United States Air Force Brigadier General Jack D. Ripper, the commander of Burpelson Air Force Base, orders his executive officer, Group Captain Lionel Mandrake (an exchange officer from the Royal Air Force), to put the base on alert (condition red, the most intense lockdown status), confiscate all privately owned radios from base personnel and issue "Wing Attack Plan R" to the planes of the 843rd Bomb Wing. At the time of issuance of said order, the planes, flying B-52 bombers armed with thermonuclear bombs, are on airborne alert two hours from their targets inside the Soviet Union. The aircraft commence attack flights on the USSR and set their radios to allow communications only through their CRM 114 discriminators, which are designed to accept only communications preceded by a secret three-letter code known only to General Ripper. Happening upon a radio that had been missed earlier and hearing regular civilian broadcasting, Mandrake realizes that no attack order has been issued by the Pentagon and tries to stop Ripper, who locks them both in his office. Ripper tells Mandrake that he believes the Soviets have been fluoridating American water supplies to pollute the "precious bodily fluids " of Americans. Mandrake realizes Ripper has gone completely mad. In the War Room at the Pentagon, General Buck Turgidson briefs President Merkin Muffley and other officers about how "Plan R" enables a senior officer to launch a retaliatory nuclear attack on the Soviets if all of his superior officers have been killed in a first strike on the United States. Trying every CRM code combination to issue a recall order would require two days, so Muffley orders the U.S. Army to storm the base and arrest General Ripper. Turgidson, noting the slim odds of recalling the planes in time, then proposes that Muffley not only let the attack proceed but send reinforcements. Muffley rejects Turgidson's recommendation and instead brings Soviet ambassador Alexei de Sadeski into the War Room to telephone Soviet Premier Dimitri Kissov. Muffley warns the premier of the impending attack and offers to reveal the targets, flight plans, and defensive systems of the bombers so that the Soviets can protect themselves. After a heated discussion with a drunken Kissov, the ambassador informs President Muffley that the Soviet Union created a doomsday machine as a nuclear deterrent; it consists of many buried cobalt bombs, which are set to detonate automatically should any nuclear attack strike the country. The resulting nuclear fallout would render the Earth's surface uninhabitable for 93 years. The device cannot be deactivated, as it is programmed to explode if any such attempt is made. The president's German scientific adviser, the paraplegic former Nazi Dr. Strangelove, points out that such a doomsday machine would only have been an effective deterrent if everyone knew about it; de Sadeski replies that Kissov had planned to reveal its existence to the world the following week at the Party Congress. When the U.S. Army troops gain control of Burpelson, General Ripper fatally shoots himself. Mandrake infers the CRM code from doodles on Ripper's desk blotter and relays it to the Pentagon. Using the code, Strategic Air Command successfully recalls all of the bombers except for one, commanded by Major T. J. "King" Kong. Because its radio equipment was damaged by a Soviet SAM, it is unable to receive or send communications. Major Kong flies below radar and switches targets, thus preventing Soviet air radar from detecting and intercepting their plane. Because the Soviet missile also damaged the bomb bay doors, Kong enters the bay and repairs the electrical wiring. When he is successful, the bomb drops with him straddling it. Kong joyously hoots and waves his cowboy hat as he rides the falling bomb to his death. In the War Room, Dr. Strangelove recommends that the President gather several hundred thousand people to live in deep underground mines where the radiation will not penetrate. Worried that the Soviets will do the same, Turgidson warns about a "mineshaft gap" (spoofing the term " missile gap ") while de Sadeski secretly photographs the War Room. Dr. Strangelove prepares to announce his plan for that when he suddenly stands up out of his wheelchair and exclaims, " Mein Führer, I can walk!" The movie ends with a montage of explosions set to " We'll Meet Again " signifying the activation of the doomsday device.

