In 2007, " environmentalist " Lucy Mirando becomes CEO of the Mirando Corporation, succeeding her twin sister Nancy. Announcing they have been breeding a special kind of "super pig", 26 specimens are sent to farmers around the world. In about 10 years from now, one will be crowned the winner as the best super pig. In 2017, a teenage girl named Mija lives in the South Korean mountains with her grandfather and their super pig Okja. Mija and Okja have a very close relationship as they spend much of their time together. At one point, Okja saves Mija from falling off a cliff. They are visited by Mirando spokesperson and zoologist Dr. Johnny Wilcox, who declares Okja the best super pig, and announces that they will take her to New York City. Her grandfather gives Mija a solid gold pig figurine, explaining he saved up to replace Okja when she was taken away. Devastated, Mija goes to Seoul to find Okja, where she sees her being loaded onto a truck. Mija chases down the truck, but it is intercepted by the Animal Liberation Front. In the resulting chaos, Mija and Okja run away and are eventually saved by the ALF led by Jay. The truck driver Kim Woo-shik resigns from his job. Jay asks another ALF member K to translate and tell Mija that they plan to put a recording device in Okja's ear and let her be recaptured by the Mirando Corporation to document how they mistreat animals. Mija asks them to return her to the mountains, but K purposely mistranslates and tells them Mija agrees. They leave and Okja is recaptured. To minimize PR damage to the company, Lucy pays for Mija to come to New York to stage a heart-warming reunion with her pig. Okja is taken to a laboratory where she is forcibly bred with another super pig and flesh is taken from her for a taste test. After the ALF sees the footage, K reveals that he lied to the rest of the group about Mija's support of the plan. Jay beats up K and expels him from the ALF while promising to return his equipment when they are done with it. In New York, Mija has to comply with the Mirando Corp. Jay slips into her room and tells her they plan to rescue Okja while on stage. During the Mirando parade, a battered and temporarily blinded Okja attacks Mija. Jay tries to hurt Okja to protect the girl, but Mija doesn't let him and calms Okja down. The ALF shows Okja's mistreatment to the public, who quickly turn against Mirando. Lucy surrenders Mirando back to Nancy who contacts the private security firm Black Chalk to take out the ALF members. Okja is recaptured and the ALF members are arrested except for Mija and Jay who are rescued by a remorseful K. Nancy starts full production at the slaughterhouse. K, Mija, and Jay travel to a processing plant in search of Okja and find her being forced up a ramp into a slaughterhouse. On the verge of being slaughtered, Mija shows a Mirando employee a photo of herself with baby Okja, prompting him to stop. Nancy arrives and Mija offers the gold pig in exchange for Okja's life. Although initially reluctant, Nancy agrees as she deemed it a good business deal, having Jay and K arrested by Black Chalk. As Mija and Okja are escorted away, a pair of super pigs push their newborn through the electric fence to Okja to hide and rescue from the farm. Back in the countryside, Mija resumes her life with her grandfather, Okja, and the new piglet. She then joins her grandfather for dinner as Okja looks on. In a post-credits scene, Jay is released from prison, boarding a bus with K and the other released members of the ALF. With their newest member Kim Woo-shik, who was revealed to have started mirandoisfucked.com, they plan to disrupt a major Mirando shareholders meeting as more new recruits are revealed.

Centuries ago in the Middle East, the Brotherhood of Sleep—a secret order of the Catholic Church—discovered a massive cylinder containing a swirling green liquid. Hidden even from the Vatican, the relic was eventually moved to Los Angeles and guarded in secrecy. In the present day, the last surviving member of the order dies before warning the cardinal that "the sleeper awakens." A Catholic priest sent to examine his belongings recovers a key that leads him to the cylinder, concealed beneath Saint Goddard's monastery. The priest enlists quantum physicist Professor Howard Birack to analyze the cylinder. Birack brings along his students: wise-cracking Walter Fong, demure Kelly, the highly-strung Susan Cabot, laid-back Mullins, and lovers Brian Marsh and Catherine Danforth, as well as scientists Calder, Lisa, Etchinson, Lomax, Wyndham, and Dr. Paul Leahy. The priest explains that the liquid's influence is growing and begs Birack to provide scientific proof of its nature to the public before it escapes. Soon after the team arrives, the monastery becomes encircled by increasingly hostile homeless people. Their analysis reveals that the cylinder is at least seven million years old, can only be opened from within, and contains a substance that is prebiotic yet evolving with intent, instead of decaying. Translating the Brotherhood's ancient texts, Catherine finds references to advanced mathematics predating their known discovery, while Lisa uncovers claims that the cylinder holds Satan, the son of an ancient god who was banished to the dark side. The texts describe Jesus Christ as an extraterrestrial who tried to warn humanity of the cylinder's threat but was executed by those who deemed him insane and too powerful. Birack theorizes that Satan's father may be the Anti-God, an even more powerful being trapped in a parallel realm of anti-matter. The liquid begins to exert its influence beyond its container, spraying into Susan's mouth and possessing her. She in turn infects or kills other members of the team, while anyone who tries to leave is slaughtered by the enthralled homeless. The survivors realize that, since their arrival, they have experienced a shared dream of a shadowy figure emerging from the monastery. Brian surmises that the dreams are a warning sent from the future using tachyons. Meanwhile, the remaining liquid enters Kelly, transforming her into a monstrous vessel for Satan. Displaying telekinesis and rapid regeneration, Satan attempts to free the Anti-God by reaching through a handheld mirror, but it is too small and the effort fails. The possessed attack the survivors, while Satan locates a larger mirror, and reaches through, clasping the Anti-God's clawed hand. The priest attacks with an axe, but Satan instantly regenerates and resumes the summoning. Realizing the danger, Catherine tackles Satan into the portal, sacrificing herself. The priest shatters the mirror, sealing Satan, the Anti-God, and, to Brian's horror, Catherine on the other side. Instantly, the possessed die as the liquid evaporates, and the homeless disperse. Brian, Walter, Birack, and the priest are rescued as emergency crews arrive. Later, Brian dreams once more, this time seeing Catherine as the dark figure emerging from the church. He awakens to find her disfigured body beside him, only to realize it was another nightmare. Shaken, he approaches his mirror, hesitantly reaching out toward its surface.

