Drake is a corrupt and greedy developer who is illegally dumping toxic waste into the mines around the small town of Clear Sky, causing mosquitoes to mutate into giant beasts that attack and kill anything, including humans. A lawman of the town sheriff, Roy Boone, and his reunited love Sarah Crosby, must put a stop to both the pollution and the bugs. The body counts keep rising, which causes the locals to feel that they have to move out of the city. Crosby and environmental inspector Gordon Perry try to find the origin of the waste, but certain people try to prevent them for doing so due to Drake's evil deeds, which involves some hitmen.

In January 1993, Jerry Shepard, guide at a National Science Foundation Antarctic research base, is asked to take UCLA professor Dr. Davis McClaren to Mount Melbourne to find a rare meteorite from Mercury. Since the ice conditions are poor, the best way to the mountain is by dog sled. Shepard and McClaren make it, but are called back to base camp due to an approaching storm. McClaren begs for more time and Shepard gives him half a day. En route back to base, McClaren slips down an embankment, breaking his leg and falling into freezing water. Shepard uses lead dog Maya to carry a rope to McClaren and pulls him out. They battle hypothermia, frostbite, and near- whiteout conditions as the dogs lead them to base. At base, the human crew is immediately evacuated, while the dogs are left behind. Shepard, promised that the pilot will return shortly for the dogs, tightens their collars to ensure they cannot get loose. Because of the harsh weather conditions a rescue cannot be attempted. Back in the United States, Shepard tries to return for the dogs, but no one is willing to finance the expedition. Five months later, Shepard makes one last attempt. McClaren realizing his ingratitude and uses the remainder of his grant money to finance the rescue. They fear there is little chance any of the dogs could have survived so long, but they decide to try anyway. The eight sled dogs – lead dog Maya, Old Jack, Shorty, Dewey, Truman, Shadow, Buck, and the young Max – have been waiting in the freezing conditions for Shepard to return. After a few days without eating, the dogs are prompted into action as a gull flies near, and they all begin to break free, one by one. Old Jack, by now too weak, remains attached. Maya tries to free him, but reluctantly leaves him behind when he shows no sign of wanting to leave. Maya joins the other dogs, and together they catch a few birds, getting their first food in weeks. After nearly two months on their own, the dogs rest on a slope one night under the southern lights. Fascinated by the display, they run about and play until Dewey falls down an incline and is mortally wounded. The team sleeps by his side and Dewey dies overnight. Max loyally stays by him while the others move on. By the time Max heads in their direction, he has lost the pack. Maya leads the team to the Russian base, which is unsecured and full of food, while Max finds his way back to the American base, which is locked up. Setting back out, Max recognizes the embankment the dogs traveled on their way back from Mount Melbourne. While exploring, Max finds a dead orca, but is driven off by a leopard seal nesting inside the body. Nearby, Maya and the team hear Max and join him. Max lures the seal away so the dogs can eat, but it doubles back and bites Maya, leaving her badly injured. In a rage, the five other dogs attack the seal. Overwhelmed, the seal quickly drags itself into the water, after which the dogs feast on the orca. The reunited team continues traveling. Starving, freezing, and exhausted, the injured Maya collapses into the snow. The dogs lie down beside their leader as the snow piles up. They have been on their own for six months. Shepard, meanwhile, has gone to New Zealand looking for a boat to take him to Antarctica. At a bar, he reunites with his friends and they make it to the base. Upon arrival, they are dismayed to find the body of Old Jack, still attached to the chain, and no sign of the other dogs. Then they hear barking and see Max, Shorty, Truman, Shadow, and Buck come over the horizon. After a joyous reunion, Shepard loads the dogs to leave, but Max runs off, leading Shepard to Maya, lying in the snow – weak, but alive. With six of his eight sled dogs, Shepard and his crew head back to civilization, with the last scene showing a memorial for the two fallen dogs, Old Jack and Dewey.

