In 2008, a combined task group of People's Liberation Army Special Operations Forces and Chinese police raid a drug smuggling operation in an abandoned chemical facility in southern China. The leader of the smuggling operation, Wu Ji, holds one of his own men hostage while taking cover behind a section of the facility's reinforced wall. Leng Feng, a skilled PLA sniper, ignores orders to stand down and fires three shots at a weak section of the wall, penetrating through and killing Wu Ji. Leng Feng is sent to solitary confinement as punishment, but is approached by Long Xiaoyun, the female commander of the legendary 'Wolf Warriors', an elite unit within the PLA tasked with simulating foreign tactics for the PLA to train against. Long Xiaoyun offers Leng Feng a place in the Wolf Warriors. Meanwhile, in the Philippines, crime lord Min Deng, Wu Ji's older brother, hires ex–US Navy SEAL "Tom Cat" (Scott Adkins) and his group to kill Leng Feng and avenge his brother. The Wolf Warriors participate in a training exercise in a remote and uninhabited forested region on China's southern border. During the exercise, Tom Cat and his mercenaries ambush a Wolf Warrior squad, killing one of Leng Feng's comrades. Subsequently, the PLA and the Wolf Warriors are tasked with hunting down Tom Cat's squad. The combined infantry force move into the forest but are delayed by multiple traps set by Tom Cat and pinned down by sniper fire until Leng Feng manages to kill the shooter. Afterwards, the rest of the PLA force engages Tom Cat's other mercenaries, who stage a fighting retreat but are eventually overwhelmed and killed. Meanwhile, Long Xiaoyun and the other PLA commanders deduce that Ming Deng himself is also in the training area to take possession of a smuggled cache of biotechnology, which could allow the creation of a genetic weapon that could target Chinese people exclusively. Leng Feng eventually catches Tom Cat just before China's southern border. Leng Feng is nearly defeated, but manages to kill Tom Cat with his own knife. Medical personnel claiming to be from a PLA relief force arrive, but Leng Feng recognises the wrist tattoo of a medic and realizes that they are Min Deng's men in PLA uniforms. He attacks them, eventually holding Min Deng at bayonet point on the very edge of the Chinese border. Min Deng's paramilitary force approaches from the other side of the border, but so do the rest of the Wolf Warriors and PLA soldiers. Min Deng's force retreats, leaving him to be arrested.

Jang Kyung-chul, a school bus driver, encounters a woman named Jang Joo-yun and offers to fix her flat tire. After beating her unconscious and bringing her to his house, Kyung-chul methodically dismembers her, unaware of her ring falling into a floor drain. Kyung-chul scatters the body parts into a local river, where it is discovered, prompting the police to conduct a search led by Squad Chief Jang, Joo-yun's father, and Squad Chief Oh. Joo-yun's fiancée, Kim Soo-hyun, an NIS agent, vows to exact revenge on the perpetrator. After learning of the four suspects from Jang (Joo-yun's father), Soo-hyun privately interrogates two of them. The violent encounter (part torture) of the first two suspects absolves them as his wife's killer. But they are not without fault, one suspect turns himself in for killing multiple schoolgirls in fear of Soo-hyun's return and seeks help from the police in the hospital. Upon searching the home of Kyung-chul (the third suspect), Soo-hyun finds Joo-yun's ring which confirms Jang Kyung-chul to be his fiancé's killer. A short time later, Kyung-chul brings a schoolgirl home and begins to rape her. Soo-hyun interrupts and knocks him unconscious. Instead of killing Kyung-chul, Soo-hyun forces him to swallow a GPS tracking transmitter, allowing him to track Kyung-chul's movements and listen to his conversations while also fracturing his left arm. Waking up, Kyung-chul is offered a ride by a taxi, which already carries a passenger. The taxi had a license with a profile picture of the taxi's owner, which Kyung-chul notice is not the one driving this taxi. He has stepped into a hijacked vehicle and the occupants are acting strange. Kyung-chul attacks them seconds before they attack and murders them. Kyung-chul checks the trunk of the taxi and finds a murder victim (presumably the taxi driver) and a bag of fresh clothes. He leaves their bodies on the side of the road, and cleans up in a nearby river. Kyung-chul drives to a clinic to have his wounds looked at. After being treated, Kyung-chul proceeds to rape a nurse. Soo-hyun arrives, subdues him, and slashes his achilles tendon before leaving. At this point, Soo-hyun's intention becomes