One night while leaving a business party in the Hollywood Hills, corporate raider Edward Lewis takes his lawyer Philip's Lotus Esprit and finds himself in the red-light district on Hollywood Boulevard, where he meets street walker Vivian Ward. Lost and struggling to operate the stickshift car, Edward accepts Vivian's offer to drive him to the Regent Beverly Wilshire Hotel. Impulsively, he hires her for the whole night, and despite initial awkwardness, they have sex in his penthouse suite. The following day, Edward asks Vivian to stay for the week, as he must attend a series of business events while attempting to acquire Jim Morse's shipbuilding company. After negotiating, Edward and Vivian agree on $3,000. He also gives her money to buy appropriate clothes. When Vivian tries to shop on Rodeo Drive, snobbish and rude saleswomen turn her away because of the way she looks. She asks hotel manager Barney for assistance. He gets store saleslady Bridget to find her a cocktail dress for that evening's business dinner. Later, she gets Barney to teach her table etiquette. Edward is astounded by Vivian's transformation. At dinner, he introduces Vivian to Morse and his grandson David, who is to take over the company. The dinner does not go well, as they are unhappy with Edward's plan to dismantle their company. Later, Edward tells Vivian about his personal and business life, including his estranged relationship with his late father. Edward takes Vivian along as his date to a polo match. When Philip sees Vivian talking to David Morse, he tells Edward his suspicions that she is a corporate spy. Edward dismisses Philip's concerns by explaining their arrangement. With the knowledge of Vivian's true background, the married Philip talks to her alone and crudely propositions her for her services. Back in Edward's suite, Vivian is angry with Edward for exposing her in that way. He apologizes, admitting that he was jealous of Vivian talking to David. Edward takes Vivian by private jet to see La traviata at the San Francisco Opera, a story about a prostitute who falls in love with a wealthy man. She is moved, and she breaks her "no kissing" rule before having sex with him. Believing Edward has fallen asleep, Vivian says she loves him. As the week is almost finished, Edward offers to get Vivian a condominium and an allowance, promising to visit her regularly. However, Vivian feels he is treating her like a prostitute. She shares her childhood fantasy of being rescued by a knight on a white steed. Edward meets with Morse, but chooses to work with him to save his company instead of dismantling it. Philip, furious that Edward's new direction has cost him a fortune, goes to the Beverly Wilshire to confront him. He finds Vivian. Blaming her for Edward's changes and angry at his business decision, Philip hits her and attempts to rape her. Edward arrives, pulls Philip off Vivian, punches him, and fires him. After completing his business in Los Angeles, Edward asks Vivian to stay with him for one more night, but only if she wants to, not because he is paying her. She gently refuses and leaves after telling him she thinks he has "lots of special gifts". Vivian returns to her apartment hotel to pack for her move to San Francisco to get a new job and a high-school diploma. She gives her roommate, fellow prostitute Kit De Luca, some money and tells her she has "a lot of potential". Kit leaves sex work and enrolls in beauty classes. Vivian then waits in the apartment for the bus. Edward has the chauffeur take him to her apartment. He climbs out of the white limousine's sunroof and ascends the fire escape to "rescue" Vivian, just like the knight in her childhood fantasy. When he asks her what happens after the knight rescues her, she responds, "She rescues him right back", and kisses him.

