In 2293, the Federation starship Excelsior, commanded by Captain Hikaru Sulu, discovers that the Klingon moon of Praxis has been destroyed in a mining accident. The loss of Praxis and the ecological devastation of the Klingon homeworld throws the Klingon Empire into turmoil. No longer able to afford war with the Federation, the Klingons pursue peace. Starfleet sends the Federation starship Enterprise to meet with the Klingon Chancellor Gorkon and escort him to negotiations on Earth. Enterprise Captain James T. Kirk, whose son David was murdered by Klingons, opposes peace and resents the assignment. Enterprise and Gorkon's battlecruiser rendezvous and continue towards Earth, with the two command crews sharing a tense meal. Later that night, Enterprise appears to fire torpedoes at the Klingon ship, disabling its artificial gravity. During the confusion, two men wearing Starfleet spacesuits and magnetic boots beam aboard the Klingon vessel, kill two crew members, and mortally wound Gorkon before escaping. Kirk surrenders to avoid armed conflict and beams aboard with Doctor Leonard McCoy to try and save Gorkon's life. The chancellor dies, and Gorkon's chief of staff, General Chang, arrests Kirk and McCoy for his assassination. A Klingon court finds the pair guilty and sentences them to life imprisonment on the frozen planetoid Rura Penthe. Gorkon's daughter Azetbur becomes the new chancellor and continues diplomatic negotiations; the conference is relocated for security, and the new location is kept secret. While several senior Starfleet officers want to rescue Kirk and McCoy, the Federation president refuses to risk full-scale war; Azetbur likewise refuses to invade Federation space. Kirk and McCoy arrive at the Rura Penthe mines and are befriended by Martia, a shapeshifter, who offers them an escape route; in reality, it is a ruse to make their arranged deaths appear accidental. Once her betrayal is revealed, Martia transforms into Kirk's double and fights him, but is killed by the prison governor to silence any witnesses. Kirk and McCoy are beamed aboard Enterprise by Spock, who has assumed command and launched an investigation in Kirk's absence. Determining that Enterprise did not fire the torpedoes, the crew searches for the assassins. Kirk and Spock set a trap to draw out the accomplice in sick bay and discover that the killer is Spock's protégé, Valeris. To find the identity of the other conspirators, Spock initiates a forced mind-meld and learns that Federation, Klingon, and Romulan officials conspired to sabotage the peace talks. The torpedoes that struck Gorkon's cruiser came from Chang's ship, which has the unique ability to fire its weapons while cloaked. Enterprise and Excelsior race to Khitomer, the location of the peace talks. Chang's cloaked ship attacks and inflicts heavy damage on Enterprise. At the suggestion of Spock and Uhura, Spock and McCoy modify a torpedo to home in on the exhaust emissions of Chang's ship. The torpedo impact reveals Chang's location, and Enterprise and Excelsior destroy his ship with a volley of torpedoes. The crews from both ships beam to the conference and thwart the assassination attempt on the Federation president's life. Starfleet Command orders Enterprise to return to Earth to be decommissioned. Kirk decides to take his ship on one last cruise instead, and notes in his log a new generation of explorers will continue their legacy.

Architect Sam Baldwin moves from Chicago to Seattle with his eight-year-old son, Jonah, to start a new life following the death of his beloved wife, Maggie. Over a year later, on Christmas Eve, Jonah calls a nationally syndicated radio talk show seeking advice on how to help his father find happiness again. He persuades a reluctant Sam to go on the air and talk about how much he misses Maggie. Sam describes her as his soulmate, explaining that he knew she was the one when he first took her hand and believes he could never find true love twice. Touched by his story, thousands of women across the country write to him. One listener is Annie Reed, a Baltimore Sun reporter. She is engaged to the sensible and supportive Walter, but feels something is missing from their relationship. Her friend and editor, Becky, suggests Annie longs for the kind of destined romance found "in a movie", although Annie dismisses the idea of magical love or fate. Inspired by the romance film An Affair to Remember, Annie writes Sam a letter proposing they meet atop the Empire State Building in New York City on Valentine's Day. She decides against sending it, but Becky secretly mails it. Encouraged by the response to his radio appearance and by his friends, Sam begins dating a co-worker, Victoria, whom Jonah vehemently dislikes. When Jonah reads Annie's letter, he instinctively believes she could be the one for his father, but Sam dismisses the idea because of the distance between Seattle and Baltimore. Jonah's friend Jessica urges him to reply on Sam's behalf, agreeing to the meeting. After Jonah calls the radio show again and reveals that Sam is dating, Annie travels to Seattle on a work assignment arranged by Becky as a pretext to learn more about him. While dropping Victoria off at the airport, Sam notices Annie leaving her flight and is immediately captivated by her, unaware of who she is. Later, Annie secretly watches Sam and Jonah playing together on the beach. The following day, she visits Sam's houseboat but mistakes his sister, Suzy, for Victoria. A passing vehicle nearly strikes Annie and sounds its horn, alerting Sam to her presence. They briefly stare at one another before Annie, embarrassed, leaves. Back in Baltimore, Annie reads Jonah's immature reply and concludes she has made a mistake pursuing Sam. She decides to commit to Walter and travel to New York to meet him on Valentine's Day. Meanwhile, Jessica uses her travel agent mother's computer to book Jonah a flight to New York to find Annie. When Sam learns where Jonah has gone, he flies after him, and they reunite on the Empire State Building's observation deck. During dinner with Walter, Annie confesses her doubts about their relationship, everything that has happened since hearing Sam's radio broadcast, and they amicably end their engagement. Seeing the Empire State Building illuminated in the shape of a heart, Annie takes it as a sign. She rushes there, arriving on the observation deck moments after Sam and Jonah have left in the elevator. When Sam and Jonah return to retrieve Jonah's misplaced backpack, Sam and Annie recognize each other. After introducing themselves, Annie takes Sam's hand, and the three leave together.