clear: he wants to torture Kyung-chul as long as possible. Kyung-chul visits the home of his friend Tae-joo, a cannibalistic murderer and meets his girlfriend Se-jung who seems nonchalant about the meeting. After learning of the situation, Tae-joo remarks that his tormentor must be related to one of his victims. Kyung-chul deduces Soo-hyun's identity after recalling that his wedding ring matched that of Joo-yun. Soo-hyun arrives and incapacitates Kyung-chul, Tae-joo, and his girlfriend Se-jung. The next day, Tae-joo and Se-jung, still unconscious, are arrested by the police and sent to the hospital. Soo-hyun and Kyung-chul receive treatment for their wounds, aided by Soo-hyun's trusted subordinate, who helps them evade the cops. Kyung-chul wakes up and overhears Soo-hyun and the subordinate talking about the transmitter. After being released, Kyung-chul steals and uses laxatives to excrete the transmitter, where he plants it on a taxi driver at a truck stop. Soo-hyun enters Tae-joo's hospital room to question him and learns that Kyung-chul is going after Jang (Joo-yun's father) and his other daughter, Jang Se-yun. Enraged by Tae-joo telling him the details of Joo-yun's murder, Soo-hyun rips his mouth open. Kyung-chul arrives at Jang's house, brutally assaults him, and kills Se-yun. Kyung-chul attempts to avoid Soo-hyun's revenge by surrendering himself to the police, but Soo-hyun abducts Kyung-chul in a car before the police can apprehend him. Soo-hyun drives to Kyung-chul's house, where he tortures him, places him under Kyung-chul's makeshift guillotine and leaves him holding a rope between his teeth to keep the blade from falling. Though he mocks Soo-hyun, Kyung-chul begins to panic when he learns that his son and elderly parents, whom he had abandoned some time ago, have arrived and are trying to visit him. As his family opens the door, the guillotine blade is Booby-trapped to fall and beheads Kyung-chul. Listening to the family's anguish through the transmitter which he placed next to Kyung-chul's head, Soo-hyun breaks down and begins crying hysterically as he walks away from the scene.

In 2003 New York City, Kim Baker is a struggling television journalist covering low-profile stories. To help her career, she takes a short assignment as a war correspondent in Afghanistan during Operation Enduring Freedom, to the disappointment of her boyfriend Chris. Assigned to modest living quarters with other international journalists, Kim befriends noted BBC correspondent Tanya Vanderpoel and lecherous Scottish freelance photographer Iain MacKelpie. She adjusts to her new duties aided by her Afghan " fixer " Fahim Ahmadzai. She elicits frank remarks on camera from soldiers questioning the value of their assignment and puts herself in harm's way to capture combat incidents on video. Marine General Hollanek sees her as an inexperienced nuisance. Despite the danger, Kim stays in Afghanistan for years beyond her original assignment. She catches Chris with another woman during a middle-of-the-night video call, ending their relationship and her sexual flirtation with Iain develops into something more meaningful. Although Afghan Islamic society places restrictive roles on women, she uses her sex to her advantage and gains access to female villagers who have been sabotaging the US-built well because they welcome the daily walk to the river away from the men. She uses her own sexuality to develop Afghan Attorney General Ali Massoud Sadiq as a news source. Fahim, who treated opium addicts before the war, cautions her that danger can be as dangerous as a drug. Despite their mutual friendliness, Kim competes with other journalists for stories and resources from their employers. After three years in Afghanistan, Kim flies to New York to argue for more support from her network's new boss, and discovers Tanya is slated to take over her Afghan assignment. Iain is kidnapped for ransom while covering a developing story he had offered to share with Kim. She returns to Afghanistan and blackmails Ali for information about Iain's whereabouts, impressing on Hollanek the political value of rescuing Iain. The mission is a success, militarily and journalistically but Kim becomes disillusioned with her tentative relationship with Iain and her station. She returns to the United States for good, and looks up a Marine whose on-camera comments to her might have led to his transfer and subsequent loss of his legs to an IED. She tries to apologize to him but he refuses to let her take the blame. Kim takes an on-camera desk job and finds herself interviewing Iain, who will be in New York as part of a new book tour. He invites her to meet him for coffee.