A young Butch Coolidge is visited by Captain Koons, an Air Force pilot. Koons reveals a gold watch to Butch and explains that the watch is a family heirloom and belonged to Butch's father, who served with Koons and died in a POW camp in the Vietnam War. Koons continues the tradition by giving the watch to Butch. In Los Angeles, two hitmen, Jules Winnfield and Vincent Vega, drive to an apartment to retrieve a briefcase from Brett, a dishonest business partner for their boss, gangster Marsellus Wallace. Vincent mentions that Marsellus has instructed him to take his wife, Mia, to dinner the following night. At the apartment, they find Brett, Roger and an informant for Marsellus, Marvin. When Brett attempts to appease the two hitmen, Jules casually shoots Roger. He then recites a paraphrased passage from the Book of Ezekiel before he and Vincent kill Brett. Another man bursts out of the bathroom and fires at them, but misses. Jules and Vincent kill him and leave with the briefcase and Marvin. While Jules is driving, Vincent accidentally shoots Marvin in the head, covering them in blood. They hide the car at the home of Jules' friend Jimmie, who demands they dispose of Marvin's corpse and the blood-stained car before his wife, Bonnie, comes home. Marsellus sends a cleaner, Winston Wolfe, who directs Jules and Vincent to hide the body in the trunk, clean the car, dispose of their bloody clothes and take the car to a junkyard. Afterwards, Jules and Vincent eat breakfast at a diner. Jules tells Vincent that he plans to retire from his life of crime, convinced that their survival at the apartment was divine intervention. While Vincent is in the bathroom, a pair of thieves, Pumpkin and Honey Bunny, hold up the diner and demand Marsellus' briefcase from Jules. Jules overpowers Pumpkin and holds him at gunpoint, making Honey Bunny hysterical. She points her gun at Jules; Vincent returns and points his gun at her. Jules defuses the situation, allowing the two to keep the money from only his wallet and letting them leave. Jules and Vincent meet Marsellus at a bar, where Marsellus is bribing an aging Butch to intentionally lose in his upcoming boxing match. The following night, Vincent purchases heroin from his drug dealer, Lance. He shoots up and drives to meet Mia at her house. They eat at a 1950s-themed restaurant and participate in a twist contest, then return home. While Vincent is in the bathroom, Mia finds his heroin, mistakes it for cocaine, and snorts it. She passes out from an overdose, and Vincent rushes her to Lance's house, where they revive her by injecting her heart with adrenaline. Vincent and Mia agree never to tell Marsellus about the incident. Butch double-crosses Marsellus by killing his opponent. He plans to flee with his girlfriend, Fabienne, but discovers that she has forgotten to pack the gold watch. Returning to his apartment to retrieve it, he notices a gun on the kitchen counter and hears the toilet flush. Vincent, who has been staking out Butch's apartment, emerges from the bathroom. Butch kills him with the gun and leaves. While returning to the motel, he sees Marsellus crossing the road. Marsellus chases Butch into a pawnshop. Maynard, the shop owner, captures them at gunpoint and gags them in the basement. Maynard and his accomplice, Zed, take Marsellus into another room and rape him. Butch breaks free and kills Maynard with a katana, freeing Marsellus who incapacitates Zed. Marsellus instructs Butch to tell no one about the incident and leave Los Angeles forever while he himself intends to "get medieval" on Zed. Butch picks up Fabienne on Zed's motorcycle.

Robert, a brilliant mathematician who used to work at the University of Chicago, startles his daughter Catherine while she watches TV. He gives her a bottle of champagne for her birthday, and they chat. All of this turns out to be a dream; Robert died the previous week, after a long period of crippling mental illness, and his funeral is tomorrow. Meanwhile, Hal, a former graduate student of Robert's, is reading through the latter's notebooks, which are filled with meaningless notes. Hal believes that Robert's genius may have withstood his mental illness, and clues to that genius might lie in one of his notebooks. When Hal comments on the vast amount of work Robert did, a suspicious Catherine searches Hal's backpack. A notebook eventually falls out of his coat. He explains that he wanted to give the notebook as a birthday present because it "had something written in it about her". Hal is forced to leave, giving the notebook as intended, when Catherine calls the police. The next day, Catherine's sister, New Yorker Claire, arrives in town. At the funeral, Catherine berates the many attendees for not being there for Robert during his descent into insanity. She ends by saying that she is glad her father died and leaves mid-funeral. Claire decides to sell Robert's house back to the university and wants Catherine to come with her to New York. A wake held at the house the night is attended by academic mathematicians. Hal appears and chats up Catherine. Softening up to Hal, Catherine has emotional sex with him. In flashbacks, Robert is shown invigorated, believing that he has seen the beginnings of a new mathematical proof that will prove his triumph over mental illness. In the present, Catherine gives Hal a key to Robert's desk and tells him to check the locked drawer for a notebook which contains an important proof. Excited, he shows the discovery to Catherine and Claire. He asks how long Catherine knew about this and why she did not mention it. Catherine, a promising mathematician herself, says that she wrote it and not Robert, despite evidence to the contrary. Neither Hal nor Claire believe Catherine. Hal believes that the proof's mathematics are beyond Catherine, while Claire suspects that Catherine is suffering the onset of mental illness. Hal decides to take the notebook to the math department to verify the proof's accuracy. He eventually returns as Claire and Catherine are leaving, with news that the math department believes the proof to be valid. Hal does not think that Robert wrote the proof because it employs newer mathematics and wants Catherine to explain it. Catherine remains stung by his earlier lack of trust, and the sisters leave for the airport. Hal sprints after the car and throws the book through the window and onto Catherine's lap. In another flashback, it is revealed that, while living together, Robert challenged Catherine to work on math, which she does, ultimately completing a proof, which she describes in one of the house's notebooks. Catherine goes to tell Robert about the breakthrough, but he insists that she read aloud the proof that he is working on. To Catherine's disappointment, Robert's notebook contains only ramblings. Reading his work, Catherine realizes that Robert has not overcome his mental illness. Catherine has begun to come to terms with herself, aided by Hal's confidence in her. She decides that she does not need to go with her sister to New York and leaves the airport. She returns to the University of Chicago, where she and Hal meet up and discuss the proof.