Charlie MacKenzie is a popular local beat poet living in San Francisco who makes his frequent break-ups the subject of his poems. His best friend Tony, a recently promoted police detective, believes that Charlie is afraid of commitment and will identify (or invent) any reason to break up with someone. While purchasing Haggis for his Scottish-born parents, Stuart and May, he encounters a butcher named Harriet, and is attracted to her. During his visit with his family, Charlie and May discuss his most recent break-up, and May brings up a tabloid article about a bride known as "Mrs. X", who kills her husbands on their honeymoons using an axe. Charlie goes back to the butcher shop and offers to help Harriet. The two find common bonds and start to date. After staying at her place one night, Charlie meets Harriet's eccentric sister, Rose, who warns Charlie to be careful. He learns Harriet used to live in Atlantic City, was involved with a trainer in Russian martial arts, and screams for someone named Ralph in her sleep. Charlie arranges a dinner with her to meet his parents, who say she is their favourite of all his partners. Charlie reads the article about Mrs. X, which identifies two of her victims as a martial arts expert and a man named Ralph. Charlie becomes fearful and asks Tony to investigate Harriet and the Mrs. X story. Tony reveals that the husbands of Mrs. X were all reported missing alongside their wives, assuring that Harriet is unlikely to be Mrs. X. Charlie remains on edge, and after a few more troubled dates, breaks up with her. Tony reports that a killer in the Mrs. X story has confessed. Relieved, Charlie apologizes to Harriet by reciting one of his beat poems to her from her rooftop. They make up, and Harriet explains away some of her history, such as Ralph being the name of a woman she knows. At his parents' wedding anniversary Charlie proposes to Harriet. She accepts after some hesitation. Following the wedding ceremony, they embark on a honeymoon to a secluded mountain hotel. After they depart, Tony learns that the confessed killer is actually a compulsive liar. He sends a photo of Harriet to the known associates of the missing husbands, and all identify her as their friends' wife. With phone lines to the hotel down due to a storm, Tony charters a plane. Once he lands, he calls Charlie locally and warns him that Harriet really is Mrs. X, but the hotel phone line is knocked out and power is lost. Charlie panics and tries to stay away from Harriet without letting her know what he knows, but the hotel staff force him into the honeymoon suite for their first night together. After locking Harriet in the closet, Charlie discovers a letter, purportedly written by him, explaining his absence to Harriet. Rose appears wielding an axe and reveals herself as the Mrs. X killer. She feels that Harriet's husbands are taking her sister from her, motivating her to kill them on their honeymoon night and leave letters behind claiming to be from them, leading Harriet to believe that each husband abandoned her. Charlie flees from Rose. Tony leads the police into the hotel and arrests Harriet, still believing her to be the murderer. Charlie, having been chased to the hotel roof by Rose, gets Tony's attention as they take Harriet away. While the police make their way up to the roof, Rose swings the axe at Charlie and is thrown off the building. Tony catches her, and she is arrested and taken away. Charlie and Harriet resume their lives as a happy couple.