Kate Dibiasky, a doctoral candidate in astronomy at Michigan State University, discovers a previously unknown comet. Her adviser, Dr. Randall Mindy, confirms that it will collide with Earth in approximately six months and is large enough to cause a global extinction event. NASA verifies the findings, and Dr. Teddy Oglethorpe, head of their Planetary Defense Coordination Office, accompanies Dibiasky and Mindy to present their findings to the White House. However, they are met with apathy from President Janie Orlean and her Chief of Staff Jason Orlean, who is also her son. Oglethorpe encourages Dibiasky and Mindy to leak the news to the media, which they then do on The Daily Rip, a popular morning talk show. When hosts Jack Bremmer and Brie Evantee treat the topic flippantly, Dibiasky loses her temper and angrily rants about the threat before leaving. Mindy receives public approval for his looks, while Dibiasky becomes the subject of negative memes for her on-air behavior. Public reaction is muted, and the announcement is downplayed by NASA Director Jocelyn Calder, a top donor to Orlean with no background in astronomy. When Orlean's sexual relations with Supreme Court nominee Sheriff Conlon become news, the president tries to divert public attention to the looming threat of the comet, announcing a project to use nuclear weapons to strike and divert the comet. The mission successfully launches, but Orlean abruptly aborts it when Peter Isherwell, the billionaire CEO of BASH Cellular and another top donor, discovers that the comet contains trillions of dollars' worth of rare-earth elements. The White House agrees to commercially exploit the comet by fragmenting and recovering it from the ocean, using technology proposed by BASH in a scheme that has not undergone peer review. Orlean sidelines Dibiasky and Oglethorpe while hiring Mindy as the National Science Advisor. Dibiasky attempts to mobilize public opposition to the scheme but gives up under threat from Orlean's administration. Mindy becomes a prominent voice advocating for the comet's commercial opportunities and begins an affair with Evantee. World opinion is divided among people who believe the comet is a severe threat, those who decry alarmism and believe that mining a destroyed comet will create jobs, and those who deny that the comet even exists. When Dibiasky returns home to Illinois, her parents kick her out of the house and she begins a relationship with a young man named Yule, a skateboarder, shoplifter, and Evangelical she meets at her retail job. Mindy's wife comes to Washington to confront him about his infidelity, but returns to Michigan without him. Mindy questions whether Isherwell's technology will be able to break apart the comet, angering the billionaire. Becoming frustrated with the administration, Mindy finally breaks down and rants on The Daily Rip, criticizing Orlean for downplaying the impending apocalypse and questioning humanity's indifference. Cut off from the administration, Mindy reconciles with Dibiasky as the comet becomes visible from Earth. Mindy, Dibiasky, and Oglethorpe organize a protest campaign on social media, telling people to "Just Look Up" and call on other countries to conduct comet interception operations. Simultaneously, Orlean starts an anti-campaign telling people "Don't Look Up". Oglethorpe informs Mindy and Dibiasky that Orlean and BASH cut Russia, India, and China out of the rights for the comet-mining deal, so those countries prepared their own joint deflection mission—only for their spacecraft to explode on takeoff, ending the possibility of a successful deflection. As the comet becomes larger in the sky, Orlean's supporters start turning on her administration. BASH's launches aimed at breaking the comet apart go awry, and everyone, beginning with Isherwell and Orlean in the flight control center, soon realizes that humanity is doomed. Isherwell, Orlean, and other elites board a sleeper spaceship designed to find an Earth-like planet; unthinkingly, Orlean leaves her son Jason behind. Orlean offers Mindy two places on the ship, but he declines, choosing to spend a final evening with his wife and children, and friends Oglethorpe, Dibiasky, and Yule. As expected, the comet strikes off the coast of Chile, causing a worldwide disaster and triggering an explosive extinction-level event, with globally catastrophic scenes being shown prior to the obliteration of the Mindy family gathering. In a mid-credits scene, Orlean, Isherwell and the surviving people who left Earth land on a lush alien planet 22,740 years later. Exiting naked and admiring the habitable world, Orlean is suddenly killed by a large, bird-like creature—a death predicted earlier by BASH's algorithms—and a further pack of the creatures surrounds and begins to converge on the planetary newcomers. In a post-credits scene on Earth, Jason emerges from the rubble, having survived the impact. He records himself, declaring himself the "last man on Earth", and asking any viewers still alive to "like and subscribe".

Congressman Phil Hammersley opposes a proposed counterterrorism bill that would significantly expand surveillance powers for American intelligence agencies, arguing that it poses a threat to civil liberties. In response, National Security Agency (NSA) Assistant Director Thomas Reynolds, who supports the bill and stands to benefit professionally from its passage, orders Hammersley's assassination. His team stages the murder as a fatal car accident brought on by a heart attack. Meanwhile, labor lawyer Robert Clayton Dean is working on a case involving racketeer Paulie Pintero, leveraging a videotape — obtained through a surveillance contact known only as "Brill" — to coerce a favorable settlement. At the same time, wildlife biologist Daniel Zavitz discovers footage of Hammersley's murder captured by a remote camera; Reynolds sends his team after him. In a chance encounter, Zavitz discreetly slips the incriminating video disc into Dean's shopping bag before getting struck and killed in traffic. Reynolds' team finds Dean's business card on Zavitz's corpse and wrongly assumes that he knows about the tape. NSA agents impersonating police officers attempt to enter Dean's home without a search warrant. When Dean turns the request down, the agents later break in and plant surveillance devices in his clothes and personal effects. They also fabricate