Three young men arrive at a borstal by prison van: Carlin, who has taken the blame for his brother's theft of scrap metal; Angel for stealing a car; and Davis for escaping from an open institution. Each is allocated a room; Angel and Davis get single rooms, while Carlin is sent to a dormitory. Carlin, having been transferred for assaulting a warden, wants to keep a low profile. He meets and befriends Archer, an eccentric and intellectual inmate serving two years for workplace fraud who is intent upon peacefully inconveniencing the staff as much as possible through nonviolent resistance. Archer tells Carlin how his reputation is already known: Banks, the current "Daddy" (the inmate who controls the wing), is seeking Carlin for a fight to maintain his dominance over the wing. Banks's status appears to have been achieved by petty bullying and intimidation with the aid of his henchmen Richards and Eckersley and the passive assent of the staff. Carlin struggles to settle into the dormitory and, after witnessing the timid and vulnerable Davis hazed and attacked by Banks, is himself viciously beaten and headbutted by Banks in an unprovoked attack. Angel is brutally beaten up by Banks and Richards in his room. Davis is framed for theft of a radio by Eckersley and placed on report. Soon sentenced to arrest, the three newcomers find themselves in solitary confinement. Realising there is no hope of being allowed to serve his term as a borstal trainee in peace, Carlin exacts revenge and establishes dominance. Walking through the association (rec) room, he picks up two snooker balls and puts them in a sock. Using this improvised cosh on Richards, Carlin orders Eckersley to desist from informing, then goes to find Banks. Surprising him in a washroom he gives Banks a severe beating and then tells him who the "Daddy" of the wing now is: one who will 'kill him' if Banks ever interferes with his wellbeing. This ambush required cooperation and information from other inmates, showing how Carlin has soon won both respect and amity. Several days later, Carlin is challenged by an adjacent wing's Daddy whom he viciously beats but allows to continue to manage his wing under Carlin's overall control. Things improve for the inmates under Carlin, with victimisation of younger, weaker prisoners prevented, along with racially motivated violence. He keeps to the same seat at table in the dining hall, to where information and requests are directed, and with his associates such as Archer, Betts, Rhodes and Meakin – a contrast to Banks and his bullies. Carlin's status is recognised by the warders: he requests and gets a single cell in return for agreeing to be a responsible "natural leader" to the housemaster Mr Goodyear. Meanwhile, Meakin's friend Toyne learns through a letter from his in-laws that his wife has died. He becomes severely depressed, his despair being noticed by the warders, who scold him for "moping". Toyne slashes the arteries in his arms. He is transferred to an adult prison where, Meakin is informed by Dougan that he died after a second suicide attempt. Meakin is outraged by this and berates the staff for their negligence before storming out of the meeting. Dougan and Meakin are sent to solitary confinement whilst Carlin is instructed by Mr. Goodyear to keep the inmates under control, but while working alone in a greenhouse, Davis is gang-raped by three opportunistic youths who had requested a smoking break. Their supervising warder Sands sees what happens but reacts with a grin and then ignores the dishevelled state of the semi-undressed trio as they return. That night, a distraught Davis kills himself with a razor blade. While bleeding to death, he presses the button in his cell for help, but is ignored by warden Greaves. Davis's suicide is the last straw for the Borstal inmates. In the dining hall, having collected their food, the inmates sit silently, refusing to eat. Carlin initiates a full-scale riot in the dinner hall. Carlin, Archer and Meakin are later shown being dragged, bleeding and unconscious, into solitary confinement after having been beaten by the wardens. The Borstal's Governor later informs them the damage to the dinner hall will be repaid through lost earnings. The Governor then declares a minute's silent prayer for Davis.

In 1980, ex-convict Cuban refugee Tony Montana arrives in Miami as part of the Mariel boatlift with his friend Manny Ribera and their companions, Angel and Chi-Chi. Miami drug lord Frank Lopez arranges green cards for them in exchange for murdering a former henchman of Fidel Castro. Dissatisfied with their jobs as restaurant dishwashers, Tony and Manny meet with Frank's right-hand man, Omar Suarez, who sends the four to purchase cocaine from Colombian dealers. Tony and Angel are taken at gunpoint; Tony is made to watch as Angel is slaughtered with a chainsaw, before Manny and Chi-Chi rescue him. They kill the dealers and deliver the drugs and money to Frank in person, suspecting Omar set them up. Tony and Manny begin working for Frank while Tony is attracted to Frank's trophy wife, Elvira Hancock. Tony visits his mother, and sister Gina. Tony gives his mother $1,000, claiming he earns money as a political organizer. Tony's mother is angered by his lie, berates Tony for his criminal lifestyle and kicks him out. Gina, however, keeps the money. Tony warns Manny to stay away from Gina. Frank sends Tony and Omar to Bolivia to meet cocaine kingpin Alejandro Sosa. Omar is angered when Tony seeks to negotiate a large deal without Frank's approval. Sosa sends Omar off but keeps Tony behind to watch his men hang Omar from a helicopter, and tells Tony that Omar is a police informant and that Frank has poor judgment for trusting him. Tony says he never trusted Omar. Sosa takes a liking to Tony for his integrity and agrees to the deal, but not before delivering Tony a stern warning to never double-cross him. Back in Miami, Frank is furious at Tony for his unauthorized deal with Sosa and Omar's demise. Severing business ties with Frank, Tony sets up his own cocaine operation and