In 2293, retired Starfleet officers James T. Kirk, Montgomery Scott, and Pavel Chekov attend the maiden voyage of the USS Enterprise -B. During the shakedown cruise, the starship is pressed into a rescue mission to save two El-Aurian refugee ships that a massive energy ribbon has snared. Enterprise saves some of the refugees before their ships are destroyed, but becomes trapped by the ribbon, and Kirk goes to a control room to help the ship escape. While Enterprise is freed, Kirk is presumed lost in space and dead after the trailing end of the ribbon tears open the ship's hull. In 2371, the crew of the USS Enterprise -D is in a holodeck computer simulation, celebrating the promotion of shipmate Worf to lieutenant commander. Captain Jean-Luc Picard learns his brother and nephew have been killed in a fire, and is distraught that the Picard family line will end with him. Enterprise receives a distress call from a stellar observatory, where an El-Aurian, Dr. Tolian Soran, launches a probe at the nearby star. The probe causes the star to implode, creating a shockwave that destroys its planetary system. Soran kidnaps Enterprise engineer Geordi La Forge and is transported off the station by a Klingon Bird of Prey belonging to the Duras sisters. Enterprise crewmember Guinan tells Picard that she and Soran were among the El-Aurians rescued in 2293. Soran—who lost his family when their homeworld was destroyed—is obsessed with returning to the energy ribbon to reach the "Nexus", an extra-dimensional realm of wish fulfillment outside normal space-time. Picard and Data determine that Soran, unable to safely fly a ship directly into the ribbon, is altering its path by removing the gravitational effects of nearby stars. Soran plans to destroy another star to bring the ribbon to the planet Veridian III, consequently killing millions on a nearby inhabited planet. Upon entering the Veridian system, Picard offers himself to the Duras sisters in exchange for La Forge but insists on being transported to Soran directly. La Forge is returned to Enterprise, but unwittingly exposes the ship's defense details through the transmitter installed in his VISOR device. The Duras sisters attack, and Enterprise sustains critical damage before destroying the Bird of Prey by triggering its cloaking device, and firing photon torpedoes when its shields drop. When La Forge reports that the starship is about to suffer a warp-core breach as a result of the attack, Commander William Riker evacuates everyone to the forward saucer section of the starship, which separates from the engineering section just before the breach occurs. The resulting shockwave sends the saucer-section crashing onto the surface of Veridian III. Picard fails to stop Soran from launching another probe. The Veridian star's resulting destruction alters the ribbon's course, and Picard and Soran enter the Nexus before the shockwave destroys Veridian III. Picard is surrounded by an idealized family, but realizes it is an illusion. He is met by an "echo" of Guinan left behind in the Nexus. Guinan sends him to meet James T. Kirk, who is safe in the Nexus. Though Kirk is initially entranced by the opportunity the Nexus offers to atone for past regrets, he realizes it lacks danger and excitement. Having learned that they can travel whenever and wherever desired through the Nexus, Picard convinces Kirk to return with him to Veridian III, shortly before Soran launches the probe. Working together, Kirk and Picard distract Soran long enough for Picard to lock the probe in place; it explodes on the launchpad and kills Soran. Kirk is fatally injured in the effort, and Picard buries him at the site. Three Federation starships arrive to retrieve the Enterprise survivors from Veridian III. Picard muses that, given the ship's legacy, the Enterprise -D will not be the last vessel to carry the name.

In the 24th century, Captain Jean-Luc Picard awakens from a nightmare in which he relives his assimilation by the cybernetic Borg six years earlier. He is contacted by Starfleet, who inform him of a new Borg threat against Earth. Concerned that Picard is too emotionally involved with the Borg, Starfleet orders the USS Enterprise to patrol the Neutral Zone in case of Romulan aggression. During their patrol, the Enterprise learns that the fleet is losing the battle against the Borg. Picard and his crew disobey orders and head for Earth, where a single Borg Cube ship holds its own against a group of Starfleet vessels. Enterprise arrives in time to assist the crew of USS Defiant and its commander, the Klingon Worf. Picard takes command of the fleet and directs the surviving ships to concentrate their firepower on a seemingly unimportant point on the Borg ship. The Cube launches a smaller spherical ship towards Earth before being destroyed. Enterprise pursues the sphere into a temporal vortex. As the sphere disappears, Enterprise discovers Earth has been altered—Borg now populate it. Realizing the Borg have used time travel to change the past, Enterprise follows the sphere through the vortex. Enterprise arrives hundreds of years in the past on April 4, 2063, the day before the historic warp drive flight that leads to humanity's first encounter with alien life. The crew surmise that the Borg are trying to prevent first contact and assimilate humanity while the planet is recovering from World War III. After destroying the Borg sphere, an away team transports down to Zefram Cochrane 's warp ship, Phoenix, in Bozeman, Montana. Beverly Crusher and Cochrane's assistant Lily Sloane return to the Enterprise to treat her radiation sickness. Picard and Data also return to the ship after suspecting the Borg have survived their sphere's destruction, leaving Commander William T. Riker on Earth to make sure Phoenix ' s flight proceeds as planned. While in the future Cochrane is seen as a hero, in reality he built the Phoenix for financial gain and is reluctant to be the historic figure the crew describes. A group of Borg invade Enterprise ' s lower decks, assimilating some of the crew and modifying the ship. Picard and a team attempt to reach engineering to disable the Borg with a corrosive gas, but are forced back; the android Data is captured in the melee. A frightened Lily corners Picard with a weapon, but he gains her trust. The two escape the Borg-infested area of the ship by creating a diversion in the holodeck. Picard, Worf, and the ship's navigator, Lieutenant Hawk, travel outside the ship in space suits to stop the Borg from using the navigational deflector to call for reinforcements, but Hawk is assimilated in the process. As the Borg assimilate more decks, Worf suggests destroying the ship, but Picard angrily calls him a coward. Lily confronts the captain and makes him realize he is acting irrationally because of his past with the Borg. Picard apologizes to Worf and orders the activation of the ship's self-destruct and evacuation of the crew to escape pods, while he stays behind to rescue Data. As Cochrane, Riker, and engineer Geordi La Forge prepare to activate the warp drive on Phoenix, Picard discovers that the Borg Queen has grafted human skin onto Data, giving him the sensation of touch he has long desired so that she can obtain the android's encryption codes to the Enterprise computer. Although Picard offers himself to the Borg in exchange for Data's freedom, Data refuses to leave, deactivates the self-destruct, and fires torpedoes at Phoenix. At the last moment, the torpedoes miss, and the Queen discovers that Data has deceived her. The android ruptures a coolant tank, and the corrosive vapor eats away the biological components of the Borg and Data's new skin. With the Borg threat neutralized, Cochrane completes his warp flight. Later that night, the crew watches from a distance as an alien Vulcan ship, attracted by the Phoenix warp test, lands on Earth. Cochrane greets the aliens. Having ensured the correction of the timeline, Picard bids Lily farewell, and the Enterprise crew slips away and returns to the 24th century.