Slacker David Wong recalls confronting a zombie skinhead he beheaded a year earlier and wonders if an axe that had its handle and head replaced over time is still the same axe. In the present day, he meets with a reporter, Arnie Blondestone, to recount the supernatural events that plagued the small, undisclosed city he lives in. Some time ago, David is at a party with his friend John, with acquaintances Fred Chu, Justin White, and Amy Sullivan, who has had a hand amputated. David learns that Amy's dog, Bark Lee, has gone missing after biting Robert Marley, a drug dealer who pretends to be Jamaican. The dealer claims to have powers and knows things about David that he shouldn't. As he leaves the party, David sees Bark next to his car. John calls Dave, demanding he come over at once. At John's apartment, David, oblivious to a bizarre creature only John can see, finds a syringe containing a black-colored drug, John tells David that the drug, "Soy Sauce", given to him by Marley, grants inhuman knowledge when taken, along with dumping the user in alternate dimensions and timestreams, as demonstrated by a past version of John calling present Dave. As they drive off, David accidentally stabs himself with the syringe, propelling him through alternate dimensions. Returning to the present, a strange man, Roger North, appears in the backseat. Roger puts a strange creature down David's shirt and tells him to drive. David uses the cigarette lighter to burn off the creature. He stops the car and threatens Roger, who disappears. Detective Lawrence Appleton questions the two at a police station. Appleton reveals that John and Justin White were the only survivors of a drug-fueled afterparty thrown by Robert Marley. Everyone else either disappeared or suffered grisly, bizarre deaths. In the present, an incredulous Arnie tries to leave, but Dave convinces him to stay after showing him a strange monster in his car that can't be easily seen. During questioning by the cops, John dies for unknown reasons. While one of the interrogators leaves to investigate John's death, John telepathically contacts Dave. John helps Dave realize the other cop in the room is a ghost and helps him escape from the police station. Dave is then guided to Marley's house. Marley's Soy Sauce knocks Dave unconscious. He wakes up to see Appleton preparing to burn down the trailer, who tells him John's body disappeared and that the Soy Sauce is letting in some kind of evil force. Appleton shoots David, who survives by time-traveling and tampering with the round he was shot with. Bark, controlled by John, drives David's car through the wall, allowing him to escape. Justin White, possessed, appears in David's apartment and subdues him. Dave tries to kill him but he's infected. Justin kidnaps David, Fred, Amy, Bark, and John and takes them to an abandoned mall, hoping to use a ghostly door inside to travel to another dimension. John manipulates White into going outside, where Appleton kills him. Appleton then explodes into a swarm of demonic insects who then possess Fred, whom David reluctantly kills. Amy opens the ghost door with her phantom limb, allowing John and Dave passage. There they meet North and Albert Marconi, celebrity psychic and exorcist. They reveal the source of the strange happenings is Korrok, an eldritch biological supercomputer who has turned into a genocidal god who wants to travel to new dimensions and conquer them. Marconi gives David and John an LSD-laced C4 explosive to incapacitate Korrok. The duo steps through a portal to an alternate Earth. Disciples of Korrok greet them as "chosen ones" and present a brutal totalitarian society, where dissenters are maimed by Korrok's monsters. The duo are brought before Korrok, who plans to devour them, absorb their knowledge of dimensional travel, and conquer their dimension. John tries to activate the bomb but fumbles. Bark Lee, who followed the two, grabs the bomb and flings himself into Korrok, sacrificing himself to destroy Korrok. Upon escaping, David and John meet Marconi and learn that Bark was meant to defeat Korrok all along. After biting a Soy Sauce-addled Marley, it linked him to Marconi and North. Amy becomes David's girlfriend. With Marconi's help, David and John become exorcists and demon hunters. In the present, Arnie decides to publish the story. Dave realizes he perceives Arnie differently than how he really looks, and the two find the real Arnie decapitated in the trunk of his car, who was killed after first contacting Dave. Dave tells Arnie that Dave's mind projected his current shape. Arnie tries to deny this but soon vanishes into thin air. Later, John and Dave play basketball and inadvertently throw their ball into a post-apocalyptic dimension. After going in after it, a paramilitary organization informs them they are chosen ones who will restore the world, but an annoyed John and Dave walk off.