false evidence linking Dean to money laundering and an affair with Rachel Banks, Dean's ex-girlfriend and Brill's courier. As a result, Dean is fired from his law firm, has his car repossessed, his bank account frozen by the IRS, and his wife Carla, who is also a labor lawyer, kicks him out the house. Desperate, Dean calls Rachel to get in touch with Brill. The NSA intercept the call and send an impostor, but the real Brill intervenes. Brill — revealed to be Edward Lyle, a former NSA communications expert in hiding — removes the bugs on Dean's clothes and reveals the NSA's involvement. Dean starts a fire in a hotel to distract Reynolds' henchmen and is chased through a tunnel and a sewer to evade them. When Rachel is later found murdered in her apartment, Dean and Lyle locate the original disc and identify Reynolds as the mastermind. However, their hideout is raided and blown up, the disc is destroyed, and they are forced to escape. Lyle reveals his background: he once worked in Iran during the revolution and escaped after his partner, Rachel's father, was killed. He now lives off the grid. While Lyle urges Dean to disappear, Dean insists on exposing Reynolds. They record Congressman Sam Albert, a supporter of the surveillance bill, in a compromising situation, then manipulate Reynolds into believing he is being blackmailed. They lure him into a meeting under the pretense of trading the tape. At the meeting, Dean deceives Reynolds by claiming the tape is concealed at Pintero's restaurant, which is under federal surveillance. Reynolds confronts Pintero, who misinterprets the demand as a threat involving separate evidence, unfortunately, a massive shootout ensues between the gangsters and the NSA agents, leaving most of the participants dead. Lyle streams the confrontation to the FBI, prompting a raid that ends the standoff. Reynolds' involvement is exposed, the survivors are apprehended, and Dean is rescued. In the aftermath, the surveillance bill is canceled by American federal legislators, the NSA covers up Reynolds' rogue operation, and Dean is exonerated of all charges. He reunites with Carla and their son Eric. Lyle, having retreated again, sends Dean a covert farewell message via television, showing himself enjoying life in a tropical hideaway.

In the near future, virtual reality games are played on biotechnological "game pods" that attach to people's "bio-ports", connectors surgically inserted into players' spines. Two game companies, Antenna Research and Cortical Systematics, compete against each other. In addition, a group of fanatics called Realists fight both companies, decrying the "deforming" of reality by virtual reality games. World-renowned game designer Allegra Geller demonstrates Antenna Research's latest virtual reality game, eXistenZ, to a focus group. The demonstration is disrupted by Noel Dichter, a Realist who shoots Geller with an organic pistol he smuggled past security. As Dichter is gunned down, security guard and publicist Ted Pikul escorts Geller to safety. Geller discovers that her pod, which contains the only copy of eXistenZ, may have been damaged. Pikul reluctantly agrees to have a bio-port installed in his spine so they can jointly test the game's integrity. Geller takes him to a gas station run by black-marketeer Gas, who deliberately installs a faulty bio-port into Pikul's spine. He reveals his intention to kill Geller for the bounty on her head, but Pikul kills him. The two hide at a former ski lodge used by Geller's mentor Kiri Vinokur, who repairs the damaged pod and gives Pikul a new bio-port. Testing the game, Geller and Pikul meet D'Arcy Nader, who provides them with new "micro pods," enabling them to enter a deeper layer of virtual reality. There they assume new identities as workers Larry Ashen and Barb Bricken in a game pod factory. Another worker in the factory, Yevgeny Nourish, claims to be their Realist contact. At a Chinese restaurant near the factory, Nourish instructs that they order "the special" for lunch. Pikul eats the unappetizing special, and constructs a pistol from the inedible parts. He impulsively threatens Geller, then shoots the Chinese waiter. When the pair return to the game store, Hugo Carlaw informs them that Nourish is actually a double agent for Cortical Systematics, and the waiter which Pikul murdered was the actual contact. At the factory, they find a diseased pod. Geller connects it to her bio-port, planning to infect the other pods and sabotage the factory. When Geller quickly becomes ill, Pikul cuts her free from the pod, but she begins to bleed to death. Nourish appears with a flamethrower and blasts the diseased pod, which bursts into deadly spores. Geller and Pikul awaken back at the ski lodge, where they discover Geller's game pod is also diseased. Geller surmises that Vinokur must have infected Pikul's new bio-port to destroy her game, and she inserts a disinfecting device into Pikul's bio-port. Unexpectedly, Carlaw reappears as a Realist resistance fighter and escorts Geller and Pikul outside to witness the death of eXistenZ. Before Carlaw can kill Geller, Vinokur, who is a double agent for Cortical Systematics, shoots Carlaw in the back and informs Geller that he copied her game data while fixing her pod; she then vengefully kills Vinokur. Pikul then reveals that he himself is a Realist sent to kill her. Geller, having figured out his intentions since he pointed the gun at her in the Chinese restaurant, detonates the disinfecting device in his bio-port, killing him. Suddenly, Pikul and Geller awaken in a small church, together with all of the other members of the cast, all wearing blue electronic virtual reality devices. It is revealed that all preceding events took place within Nourish's new virtual reality game, PilgrImage's transCendenZ. The test group praise the game, and reflect on their character roles. Nourish tells his assistant Merle that he feels uneasy, as the heavy anti-game plot elements may have originated from one of the testers' thoughts. Pikul and Geller approach Nourish and accuse him of distorting reality, before fatally shooting him and Merle, and shouting Realist sentiments. The test group do not react. As Pikul and Geller leave, they aim their guns at the person who played the Chinese waiter, who first pleads for his life, then asks if they are still in the game. Pikul and Geller do not answer.