Helen Quilley is sacked from her public relations firm. As she leaves the office building, she drops an earring in the lift, and a man picks it up for her. She rushes downstairs to the London Underground, when a young girl slightly delays her, and the sliding doors shut before she can board the train. Time seems to rewind, and restart, but this time, the girl's mother pulls her child out of Helen's path downstairs, and Helen forces open the nearly closed sliding doors to board the train. Two different versions of Helen continue on with their lives, alternating between two diverging stories. Helen, who boards the train, sits beside James, the man who had picked up her earring in the lift, and they strike up a conversation that cheers her up. She gets home to catch her boyfriend, Gerry, in bed with his American ex-girlfriend, Lydia. Helen leaves him and moves in with her friend Anna. At Anna's suggestion, Helen cuts her hair short and dyes it blonde to make a fresh start. James befriends Helen and she begins to move on from Gerry as he cheers her up and encourages her to start her own small PR firm. They fall in love, despite her reservations about beginning another relationship so soon after her ugly breakup with Gerry. Eventually, Helen discovers that she is pregnant by James. She goes to see him at his office and is stunned to learn from James's secretary that he is married. Having discovered that Helen has learned he is married, James searches frantically for her before finding her on a bridge and explaining that while he is married, he is separated and will soon be divorced, and that he and his wife maintain the appearance of a happy marriage for the sake of his sick mother. After she and James reconcile and declare their love, Helen walks into the road and is hit by a van. Helen, who missed the train, is further delayed by an attempted mugging, which leads to a hospital visit where the cut to her forehead is treated. She arrives home after Lydia has left, and remains oblivious to Gerry's infidelity. Unable to find another PR position, she takes two part-time jobs to pay the bills to support Gerry, who is unemployed and struggling to finish his novel. Gerry continues to juggle the two women in his life, and Helen gradually becomes suspicious. She discovers she is pregnant but does not tell Gerry. Lydia soon realizes Gerry will never leave Helen for her and angrily breaks things off with him, to Gerry's relief. Lydia also realizes she is pregnant by Gerry and summons Helen under the guise of a job interview, but instead reveals the affair and her pregnancy to Helen. Distraught, Helen flees and falls down the stairs. In both timelines, Helen is taken to the hospital and loses her baby. Helen who boarded the train, succumbs to severe injuries and dies with James at her bedside, expressing his gratitude at meeting her on the train. Helen who missed the train recovers and tells Gerry to leave for good. James, who is visiting his mother, picks up Helen's dropped earring in the hospital lift, encouraging her to "Cheer up. You know what the Monty Python boys say..." (the same joke he told Helen in the other timeline), but this time, Helen preempts James, correctly quoting the punch line, " No-one expects the Spanish Inquisition." They turn and gaze at each other.

In 1859, a meteorite streaks across the sky and crashes into the Gela Alta glacier in western Greenland, causing a massive explosion that kills an Inuk fisherman. In present-day Copenhagen, Smilla Jaspersen, a transplanted Greenlander, is studying ice crystals at a university lab. Although an Arctic ice specialist, Smilla has not completed her credentials and is unemployed, with a troubled past. When she returns to her apartment complex at the end of the day, she finds the body of six-year-old Isaiah Christiansen, a neighbor Inuk boy. He is lying in the snow by the edge of the building. The police say that he must have been playing and fallen from the roof. Smilla knew he was afraid of heights and, on the roof, sees that his footprints show he ran straight to the edge of the roof, as if threatened. At the morgue Smilla meets with Dr. Lagermann. She is surprised when he tells her that a prominent professor, Dr. Johannes Loyen, performed the autopsy on the boy, who was from a poor working-class family. When she consults with Loyen the next day, he declares the boy's death to be an accident. Unconvinced, Smilla files a complaint with the District Attorney. She goes to Lagermann's home seeking more information, and he says that he found a puncture wound on the boy's thigh, made by a biopsy needle after his death. He also says that Loyen was examining the boy every month. At the funeral, Smilla notices Dr. Andreas Tork, the CEO of Greenland Mining, offering money to Isaiah's mother, who rejects it angrily. Following her husband's accidental death in Greenland in mining, the company had offered her a pension. Detective Ravn from the District Attorney's office agrees to look into the case, but Smilla discovers he is involved with Tork. Smilla tracks down the company's former accountant, and gains access to a company report about activities in Greenland. A neighbor mechanic becomes involved and offers to help her. Detective Ravn threatens Smilla with jail for stealing Greenland Mining property. She agrees to suspend her investigation but, after learning from Isaiah's mother that her husband died from something in the mine's melt water, she continues. Smilla asks her father, Moritz Jaspersen, to help her in making sense of the Expedition Report; he agrees to look into it. At the apartment complex, Smilla searches around Isaiah's former hiding place by a stairwell, and discovers a cassette tape hidden behind the wall. Unable to understand the audio, she