Agent Maxwell Smart is called back into service in order to stop a nefarious KAOS terrorist plan from exploding a bomb that destroys only clothing, so as to leave KAOS as the only supplier of clothes to the entire world. Norman Saint-Sauvage, the KAOS fashion designer, finds everyone else's clothing designs gauche, so he builds a machine capable of cloning his favorite seamstress and implements the Nude Bombs. He wears a costume including thimbles over each finger, and his mountain lair is entered via a giant zipper.

A New York couple, Rachel and Alvy, live in a not-so-distant future. A rising tech company executive, Rachel lands a coveted spot on the waitlist for the Womb Center, which offers couples maternity by way of detachable artificial wombs, or pods. Alvy, a botanist with an affection for nature, prefers a natural pregnancy. Despite their different perspectives, they decide to go forward with the Womb Center's services in order to conceive a child.

Michael Lander is a Goodyear Blimp pilot who flies over National Football League games for network television coverage. Secretly deranged by years of torture as a POW in the Vietnam War, he had a bitter court martial upon his return and a failed marriage. He longs to kill himself and to take with him as many as possible of the cheerful, carefree civilians he sees from his blimp each weekend. Lander is desperately in love with Dahlia Iyad, an operative from the Palestinian terrorist group Black September, who controls and manipulates him. They conspire together to launch a suicide attack using a bomb composed of plastique and a quarter-million steel flechettes. They plan to mount the bomb on the underside of the gondola of the Goodyear blimp and detonate it over the Miami Orange Bowl during Super Bowl X, killing over 80,000 spectators, including the President of the United States, in order to call attention to the plight of the Palestinians and to punish the United States for supporting Israel. During a raid on a Black September safehouse in Beirut, the Israeli counter-terrorist Mossad agent David Kabakov surprises Iyad while she is showering. His mission was to kill everyone in the unit; however, seeing her unarmed and naked, he spares her life and turns his attention to clearing the rest of the safehouse, and she escapes. When the raid is complete, Kabakov finds a recorded message which Iyad had planned to publish after the terrorist attack. The recording explains the motive for the terrorism, but does not include any specific information about the attack plan itself. Collaborating with FBI agent Sam Corley, Kabakov and his partner Robert Moshevsky try to learn the details of the plan. Meanwhile, in Long Beach, Black September bribes freighter captain Tekiaki Ogawa to transport the plastic explosives, disguised as statuettes. Ogawa puts the explosives aboard Iyad and Lander's motorboat, but the two terrorists are discovered by the Coast Guard and forced to flee. Ogawa is interrogated by Kabakov and Moshevsky, only for a bomb Lander had secretly planted to explode, killing Ogawa and hospitalizing Kabakov. Iyad disguises herself as a nurse to infiltrate the hospital and assassinate Kabakov, only for Moshevsky to discover her before she kills him and departs. Kabakov questions Muzi, a local businessman and uses a contact in the Egyptian government named Riaf to discover her identity, and Corley tracks Iyad and her superior Mohammed Fasil to a hotel in Miami. They attempt to capture them, but Iyad retreats, while Fasil is killed by Kabakov in a shootout. After searching Iyad's room, Kabakov realizes that they are targeting the Super Bowl. Corley and Kabakov form a security detail to search the crowd for any sign of suspicious activity. During the Super Bowl game, Kabakov figures out that Iyad and Lander have mounted the bomb on the Goodyear blimp. He and Corley commandeer a helicopter and set out in pursuit of the blimp, accompanied by a police helicopter. Loaded with the bomb, the blimp approaches the stadium. Lander pilots the blimp while Iyad exchanges deadly gunfire with policemen in the pursuing cars and helicopters. From his place in one helicopter, Kabakov sees Iyad's face, and they both recognize each other from the Black September raid in Beirut, where he spared her life. This time, Iyad hesitates, but Kabakov does not and he shoots and kills her. Lander has been mortally wounded, but he lives long enough to succeed in flying the blimp straight into the Super Bowl, causing mass chaos and destruction in the stadium. Just before dying, with the electronic detonator destroyed, Lander lights the backup fuse of the weapon. With the weapon just minutes away from detonation, Kabakov lowers himself from the helicopter to the blimp, and hooks it up with a cable to the helicopter, which hauls it out of the panicked stadium and over the ocean. Kabakov unhooks the cable from the blimp, and clings to the cable as the helicopter moves away to a safe distance. A few seconds later, the bomb detonates, destroying the blimp and firing the flechettes harmlessly into the sea.

Eighth grader Kayla Day is in her final week at Miles Grove Middle School, a public middle school in a small New York town. She posts motivational vlogs on YouTube about confidence and self-image that receive few to no views. Timid and struggling to make friends at school, she is voted "Most Quiet" by her classmates. Meanwhile, her single father Mark struggles to connect with her and break her reliance on social media. Kayla is invited to popular classmate Kennedy's pool party by Kennedy's mother. At the party, she has a panic attack in the bathroom but eventually goes outside to swim, where she meets Kennedy's nerdy cousin Gabe. After trying to leave early, she has an awkward encounter with her crush Aiden, who encourages her to stay. She overcomes her anxiety and volunteers to partake in karaoke. After hearing that Aiden broke up with his last girlfriend because she refused to send him nude photos of herself, Kayla lies to Aiden and tells him that she has a folder of explicit photos of herself on her phone, piquing his interest. He asks if she gives blowjobs and she says yes, despite not knowing what he means. She later looks up instructions online and is disgusted by what she finds. During a high school shadow program, Kayla meets a friendly senior named Olivia who shows her around the school before exchanging phone numbers and inviting her to the mall with some friends. At the mall, Kayla is mortified to see her father spying on the group from afar and orders him to leave. While giving Kayla a ride home, Olivia's friend Riley initiates an awkward and invasive game of truth or dare, culminating in him removing his shirt and encouraging her to do the same. When she refuses, he becomes angry and claims he was just trying to help her gain some sexual experience. At home, Kayla breaks down and is comforted by Mark. She makes another vlog announcing that she intends to stop making videos, as she is not the confident person she pretends to be and feels unfit to give advice. She opens a time capsule she created for herself in sixth grade and watches a video in which her past self asks about her current friends and love life. After enlisting Mark's help in burning the time capsule, she asks him if she makes him sad. He tells her that she fills him with pride and could never make him sad, prompting her to hug him. Shortly before graduation, Kayla finally calls out Kennedy for acting indifferent and dismissive toward Kayla's attempts at befriending her. She later has dinner at Gabe's house and they enjoy their time together. Kayla makes a new time capsule that she and Mark bury in the backyard, and leaves a video message for her future high school senior self, encouraging her to persevere through tough times.

On the morning of 6 April 1941 in Belgrade, the capital of the Kingdom of Yugoslavia, two bon vivants, Petar Popara, nicknamed Crni (Blacky) and Marko Dren, head home. They pass through Kalemegdan and shout salutes to Marko's brother Ivan, an animal keeper in the Belgrade Zoo. Marko lets Blacky's pregnant wife Vera know that they have enrolled Blacky in the Communist Party (KPJ).