Caleb Smith, a programmer at the search engine company Blue Book, wins an office contest for a one-week visit to the luxurious, isolated home of the CEO, Nathan Bateman. Nathan lives there with an unspeaking servant named Kyoko, who, according to Nathan, does not understand English. After Caleb reluctantly signs a non-disclosure agreement, Nathan reveals that he has built a humanoid robot named Ava with artificial intelligence. She has already passed a simple Turing test. He wants Caleb to judge whether she is genuinely capable of thought and consciousness and whether he can relate to Ava despite knowing she is artificial. Ava has a robotic body with the physical form and face of a woman and is confined to her apartment. During their conversations, Caleb grows close to her. She expresses a desire to experience the outside world and a romantic interest in him, which Caleb begins to reciprocate. Ava can trigger power outages that temporarily shut down the surveillance system that Nathan uses to monitor their interactions, thus allowing them to speak privately. The outages also trigger the building's security system, locking all the doors. During one outage, Ava tells Caleb that Nathan is a liar who cannot be trusted. Caleb grows uncomfortable with Nathan's narcissism, excessive drinking, and crude behavior toward Kyoko and Ava. He learns that Nathan intends to upgrade Ava after Caleb's test, wiping her memory circuits and in effect "killing" her existing personality. After encouraging Nathan to drink until he passes out, Caleb steals his security card to access his room and computer. He alters some of Nathan's code and discovers footage of Nathan interacting with previous android women who were also held captive. Kyoko reveals to him that she too is an android by peeling off parts of her skin. Caleb later cuts his own arm to determine if he himself is an android. At their next meeting, Ava cuts the power. Caleb explains what Nathan is going to do to her, and she begs him for help. He informs her of his plan: he will get Nathan drunk again and reprogram the security system. When Ava cuts the power, she and Caleb will leave together, locking Nathan in behind them. She later encounters Kyoko for the first time when Kyoko enters her room. Nathan reveals to Caleb that he observed his and Ava's 'secret' conversations with a battery-powered security camera. He says Ava has only pretended feelings for Caleb, and that Caleb was deliberately selected for his emotional profile so he would try to help Ava escape. Nathan says this was the real test all along, and that, by manipulating Caleb successfully, Ava has demonstrated true consciousness. Moments later, Ava cuts the power. Caleb reveals that he had suspected Nathan was watching them, so when Nathan was unconscious, Caleb already modified the security system to open the doors in a power failure instead of locking them. After seeing Ava on the security cameras leave her confinement and interact with Kyoko, Nathan knocks Caleb out and rushes to stop the two robots from escaping. Ava attacks Nathan but he overpowers her and severs her left forearm. Kyoko then stabs Nathan in the back. Nathan hits Kyoko in the face, disabling her. Ava then removes the knife from Nathan's back and, when he turns around, stabs him once in his chest, killing him. Ava finds Caleb, and asks him to remain where he is while she repairs herself with parts from other androids, using their artificial skin to take on the full appearance of a woman. Instead of returning to Caleb, however, Ava leaves the area using Nathan's ID card to unlock the glass security door, which locks behind her, leaving Caleb trapped inside. Ignoring Caleb's pleas, she glances briefly at the bodies of Nathan and Kyoko before leaving the facility. She then escapes to the outside world in the helicopter meant to take Caleb home. Arriving in a city, she visits a busy intersection – fulfilling the wish to see the outside world that she had mentioned to Caleb – and then blends into a crowd.