takes the tape to a blind audio expert, Licht. Shortly after he tells her that it is Isaiah's father talking to his son, Licht is murdered. Smilla barely escapes with her life and the mechanic picks her up. They follow their pursuers to a ship, which Tork is preparing for another Greenland expedition. Smilla's father shows her medical x-rays from the report, which reveal that a type of lethal, prehistoric "Arctic worm," long thought to be extinct, apparently was the cause of the "accidental" deaths of mine workers. When the worm entered individual's bodies and attacked organs, it caused toxic shock and death. Aided by others, Smilla gets aboard the mining ship as an employee. She meets Nils Jakkelsen, who helps her discover videotapes that reveal the mining company had discovered an energy-producing meteorite along with the parasitic worm. Tork believes the meteorite will give his company a dominant position in the industry. There is also a video tape of Prof. Loyen medically examining Isaiah. Smilla is chased throughout the ship by Tork's men, who kill Nils. Smilla is helped again by the mechanic, who tells her he has been working for the government to investigate the company. As the ship approaches shore, Smilla leaves and makes her way across the frozen landscape. She finds the entrance to the Greenland Mining ice cave, where the company is conducting research on the meteorite. Prof. Loyen is among those present. Tork explains that Isaiah's father was a diver who went into the water around the meteorite and contracted the parasitic worm. Isaiah was also potentially infected as well. Prof. Loyen then monitored Isaiah for a time to see if he was indeed infected. An armed confrontation takes place, but Smilla is rescued by the mechanic and another man. During a struggle, Prof. Loyen falls into the icy pool (containing said meteorite) in the cave, instantly freezing to death (as he sinks below the depths). Tork is wounded and runs out across the ice. Smilla pursues him and recounts what happened with Isaiah. Tork had followed the boy home in hopes of recovering the recording and in the resulting pursuit, Isaiah fled to the roof of his building and fell off the edge. From outside, the mechanic/agent sets off a powerful bomb that destroys the cave and buries all still inside. The resulting waves cause Tork to fall from the ice and drown in the freezing water. Smilla gazes over the landscape of ice and snow, the land of her childhood.

At a corporation's base on the Neptunian moon Triton, mercenaries are setting up a defense perimeter to try to hold off an unstoppable cyborg warrior. The company's CEO E.J. Saggs and chief scientist Dr. Nabel seal themselves inside the control room. The cyborg destroys the soldiers' tank and then attacks a helicopter, which crashes into the control room. The soldiers are killed one by one, until Nabel finally deactivates the cyborg with a remote control. The remaining corporate employees discover that the cyborg was created by Nabel for the company. Saggs takes the remote and reactivates the cyborg, ordering it to kill Nabel. Meanwhile, John Canyon, one of the last independent "space truckers", drops off his cargo of square pigs at a "truck stop" space station, but becomes embroiled in a brawl with the trucking company head, Keller, who is sucked out into space. He and his two passengers—Cindy, a waitress who has promised to marry him in exchange for a ride to Earth to see her mother, and Mike, an up-and-coming trucker working for the company—take on a deal to transport alleged sex dolls to Earth. Chased by police investigating Keller's death, John takes his rig into the "scum cluster", a region controlled by pirates. The rig takes damage, leaving them adrift; they are soon captured by the pirate ship Regalia, commanded by the company-hating Captain Macanudo. Cindy agrees to have sex with him if he would take the cargo and let them go. The captain is revealed to be Nabel, who rebuilt his grievously injured body and went into piracy as revenge against Saggs for betraying him. The cargo that John's rig is carrying is in fact a full supply of the cyborg warriors Nabel designed and built for Saggs' company. One of the cyborgs activates, kills most of the crew, and severely damages the ship. John, Cindy and Mike take their rig and escape as the Regalia explodes. As they make their way back to Earth, John and Mike find a mortally wounded Macanudo in the hold, who reveals the true nature of the cargo to them. John releases Cindy from any obligation of marrying him, and tells her and Mike to take the escape pod while he releases the cargo in the atmosphere, where it will burn up on re-entry. Cindy and Mike land safely, but the rig is unable to return to space and explodes in the sky; however, John is able to safely escape before the explosion. John, Cindy and Mike go to the hospital to see Cindy's mother, who became sick twenty years earlier and was frozen until a cure was found; John is smitten with her at first sight. Meanwhile, Saggs—now President of Earth after the government was privatized—visits John, Cindy and Mike in the hospital, where he offers John a new rig and gives the trio a suitcase full of money to keep them quiet about his cyborg invasion plan. John tactfully agrees to the deal, convinced they will all be assassinated if they don't accept, but Mike angrily throws the suitcase out the window. Below, Saggs re-enters his presidential limousine; having planted a bomb in the suitcase, he triggers the detonator just as the suitcase lands on his limousine's roof, killing him. With Saggs dead and Earth safe, but also having inadvertently blown up the president, Mike, Cindy, John and Cindy's mother quietly escape to the spaceport and blast off in their brand new rig.