Best friends Dave Goodman, Sam Schecter, and Jeff Davis have spent almost four years at Holden University scamming their way through college. During one exam scam in their final semester, Dave meets Angela Patton and asks her out while writing his phone number on her exam sheet. Ethan Dulles (who calls himself "Cool Ethan"), a nerdy student who is obsessed with Angela, observes Dave and grows jealous. Ethan takes Angela's exam question sheet after she leaves and uses it to blackmail the guys into setting up a successful date for him with Angela. The guys set Ethan up in multiple situations to try to convince Angela to like him, while Dave tells Sam during their research that Angela is no more important to him than any other scam they have pulled. Ethan fails to attract her after frequent confrontations based on his delusional behaviour, immaturity, and flouting of social norms. While trying to convince Angela to go out with Ethan, Dave and Angela develop a mutual attraction. After telling Ethan that he has failed to convince Angela to go out with him, Ethan reveals to Dave that he has been obsessing over Angela for quite some time. He reminds Dave that he still intends to get Dave and his friends expelled if they fail him. Angela and Dave go on an impromptu date after a study session. Ethan finds out, follows, and records them. Dave and Angela share a romantic swim and lovemaking session, which Ethan records. He shows the tape of Dave and Angela making love to Sam and Jeff to establish that Dave intends to keep Angela for himself. Sam and Jeff, unhappy with Dave's dishonesty, hand over their research on Angela. Ethan shows Angela the file, telling her that Dave and his friends were actively stalking her. Dave punches Ethan in the face, but Ethan thinks he won Angela. After a falling-out with everyone, Dave returns to the dorm and admits to Sam and Jeff that he genuinely cares for Angela. After making amends, the guys sabotage Ethan's job interview with a law firm, and, during the final exam, Dave confesses to Angela in front of the whole class about his years-long practice of cheating. Jeff plants an answer key in Ethan's backpack while tipping off the teaching assistant proctoring the exam. The men get expelled, but Dave and Angela get back together, and Sam ends up in a relationship with Angela's roommate, Reanna Cass. Jeff falsifies their diplomas from Holden University after Angela and Reanna graduate. Ethan, miserable that he lost Angela forever and got expelled from college after it was revealed he was stalking her, continues to work his dead-end restaurant job, as he continues to pine for Angela and nurse a hatred for Dave.

Jack Stanfield is chief of security of Landrock Pacific Bank in downtown Seattle. He is visited by a collection agency, claiming he owes $95,000 to their online gambling site. Believing the incident is due to an identity theft, Jack entrusts his colleague Harry Romano to take care of the claim. Jack goes out for a drink with Harry who introduces him to Bill Cox, a potential partner. After they leave, Cox climbs into Jack's car and forces him at gunpoint to drive home. There, Jack finds his wife Beth and his two children unharmed, but under surveillance by Cox's man, Willy. The next morning, Jack is instructed to transfer $10,000 from each of the bank's 10,000 largest depositors – $100 million total – to Cox's offshore accounts. Cox rigs him with a camera and microphone to hinder his ability to ask anyone for help. At Landrock Bank, Cox visits Jack under the alias Bill Redmond, requesting a tour of the bank's security system. On the way back home, Jack attempts to bribe Willy to betray Cox, to no avail. After Willy slipped up (unaware that Jack slipped the camera onto his secretary Janet), Cox kills him. At home, Jack attempts an escape with his family, but is foiled when they discovered Willy's dead body in the car. In retaliation, Cox gives Jack's son Andy a cookie containing nut products, sending him into anaphylactic shock. Cox withholds the treatment, an EpiPen, until Jack acquiesces to their plan. The next day, Cox forces Jack to fire Janet, fearing she is growing suspicious. Jack complies, but it doesn't end well. Jack initiates a wire transfer to send the money to Cox's offshore accounts. Before leaving, Jack uses an employee's camera phone to take a picture of the account information on the screen. Cox then begins covering his tracks. He forces Jack to delete security data and surveillance tapes and use a virus to