In late 2010, Matt Ryder is an A&R representative at a Manhattan record label who is in danger of losing his job after his company's biggest client signs with another label. He is estranged from his father Ben, a famous photographer. Ben's assistant and nurse Zooey informs Matt that Ben is terminally ill with liver cancer. Though they have not spoken in over ten years, Ben has requested that Matt drive him to Dwayne's Photo in Parsons, Kansas, the last shop that develops Kodachrome film. Ben has several rolls he wants to have processed before he dies, and time is short as even Dwayne's Photo will soon stop operating because Kodak is no longer making the dyes. Ben's manager Larry persuades Matt to make the trip by arranging a meeting between Matt and the Spare Sevens, a band he has been trying to sign. Matt, Ben and Zooey start the journey, and Ben insists on taking backroads so he can take photos and enjoy the scenery. In Ohio, the group visits Ben's brother Dean and Dean's wife Sarah, who were Matt's surrogate parents following his mother's death. Zooey and Matt bond over Matt's old music collection, and later a drunk Matt leans in to kiss her, but falls off the bed. He sleeps on the floor, and they share stories of their failed marriages. The next morning, Zooey is awakened by Ben, who has fallen in the bathroom and needs help to stand. Ben irritates Dean and Sarah at breakfast by mentioning that he and Sarah once had a sexual relationship. Sarah explains that it was before she and Dean dated, which does little to assuage Dean's anger. In Chicago, Matt makes his pitch to the Spare Sevens, and follows his father's advice not to tell the band how great they are, but to point out what they are doing wrong and why they need Matt to fix it. Lead singer Jasper and the other members admire Matt's nerve and begin to agree to the outlines of a deal, but start to mock Ben when he accidentally urinates on himself. Though it will probably cost him his job, Matt tells them he does not respect them and leaves the meeting to check on his father. At their hotel, Ben expresses disappointment that Matt did not close the deal. Zooey points out that Matt made a career-ending decision to defend his father, which leads to Ben firing her. Zooey joins Matt at a bar, where he receives several texts from his boss confirming that he has been fired. They continue to drink, then spend the night together. The next morning, Zooey says she regrets spending the night with Matt and returns to New York. Matt receives no answer at Ben's door and has hotel staff open it. Ben is unconscious on the floor, and Matt rushes him to the hospital. The doctor tells Matt that Ben's cancer can no longer be treated, he cannot travel, and he should be placed in hospice care. That night, Ben struggles to load film into a camera, eliciting Matt's help. Through tears, Ben tells Matt that he does not expect forgiveness for his shortcomings as a father, but that he loves him. Matt and Ben embrace. The next day, Matt and Ben leave the hospital to finish the trip to Parsons, which will require driving nonstop overnight to make it to the photo lab in time. They drop off Ben's film at Dwayne's, where Ben is recognized by several patrons, most of whom are well-known photographers. Several ask to have photos taken with Ben, giving Matt insight into his father's influence and legacy. In their hotel room, Ben is cleaning his camera when he dies. Larry arrives to make funeral arrangements and Dwayne delivers the developed photos. Matt offers them to Larry, but Larry refuses, saying Ben's wish was for Matt to curate them for a showing. At Ben's home, Matt loads the photo slides into a projector and is surprised to see dozens of pictures of himself as a boy, many with his deceased mother, and some with his father. Zooey arrives and asks if he would like company, then they stand together as they view Ben's slides.

During the winter on the Wind River Indian Reservation, U.S. Fish and Wildlife Service Agent Cory Lambert discovers the frozen body of 18-year-old Natalie Hanson of the Northern Arapaho tribe. FBI special agent Jane Banner arrives to investigate the possible homicide. Banner learns from Natalie's father, Martin, that his daughter was dating a new boyfriend whose name he does not know. Natalie's autopsy shows signs of blunt trauma and rape and confirms Lambert's deduction that Natalie died from pulmonary hemorrhage caused by inhaling subzero air. The medical examiner refuses to classify the death as a homicide, so Banner cannot get additional help from her supervisors. Lambert is informed by Natalie's brother Chip that Natalie's boyfriend is Matt Rayburn, a security guard at a nearby oil-drilling site. Lambert and Banner soon find Matt's naked, mutilated body in the snow. Lambert reveals to Banner that his 16-year-old daughter Emily, Natalie's best friend, died in a similar manner to Natalie three years earlier, and the case remains unsolved. Banner, tribal police Chief Ben Shoyo, and other law enforcement officers visit the drilling site, where Curtis, the security supervisor, and several security guards meet them. They claim Matt left a few days prior, following an argument with Natalie. One guard mentions they heard about Natalie's body being found, and Banner states that Natalie's name has not been released to the public. The guards claim they learned it by monitoring a police scanner. One of Banner's team notices the guards slowly surrounding them and draws his weapon. The