Gregorio and Ingrid Cortez are spies with two children, Carmen and Juni, whom they shield from their lives to protect them from inherent danger. They work for the Organization of Super Spies (OSS) doing office consultant work, but are suddenly called back to active field work to find missing agents. Gregorio suspects children's television host Fegan Floop has kidnapped them, mutating them into his "Fooglies" – creatures on his show, a program that Juni avidly watches. The children are left in the care of their uncle, Felix Gumm. Gregorio and Ingrid are captured by Floop's "Thumb-Thumbs" (robots whose arms, legs, and heads resemble oversized thumbs) and taken to his castle. Felix is alerted to the parents' capture, activates the fail-safe, and tells the children the truth about their parents, and that he is not their uncle, but an agent sent to watch over them. The house is attacked by Ninja Thumb-Thumbs, and Felix is captured while the children escape alone via a miniature submarine set to autopilot to a safe house. At the safe house, the children accept that their parents were spies and decide to rescue them. Inside Floop's castle, he introduces his latest creation, small child-shaped robots, to Mr. Lisp. They plan to replace the world leaders' children with these super-strong robots to control the world, but since the androids have no artificial intelligence yet, they are unable to function outside their regular programming. Lisp is furious, demanding usable androids. Floop, with his second-in-command Alexander Minion, interrogates Gregorio and Ingrid about 'The Third Brain'. Ingrid knows nothing of it, while Gregorio claims he had destroyed the brain years ago. After Floop leaves, Gregorio reveals to Ingrid that the Third Brain was a secret OSS project he had worked on: an AI brain with all the skills of the entire OSS. The project was scrapped for being too dangerous, and many scientists demolished the brains that they were working on, but Gregorio refused to destroy the final prototype. At the safe house, Carmen and Juni are visited by OSS agent Ms. Gradenko. Giving Carmen a bracelet as a sign of trust, she asks about the Third Brain, but Carmen is confused. Gradenko orders the house to be dismantled, and the siblings realize Gradenko is a traitor when they see ninja Thumb-Thumbs destroying the escape submarine. With Gradenko's intentions revealed, Juni accidentally exposes the Third Brain, and a chase ensues. Carmen gets the brain, and she and Juni escape. She realizes too late that the bracelet from Gradenko has a tracking device, and she and Juni are attacked by their robot counterparts, who steal the Third Brain and fly away. Meanwhile, back at the castle, Gregorio tells Ingrid that Minion used to work for the OSS, but was fired after he reported him tampering with the Third Brain project. With it, Floop can achieve his goal, but he wishes to continue his children's TV show. Minion has different plans and takes over, locking Floop inside his "virtual room", the chamber where he films his television series. Carmen and Juni receive reluctant help from Gregorio's estranged brother Isador "Machete" Cortez when they show up at his spy shop. He refuses to accompany them, so they steal some gear and take his spy jet to fly to Floop's castle. After a few mishaps, Carmen and Juni eject themselves from the plane before it crashes into the castle, and they enter via the underwater entrance. While the children infiltrate the castle, Juni rescues Floop, who helps him and Carmen release their parents. Together, they trap Minion in Floop's Fooglies machine, mutating him into a Fooglie. Confronting Lisp and Gradenko, the family is beset by all 500 robot children. Suddenly, Machete busts through the window, reconciling with Gregorio and joining the family to fight. However, at the last moment, Floop reprograms the robots to change sides. The 500 superhuman robots quickly overpower Minion, Lisp, and Gradenko. With advice from Juni, Floop introduces the robot versions of Carmen and Juni on his show. At home, some time later, the family's breakfast is interrupted by Devlin, the head of the OSS, with a mission for Carmen and Juni. The children tell him they will only accept if all the Cortezes can work on the mission together as a family.