cripple the building's system into disarray. Returning home, Jack finds the house empty except for Liam, Cox's enforcer. After realizing that Cox never had any intention of letting him and his family live from the beginning, so as to cover up his crimes, Jack overpowers and kills Liam with a heavy glass blender. He calls Harry, but he does not answer. Jack goes to Harry's house to inquire about Cox, but hearing and witnessing the two entering the house, he goes to hide, where he watches Cox killing Harry with his gun that was confiscated earlier. Beth, held at gunpoint, leaves a message suggesting an affair on Harry's answering machine, implicating Jack in his colleague's death. In addition, the $95,000 debt will be considered motive for Jack embezzling the bank's money. Jack turns to Janet and reveals the truth. She agrees to help him retrieve the phone with the picture of Cox's account information. Jack hacks into Cox's Cayman Island accounts and transfers the money away. He calls Cox with Liam's phone and they arrange to free his family in exchange for returning the money. During the conversation, Jack hears the family dog Rusty in the background and realizes he can locate his family by the GPS tracking unit in the dog's collar. Cox's gang ditches the dog during mid-drive, but Jack managed to track them to an abandoned farmhouse. He tells Janet to call 911 and approaches the house. Vel, Cox's tech guy, takes pity on the family and attempts to intervene with killing the family, forcing Cox to kill him. Jack's daughter Sarah runs out of the house. Another henchman, Pim, chases after her, but Jack kills him by ramming him with Janet's car, then hits an RV that explodes and destroys the car. Cox takes Beth and Andy to the upper floor, but Jack enters the house and engages him in a final showdown. Their fight eventually leads them into the ditch Cox had dug for Jack's family. Cox temporarily gains the upper hand, but Jack impales him with a pickaxe, killing him and saving his family. Jack reconciles with them before they head back home together.

Sir William "Billi" Sedgewick is a veterinarian and resides with Gordon, a goat who behaves like a dog, outside the small town of Catterness, located within the Scottish Highlands. On orders of the Scottish government, beavers have become illegal in Scotland and are to be sent to Norway. During one such removal, a lorry carrying a large group of beavers is involved in an accident, letting loose some beavers. The officers in charge of the operation, McKenzie and McTavish, manage to recapture most beavers, but one escapes. The escapee, Bessie Boo, is subsequently adopted by a family of rabbits. McKenzie, posing as a police officer, mounts an obsessive search for Bessie. Five years pass as McKenzie continues his search for Bessie. Meanwhile, Bessie and the rabbits partake in a tobogganing race. Bessie's adoptive brother, Wee Dave, and their mother fall into a river due to the former's carelessness, leading Bessie to attempt to rescue them. Billi, Gordon, and Billi's grandson, Jake, drive towards Catterness when another rabbit alerts them of the problem. Billi organises a deputation in the town square before noticing McKenzie acting strangely and questioning his identity. During the group's search, Billi finds and resuscitates Bessie's mother and soon locates Bessie and Dave approaching Baron McToff's dam. McToff, despite his protests, accepts Billi's demands to turn off the turbines. The group manages to rescue Dave, only to miss Bessie. Gordon bungee jumps down to catch Bessie but falls into the river. The group retrieves Gordon, but they are distracted by a submarine. Billi gathers a group to save Gordon with a trampoline, but Gordon gets knocked out. Victoria, a pilot duck assisting with the group's rescue, throws Billi a bottle of water, which he uses to revive Gordon. Lady Serena, Billi's daughter, hands Bessie to the submarine's pilot, but McKenzie absconds with Bessie. McKenzie then hijacks Billi's Land Rover, causing Billi to give chase in his Aston Martin and eventually on his skateboard across the Highlands. Ending up outside a military base, McKenzie tries to have Billi arrested before they are both confronted by the police. McKenzie is arrested for his crimes, while Billi promises to reunite Bessie with her family. The townspeople celebrate their victory at the Catterness Inn while Bessie gets returned to her mother. Billi and his consort, Toni Turner, leave the celebration to drive off into the moonlight.