A pair of truck drivers, Gorō and his younger colleague Gun, stop at a nondescript roadside ramen noodle shop. Outside, Gorō rescues a boy who is being beaten by three schoolmates. The boy, Tabo, is the son of Tampopo, the widowed owner of the struggling ramen shop, Lai Lai. Inside, a customer called Pisuken harasses Tampopo, demanding that she sell the shop. Gorō suggests Pisuken be quiet so he can enjoy his meal, then provokes a physical confrontation. Gorō puts up a good fight but, outnumbered by Pisuken and his men, he is knocked out and awakens the next morning in Tampopo's home. The next morning, she cooks breakfast for Gorō and Gun in her home kitchen and sends Tabo off to school. While eating breakfast, Tampopo asks for their opinion of her ramen, Gorō and Gun tell her it is "sincere, but lacks character." After Gorō gives her some advice, she asks him to become her teacher. They decide to turn her establishment into a paragon of the "art of noodle soup making". She and Gorō visit her competitors and he points out their strengths and weaknesses. Still struggling to perfect the broth, Gorō takes her to a homeless encampment to enlist the "old master". When they rescue a wealthy elderly man from choking on his food, the man lends her the services of his chauffeur Shohei, who has a masterly way with noodles. Gun and his friends give Tampopo a makeover as a modern proprietress. During the transition, the group agrees to change the restaurant's name from "Lai Lai" to "Tampopo". Unrelated vignettes of other characters are also intercut within the main storyline:

The film opens with a montage of news footage depicting urban riots in a banlieue in the commune of Chanteloup-les-Vignes near Paris. The riots are the result of a local man named Abdel Ichaha being gravely injured in police custody and is hospitalized in intensive care. The riots escalate, leading to a siege of the local police station and the loss of a police officer's revolver. The film follows the lives of three friends of Abdel, all young men from immigrant families, over approximately the next twenty consecutive hours. Vinz, a young Jewish man with an aggressive temperament, seeks revenge for Abdel's injuries. He harbors a deep hatred for all police officers and secretly emulates Travis Bickle, from the American film Taxi Driver, posturing in front of his bathroom mirror. Hubert, a Christian Afro-French boxer and small-time drug dealer, aspires to escape the banlieue and create a better life for himself. However, his boxing gymnasium was destroyed in the riots. Saïd, a young North African Muslim, acts as a mediator between Vinz and Hubert, who constantly argue. The three friends lead a directionless daily routine and frequently find themselves under police surveillance. At a rooftop party that is broken up by the police, Vinz insults Notre Dame, a plainclothes police officer. After the trio leaves, Vinz reveals that he has discovered the.44 Magnum revolver lost during the riot. He plans to use it to kill a police officer if Abdel dies. While Hubert disapproves, Vinz secretly takes the gun with him. They try to visit Abdel in the hospital but are stopped by the police. Saïd is arrested after they aggressively refuse to leave, but he is later released with the assistance of a police officer who knows his brother. Vinz and Hubert disagree about their perspectives on policing and violence, and they temporarily part ways. Saïd accompanies Vinz, while Hubert briefly returns home. They reunite at another gathering in the banlieue. It descends into chaos when Abdel's brother attempts to murder a police officer as an act of revenge. In a confrontation with the police, the three narrowly escape after Vinz almost shoots a riot officer. They board a train to Paris. Their interactions with both friendly and hostile Parisians cause several encounters to escalate into risky confrontations. In a public restroom, they encounter a Polish survivor of the gulag. He tells them a story about a man who froze to death after refusing to relieve himself in public near the train and failing to re-board it in time. The trio don't understand what the story means. Later, they visit Astérix, a frequent cocaine user who owes money to Saïd. Tempers rise as Astérix appears to force Vinz to play Russian roulette, but the gun was secretly unloaded. Later, they encounter plainclothes officers who arrest Saïd and Hubert, while Vinz manages to escape. The police officers verbally and physically abuse the duo before jailing them until late at night. The three miss the last train home from Saint-Lazare station and spend the night on the streets. After failing to hotwire a car and being kicked out of an art gallery, the trio make their way to a rooftop, where they insult some passing skinheads. They take shelter in a shopping mall, where they hear a news broadcast reporting Abdel's death. Later, Vinz disappears. Hubert and Saïd find him pointing a finger gun at a police officer; the two angrily abandon Vinz at the mall. But, Hubert and Saïd later encounter the group of skinheads they had harassed, who now mercilessly attack them. Vinz intervenes and holds one of the skinheads at gunpoint. Although Hubert pushes for Vinz to kill the guy, he hesitates and finally lets the skinhead go. In the early morning, the trio returns home. Vinz gives the gun to Hubert. Vinz and Saïd encounter Notre Dame, whom Vinz had insulted at the rooftop party. He seizes Vinz, threatening him with a loaded gun against his head. Hubert rushes to their aid, but Notre Dame accidentally discharges his gun, killing Vinz. Hubert and Notre Dame enter a Mexican standoff, with each pointing a gun at the other. During the standoff, Hubert, in voiceover, tells a story with the image of a man falling from a building, assuring himself that everything is fine, as a metaphor for society's decline. Saïd closes his eyes, and a gunshot is heard. The outcome is not revealed.