confrontation quickly escalates into an armed standoff, which Banner defuses. In a flashback, Matt's drunken colleagues barge into his trailer while he is in bed with Natalie. Matt is provoked to violence, and the other guards continue the attack while one guard, Pete, rapes Natalie. Matt is beaten to death, but his attempt to fight back allows Natalie to try to escape by running cross-country to the mobile home where her brother lives. In the present, Lambert traces the tracks from where Matt's corpse was found back to the drilling camp. As Banner and the others approach Pete's trailer, Lambert radios a warning to Shoyo. Pete responds to a veiled warning from Curtis by firing a shotgun through the door, wounding Banner. A gunfight ensues, and Shoyo and the other officers are killed. As the remaining guards prepare to execute Banner, Lambert kills four with his rifle. A wounded Pete flees on foot, but Lambert apprehends him. At Gannett Peak, Lambert forces Pete to confess before offering him the same chance Natalie had: try to stay alive by running to a distant road barefoot and wearing lightweight clothing. Pete runs but quickly succumbs as his lungs give out from the frigid air. Lambert visits Banner in the hospital and praises her toughness. He visits with Martin and they share grief over the deaths of their daughters. A title card reads, " While missing person statistics are compiled for every other demographic, none exist for Native American women. "

In Reed College, in 1974, the high tuition costs force Steve Jobs to drop out, but Dean Jack Dudman allows him to sit in on classes. Jobs is particularly interested in a calligraphy course. Influenced by Baba Ram Dass 's book Be Here Now and their experiences with LSD, Jobs and his friend Daniel Kottke spend time in India. His philosophical ideas lead Jobs to the decision not to wear any footwear. Two years later, Jobs is back in Los Altos, California, living with his adoptive parents Paul and Clara. While working for Atari, Inc. as a video game developer, Jobs develops a partnership with his friend Steve "Woz" Wozniak. Jobs is charged by his boss Al Alcorn to re-develop arcade video game Breakout, which he ends up having Wozniak build in his place. The job is such a success that Alcorn presents it to President Nolan Bushnell, but Jobs inequitably distributes the salary for Breakout 's development between Wozniak and himself. Later, Jobs discovers that Wozniak built a prototype for the Apple I, a " personal home computer " which he expresses interest in commercializing. They name their new company Apple Computer. After a failed sale at his employer company HP, Wozniak reluctantly demonstrates the Apple I at the Homebrew Computer Club to a bored audience. Jobs is later approached by store owner Paul Terrell who shows interest in the Apple I. Jobs persuades his father Paul to let them set up their new company in the family's garage workshop. Jobs also recruits Kottke, fellow engineer Bill Fernandez, and young neighbor Chris Espinosa to the Apple team. Terrell's disappointment in the Apple I (in his opinion, being only a motherboard and not a full computer as promised), inspires Jobs to restart with a second model. He hires Rod Holt to re-conceptualize the power supply for what will be called the Apple II. Venture capitalist Mike Markkula notices Jobs and Wozniak's work, and also joins Apple. The Apple II is released at the 1977 West Coast Computer Faire, where it is a success. Apple's success causes Jobs to distance himself from his friends. Upon learning that his high-school girlfriend Chrisann Brennan is pregnant, Jobs ends their relationship. Brennan gives birth to Lisa, whom Jobs denies is his child. Kottke (now an Apple II Plus repairer) meanwhile leaves the company after acknowledging that Jobs (who hardly even has any time to talk to him) is not rewarding the Apple I team with any Apple stock. John Sculley is recruited as CEO of the company. As Jobs' behavior grows more erratic, Jobs is moved from the Apple Lisa development team to the Macintosh Group, where he works with Bill Atkinson, Burrell Smith, Chris Espinosa, and Andy Hertzfeld. Despite the change, his behavior does not change: he forces out Jef Raskin, the original Macintosh group leader, and then takes his place. Later, he phones Microsoft founder Bill Gates, legally threatening him because their Word software is, in his opinion, a plagiarism of Apple's word processor. Wozniak, still part of the Apple IIe team, decides to leave the company, feeling that it has lost its way. Though the Macintosh is introduced with great fanfare in 1984, including a high-budget commercial, it is seen as a failure due to the disproportionately high cost (as compared to IBM PC compatibles). Jobs, convinced that the error is the limited random-access memory of the system, launches a more advanced version, but Sculley forces him out of the company in 1985. In 1996, Jobs is married to Laurene Powell and has accepted Lisa as his daughter (she now lives with them). He has a son, Reed, and also runs NeXT. When Apple buys NeXT, then-CEO Gil Amelio asks Jobs to return to Apple as a consultant. Jobs is named the new CEO, fires Amelio and relieves the Board of Directors. Jobs becomes interested in the work of Jony Ive, particularly during the design of the iMac and strives to reinvent Apple. Jobs later records the dialogue for the Think Different commercial in 1997. In 2001, Steve Jobs introduces the iPod at an Apple Town Hall meeting.