continues flirting with Elvira, further infuriating Frank. Mel Bernstein, a corrupt detective on Frank's payroll, attempts to extort Tony for police protection. Tony confronts Gina, who's making out with a man in a club bathroom. At the club, hitmen seek to assassinate Tony, who escapes with minor wounds. He later confronts Frank and Bernstein about the attack, forcing Frank to confess. Tony has Manny kill Frank before killing Bernstein. Tony then takes complete control of Frank's drug operation and assets, making everything his own, and assembles the Montana Cartel. He marries Elvira and becomes the distributor of Sosa's cocaine. This makes Tony one of the most powerful drug lords in Miami, overseeing his rapidly growing drug empire and cartel in a large, heavily guarded estate. In 1983, a sting operation by federal agents sees Tony charged with tax evasion and facing prison time. Sosa offers to keep Tony out of prison via his government connections if Tony kills a journalist about to expose Sosa. During a restaurant dinner a drunken Tony blames Manny for his arrest and calls Elvira an infertile junkie, prompting Elvira to call out his criminality to the other patrons and leave him. Sosa's henchman, Alberto, puts a radio-controlled bomb under the journalist's car, but Tony tries to cancel the hit upon seeing the journalist is accompanied by his wife and children. Alberto refuses and Tony kills him before he can detonate the bomb. A furious Sosa vows revenge for Tony allowing the journalist to deliver the exposé. At his mother's behest, Tony, high on cocaine, tracks down Gina and finds her with Manny. Tony shoots Manny dead before learning Gina has just married him. Tony takes Gina to his estate and begins a cocaine binge in his office. Gina accuses him of wanting her for himself. She shoots and wounds him, and is killed by one of Sosa's men whom Tony kills in return. Sosa's men invade the grounds and kill Tony's guards, including Chi-Chi, as Tony takes a rifle with a grenade launcher to the invaders, killing many, but suffering gunshot wounds. He taunts his attackers until an assassin shoots him in the back with a shotgun. Tony's body falls from the balcony into the pool, near the base of a globe with the motto "The World Is Yours".

Nerdy freshmen Lewis Skolnick and Gilbert Lowe enroll at Adams College in Tucson to study computer science, meet women, and become adults. The jock Alpha Beta fraternity, led by star quarterback Stan Gable, accidentally burns down its house and, with Coach Harris's support, violently takes over the freshman dormitory as a replacement, forcing Lewis, Gilbert, and the other new students to live in the gym. While many students are taken in by fraternities, Stan's girlfriend, Betty Childs, tricks Lewis and Gilbert into pledging Alpha Beta, leading to their hazing and humiliation. Despite this, Lewis becomes attracted to Betty, while Gilbert grows close to fellow nerd Judy. Out of options, Lewis, Gilbert, and their fellow nerds—including shy genius Arnold Poindexter, child prodigy Harold Wormser, lewd misfit Dudley "Booger" Dawson, flamboyant Lamar Latrelle, and quiet outsider Toshiro Takashi—rent and renovate a dilapidated house near campus. They attempt to form their own fraternity but are rejected by the college's Greek Council, presided over by Stan, because they lack backing from a national fraternity. After being turned down by numerous fraternities because of their nerd status, they are finally, and reluctantly, accepted on probationary status by the Black fraternity Lambda Lambda Lambda (the Tri-Lambs), led by U.N. Jefferson. Learning that the nerds are planning a party to impress Jefferson, Stan has Betty and her Pi Delta Pi sorority sisters trick them into thinking they will attend, only to abandon them. Desperate, Judy invites her own Omega Mu sorority—made up of nerdy women—to attend instead. The party is initially dull, as most attendees are shy, until Booger brings cannabis, which leads to dancing, fun, and hookups. The Alpha Betas and Pi Delta Pi then sabotage the party by releasing pigs into the house. Although disheartened, the nerds retaliate by installing surveillance cameras to spy on the naked Pi Delta Pis and by pouring liquid heat into the Alpha Betas' jockstraps. Impressed that the nerds have stood up for themselves, Jefferson grants them full membership. However, Alpha Beta's harassment continues, and Stan blocks any attempt by the Greek Council to sanction them. The nerds conclude that the only way to gain justice is to replace Stan as Council president by winning the Homecoming carnival. Partnering with the Omega Mus, they use ingenuity and technical skills to compensate for their lack of athletic ability in competitions against the Alpha Betas and Pi Delta Pis. At the charity fundraiser, the nerds outsell the Alpha Betas by selling pies containing nude photos of Betty and other Pi Delta Pis. Lewis, having fallen in love with Betty, steals Stan's mask and costume and seduces her, believing he is Stan. When the truth emerges, Betty—impressed by Lewis's physical attentiveness—has a change of heart and falls for him. The nerds then dominate the musical competition with a technology-themed electronic performance, securing overall victory, after which Lewis nominates Gilbert as the new Greek Council president. Enraged at losing to the nerds, Coach Harris berates the Alpha Betas, and Stan leads them in vandalizing the Tri-Lamb house. The nerds are left despondent until Gilbert interrupts the Homecoming pep rally to protest their treatment. The Alpha Betas attempt to stop him, but Jefferson arrives with a large group of national Tri-Lamb members, intimidating them and allowing Gilbert to deliver a speech on embracing differences and standing up to prejudice. Lewis, the other Tri-Lambs, alumni, Judy, and Betty join in supporting him, publicly shaming the Alpha Betas. An emboldened Dean Ulich then orders that the Tri-Lambs move into the Alpha Beta house, while the Alpha Betas must live in the gym until they repair the damage to the Tri-Lamb house.

