In a secret military laboratory operating under the guise of a pesticide manufacturer, a sealed tube is broken, starting an outbreak of a virulent bacteria. Detecting the release of the biological weapon, Joanie Morse, the plant's security officer, activates "Protocol One," a procedure sealing all of the workers inside from the outside world. Tom Schmidt, believing the cause for the lock down to be a pump malfunction, and co-worker Bob restart the pump. Cal Morse, a County Sheriff and Joanie's husband, is advised to retain the help of Dr. Dan Fairchild, a past employee who is a known alcoholic. Fairchild created an antidote to the weapon. Vic Flint, Bob's father, joins the mission. The United States government's Accident Containment Team (USACT), led by Major Connelly, arrives and sets up quarantine procedures. Connelly tells the public a cover story of the contamination of experimental yeast while a rescue team arrives to administer the antidote to the workers. Upon the release of the weapon, workers sanitize the lab, destroy animals, and inoculate themselves with the antidote. Hours later, the USACT team locate Dr. Nielsen and his team incapacitated on the floor near an air lock. They later notice that the bodies have disappeared, the air lock smashed open from inside, and a power outage caused by Dr. Ramesh Kapoor, a P4 worker, by destroying a power box. A group of workers—including Bob, Schmidt, and Tippett—believe themselves to be unaffected and want to leave, despite the quarantine. Unbeknownst to the workers, they became infected by the breach of the air lock, the bypassed pump circulating contaminated air throughout the building, and Schmidt's contact lens contaminating the building with the weapon. Joanie destroyed the piece of paper containing the code to deactivate the lockdown, but remembers the code. The group, now led by Tippett, torture her for the code, which is discovered to be invalidated once USACT tapped into the system. The rescue team eventually encounters this group of workers. The team order the group to remain under quarantine; Tippett is killed when he refuses. The rest are placed in a room to await inoculation when the team returns with the antidote. Fairchild directs the team into an unoccupied service conduit as a direct way to the P4 lab. The team encounters Nielsen. Suspecting something to be wrong, Fairchild directs the team to retreat, leaving Nielsen behind. The team are ambushed and murdered by the P4 workers, one of which is murdered by Kapoor. Despite being inoculated, the antidote did not work; suffering from the effects of the weapon, all of the infected workers become homicidal maniacs. Upon the rescue team's death, USACT activates "Protocol Two", leaving all employees to await the deadly effects of the weapon and sanitize the location afterwards. Hearing this, Cal urges Fairchild to assist him in retrieving the antidote, stopping the contagion, and saving Joanie. At the facility, Cal and Fairchild encounter an infected Bob. He tries to attack, but is killed by Cal, armed with the revolver. Most of the workers succumb to their infections, but Joanie is unaffected. Schmidt convinces her to go to the P4 lab to retrieve the antidote. En route, they encounter Nielsen, who wants to contain the knowledge of the incident, and Kapoor, who wants to kill them. They eventually escape the attack. While in the P4 lab, Schmidt succumbs to his infection while the P4 workers hunt them down. Joanie retrieves the antidote and flees while Schmidt attacks the workers, breaking Kapoor's neck before being killed by the rest. Joanie eventually encounters Cal and Fairchild. They later repel a group of workers who rip Fairchild's biohazard suit, exposing him. They enter the P4 lab to learn why Joanie is unaffected while the antidote did not work. A test discovers that her blood is full of estrogen, progesterone, and antibodies; she is pregnant. While attempting to enter P4 to attack the trio, workers are set on fire by booby traps. One worker rips Cal's biohazard suit before being killed by Joanie. Before being incapacitated by his infection, Fairchild enters a recipe for a new antidote based on Joanie's condition into a computer; it contains thorazine to make the patient sleep during their recuperation. They try out the new antidote on Fairchild, and it works. Armed with injection guns, Cal and Fairchild inoculate infected workers while Joanie takes a batch of the new antidote to the building's decontamination system. Nielsen, refusing to be injected, flees back to the lab. Eventually realizing his failure, he commits suicide. Using the decontamination system, Joanie administers the new antidote throughout the building, eradicating the weapon and treating workers breathing in the aerosolized antidote. Joanie then deactivates the quarantine and Fairchild inoculates Cal. USACT then evacuates the victims, retrieves the dead and seals the building.

