the trappers camping out with the tribe, a small altercation breaks out over Lianne, whose feedbag Packer finds in their possession. In the present time, Packer is sentenced to death by hanging, with his execution to occur in Lake City. That night, Polly reveals her growing affection for him through song. The next day, Polly visits Packer once again in prison, where he continues his story. The men set out in the wilderness and begin to suspect that Packer is really only interested in following the trappers to find his horse. They soon run out of food, resorting to eating their shoes as they become lost in the snow-covered Rocky Mountains. An optimistic Swan sings about building a snowman; Bell shoots him in the head out of frustration. The men discuss their dire situation that night over the fire, speaking of the cannibalism that the Donner Party had to resort to in California. They decide to consume the body of their dead companion as Miller cuts up Swan's body, and only Bell refuses to partake in the cannibalism. After a few more days, the party loses hope, which leads to talk of sacrificing one of their own. Packer convinces them for one more chance for a scouting trip, but when he returns, Bell has killed the others, claiming they planned to kill and eat him after Packer left. Packer is forced to throw a cleaver at Bell, seemingly killing him. He is then forced to cannibalize the others to wait out the rest of the winter. Arriving in Saguache sometime later, Packer finds Lianne, who has taken to Cabazon, upsetting Packer. The sheriff of Saguache, suspicious of Packer arriving without the rest of his party, eventually finds out the fate of the other members and attempts to arrest Packer for cannibalism at a saloon. A bar-fight between Packer and the trappers occurs, which Packer wins after brutally attacking Cabazon's groin using fighting techniques he learned from the Nihonjin chief, leaving Cabazon incapacitated. Following this, Packer attempts to flee to Wyoming, only to later be arrested there and brought back to Colorado to await judgment. However, he is saved at the last minute by Polly, who arrives on the scene with Lianne. Meanwhile, Cabazon, wants revenge against Packer for their fight in Saguache. The Nihonjin chief saves Packer by cutting his rope with a katana before beheading Cabazon. Packer, seeing that Polly brought back Lianne, he realizes he does not need her anymore and chooses Polly, the two kiss, only to be frightened by a still-alive but badly maimed Bell.

Rushon Askins, a tender-hearted, upwardly-mobile man, has been dating his self-righteous-to-a-fault girlfriend Nikki for seven weeks. They really like each other, but their relationship has not yet been consummated; Nikki is unsure if their relationship is ready for the next stage. Rushon asks Nikki out to dinner, but Nikki wants it to be a double date. She brings her opinionated friend and neighbor Lysterine "Lysti", and Rushon comes with his "bad boy" buddy Bunz. Lysti and Bunz soon end up bonding as both are sexually adventurous and completely uninhibited, despite some initial bickering and resentment towards one another as each of them overplayed their roles by trying to come off as a player (Bunz) or overly high-maintenance (Lysti). Meanwhile, the more conservative and prudish Nikki decides it is time for her and Rushon to take their relationship to the next level, much to Rushon's surprise and excitement. However, they have one small problem: this is the 1990s, and Nikki wants to practice safe sex. Rushon produces a condom and just as he removes the wrapper, Nikki's mischievous, poorly trained, small terrier dog named "Killer" snatches and destroys Rushon's only condom, forcing him to have to go out and buy more condoms. Nikki then calls Lysterine and urges her to make Bunz (also condomless) use a condom as well. Therefore, Rushon (who has to take Killer along for his walk) and Bunz go on wild, late night adventures from store to store trying to find "protection" before everyone's mood evaporates. The two friends run across a wild assortment of characters which includes a Chinese medicine store owner, wacky Punjabi convenience store owners, a would-be armed robber, a hypocritical judge (Bernie Mac) and his female clerk/secret lover, and last but not least, a disobedient Killer who escapes his leash while Rushon and Bunz are in a store and leads them on a blocks-long chase. Things soon lead to all four friends being at the hospital when Bunz accidentally shoots Rushon in the leg with a gun he took from a paranoid cabbie moments earlier. The group initially encounters a rude, unsympathetic admissions nurse who denies Rushon entry into the hospital because he has no insurance until Bunz runs across a doctor's credentials and impersonates the doctor to get his buddy admitted into the facility. However, "Doctor" Bunz is soon called in to help deliver a baby, which takes priority over a flesh wound, and he loses track of Rushon who is mistaken for a patient who is scheduled to be castrated (that patient shrewdly switched charts with Rushon upon finding out about his operation). The real doctor whom Bunz is impersonating eventually surfaces which leads the admissions nurse and security to search the hospital for the group. Bunz, Lysterine, and Nikki frantically search for Rushon who is soon anesthetized and prepared for castration. Nikki finds him right before the surgery begins and abruptly stops it by yelling that Rushon has no insurance. As both couples leave the hospital, everyone make up as both women take their men home for some long-delayed, kinky but safe sex.

Ghost Dog sees himself as a retainer of Louie, a local mobster, who saved Ghost Dog's life years earlier. While living as a hitman for the American Mafia, he adheres to the code of the samurai, and interprets and applies the wisdom of the Hagakure. Louie tells Ghost Dog to kill a gangster, Handsome Frank, who is sleeping with the daughter of local mafia boss Vargo. Ghost Dog arrives and kills the gangster, before seeing that the girl is also in the room; he leaves her alive, and she gives him a copy of the book Rashōmon to read. To avoid being implicated in the murder of a made man, Vargo and his associate Sonny Valerio decide to get rid of Ghost Dog. Louie knows practically nothing about Ghost Dog, as the hitman communicates only by homing pigeon. The mobsters start by tracing all the pigeon coops in town. They find Ghost Dog's cabin atop a building and kill his pigeons. Ghost Dog realizes he must kill Vargo and his men or they will kill him and his master. During the day, Ghost Dog frequently visits the park to see his best friend, a French-speaking ice cream man named Raymond. Ghost Dog does not understand French and Raymond does not understand English but the two nonetheless seem to connect with each other. Ghost Dog also befriends a little girl named Pearline, to whom he lends the book Rashōmon. Eventually, Ghost Dog invades Vargo's mansion and kills almost everyone single-handedly, sparing only Louie and Vargo's daughter. That night, Ghost Dog kills Sonny Valerio at his home by shooting him through a pipe. Ghost Dog expects that Louie will attack him, as he feels that Louie is obliged to avenge the murder of his boss Vargo. He goes to the park and gives Raymond all his money, helping him to stay in the country. Pearline appears and gives back Rashōmon to Ghost Dog, saying that she liked it. Ghost Dog gives Pearline his copy of Hagakure and encourages her to read it. Though Louie feels some loyalty to Ghost Dog, he finally confronts him at Raymond's ice cream stand with Raymond and Pearline watching. Ghost Dog is unwilling to attack his master and allows Louie to kill him. His last act is to give Louie the copy of Rashōmon and encourage him to read it. Pearline takes Ghost Dog's empty gun and aims at Louie as he flees. Ghost Dog dies from his wounds, lying on the asphalt. Raymond weeps while Pearline watches Louie leave; Louie gets into a car with Vargo's daughter (who now has replaced her father as his boss). Later, Pearline reads the Hagakure.