At a sleepy gas station, the pump attendant is attacked by an animal infected by an unknown organism manifesting as large protruding splinters. A young couple, Seth Belzer and Polly Watt, drive for a romantic camping trip in the forests of Oklahoma, but are car-jacked by an escaped convict, Dennis Farell, and his drug-addict girlfriend, Lacey Belisle. The group gets a flat tire when they run over a splinter-infected animal on the road. They find shelter at the now-abandoned gas station. Lacey discovers the horribly-infected pump attendant, writhing in the bathroom. She is attacked and killed by the monster, but her corpse slowly reanimates and becomes a new creature, which attacks the remaining survivors. While fighting her, Seth, Polly and Dennis discover that severed pieces of the infected victims are capable of attacking on their own. Sheriff Terri Frankel arrives and attempts to arrest Dennis, but is ripped in half by Lacey's corpse. The creature takes the top half of the officer's body and bonds with it, becoming a larger creature. The trio hide in the walk-in refrigerator when a piece of the creature's arm attacks them. It is discovered that Dennis has been infected, as his left arm violently twists on its own. Seth and Polly amputate his arm to prevent the infection from spreading. Dennis explains that he had been pricked by a splinter from the dead creature they encountered on the road. Seth discovers that the creatures themselves are a fungus taking control of the corpses they infect and consuming the blood in the body, using the currently zombified host to seek out fresh and new hosts. Because of this, they hunt based on temperature and attack the warmest thing they can find. By lowering his body temperature with bags of ice, Seth sneaks past the creature to the police car, while Polly and Dennis distract it with fireworks. Seth discovers that, without the keys, the car and the police radio inside are useless. His body temperature rises again, forcing Dennis to leave the gas station to lure the creature away from him. The creature enters the gas station, and Dennis and Polly hide in the freezer. The discarded fireworks ignite a trail of flammable liquid, and the gas station catches on fire. Seth retrieves a shotgun from the police car and helps Polly and Dennis escape. Dennis is infected after helping to keep the creature at bay while Seth and Polly escape. He shoots one of the gas pumps with the shotgun, and the creature is engulfed in flames, killing it. Dennis, still infected, gives Seth and Polly a key to a bank account, telling them to give it to the wife of a man he shot, who later died. Dennis shoots directly into the propane tanks, incinerating himself, the station, and any remaining infected corpses. Seth and Polly wander into the distance as other infected creature corpses lie dormant in the woods.

Eric, 19, is "starred up" from a juvenile prison to a high security adult prison, based on his age and his history of violent behaviour. His father, Neville, is serving a life sentence at this prison, and is a lieutenant for the crime boss that runs the prison. Eric soon begins attacking guards and inmates alike, but is rescued from retribution from the guards by Oliver, a volunteer prison therapist, who convinces Eric to join his therapy group. The group is composed of black men who also have violent pasts, which they are trying to confront. The sessions often degrade into angry, posturing tirades by members against others, which Oliver de-escalates but uses to help them understand their rage. Eric begins to observe this format, and also bond with the other group members. While his father has ordered him to "learn to behave" from the therapist, he is annoyed by his son "fraternising" with blacks. But when three inmates are paid with drugs to "dunk" Eric in his toilet, one of his black group-mates steps in to save him. The father and son have an explosive up and down relationship, with the father attempting to instill his dominance, and make Eric follow the prison rules so he can get out. When Eric however attempts to explain his feelings to the uncomfortable Neville, Eric intuits that his father is in a romantic relationship with his cellmate, and is disgusted by it. The boss, Dennis, appears to begin to mentor Eric, seeing his younger self in Eric. However, Eric is disinterested and ends up attacking Dennis during an argument with Neville. Dennis then orders the prison director to kill Eric. While Neville is telling Dennis that he will not abide the death of his son, prison guards in the basement begin to hang Eric, so it will look like suicide. But when Dennis goes to stab Neville, Neville overpowers him and stabs him, then runs down and rescues Eric. As Neville is being transferred out, the guards allow father and son a tender moment.