Nerdy social outcast students Gary Wallace and Wyatt Donnelly of Shermer High School are humiliated by senior jocks Ian and Max for swooning over their cheerleader girlfriends Deb and Hilly. Humiliated and disappointed at their direction in life and wanting more, Gary convinces the uptight Wyatt that they need a boost in popularity in order to win their crushes away from Ian and Max. Alone for the weekend with Wyatt's parents gone, Gary is inspired by the 1931 film Frankenstein to create a virtual woman using Wyatt's computer, infusing her with everything they can conceive of to make the perfect dream woman. After they hook electrodes to a doll and hack into a government computer system for more power, a power surge creates Lisa, a beautiful and intelligent woman with reality-altering powers. She promptly produces a pink 1959 Cadillac Eldorado convertible to take the boys to a blues dive bar in Chicago, using her powers to procure fake IDs for them. They return home drunk, where Chet, Wyatt's mean older brother, extorts $175 from Wyatt in exchange for his silence. Lisa agrees to keep herself hidden from him, but she realizes that Gary and Wyatt, while sweet, are very uptight and need to unwind. After another humiliating experience at the mall when Max and Ian pour a slushie on Gary and Wyatt in front of a crowd, Lisa tells the bullies about a party at Wyatt's house, before driving off in a Porsche 928 she conjured for Gary. Despite Wyatt's protests, Lisa insists that the party take place. She meets Gary's parents, Al and Lucy, who are shocked and dismayed at the things she says and her frank manner, to Gary's embarrassment. After she pulls a stainless steel.44 Magnum handgun on them (later revealed to Gary to be a water pistol), she alters their memories so that Lucy forgets about the conflict; however, Al forgets altogether that they have a son. At the Donnelly house, the party has spun out of control. Gary and Wyatt take refuge in the bathroom, where they resolve to have fun despite having embarrassed themselves in front of Deb and Hilly. In Wyatt's bedroom, Ian and Max convince Gary and Wyatt to recreate the events that created Lisa, but the process fails. Lisa chides them over their misuse of the process to impress their tormentors. She also explains that they forgot to connect the doll; thus, with the bare but live electrodes resting on a magazine page showing a Pershing II medium-range ballistic missile, a real missile emerges, erupting through the floor and ceiling of the house. Meanwhile, Wyatt's grandparents arrive and confront Lisa about the party, but she places them in a frozen, catatonic state and hides them in a kitchen cupboard. Lisa realizes that the boys need a challenge to boost their confidence and has a gang of mutant bikers crash the party, causing chaos and terrorizing the guests. The bikers take Deb and Hilly hostage. Wyatt and Gary confront the bikers, which causes Deb and Hilly to fall in love with the boys. The bikers leave. The next morning, Chet returns from duck hunting to discover his home in disarray: A localized snowstorm fills his room, and a huge missile stands in the middle of the house. Lisa has the boys escort the girls home while she talks to Chet alone. Gary and Wyatt proclaim their feelings, and both girls reciprocate. Returning to the house, the boys discover Chet, now transformed into a foul, talking toad-like creature. He apologizes to Wyatt for his behavior. Upstairs, Lisa assures them that Chet will soon return to normal, and, realizing that her purpose is complete, tearfully hugs both Gary and Wyatt before de-materializing. As she leaves, the house is "magically" cleaned and everything transformed back to normal, including Chet. Wyatt's parents return home, completely unaware that anything unusual has happened. Later, Lisa turns up as the new gym teacher at Shermer High School.