In 1991, Maksymilian "Max" Paradys and Albert Starski volunteer themselves for the first human hibernation experiment, created by professor Wiktor Kuppelweiser. Instead of being awakened 3 years later in 1994 as planned, they wake in the year 2044, in a post-nuclear world. They think they are in a clinic being taken care of by women; Max becomes attracted to Lamia Reno. After asking for professor Kuppelweiser, they are informed that he "doesn't exist", and that there was a war long ago and that males have long been extinct. The men are under constant surveillance; Lamia informs them their society reproduces without males through parthenogenesis. During a briefing, Max kisses Lamia, for which she knocks him down and threatens both men with euthanasia. However, the kiss causes Lamia's drug-inhibited passions to resurface. She finds the oldest living woman Julia Novack, who tells Lamia that the old world with two sexes should be restored. After several days, Max and Albert are permitted to go out to meet with Her Excellency, the supreme ruler of women. Waiting for her in the bio-sanctuary, they spot a tree with two tiny apples and eat them, having had enough of synthetic food. At the meeting they ask what womankind did to mankind. The women reply the extinction of men is not their fault, but Kuppelweiser's, who, during the war, invented an agent which was supposed to temporarily paralyze male genes, but instead destroyed male genes permanently. Max proposes he and Albert serve as reproducers to restore the male population. However, the women do not wish the old order to return; Her Excellency gestures to the "sacred apple tree " and says it was planted by Arch Mother, and from which, when once in paradise, a male took an apple and seduced a woman with it, by which act paradise was lost. Noticing the missing apples, Her Excellency becomes enraged and demands the men be confined again. Max and Albert escape by damaging the electric power grid, but are ultimately caught. The women provide them to submit themselves for "naturalization" - undergoing a sex reassignment surgery. When they refuse, the ceiling above the room reveals an assembly of women to determine their fate. In a trial, the women blame males for oppression, evil and vices, and praise their new society. They engage in historical revisionism by claiming that scientists such as Copernicus, Einstein and Pincus were women. When Max and Albert are taken away, the assembly votes on whether the men should undergo forced 'naturalization' or be 'liquidated'. Naturalization is passed by one vote. The men escape again, and encounter other women who have never seen a man. They are cornered by the security team and escape down a waste chute. They discover the nest of "decadency" - one of the anarchist, " hippie " women's groups, who do not wish to be part of the oppressive regime, playing loud music, and some engaging in lesbian relations. They mistake Max and Albert for government spies and, in the meantime, the pursuing regime forces attack, and subsequent chaos provides the men with an opportunity to escape. During their escape, the men stumble upon Lamia, who provides them with a way to see the outside - a periscope - and reveals that they live deep underground in expanded old mines. The periscope shows a dark, rocky landscape above ground, and sensors indicate high levels of "Kuppelweiser radiation ", a side effect of the M bomb. However, it transpires that Lamia's "help" was a ruse to capture the men and force them into surgery. Lamia is congratulated by Tekla and Emma Dax, but they also inform her that their section will now be in charge of the males, which devastates Lamia. In the hands of Tekla, the fate of the males is to be different. Their organs will be extracted for transplantation, and their remains will be tested as a food source due to a protein shortage. The chief surgeon, Dr Yanda, an old lady, is revealed to be Max's daughter, who now delights in taking revenge for his abandonment of his wife and child in favor of hibernation for profit. Lamia sabotages the surgery and helps the men escape as revenge for Tekla and Dax taking the men and her research. In the periscope room Lamia tells the guards she will blast the whole block if they do not give her the code activating a capsule reaching the surface, while Max and Albert find and change into protective suits. The guards claim that only Her Excellency knows the password required; enraged, Max shouts "kurwa mać!" (a popular Polish profanity as versatile as " fuck " in English, lit. " mother's a whore"), and the capsule is activated. Exploring the barren surface, Max bumps against an invisible barrier and is unable to go further. He cuts the fabric of the barrier, revealing a dazzling light. They all go through the hole and find themselves on a beach, the periscope area surrounded by a small tent-like structure with the barren landscape panorama painted on the inside of the canvas. They reach a forest, but the suits are running out of oxygen. Max points skyward to a flying stork and declares "if it can live, it means we can live too". After removing the suits, they come across a villa with food. While eating in the garden, they are found by Emma; armed with a harpoon, she demands their surrender, but she faints from lack of oxygen. Albert performs CPR on her. When she regains consciousness, Emma begins to fight with Albert; on the TV they see an official government broadcast of events, stating that Lamia and Emma are dead and including an interview with "naturalized" Max and Albert, who claim to be feeling well. Emma is shocked, unable to understand such lies and all the strange environment "with too much air". Max goes with Lamia to a bedroom and tries to explain to her what mating is, while Albert tries his luck with Emma. In the living room, Her Excellency emerges from the elevator hidden within a closet to feed her caged birds. When she opens the wardrobe, she is attacked by Max who was hiding inside. Her Excellency's breasts and hair are stripped, revealing that 'she' is a male in disguise. 'Her' Excellency tells the men that after the war, when the League of Women took power, the few boys remaining were naturalized into girls, but he was hidden by his mother. Growing up in a female disguise, he joined the League and was eventually elected 'Her Excellency'. He was too afraid of women to form a relationship with any and, by revealing himself, to try to restore the old order. The government has been exaggerating the radiation level to keep the inhabitants easier to control; likewise, the inhabitants are medicated to remove sexual desire. The three make a deal: Max and Albert will not compromise 'Her' Excellency's true identity, but they will stay in his home with Lamia and Emma. Later, Max and Albert, disguised as laboratory workers, add male gametes to flasks in the incubation centre. Months later, a nurse, routinely wrapping newborns in blankets, is horrified to see a penis.