Primary school teacher Gemma and her boyfriend Tom, a landscaper, visit a housing development called Yonder, where all the homes appear identical. They are shown house number 9 by an unusual real estate agent named Martin, who unsettlingly mimics Gemma's answer after asking if they have children. After a tour, Martin disappears without explanation. Gemma and Tom attempt to leave the development but inexplicably end up going back to house 9, after which the couple drives through the seemingly endless, identical streets until eventually running out of fuel. Gemma and Tom sleep in the house and attempt to escape on foot but repeatedly return to the same house. Outside, they find a box containing vacuum-sealed, flavorless food. Tom sets the house on fire and the couple sleeps on the pavement. By morning, however, the fire has left no damage, and a new box appears, this time containing an infant and a message instructing them to raise the child in order to be released. After 98 days, the child has grown rapidly to the size of a ten-year-old, mimicking Tom and Gemma and shrieking when hungry. When it calls Gemma "Mother", she denies the role, while Tom refers to the child as "it". The couple waits in the garden with a pickaxe to ambush whoever is delivering the food, but no one appears. Tom begins digging a hole in the garden while growing withdrawn. Meanwhile, the Boy watches abstract, fractal-like patterns on television. Tom locks the Boy in their car in hopes of luring whoever is responsible. However, Gemma takes pity and releases the Boy. Tom continues digging and begins sleeping in the hole. One day, the Boy disappears and returns with a strange book filled with symbols and drawings of humanoid figures with throat sacs. When Gemma asks him to mimic the person who gave him the book, he makes rasping sounds and inflates his own throat sacs. The Boy matures to resemble a young adult and Tom becomes ill. The Boy leaves each day and Gemma tries to follow him but always finds herself back at number 9. Tom continues to dig and finds a corpse in a vacuum bag. The Boy locks Gemma and Tom out of the house. Gemma pleads with the Boy for medicine for Tom but is denied. Tom dies and the Boy zips him into a vacuum bag and throws it into the hole. Gemma wounds the Boy with the pickaxe. The Boy hisses and crawls into a labyrinth under the sidewalk. Gemma follows and crashes through a door into multiple rooms in other houses with more Boys and several strangers, one of whom is dead. She lands back in number 9, weak and moaning. The Boy is cleaning the house. He carries her to a vacuum bag explaining that mothers die after raising their sons. She dies as he zips her in. The Boy buries her with Tom, and the grass reforms over the defect. He drives back to the real estate office, where an aged Martin lies dying. Martin gives the Boy his name tag and dies. The Boy zips Martin into a vacuum bag and puts him into a garbage chute disguised as a file drawer. When a couple walks in the door, the Boy greets them just as Martin did.

A 15-year-old drifter named Gary asks Joe Ransom, the even-tempered tattooed chain-smoking boss of a Texan tree-poisoning crew, for a job, and impresses him with his industriousness. The next day, Gary brings his alcoholic father, Wade, to work, but Wade's poor attitude and laziness get them fired. Joe witnesses Wade beat Gary and take his money. Gary later goes to Joe's house to ask for his job back, swearing he'll make up for his father's behavior. Joe agrees, and Gary begins working for him, hiding his money from Wade. Willie Russell, a criminal with whom Joe has a long-standing feud, shoots and wounds Joe as he leaves a friend's house. Later, Gary meets Willie and asks for a ride home; when Willie makes lewd comments about Gary's younger sister, Dorothy, Gary beats him up. Later, Wade beats to death a homeless man, stealing his liquor. Willie confronts Joe at a bar and asks where Gary lives in order to seek revenge. Joe does not answer and, when Willie presses him, beats him up. Joe tells the bartender to call the police before fleeing to a brothel but leaves after getting spooked by a guard dog. He goes home, getting his dog Faith and returns to the brothel, setting it on the guard dog, and has a prostitute give him oral sex. He leaves with his dog, who has killed the guard dog. Two police officers stop him at gunpoint, and Joe challenges them to a fight. Joe is arrested but released. Wade asks Gary for money, but Gary