The movie opens by explaining current events such as the passing of the "Freedom of Observation Act" and the subsequent implementation of ODIN (Optical Defense Intelligence Network), including the development of a new type of mobile camera drone, the eponymous "eyeborg". The system is administered by the Department of Homeland Security (DHS). Sankur (Dale Girard) is making a deal to purchase a shotgun while an eyeborg watches the transaction. The eyeborg is discovered and the deal is aborted. Homeland Security agents rush in to find that Sankur has escaped and the other party in the gun deal is dead. Brandon (Devin McGee), the lead singer of a band known as "Painful Daze", is in a car with a girl. "G-Man" (Danny Trejo), approaches them to deliver a rare bag of banned North Carolina tobacco. After G-Man leaves, the two begin smoking the tobacco - but are interrupted and killed by a large six-armed eyeborg. With Brandon missing, Jarett (Luke Eberl) becomes the lead singer of "Painful Daze" at the next night's gig. As he sings, eyeborgs search for Sankur, who has entered the building. They signal an alarm that causes a panic, during which Sankur tries to shoot Jarett. An eyeborg blocks the shot. Jarett falls, unharmed, but breaks his guitar. It is revealed that Jarett is the President 's nephew. Sankur is captured and taken to the regional DHS office. During interrogation, Sankur is shown video footage of his earlier gun deal, showing him to be the dealer's killer. Sankur protests his innocence despite the apparent proof of the video. Agent Gunner (Adrian Paul) gets a message to report to the front desk, leaves the room with his partner, and locks the door. Four eyeborg security cameras detach to attack Sankur, but the door opens, allowing him to escape. A foot chase occurs, stranding him on level six. When the elevator he is waiting for opens, a large eyeborg emerges and pushes him over the banister, causing him to fall to his death. Jarett and Ronni (Julie Horner) are making out when the news is announced that the President has declared war on the (fictional) country of Zimbekistan, which catches Ronni's attention. She shows Jarett a bank error where a large sum of money has been deposited in their account from Zimbekistan. Back at the regional DHS office, Agent Gunner comes under fire over security footage showing that he failed to lock Sankur's door. Meanwhile, Barbara (Megan Blake) (newswoman) and Eric (Juan-Carlos Guzman) (cameraman), who earlier witnessed Sankur's death, find a video file in Sankur's apartment. Meanwhile, Jarett goes to G-Man, whose face is finally revealed, and asks him to fix his guitar. During their meeting they discuss the eyeborgs, which Jarett approves of and which G-Man doesn't trust. Eric analyzes the video from Sankur's apartment and calls Barbara to tell her the video file is fake. En route in a news van to give her the evidence, he is attacked by a new type of eyeborg. It force feeds him a bottle of whiskey and causes him to crash, attempting to make it look like the result of drunk driving. While he manages to get out of the news van alive, he is immolated by a flamethrower carried by the eyeborg that attacked him. Barbara is notified of the wreck and, when told that he was drunk at the time of the accident, she doesn't believe it. Shortly thereafter, G-Man is attacked and killed by a large eyeborg. Jarett arrives and is momentarily pinned to the ground by the escaping eyeborg, after which he finds G-Man's body. He tells Gunner what he saw, but video of the alley shows a human leaving G-Man's place rather than an eyeborg. Growing increasingly suspicious, Gunner asks Jarett to meet him and tells him that he believes that Jarett did see an eyeborg leaving the scene of G-Man's murder, and that he suspects that the system is compromised and that the President may be in danger. He asks Jarett for help in warning the President, since Jarett has been asked to play at the President's campaign debate. While Jarett is out, Ronni is attacked by two eyeborgs and manages to call him, but the call is cut short. When he arrives, he finds her dead, with her wrists slit as though she has committed suicide. Jim Bradley (John S. Rushton) and Gunner go back to G-Man's to see if they missed anything. They find a secret room containing plans for weapon-carrying eyeborgs, plus a malleable C4 variant which was formed into the pickguard on Jarett's guitar. They try to leave to warn the President that Jarett's guitar is a bomb but Jim is killed by an eyeborg, which Gunner manages to disable. Gunner gets to the Millennium Center, where the Presidential debate is being held. But when he arrives on stage, there is no President or crowd present. He realizes that the President is dead, and that ODIN is in control and has been using Presidential power to declare war so that it can spread. A group of warbots shows up and begins firing on the DHS agents. Barbara is run into by her new camera bot, but she tells Gunner where he can find Jarett. Gunner and his