Members of the Lambda Lambda Lambda (Tri-Lambs) fraternity of Adams College—proud nerd Lewis Skolnick, shy genius Arnold Poindexter, child prodigy Harold Wormser, lewd misfit Dudley "Booger" Dawson, and flamboyant Lamar Latrelle—travel to the United Fraternity national convention in Fort Lauderdale, Florida. Upon arriving at the luxurious Royal Flamingo Hotel, the Tri-Lambs discover that their reserved rooms have been reassigned to members of the national Alpha Beta fraternity by the acting manager, Buzz, who does not want nerds staying at his hotel. The receptionist, Sunny Carstairs, unsuccessfully attempts to persuade him to reconsider. Poindexter secures alternative accommodations at the Hotel Coral Essex, but the group soon discovers it is a dilapidated property in a rough neighborhood. Meanwhile, the Alpha Betas—led by local president Roger Latimer and joined by Ogre from Adams College—plot to drive the Tri-Lambs from the conference. Roger gives the Tri-Lambs incorrect directions to a pre-conference barbecue, leading them into a trap in which they believe they are surrounded by a tribe of Seminole Indians conducting a ritualistic killing. The disguised Alpha Betas force the Tri-Lambs to strip to their underwear before chasing them away, humiliating them publicly. Despite this, the Tri-Lambs refuse to withdraw from the convention and confront Buzz and the Alpha Betas after Buzz fires the hotel bellboy, Stewart, for objecting to his sexual harassment of Sunny. In retaliation, Roger proposes "Proposition 15", a bylaw requiring fraternities to meet both academic and physical standards, effectively targeting the intellectually gifted but physically unimposing Tri-Lambs. Determined to fight back, the Tri-Lambs host a party at the Coral Essex and perform a musical number opposing the measure, winning over the delegates and defeating the proposal. Roger then feigns reconciliation, offering to introduce a new bylaw stating that any fraternity found guilty of criminal conduct will be expelled from the conference and have its charter revoked. Trusting Roger's apparent goodwill, the Tri-Lambs accept an invitation to stay in a luxury suite at the Royal Flamingo. Roger subsequently arranges for Sunny and two other women to take the Tri-Lambs to the beach in his car. After Sunny and Lewis grow closer, Roger's women persuade the Tri-Lambs to borrow Roger's car to buy beer, unaware that Roger has reported it stolen. The Tri-Lambs are arrested. Sunny and Stewart bail them out of jail. Disillusioned and convinced that Sunny was complicit, Lewis announces his intention to abandon the conference. The Alpha Betas then kidnap the Tri-Lambs, Sunny, and Stewart, abandoning the men on an uninhabited island; disgusted by Roger's actions, Sunny chooses to stay with the Tri-Lambs. Fearing Ogre may boast about the scheme, the Alpha Betas throw him overboard as well, despite him being unable to swim, but Wormser rescues him. After sharing marijuana, the Tri-Lambs and Ogre realize they have more in common than they thought. That night, Lewis dreams of his friend Gilbert Lowe, who encourages him not to give up and to reconsider his mistrust of Sunny. The next morning, Lewis apologizes to Sunny and inspires the group to escape the island. They discover a hidden cache of military equipment, including an amphibious vehicle. As Roger presides over a vote to expel the Tri-Lambs, they dramatically crash the conference, driving the amphibious vehicle through the wall before plunging into the hotel pool. Sunny exposes Roger's plot to the delegates, and Lewis punches Roger into the water. The crowd cheers before Lewis and Sunny kiss. Back at Adams College, Lewis and Gilbert preside over an induction ceremony welcoming Ogre as the newest member of Lambda Lambda Lambda.