Jim Bloggs and his wife Hilda are an aging couple, living in an isolated cottage in rural Sussex, England. Jim frequently travels to the local town to read newspapers and keep abreast of the deteriorating international situation regarding the Soviet–Afghan War, which is threatening to escalate into a nuclear conflict between the Western Allies and the Soviet Union. Hearing a radio news report stating that a war may be only days away, Jim follows the instructions outlined in the government-issued Protect and Survive pamphlets to build a fallout shelter, including covering the windows with white paint and readying sacks to lie down in when a nuclear strike hits. Jim and Hilda are confident they can survive, as they did the Second World War, and that a Soviet defeat will ensue. As a radio transmission warns of an imminent ICBM strike and civil defence sirens sound, the couple rush to their shelter, just escaping as distant shock waves batter their home. They emerge after a few nights to find all utilities, services, and communications destroyed. Jim (incorrectly) speculates that most have temporarily ceased due to "wartime measures". The couple remains stoic and tries to resume their daily routine, preparing tea and dinners on a camping stove, noting numerous errands they will have to run once the crisis passes, and trying to renew their evaporated water stock with rainwater. Fallout dust is visible in the air throughout the house. Jim believes that a rescue operation will soon be launched to help civilians. The couple venture outside where radioactive ash has blocked out the sun and caused heavy fog. They are oblivious to the dead and dying animals strewn across the landscape, the destroyed buildings of the nearby town, and the scorched vegetation outside their cottage. Their optimism begins to fade due to the prolonged isolation, lack of food and water, growing radiation sickness, and absence of communication from the authorities. Jim worries that the Soviets will soon invade, experiencing a vision where a Soviet soldier breaks into their house. Hilda, whose symptoms are worsening, encounters a rat in the dried toilet, which traumatises her. Coupled with her worsening symptoms - bloody diarrhea, bleeding gums - she begins to lose hope. Jim tries to comfort her, still optimistic that he may be able to get medications for her from the chemist. After a few days, the Bloggs are practically bedridden, and Hilda is despondent when her hair begins to fall out. Jim clings to his belief that emergency services will arrive. Hilda suggests they lie down in the paper sacks. Jim, now resigned to their fate, agrees. As they crawl into the sacks Jim tries reciting prayers, including Psalm 23, but, forgetting the lines, starts to read " The Charge of the Light Brigade ", whose militaristic and ironic undertones distress the dying Hilda, who weakly asks him not to continue. Finally, Jim's voice mumbles away into silence as he finishes the line, "...rode the Six Hundred..." Outside, the smoke and ash-filled sky begins to clear, revealing the sun rising through the gloom. Towards the end of the credits, a Morse code signal taps out "MAD" - mutually assured destruction.

Tess McGill is a working-class woman from Staten Island who dreams of climbing the corporate ladder to an executive position. Having earned a business degree via night school, she works as a secretary at a stockbroker firm in lower Manhattan. There, Tess's boss and male co-workers treat her like a bimbo, despite benefiting from her intelligence and business instincts. After one humiliation too many from her scornful boss (he fixes her up with a rival executive, who only wants to do cocaine and have sex), Tess retaliates by posting on a VDT what she thinks of him and of what he's done. This greatly amuses Tess's colleagues, but also gets her fired. Shortly thereafter, Tess lands another job, this time as an administrative assistant to Katharine Parker, an associate partner at the mergers-and-acquisitions firm Petty Marsh. At first, Katharine seems supportive of Tess, encouraging her to share ideas. Eventually, however, she insists that Tess's proposed purchase of a radio network by Trask Industries would not work out. When Katharine breaks her leg skiing, she asks Tess to house-sit. While there, Tess discovers meeting notes which reveal Katharine's intention to pass off the Trask Industries idea as her own. Returning home, Tess finds her live-in boyfriend having sex with another woman. Tess dumps him. With Katharine still in the hospital, Tess uses her boss's connections and clothes to ramrod the Trask proposal. With help from her friend Cyn, Tess gives herself a makeover, borrowing Katharine's stylish clothes to look more professional. Tess