team manage to free Jarett, whose likeness is being scanned for use by ODIN, just as two newer and more deadly eyeborgs attack and kill all but Jarett, Gunner, and Barbara. As Gunner is leaving with Jarett, Barbara gives him the only video evidence of what happened at the Millennium Center. Too injured to leave herself, she shoots the eyeborgs to distract them before shooting the guitar, detonating it and the barrels of flammable liquid in the basement, destroying the Millennium Center. With the explosion of the Millennium Center broadcast on national television, the President is considered dead. The news shows the vice-president being sworn in, and in an address to the public declares Jarett a traitor and shows video of him detonating his guitar in the debates, killing the President and all in attendance. Gunner goes to see Jarett, who is alive and disguised as an altar boy, and tells him that Barbara's video has gone viral and even ODIN cannot stop it. The movie ends with Gunner shooting an eyeborg in an alley and declaring he does not need their eyes anymore.

Eight candidates dress for an employment assessment exam at the company Biorg. The group enters a room and sits at individual desks. Each desk has a paper printed with the word "candidate" and a number from one to eight. The Invigilator explains that they have 80 minutes to answer one question, but there are three rules: the candidates must not spoil their paper, leave the room, or talk to him or the armed guard at the door. If they do, they will be disqualified. The Invigilator asks them if they have any questions, then leaves. As the exam starts, it turns out that the papers are otherwise blank. Within minutes, Candidate 2 is disqualified for spoiling her paper by writing on it. The seven remaining candidates realize it is permissible to talk to each other and collaborate. One candidate, "White", assigns nicknames to each candidate based on hair color and skin color: Black, Blonde, Brown, Brunette, Dark, and Deaf (for one candidate who does not speak or respond to the group). In the hour that follows, the candidates use lights, bodily fluids, and fire sprinklers in attempts to reveal hidden text on their papers, to no avail. They speculate on the exam's purpose and the nature of the company. Dark claims that the CEO is highly secretive and has not been seen since the initial public offering. It is gradually revealed that the company is responsible for a miracle drug designed to treat a condition afflicting a large part of the population due to a viral pandemic. In the chaos, White takes control of the group and engineers the disqualifications of Brunette and Deaf for spoiled papers. White also begins taunting the others, saying he has figured out the question but will not tell them. In response, Black knocks White unconscious and ties him to a chair. As White passes out, he pleads for his medication, implying he has the virus. Brown turns his attention to Dark, who demonstrates knowledge of the company's internal workings, and tortures her into revealing that she works for the company. It is revealed that Black is a carrier of the disease. White goes into convulsions; Dark pleads to the Invigilator for help and is disqualified. Blonde retrieves White's medication, which was stolen from him earlier by Brown, and uses it to revive him. The others release White and demand to know the question. White suggests that there is no question and the company will simply hire the last remaining candidate. Black steals the guard's gun, but it requires the guard's fingerprint to fire, giving White time to retrieve it. By forcing the guard's hand into the trigger, White coerces Brown to leave the room, disqualifying him. As Blonde also exits, she turns off the voice-activated lights, allowing Black to attack White. The lights come back on after Black is hit by a gunshot. Blonde hides in the hallway, still holding one foot inside the room. Before White can kill her, the exam timer runs to zero. White addresses the Invigilator, sure of his success, but is disqualified. It is revealed that Deaf had earlier removed a few minutes from the countdown clock. Blonde remembers that Deaf had been using glasses and a piece of broken glass with an exam paper earlier. Taking the abandoned glasses, she finds the phrase "Question 1." on the exam paper in minuscule writing. Blonde realizes that Question 1 refers to the only question asked of the group by the Invigilator at the beginning of the test ("Any questions?"). Blonde answers "No." The Invigilator enters and reveals that Deaf is the CEO of the company. He found the virus cure but also discovered a method of rapid cell regeneration capable of providing "the gift of life". The bullet that hit Black contained this cure, reviving him. With high demand for the drug and a limited supply, the company needed an administrator capable of making tough decisions with attention to detail while showing compassion, all traits that Blonde displayed during the exam. Blonde accepts the job.