During a commencement gala at the newly opened Los Angeles headquarters of Nakamoto, a Japanese keiretsu, a call girl, Cheryl Lynn Austin, is strangled while having rough sex on the boardroom table. LAPD Lieutenant Webster "Web" Smith and John Connor, a former police captain and expert on Japanese affairs, are sent to act as liaison between the Japanese executives and the investigating officer, Smith's former partner Tom Graham. During the initial investigation, Connor and Smith review surveillance camera footage, and realize that one of the discs is missing. Smith and Connor suspect Eddie Sakamura, Cheryl's boyfriend and agent of a Nakamoto rival, of killing her, and interrogate him at a house party. Sakamura promises to bring Connor something, and Connor reluctantly lets him go after confiscating his passport. Ishihara, a Nakamoto employee whom Connor had previously interrogated, delivers the missing disc, which clearly shows Sakamura having sex with Cheryl and strangling her. Graham and Smith lead a SWAT raid on Sakamura's house. He tries to flee in a Vector W8 sports car, but crashes and is killed. Smith learns that Sakamura had attempted to contact him about the missing disc, so he and Connor take the disc to an expert, Jingo Asakuma, who reveals that the disc has been digitally altered to implicate Sakamura. Nakamoto is in the midst of sensitive negotiations for the acquisition of an American semiconductor company, with Senator John Morton, a guest at the party, abruptly changing his stance on a bill that would prevent the merger from going through. Suspecting his sudden shift is somehow related to the murder, Connor and Smith attempt to interview him at his campaign office, but without success. Upon returning to Smith's apartment, the duo find Sakamura alive and well. He reveals that he was being tailed that day by Tanaka, a Nakamoto security agent attempting to locate the original disc. Not wanting to be seen with Sakamura, Tanaka stole his sports car and committed suicide by crashing it. Sakamura gives Connor the original disc, but before he can leave, Lt. Graham arrives with Ishihara. Sakamura is killed fighting off Ishihara's men, and Smith is shot and left for dead, surviving only thanks to a bulletproof vest. After being interrogated, Smith is put on paid leave due to an ongoing investigation of an earlier corruption charge. Regrouping with Connor and Jingo, the three view the original surveillance footage, which shows Senator Morton having sex with Cheryl and performing erotic asphyxiation on her. Falsely believing he killed her, Morton changes his position on the regulation bill to stay in Nakamoto's good graces. After leaving the boardroom, the footage shows another figure approaching and killing Cheryl by strangulation. Hoping to draw the killer out, Connor and Smith fax Morton stills of the footage showing his involvement in the murder. Morton contacts Ishihara, revealing the executive to be in on the cover-up, and then Morton commits suicide. Connor, Smith, and Jingo interrupt the merger negotiations to show Nakamoto President Yoshida the surveillance footage. Bob Richmond, an American lawyer working for Nakamoto, reveals that he is the real killer and tries to run away, only to be killed by Eddie Sakamura's yakuza friends. Yoshida maintains his and his colleagues' innocence, quietly exiling Ishihara to a desk job back in Japan. Smith drives Jingo home, where she casts doubt on whether Richmond was really the murderer, or if he was simply taking the fall to protect someone higher up in the company.

At a bistro in Montmartre, IRA operative Deirdre meets with two Americans, Sam and Larry, and a Frenchman, Vincent. She takes them to a warehouse where Englishman Spence and German Gregor are waiting. Conversations among the men reveal that they are former government and military agents who have become mercenaries. Deirdre briefs the group on their mission: to attack a heavily armed convoy and steal a large, metallic briefcase, whose content is never revealed. The team's first preparation task is to acquire firearms, which turns into an ambush; the team survives and gets the weapons. Deirdre meets with her handler, Seamus O'Rourke, who tells her that the Russian mafia is bidding on the briefcase and that the team must intervene to prevent them from winning. Spence is exposed as a fraud by Sam; he is dismissed by Deirdre, and the others continue their mission. Deirdre's team successfully ambushes the convoy at Villefranche-sur-Mer and pursues the survivors to Nice. During the gunfight, Gregor steals the case and replaces it with explosives in an attempt to sabotage the others. He attempts selling it to the Russians, but his contact betrays him; Gregor kills the contact and has Mikhi – the Russian mobster in charge of the deal – agree to another meeting. The team tracks Gregor through one of Sam's old contacts and corners him in the Arles Amphitheatre during his meeting with two of Mikhi's men. Sam chases Gregor, who flees but is caught by Seamus. Deirdre and Vincent confront the two Russian hoods, prompting a shootout. Sam arrives to help, killing one, but is injured by a ricochet from the other. Seamus kills Larry and escapes with a reluctant Deirdre and the captured Gregor. Vincent takes Sam to a villa that is owned by his friend Jean-Pierre. After removing the bullet and letting Sam recuperate, Jean-Pierre compares Sam's situation to the tale of the 47 Ronin. Vincent asks Jean-Pierre to help them find Gregor and the Irish operatives. In Paris, Gregor is persuaded through violent interrogation to return the case to Seamus and Deirdre. After retrieving it from a post office, they are pursued by Sam and Vincent in a high-speed chase. Vincent shoots out their tire, sending their car off an overpass. Gregor escapes with the case while road workers rescue Deirdre and Seamus from the burning vehicle. Doubtful of where to go next, Sam and Vincent decide to track down the Russians after discovering that the decoy case that Gregor used in his theft of the original is used for carrying ice skates; one of Jean-Pierre's contacts informs them that the Russians may be involved with figure-skater (and Mikhi's girlfriend) Natacha Kirilova, who is performing at Le Zénith. During Natacha's show, Mikhi meets with Gregor, who says that a sniper in the arena will shoot Natacha if Mikhi betrays him. Mikhi kills Gregor and takes the case, allowing Natacha to be killed by the sniper. Amid the ensuing chaos from Natacha's shooting, Sam and Vincent leave the arena in time to see Seamus kill Mikhi and steal the case. Sam and Vincent split up; Vincent pursues Seamus but is wounded in a gunfight. Sam finds Deirdre waiting in a getaway car and convinces her to leave, after explaining that he is still in the CIA and is after Seamus, not the case. As she drives away, Seamus is forced to return to the arena as Sam gives chase. Seamus ambushes Sam but is shot dead by Vincent before Seamus can kill Sam. Sam and Vincent have coffee in the bistro where they first met. A radio broadcast announces that a peace agreement between Sinn Féin and the British government has been reached, partially as a result of Seamus's death. Sam keeps glancing at the door as patrons enter, but Vincent convinces Sam that Deirdre will not be coming back. They shake hands and part ways, but not before Vincent asks what was in the case. Sam replies that he does not remember. Sam drives off with his CIA contact as Vincent pays the bill and leaves.