schedules a meeting with Jack Trainer, a mergers-and-acquisitions associate from another company. The night before the meeting, she attends (on Katharine's behalf) a dinner hosted by Trainer's firm. Trainer is attracted to Tess, and approaches her at the bar. Yet Jack does not reveal his name, even after she asks directly whether he knows the man she's slated to meet with (himself). Trainer brings Tess to his apartment, after she passes out in a cab from a combination of Valium and alcohol. Tess leaves early the next day, believing that they slept together. Arriving for her meeting with Trainer and his associates, she is surprised to recognize him from the previous night. They both feign non-recognition. After the meeting, Tess worries that her deal has failed, until Jack arrives at Tess's office. He assures her that they did not sleep together, and that he wants to move forward with her idea. Together, they prepare the financials for her merger proposal, which they present successfully to Trask. Tess and Jack celebrate by giving in to their attraction, and ending up in bed. Thereafter, Tess discovers that Jack has been involved with Katharine, but was planning to break up with her when she went skiing and got injured. Katharine returns home on the day of the merger meeting. While Tess is helping her get settled, Katharine brings up the Trask merger, claiming she was intent on taking it to Jack, and on eventually giving Tess credit for it. Katharine adds that Jack's strict ethical code has prevented him from looking at another's ideas without verifying the source, ever since he was accused of stealing himself. Jack arrives in response to a call from Katharine, who unsuccessfully tries to seduce him. Tess avoids running into Jack at Katharine's apartment, but accidentally leaves her notebook there before she departs for the meeting. Katharine discovers Tess's deception by finding the notebook, which includes Jack's phone numbers and the scheduled merger meeting. At the meeting, Tess brings up what Katharine told her about Jack's ethical code, and about his being accused of stealing. Jack insists that it was all a lie. Then Katharine crashes the meeting and outs Tess as her secretary. She accuses Tess of stealing the Trask merger idea. Unable to defend herself, Tess apologizes profusely and leaves. Tess returns to Petty Marsh a day later, intent on cleaning out her desk. Instead she encounters Jack, Katharine, Trask, and members of Trask's board. Jack sticks up for Tess, who points out a news item which presents a possible risk to the merger's success. In an elevator pitch she explains to Trask what inspired her plan for his radio acquisition. Trask confronts Katharine, who, when she is unable to explain where Tess's plan came from, is fired. Tess lands an entry-level job with Trask Industries. She also moves in with Jack. On her first day at Trask, Tess meets a colleague named Alice, whom she takes for her new supervisor. Alice explains that she is actually Tess's secretary. Tess makes it very clear that she considers Alice a colleague, thus proving herself very different from Katharine. At the first opportunity, Tess calls Cyn from her new office and tells her that she has made it.

In the early 1950s, Pete Verrill is invited by his friend, director John Wilson, to rewrite the script for Wilson's latest project: a film with the working title of The African Trader. The hard living, irreverent Wilson convinces producer Paul Landers to have the film completely shot on location in Africa, even though doing so would be extremely expensive. Wilson explains to Verrill that his motivation for this has nothing to do with the film - Wilson, a lifelong hunter, wants to fulfill his dream of going on an African safari; he even purchases a set of finely crafted hunting rifles and charges them to the studio. Upon landing in Entebbe, Wilson and Verrill spend several days at a luxury hotel while Verrill finishes the script and Wilson makes arrangements for the safari. Verrill finds himself growing fond of Wilson after the latter defends him against a fellow guest who makes antisemitic remarks in front of Verrill (who happens to be Jewish) and challenges the hotel manager to a fistfight after witnessing him insult and belittle a black waiter for spilling a drink, which Wilson loses. The two men constantly argue over Verrill's changes to the script, particularly his insistence that Wilson does not use his original planned ending, where all of the main characters are killed on-screen. Wilson hires a pilot to fly him and Verrill out to the hunting camp of safari guide Zibelinsky and his African tracker Kivu, whom Wilson is quick to bond with. The film's unit director, Ralph Lockhart, is also present