Dr. Alice Howland, a linguistics professor at Columbia University, celebrates her 50th birthday with her physician husband John and their three adult children. After she forgets a word during a lecture and becomes lost during a jog on campus, Alice's doctor diagnoses her with early onset familial Alzheimer's disease. Alice's elder daughter, Anna, and son, Tom, take a genetic test to learn if they will develop the disease. Anna's test is positive, while Tom's is negative. Alice's younger daughter Lydia, an aspiring actress, declines to be tested. As Alice's memory begins to fade, she daydreams of her mother and sister, who died in a car crash when she was a teenager. She memorizes words and sets a series of personal questions on her phone, which she answers every morning. She hides sleeping pills in her room, and records a video message instructing her future self to kill herself by overdosing on the pills when she can no longer answer the personal questions. As her disease advances, she becomes unable to give focused lectures and loses her job. She becomes lost searching for the bathroom in her home and does not recognize Lydia after seeing her perform in a play. John is offered a job at the Mayo Clinic in Minnesota. Alice asks him to postpone accepting, but he feels this is impossible. At her doctor's suggestion, Alice delivers a speech at an Alzheimer's conference about her experience with the disease, using a highlighter to remind herself which parts of the speech she has already spoken, and receives a standing ovation. Alice begins to have difficulty answering the questions on her phone. She loses the phone and becomes distressed. John finds it a month later in the freezer, but Alice thinks it has only been missing for a day. After a video call with Lydia, Alice inadvertently opens the video with the suicide instructions. With some difficulty, she finds the pills and is about to swallow them, but when she is interrupted by the arrival of her caregiver, she drops the pills and forgets what she was doing. John, unable to watch his wife deteriorate, moves to Minnesota. Lydia, who has been living in California, moves back home to care for Alice. Lydia reads her a section of the play Angels in America and asks her what she thinks it is about. Alice, now barely able to speak, responds with a single word: "love".

Best friends Becky Connor and Shiloh Hunter are climbing a mountain with Becky's husband Dan, who is startled by a bat and falls to his death. A year later, Becky has given up climbing and become a recluse contemplating suicide. She has estranged herself from her father James, because he thinks Dan would not have grieved as she has if the situation were reversed. Just before the anniversary of Dan's death, Shiloh invites Becky to climb the decommissioned 2,000-foot (610 m) B-67 TV Tower in the desert before it is demolished. Shiloh suggests she scatter Dan's ashes from the top as a form of healing. A reluctant Becky accepts, hoping to finally move on from Dan's death. The next day, Shiloh and Becky arrive and climb several severely corroded ladders to a tiny platform at the top of the tower, where Shiloh goads Becky into momentarily free-hanging off the platform, while Shiloh records for her YouTube channel. Becky scatters Dan's ashes. As the two begin their descent, the ladder breaks. Becky falls but is caught by a rope connecting her to Shiloh. Shiloh pulls Becky back up and they realize they are now stranded hundreds of feet above the next intact ladder. Becky's thigh has also been cut. Their backpack with their water and a small quadcopter drone falls onto a communications dish below them. Despite the remote location, Shiloh is confident that someone heard the crash of the ladder, but help does not arrive. They try to use their cellphones, but radio interference from the communications dish blocks the signal. Shiloh sends a message for help to her Instagram followers by packing her phone in a shoe and dropping it outside the range of the interference. The pair notice a man and his dog but cannot get his attention. The man joins another man camping in an RV nearby. They wait till night and use a flare gun found in an emergency box on the platform to alert the men. The men see the flare, but they steal Shiloh's car and drive off. The pair realize Shiloh's phone dropped in the shoe must have been smashed as still no help has come. Becky notices a tattoo on Shiloh's ankle: "1-4-3", a code Dan