Ten-year-old Chihiro Ogino and her parents Akio and Yūko travel to their new home. Akio, driving down an unexpected road, ends up in front of a tunnel leading to what appears to be an abandoned resort town, which her parents insist on exploring over Chihiro's protests. Upon finding a seemingly empty restaurant stocked with food, Chihiro's parents immediately begin to eat. While exploring further, Chihiro finds an enormous bathhouse and meets a boy named Haku, who warns her to return across the riverbed before sunset. However, spirits begin to appear, and Chihiro discovers that her parents have been transformed into pigs and that she cannot cross the now-flooded river. Haku finds Chihiro and instructs her to ask for a job from the bathhouse's boiler-man, Kamaji, a yōkai spirit commanding soot sprites known as susuwatari. Kamaji instead asks a worker named Lin to bring Chihiro to Kamaji's master Yubaba, the witch who runs the bathhouse and who cursed Chihiro's parents. Yubaba tries to frighten Chihiro away but eventually gives her a work contract. As Chihiro signs the contract with her name (千尋), Yubaba takes away the second kanji in her name, renaming her Sen (千). She soon forgets her real name, and Haku later explains that Yubaba controls people by taking their names; if Chihiro completely forgets hers like he once did, she will never be able to leave the spirit world. The other workers, except for Kamaji and Lin, frequently mock Sen. While working, she invites a silent creature named No-Face inside, believing him to be a customer. The spirit of a polluted river arrives as Sen's first customer. After she cleans him, he gives her a magic emetic dumpling as a token of gratitude. Meanwhile, No-Face demands food from the bathhouse workers, granting gold copied from the river spirit in exchange. However, when Sen declines the gold and leaves to find Haku, No-Face angrily swallows some workers. Sen sees paper shikigami spirits attacking a dragon and recognizes the dragon as a metamorphosed Haku. When the seriously injured Haku crashes into Yubaba's penthouse, Sen follows him upstairs. A shikigami that stowed away on her back shapeshifts into Yubaba's twin sister Zeniba, who turns Yubaba's son, Boh, into a mouse and creates a false copy of him. Zeniba tells Sen that Haku has stolen a magic golden seal from her that carries a deadly curse. Haku strikes the shikigami, causing Zeniba to vanish. Sen and Haku fall into the boiler room, where she feeds him part of the emetic dumpling. He vomits up the seal and a slug that a disgusted Sen kills. Sen resolves to return the seal and apologize to Zeniba. She confronts an engorged No-Face and feeds him the rest of the dumpling, forcing him to regurgitate the workers. No-Face follows Sen out of the bathhouse, and Lin helps them leave. Sen, No-Face, and Boh travel to see Zeniba using train tickets from Kamaji. Meanwhile, Yubaba nearly orders Sen's parents slaughtered, but Haku reveals Boh is missing and offers to retrieve him if Yubaba releases Sen and her parents. Yubaba agrees, but only if Sen can pass a final test. The train crosses a sea to a land where Sen meets Zeniba, who reveals that Yubaba used the slug to control Haku. Zeniba tells Sen that she cannot help her parents, but she makes her a magic protective hairband. Using his dragon form, Haku flies Sen and Boh back, while No-Face decides to stay with Zeniba. Mid-flight, Sen recalls falling into the Kohaku River years earlier and being washed safely ashore, correctly guessing Haku's real identity as the spirit of the Kohaku River and restoring his memory. When they arrive at the bathhouse, Yubaba tests Sen, asking her to identify her parents among a group of pigs. After she answers correctly that none of the pigs are her parents, her contract disappears and she is given back her real name. Haku takes her to the now-dry riverbed and vows to meet her again. Chihiro crosses the riverbed to her restored parents. Shortly before leaving for her new home, Chihiro looks back at the tunnel, still wearing her hairband from Zeniba.

Nashawn Wade claims that he has loved planes since he was a child, but he has a horrible experience with a typical airline: his dog Dre is classified as checked baggage instead of a carry-on, he eats a horrible airline meal, his buttocks get stuck in the toilet while he has diarrhea, caused by his meal, during turbulence, and Dre is fatally sucked through a jet engine after a flight attendant accidentally opens the cargo door. In response to the terrible experience he endured, Nashawn sues the airline and is awarded $100,000,000 by the jury. He decides to use the money to start his own airline, called N.W.A. (Nashawn Wade Airlines), whose acronym and logo are a pop culture reference to rap group N.W.A. The airline specifically caters to African Americans and hip hop culture. The terminal at the airport is called the Malcolm X terminal, where two non-working TSA Agents, Jamiqua and Shaniece, are goofing off instead of checking belongings. The plane is a heavily modified Boeing 747SP, customized with low-rider hydraulics, spinners, and a dance club. The safety video is also a parody of the Destiny's Child song " Survivor ". After taking off from Los Angeles International Airport, Nashawn must deal with a multitude of problems, starting with his acrophobic captain, Captain Mack. At a cruising altitude of Flight Level 330, it is revealed that he has never left the ground because he learned to fly on computer simulators in prison. Meanwhile, his cousin Muggsey sets up a miniature casino and strip joint in one of the areas of the plane (as seen in the workprint and unrated versions of the film), and Nashawn's ex-girlfriend, Giselle is on board and less than happy to see him. Meanwhile, the Hunkee family, the only Caucasian passengers on board, must also deal with their own problems; Elvis' daughter Heather is turning 18 and plans to use her newfound freedom by drinking and having sex, his son has transformed from an exact duplicate of him to a stereotypical wigger, and his wife is suddenly addicted to black men after viewing pictures in a pornographic magazine. Captain Mack seemingly dies after eating mushrooms that the co-pilot, First Officer Gaemon, uses to soothe his genital crabs. Nashawn attempts to contact Gaemon, who is incapacitated after slipping near a hot tub, forcing Nashawn to attempt to land the plane himself. Nashawn lands the plane safely, using flight attendant Blanca's flight knowledge which she learned while having sex in the cockpit with the pilot on another plane. The plane lands in the middle of Central Park instead of John F. Kennedy International Airport in Queens, New York, and the spinners are stolen from the plane. Nashawn reconciles with Giselle after earlier revealing to her that he only broke up with her so she would not give up her college opportunities for him. The movie ends with Nashawn telling the audience the fate of his crew. He claims that he and his ex-girlfriend are back together and are taking their relationship slow this time around, his cousin Muggsey has started a strip club and gambling casino located in another airplane similar to the club in Nashawn's plane, Elvis has begun a sexual relationship with Jamiqua, and his son Billy has become a major music video director but has disappeared shortly after filming a Michael Jackson video. Captain Mack later wakes up to find his chain and clothing stolen.