denies having any. Wade finds food in the cupboard and questions how he can afford food. They get into an argument that ends with Wade pulling a knife. He leaves but threatens to return and find Gary's money. Gary visits Joe, who tells him that he served 29 months for assaulting police officers. Gary agrees to help Joe look for his missing dog. After spending hours together and bonding, they find the dog and Joe gives Gary his lighter as a keepsake. Joe finds Wade walking and offers him a ride. They do not get far before Wade insults Gary and accuses Joe of not paying him. Joe grabs him by the collar and threatens to hurt him if anything happens to Gary. Later on, Gary tells Joe that he has enough money to buy his truck, and Joe takes him to the dealership where he has bought a new one. Joe tells Gary to keep the money he was going to use to buy Joe's truck and use it to obtain insurance. When he questions what insurance is, Joe promises to help him with it. As Joe drives home, a patrol cop stops him and tries to make him take a breathalyzer, but Joe refuses and drives away. After an altercation, Joe beats up the officer. A senior officer, a friend of Joe's and a fellow ex-con, visit Joe and says the patrol cop had it coming but warns him to keep his nose clean. Gary arrives at Joe's house, his face bruised, and asks to borrow his truck. Gary reveals that Wade beat him up, stole his truck, and left with Dorothy, intent on pimping her out to Willie and his goon. They go after Wade. Meanwhile, Willie pays Wade $60, and prepares to rape Dorothy first. Joe arrives and subdues Willie, and Gary leaves with Dorothy for help. Willie begs an unmoved Joe for his life, but as Joe prepares to kill him, one of Willie's thugs shoots him in the side and accidentally shoots Willie as well. Joe kills the thug then finishes Willie off before limping towards Wade, who is standing on a nearby bridge. He tries to shoot him, but misses. He attempts to shoot Wade again, but finds he is out of bullets. Wade asks Joe if he is his friend, and when Joe doesn't answer, leaps to his death. Joe then collapses and looks at the gaping wound in his side. Gary arrives with the sheriff and embraces Joe as he dies. He looks down and sees his father's body. Later, it is shown that an untold amount of time has passed. Gary is seen driving Joe's car with Joe's dog. He arrives at a job interview to replant the woods Joe and his crew had originally torn down.

Zakariya Mohammed is infected and brought to the Government Medical College, Kozhikode, where he suffers from the symptoms of an unknown virus and, after a few hours, dies. Geetha, who was taking Zakariya's CT scan, gets infected by the virus. The doctors and nurses are worried and confused by her constantly fluctuating blood pressure. A nurse Akhila who treated Zakariya gets infected too. Slowly more cases are identified in the surrounding areas. Dr. Salim (a neurologist) while checking on Zakariya's father, Razak, notices symptoms related to poisoning and Japanese encephalitis and other such infections. Dr. Salim also asked Dr. Suresh Rajan to conduct a sample test for Nipah virus. The samples were collected from Suhana, sister of Zakariya. As the death toll begins to rise, Dr. Suresh Babu confirms the unknown virus to be Nipah. Nipah spreads across Kozhikode and the neighbouring districts. Sister Akhila (the nurse who treated Zakariya), dies after a long battle with the virus and before she died, she wrote a letter to her husband. The film progresses with real life experiences of people who we are aware of when it has happened and also creates a backstory for each affected patient and generates an interest in the narration. In an emergency situation, a team of medical practitioners and healthcare professionals, led by the Health Minister of Kerala C. K. Prameela and District Collector Paul V. Abraham IAS, camp in Kozhikode to tackle the crisis. There is an attempt made to justify that this is not a bio-weapon used by any country or organisation. While the film is ending, the film pays tribute to scientists, medical professionals, hospital staff, volunteers and the people who came forward to support the team to solve the virus attack. Health minister, C. K. Prameela announces Kozhikode Nipah virus free. In the end, it is shown that Zakariya saw a flying fox (a breed of bats) that was on the ground. He went there and before coming in contact with the bat, he took a picture of the bat for his Instagram story.