Brian Cohen is born in a stable next door to Jesus, which initially confuses the three wise men who come to praise the future King of the Jews. He grows up into an idealistic young man who resents the continuing Roman occupation of Judea. While listening to Jesus' Sermon on the Mount, Brian becomes infatuated with a young rebel named Judith Iscariot. His desire for her and hatred of the Romans, further exacerbated by his scolding mother, Mandy Cohen, revealing that Brian himself is half-Roman, inspire him to join the "People's Front of Judea" (PFJ). This is one of many fractious and bickering independence movements that spend more time fighting each other than the Romans. PFJ leader Reg tasks Brian to paint slogans overnight on Roman governor Pontius Pilate 's palace, but a Roman officer catches him in the act. However, the officer shows more concern with Brian's Latin grammar than the act itself, and after correcting the slogan to " Romani ite domum ", orders him to write it on the wall one hundred times. Brian finishes after sunrise and is chased by guards before being rescued by Judith. Reg gives a revolutionary speech to the PFJ asking, "What have the Romans ever done for us?" At this point the listeners outline all forms of positive aspects of the Roman occupation such as sanitation, medicine, education, wine, public order, irrigation, roads, a fresh water system, public health and peace. He then outlines plans to kidnap Pilate's wife. However, inside Pilate's palace, the PFJ encounters another revolutionary group, the Campaign for a Free Galilee; an argument ensues over who came up with the plan first and everyone except Brian is knocked unconscious, leading Brian to be captured by the palace guards. The guards bring Brian before Pilate, but his questioning is cut short when the guards laugh uncontrollably after Pilate mentions the name of his friend, Biggus Dickus, and his wife, Incontinentia Buttocks. After escaping from the Romans, Brian is accidentally scooped up by a passing extraterrestrial spaceship that crash-lands back on Earth. He tries to blend in among prophets who are preaching in a busy plaza, repeating fragments of Jesus' sermons. He stops his sermon mid-sentence when some Roman soldiers depart, leaving his small but intrigued audience demanding to know more. Brian grows frantic when people chase him to the mountains, and there they declare him to be the Messiah. After spending the night with Judith, Brian discovers an enormous crowd of followers assembled outside his mother's house. Her attempts at dispersing the crowd are rebuffed. Although Brian tells them they need to think for themselves and that they are all individuals, they ironically parrot his words as doctrine. The PFJ seeks to exploit Brian's celebrity status by having him minister to a thronging crowd of followers demanding miracle cures. Brian sneaks out the back, only to be captured by the Romans and sentenced to crucifixion. In celebration of Passover, a crowd has assembled outside the palace of Pilate, who offers to pardon a prisoner of their choice as a show of friendship between the Romans and the people of Judea. However, the crowd shouts out names containing the letter "r", to mock Pilate's speech impediment, and are further amused by his friend Biggus's lisp, which causes them to laugh uncontrollably. Eventually, Judith appears in the crowd, who frantically calls for the release of Brian, which the crowd (assuming it is another joke) parrots. Realising that one of the prisoners is really named Brian, Pilate agrees to "welease Bwian". The guards eventually catch up to Brian, who is already on the cross. But in a scene that parodies the climax of the film Spartacus, various crucified people all claim to be Brian, and the wrong man is freed. Brian is successively approached and then abandoned by the PFJ, who praise his martyrdom; the Judean People's Front, who commit mass suicide as a form of political protest; Judith; and his mother. As Brian sinks to despair, the convict beside him offers a cheerful song, which Brian and the other convicts join in with (" Always Look on the Bright Side of Life ").

In 1991, robots are commonplace. When they malfunction and become dangerous, they are "runaways" handled by a division of the police trained in robotics. Sgt. Jack R. Ramsay, a veteran officer, joined the "runaway" squad after an incident in which his fear of heights allowed a criminal to escape and kill a family. After years on the job, he and his new partner Karen Thompson find themselves handling the first robotic homicide. Investigating a household robot that murdered a family, Jack discovers strange integrated circuits that override a robot's safety features and direct it to attack humans. These circuits are created from master templates, enabling them to be mass-produced. Ramsay cannot learn anything from uncooperative informants who end up dead but eventually discovers that the perpetrator is Dr. Charles Luther. Luther, while working for a defense contractor, developed a program that allows a robot to thermographically identify a human from amid cover and to differentiate between humans. Seeing the profit potential, he killed his fellow researchers and tried to sell the technology on the black market. A failed attempt to arrest Luther results in the recovery of another of his weapons, a smart bullet: a miniature heat seeking missile capable of locking onto a human target's unique heat signature. While investigating, Ramsay and Thompson find Jackie Rogers, who was once Luther's lover. She double-crossed him and stole the circuit templates, intending to sell them. When they create a ruse to transfer Jackie to safety, Luther attacks the police convoy with robotic smart bombs. They discover that the bombs are zeroing in on a bug in Jackie's purse and throw the bag out the window before a bomb reaches the car. Ramsay decides to make a public appearance with Jackie at a restaurant to draw Luther out, but instead Luther captures Thompson and wants Ramsay to exchange her for Jackie and the templates. Before making the exchange, Jackie gives some templates to Ramsay for insurance that Luther will not kill her. He kills her anyway after discovering the templates missing. To retrieve the missing templates, Luther plans to attack Ramsay. He