used to say "I love you" to Becky. Shiloh tearfully admits to a four-month affair that ended before Becky and Dan's wedding. The next day, Shiloh climbs down using the rope to retrieve the backpack with water but nearly falls. Shiloh injures her hands but successfully ties the rope to the bag, and Becky uses all her strength to pull both Shiloh and the backpack up. Becky has a nightmare of a vulture eating Shiloh's dead body. Becky uses power from the tower's aviation obstruction lighting warning light to charge the drone, whilst being attacked by a vulture, and sends the drone to a nearby motel with a written message for help, but the drone is struck by a truck and destroyed. Becky is delirious from dehydration, but in a brief lucid moment, she realizes Shiloh fell onto one of the communication dishes when retrieving the backpack and died; Becky has been hallucinating her presence since then. The next day, Becky is awakened by a vulture gnawing at her wounded leg; she kills the vulture and eats it. Her strength partially restored, she abseils down to the dish where Shiloh's body lies. Becky types a text message to her father on a second phone, then puts it in Shiloh's shoe and shoves them into Shiloh's body before pushing the body off the tower. Shiloh's body cushions the impact and the message transmits. James alerts emergency services, who then rush to the tower. Becky and James reunite and reconcile.

Ruben Stone plays drums in the avant-garde metal duo Blackgammon, with his singer girlfriend, Lou. They live in an RV and tour the United States performing gigs. When Ruben begins to lose his hearing, he goes to a pharmacy seeking a diagnosis. The pharmacist refers him to a doctor, who finds that Ruben has lost most of his hearing and that the rest will deteriorate rapidly. Although cochlear implants may benefit him, insurance does not cover the high cost. The doctor suggests that Ruben eliminate all exposure to loud noises and undergo further testing, but Ruben continues to perform. Lou wants to stop performing for his safety, but Ruben wants to continue. She is also concerned about his sobriety, as he is a recovering drug addict. They call his sponsor, Hector, who finds a rural shelter for deaf recovering addicts run by a man named Joe, a recovering alcoholic who lost his hearing in the Vietnam War. Ruben leaves with Lou because they will not let her live there with him, and he wants only the implants. Anxious for his well-being, Lou leaves and persuades Ruben to return to the shelter. Ruben meets the other members of the shelter, attends meetings, and settles into his new life. He is introduced to schoolteacher Diane and the children in her class and learns American Sign Language. Joe tasks Ruben with writing and sitting peacefully in his study in an effort to make him comfortable with the silence. Ruben joins Diane's class and connects with the children and the rest of the community. He gives the children and Diane drumming lessons. Joe invites Ruben to stay as an employee of the community. Ruben illicitly uses Joe's office computer to follow Lou's activities and learns she is performing music in Paris. He has his friend Jenn sell his drums and other music equipment, then he sells his RV, using the money for cochlear implant surgery. Ruben asks Joe to loan him money to buy back his RV while he awaits the activation of the implants. Joe refuses, saying that Ruben is behaving like an addict. He asks Ruben if he's experienced any moments of stillness during his time in his study, before asking him to leave the community, as it is founded on the belief that deafness is not a handicap. Ruben has his implants activated but is disappointed by their distorted sound. He flies to Paris to meet Lou at the home of her wealthy father, Richard. Richard confides in Ruben that though he initially disliked him, he recognizes that Ruben made Lou happy. Lou has settled into her new lifestyle and has ceased self-harming. At a party, Lou and Richard perform a duet; Ruben's perception of the sound is distorted by the implants. When Ruben tells Lou he wants to return to their music, she responds with interest but begins scratching her arms. Ruben tells her all is well and that she saved his life. She tells him that he saved hers too. The next morning, Ruben takes his things and leaves while Lou sleeps. In a park, the ringing of a church bell is distorted by his implants; Ruben removes his processors and sits in silence.