On July 4, 2005, El Paso and Abilene, Texas are destroyed and hundreds of thousands are killed by twin nuclear attacks, sending the United States into a state of a Third World War, with the government re-introducing the draft. The PATRIOT Act extends authority, due to the overwhelming victory of the Republican Party, to US-IDENT, a new agency which keeps constant surveillance on citizens. In response to the recent fuel shortage in the wake of global warfare, the German company Treer designs "Fluid Karma", a generator of inexhaustible energy, which is propelled by the perpetual motion of ocean currents. Treer scientist Baron Von Westphalen seeks world domination using the leverage of his energy machine. In 2008 Los Angeles, Senator and GOP Vice-Presidential candidate Bobby Frost (who also seeks the presidency itself) presides over the opening of US-IDENT with his wife, Nana Mae Frost, installed as its director. Right-wing film star Boxer Santaros awakens on the beach with amnesia after a three-day disappearance. He does not remember his marriage to Senator Frost's daughter Madeline, and has instead begun an affair with former porn star turned-talk show host Krysta Now. Meanwhile, a group of Neo-Marxist revolutionaries composed of Cyndi Pinziki, Zora Carmichaels and Ronald Taverner hatch a plan to turn the national spotlight against US-IDENT. They have kidnapped Ronald's twin brother, police officer Roland, and plan to outfit Ronald in his uniform and car in order to stage a racially motivated double-murder. They have Boxer bring a video camera as he goes with Ronald, under the guise of preparing for a police officer role for his screenplay. Ronald responds to a staged domestic disturbance call where Neo-Marxists Dream and Dion, disguised as newlyweds, fake an argument. Unexpectedly, another cop, Bart Bookman arrives on the scene, murders Dream and Dion, and takes the camera. Bookman is revealed to be in cahoots with Zora when she later attacks Ronald with fluid karma, leaving him unconscious in the street. The next day, Krysta stops by Zora's apartment and takes the videotape of the double murder, mistaking it for her sex tape. At the Santa Monica beach, she puts it in a Neo-Marxist dropbox, leading to the contents later being made public, and Zora and Bookman are shot dead by police while attempting to steal back the tape. Boxer arrives at the beach and meets Starla, who called him earlier posing as a character from his screenplay, and threatens to kill herself if he does not allow her to perform oral sex on him. Iraq War veteran Private Pilot Abilene shoots her dead from his perch at the top of the pier and Boxer runs off, only to be confronted by supposed friend Fortunio, who knocks him unconscious and returns him to the Frosts. Nearby, Ronald awakens and sets out to find his brother. He encounters a young man named Martin Kefauver in an SUV and stops him from killing himself to avoid the draft, and the two go out in search for Roland, who earlier escaped the Neo-Marxist headquarters during a US-IDENT raid, only to be captured by Walter Mung, an ice cream truck-based arms dealer. The Frosts and the city prepare for an upper-class party on Von Westphalen's Mega- Zeppelin to celebrate its launch. Boxer leaves the main hall of the ship in search of answers, and finds a room with three of Westphalen's scientists, who explain that he was selected to travel through a time rift in the desert at the time of his disappearance, and is, in fact, his future self. The scientists show him the corpse of his past self, who they say killed himself. Boxer asserts that his suicide is impossible because he is a "pimp", and "pimps don't commit suicide." One of the scientists also states that dire consequences would unfold if two identical human souls were to make physical contact. Boxer presses Serpentine for details, revealing that Boxer was actually murdered in a car bomb and that Roland was the one who kidnapped Boxer and drove him through the rift. She also confirms that Roland and Ronald are the same person, with his past and present self coexisting. Outside where the city is, as a firefight ensues between rioters and the police, both Taverners crash into each other. Roland is shot in the eye but survives. Inside the ice cream truck, the Taverners hold hands, causing the truck to rise into the air along with Kefauver, who stands on top with a shoulder-mounted heat-seeking ground-to-air missile. US-IDENT headquarters is raided by Fortunio and rioters who kill Nana Mae Frost. Inside the Zeppelin, Boxer returns to the main hall and takes the stage for a dance number involving Krysta and his wife, Madeline. He interrupts the number to order an evacuation, or else he will kill himself. Kefauver fires a rocket at the Zeppelin, destroying it, and jumps off the truck. As the Taverners continue to hold hands, a time rift begins to grow in the sky. Roland threatens Ronald with suicide if he does not let go and tells him to "remember Fallujah". Ronald replies that it was not their fault, with Roland conceding that it was friendly fire. Abilene narrates that a new age is beginning, with Roland as its Messiah, concluding that he is a "pimp" and that "pimps don't commit suicide."