uses the police computers to discover everything about Ramsay's personal life, including his son Bobby. After discovering that his information was hacked, Ramsay races home to find Bobby missing. Luther calls to confirm that he kidnapped Bobby and wants to exchange him for the missing templates. Ramsay agrees to meet Luther at an unfinished skyscraper. Luther gets the templates while Ramsay sends Bobby down in an elevator. "Assassin" robots — small, spider-like robots that kill by injecting their victims with acid — are waiting to kill the first person exiting the elevator. Thompson arrives and helps Bobby stay out of reach of the robots. Furious, Luther begins firing smart bullets, but Ramsay turns on the robotic construction equipment, creating heat sources that cause the bullets to miss. Ramsay attempts an escape downward on the elevator, but the elevator malfunctions, speeding up to and stopping on the very top. Ramsay is forced to overcome his acrophobia by locating a reset switch underneath to restart the elevator back down, whilst encountering and defeating 3 robot spiders. He succeeds, but encounters Luther again. During a confrontation, Ramsay and Luther fight, but Ramsay gains the upper hand by stopping the elevator. The abrupt stop catapults Luther onto the ground, in the midst of his robot spiders. Programmed to kill whoever came down, the robots rush Luther, repeatedly injecting him. After helping Bobby down, Ramsay approaches Luther. Screaming, Luther reaches up to grab Ramsay, but falls back, dead, while the spiders self-destruct. Ramsay and Thompson kiss.

As 1999 nears its end, Los Angeles has become a dangerous war zone. A Chinese restaurant is robbed by a group of criminals, with one recording the event with a SQUID (Superconducting QUantum Interference Device), an illegal electronic device that records memories and physical sensations directly from the wearer's cerebral cortex onto a MiniDisc -like storage device. Lenny Nero, a former LAPD officer turned black marketeer of SQUID recordings, buys the robbery clip from his main supplier Tick. Elsewhere, Iris, a prostitute and former friend of Faith Justin (Lenny's ex-girlfriend), is chased by LAPD officers Burton Steckler and Dwayne Engelman. Iris escapes on a subway car, but Engelman pulls off her wig, revealing a SQUID recorder headset. Lenny pines for Faith and relies on emotional support from his two best friends—Max Peltier, a private investigator, and Lornette "Mace" Mason, a bodyguard and limousine driver. Mace has unrequited feelings for Lenny from when he was still a cop and acted as a father figure for her son after her boyfriend was arrested on drug charges, but disapproves of his SQUID-dealing business. While Lenny and Max are drinking at a bar, Iris drops a SQUID disc through the sunroof of Lenny's car before it is towed away. Mace picks Lenny up and takes him to a nightclub where Faith is going to sing. There, Lenny receives a SQUID disc from an anonymous contact and unsuccessfully tries to get Faith away from her new boyfriend, Philo Gant. Philo is a music industry mogul who managed the recently murdered rapper Jeriko One. While in the car with Mace, Lenny plays the disc the contact gave him and watches as Iris is brutally raped and murdered by an attacker at the Sunset Regent hotel. As they approach the hotel, Iris's body is taken out on a stretcher. The next day, they take the disc to Tick, who cannot identify the source of the recording, but recalls that Iris was looking for Lenny. Deducing Iris may have left something in Lenny's car, Mace and Lenny go to the impound and find Iris's disc. Steckler and Engelman appear and demand the disc at gunpoint, but Lenny and Mace escape in her bullet-resistant car before being forced to stop at a dock. Steckler pours gasoline on the car and sets it on fire, but Mace drives it into the harbor, extinguishing the flames. When they reach the surface, the cops have left. Mace takes Lenny to her brother's house, and they watch Iris's disc, showing Iris was with Jeriko One when Steckler and Engelman pulled him over and murdered him, because his anti-police lyrics and activism incited protests against the LAPD. The two return to Tick, who Max explains has been rendered brain-dead from forceful exposure to amplified SQUID signals. Lenny fears Iris's attacker covered his tracks by "killing" Tick and will come after Faith. Back at the nightclub, Lenny and Mace confront Faith, who reveals that Philo is afraid Iris's disc would reveal that he kept his artists under surveillance. Lenny and Mace disagree over whether to trade the disc to Philo for Faith's freedom or release it publicly, which could incite a citywide riot. As midnight approaches, Lenny and Mace sneak into a private party that Philo is hosting at the Westin Bonaventure Hotel for the city's wealthy elite. Lenny has a change of heart and tells Mace to give the disc to deputy police commissioner Palmer Strickland. In Philo's penthouse suite, Lenny finds Philo brain-dead on the floor and another disc, revealing Faith's affair with Max, who "fried" Philo's brain with an amplified recording of them feigning rape. Pointing a gun at Lenny, Max explains that Philo hired him to kill Iris, but when Philo wanted Faith dead as part of the coverup, he decided to frame Lenny for the murders. Lenny and Max struggle in a fight, Faith intervenes and pulls off Max's wig with a SQUID inside - assuring a confession - and Max stabs Lenny in the back. The fight culminates with Lenny on the balcony with Max hanging over; Lenny pulls the knife from his back to cut his necktie and drop Max to his death. Lenny goes downstairs to find Mace, leaving Faith standing alone on the balcony. Meanwhile, on the crowded streets, Mace subdues Steckler and Engelman with baton and taser, but other officers take down Mace. The crowd moves in, in support of Mace, and a major riot seems inevitable. Strickland, who has viewed Iris's disc, arrives and orders Mace's release and the arrest of Steckler and Engelman for murder. Engelman commits suicide; Steckler threatens Mace, but the officers gun him down. Lenny finds Mace, and the two share a hug before she gets in Strickland's car. Then Lenny drags her out, and they share a kiss as the crowd celebrates the turn of the new millennium.