Bill is a man whose daily routines, perceptions, and dreams are illustrated through multiple split-screen windows that are narrated by an uncredited Don Hertzfeldt. He often has meetings with his ex-girlfriend, but suffers from an unnamed illness which interferes with his seemingly mundane and uneventful life. One day, he visits his doctor, who informs him that his illness is getting worse; as the days pass, Bill's hallucinations and thoughts worsen until he has a hallucinogenic mental breakdown and passes out in an alley. To help him recuperate, Bill's mother comes to take care of him, but Bill mistakenly believes she is about to kill him and attacks her. He is then taken to a hospital but his health fluctuates rapidly and confuses his doctor, who concludes that Bill will not die, which surprises and inconveniences his relatives. He returns to work the following day. In a flashback to Bill's childhood, the narrator explains the death of Bill's half-brother Randall, who ran into the sea while chasing a bird. After Randall's death, Bill's mother soon became fiercely protective of Bill and rarely left home, eventually causing his stepfather to leave. The narrator details the surreal history of Bill's family, many of whom suffered from mental illness and died in unpleasant ways. A few days after leaving the hospital, Bill receives a call telling him that his mother died in a "fit of senile hysterics". After the funeral, Bill finds a notebook where his mother practiced writing love notes to send to him when he was young. Bill again visits his doctor, who is shocked to find that nothing appears to be wrong with him. However, on his way to lunch, he suffers a seizure and collapses. During the seizure, various memories of his infancy and childhood flash before him. Bill returns to the hospital, where his ex-girlfriend frequently visits him. His new doctor questions him, revealing that Bill cannot remember basic information about his life. After a brain exam, Bill is asked various questions and shown photographs that appear irregular or nonsensical. His doctor explains that Bill is having trouble understanding the difference between past and present tense, and it is implied that many of his childhood memories and family history could have been confabulated. Bill is allowed to go home for family care, but he arrives home to find no one there. He starts to repeat and then forget various tasks, such as buying food and going for walks, and he does not seem to understand that he is ill. His doctor eventually explains that he does not have long to live. Bill's outlook undergoes a stark change, such as noticing more of life's small details. This change is complemented by the film's animation style, with full-color photography of real-life images being merged into the animated scenery. Bill rents a car and starts driving to nowhere in particular, only to find that his instinct takes him to his childhood home. His uncle gives him the location of a nursing home where Bill can find his biological father, whom he has not seen since childhood. After spending time with his father, Bill forgives him and leaves to continue driving. Feeling his health failing further, Bill stops to lay down under a tree, and the film cuts to black. Rejecting the reality that Bill will almost certainly die under the tree, the narrator instead describes a different outcome: Bill becomes immortal, accomplishes many wonderful achievements, and outlives humankind and all future inhabitants of Earth. He survives until the death of the universe, looking up at the stars as they disappear one by one.

In 2063, astrophysicists on a climate change –ravaged Earth find a habitable planet. A scouting mission is sent, although the roughly 86-year flight means that only some of the original crew, expanded with their children and grandchildren, will reach the planet. The 30-person launch crew are bred on Earth through in vitro fertilisation (IVF) using genius donors, and live their infancy and childhood in isolation in order to help cope with spending their remaining lives mostly in flight. To shorten the wait for news back to Earth, the 30 are launched as preadolescents on the spaceship Humanitas; they are joined by adult program commander Richard, to guide them through the journey's early stage. The plan is for IVF to be performed when the crew turns 24, to be repeated on those offspring when they turn 24. During the tenth year of the flight, Christopher and Zac discover a chemical is added to everyone's food that suppresses the sex drive and pleasure response, keeping them docile and manageable. The pair stop taking the chemical, with their surging hormones driving them to become competitive, careless, and anxious to engage in sexual relations. Their crewmate Sela, who has trained as chief medical officer, is assaulted by one of the boys, which distresses female members of the crew as well as Richard. During a repair effort outside the Humanitas to address a failed Earth communication system, Richard is killed and a fire damages more ship systems. Christopher is voted the new chief officer, which upsets Zac, who then tells the others to stop ingesting the chemical. The mission descends into madness as many of the young men and women revert to their most primal state. A power hungry Zac tells the weak minded others that an alien killed Richard, and he will protect them, letting them eat all the (closely conserved) food they want. He convinces all but five to follow him rather than Christopher. Christopher and Sela, who have become a couple, find and repair a video disk that reveals Zac killed Richard and precipitated the further systems damage by turning on the electricity to the communications array while Richard was working on it. They show the others, but Zac convinces many that an alien is inhabiting one of them, which leads his followers to murder one of their own. Christopher inadvertently leads Zac to a weapons cache for their grandchildren to use on the planet. Three of the holdouts join Zac's mob, leaving only Christopher, Sela, and Phoebe to oppose Zac. One of Zac's mob kills Phoebe, but Sela kills him in return. She and Christopher eject Zac into space, and his followers acquiesce to living peacefully. Sela is voted chief officer. The crew permanently forgoes the suppression chemical and learn to manage their emotions. They fall in love and have children naturally rather than via the planned IVF. After another 76 years, Humanitas and its multi-generational crew arrive at the planet, which appears from orbit to be as Earth-like as hoped.