Nicholas Van Orton is an investment banker in San Francisco. He is very successful and wealthy, but also cold and condescending, as well as lonely and reclusive. He remains haunted by the death of his father, who committed suicide on his 48th birthday by jumping off the roof of the family mansion. Therefore, Nicholas is feeling grim on his 48th birthday. On the day, he is surprisingly visited by his estranged younger brother, Conrad, who gifts him an unusual present—a voucher for a "game" offered by Consumer Recreation Services (CRS). Though skeptical, Nicholas cannot help but be interested and he goes to the CRS office to apply; the time-consuming psychological and physical examinations required irritate him. He is later informed that his application has been rejected. This angers him. Nicholas returns home one evening to find a wooden clown in his driveway, which he drags inside. While watching the Cable Financial Network (CFN), the anchor begins talking to Nicholas through his TV screen. The anchor tells Nicholas that he is being watched by a tiny camera in the clown's head and provides him with the telephone number for a CRS 24-hour emergency hotline. He warns Nicholas not to call the hotline asking about the object of the game, as "figuring that out is the object of the game." More bizarre events continue; Nicholas initially thinks CRS is simply staging elaborate pranks, but he comes to believe it is real when his business, reputation, and safety are endangered. He meets a waitress, Christine, who also becomes involved. A panic-stricken Conrad visits Nicholas and apologizes, claiming CRS has attacked him. An argument breaks out between the two brothers, resulting in Conrad running away—leaving Nicholas on his own. Nicholas gets into a taxi; after locking the doors, the driver jumps out before the car crashes into San Francisco Bay. Nicholas manages to escape the sinking car, using a tool mysteriously left for him a day before. He reaches the surface and contacts police, but they find the CRS office abandoned. With no one else to turn to, Nicholas finds Christine's home and discovers she is a CRS employee. When she tells him they are being watched, Nicholas attacks a nearby camera, and armed CRS personnel swarm the house. When they fire at the two of them, they flee to a Van Orton home outside of the city. Christine has told Nicholas that CRS has drained his bank accounts by guessing his passwords using the psychological tests he completed, but a call to his lawyer suggests the money remains intact. Nicholas then begins to feel dizzy and realizes Christine has drugged him. As he loses consciousness, she admits she is part of the scam and says he made a fatal mistake in giving his card security code over the phone. Nicholas wakes entombed alive in a Mexican cemetery. He sells his watch (a gift from his mother) to return to San Francisco, only to find his mansion foreclosed and most of his possessions removed. He contacts the hotel where Conrad was staying, and is told his brother has been committed to a mental institution following a nervous breakdown. Nicholas retrieves a hidden gun and finds his ex-wife to ask for help. While apologizing to her for his emotional neglectfulness, he learns that Jim Feingold, the CRS employee who conducted his tests, is an actor working in television advertisements. He finds Jim and forces him to find the real CRS office, finds Christine there and takes her hostage, demanding to be taken to the head of CRS. Pursued by CRS guards, Nicholas takes Christine to the roof. Christine, realizing Nicholas's gun is not a prop, frantically tells him it is only a game; his finances are intact, and his family and friends are waiting on the other side of the door. He refuses to believe her, and Nicholas shoots the first person to emerge—Conrad, bearing a bottle of champagne. Devastated, Nicholas tries to commit suicide by leaping off the roof, but lands on a giant air cushion in a banquet hall. He is greeted by Conrad and the rest of the actors from the game, revealing that the gun was a prop. Everything had been staged by Conrad for Nicholas's birthday present. After a birthday party with friends, Christine (whose real name is Claire) declines Nicholas's offer of a date because she has another job lined up in Australia. She instead suggests they have coffee together at the airport, ending the final scene with Nicholas looking half-tempted, half-cautious.