and insists that Wilson start pre-production before the cast arrives, to which Wilson replies he'll do so after he shoots a "tusker". Verrill gradually becomes disenchanted with Wilson, who keeps going out to hunt despite his poor health and seems completely indifferent to the success of his movie. He even questions why Wilson would want to kill such a magnificent beast. Confronted, Wilson tells Verrill off and accuses him of "playing it safe" and not wanting to risk anything. He calls hunting a "sin that you can get a license for" and doesn't try to convince Verrill otherwise when he threatens to resign and go back to London. Landers arrives in Entebbe and insists that Verrill stay on, revealing that the studio is at risk of bankruptcy if the movie isn't finished. When Verrill does return, he is informed by Lockhart that Wilson, without consulting anyone, has decided to move the entire production to Kivu's home village despite Landers spending most of the budget on a prefabricated set. The cast, now unable to stay at the hotel, go to Zibelinsky's camp and find Wilson waiting for them with a lavish banquet. He humiliates Landers and takes advantage of several days of rain to resume his safari, now accompanied by professional elephant hunter Ogilvy. Verrill follows after Wilson again taunts him for cowardice. Wilson finally gets his chance to kill the "tusker", but when the time comes to shoot, he suddenly finds he can't pull the trigger. The elephant suddenly charges after seeing its child move too close to Wilson, and Kivu tries to scare it off only to be fatally gored by the elephant's tusks. Wilson, horrified by Kivu's death, returns to the set. He sees the villagers beating drums and asks Ogilvy what they mean. Ogilvy replies that they are communicating to everyone how Kivu died: "white hunter, black heart". Recognizing that he is ultimately to blame for what happened, Wilson tells Verrill that he was right: the film does need a happy ending after all. Sitting in his director's chair as the actors and crew take their places to film the opening scene of The African Trader, a now humbled Wilson quietly mutters "Action".

In 2500, sea level rises have put every continent on Earth underwater. The remains of human civilization live on makeshift floating communities built out of scavenged materials known as atolls, having long forgotten about living on land. Rumors of a "Dryland" still exist, but it is considered a myth by most. The Mariner, a lone drifter, arrives at an atoll on his trimaran to trade dirt, a rare commodity, for supplies. When the locals see that the Mariner is a mutant, with gills and webbed feet, several accost him and he kills one in self-defense. As a result, the Mariner is sentenced to be drowned in a tank of organic sludge. While the Mariner is trapped in the tank, the atoll is attacked by the Smokers, a formidable pirate gang that has been systematically raiding and destroying atolls. Helen, a strong-willed atoll resident, tries to escape on a gas balloon dirigible with her young ward Enola and inventor Gregor. However, Gregor accidentally departs with only himself on board, stranding the two. She frees the Mariner on the condition he takes them with him. The Mariner skillfully fights his way out, damaging the Smokers' forces and causing an explosion that blinds its leader, Deacon, in one eye. The Mariner, Helen and Enola board the trimaran and escape. Following a brief skirmish with the Smoker's scout seaplane, the trio encounters a drifter suffering from cabin fever whom the Mariner kills after a trade gone awry, and a mutated shark the Mariner kills for food. Despite his initial reluctance and gruff attitude, the Mariner slowly warms up to his companions and has a bonding moment with Enola teaching her to swim. After evading a trap set by the Smokers, the Mariner confronts Helen about their unusual persistence. She admits they are after Enola for the supposed directions to Dryland tattooed on Enola's back. Helen then demands to know where the Mariner collected his dirt. He takes her in a jury-rigged diving bell and shows her the underwater remains of Denver, Colorado, and the soil on the ocean's floor, crushing her belief in Dryland. When they surface, the pair find that the Smokers have caught up. They capture Enola and try to kill Helen and the Mariner before the two dive underwater. The Smokers set the trimaran on fire and leave. Sorting through the wreckage of his boat, the Mariner sees a collection of National Geographic magazines and compares their images to Enola's doodles, realizing she was drawing Dryland objects. Gregor, having spotted the smoke from his dirigible, finds Helen and the Mariner and takes them to a new makeshift atoll. The Mariner takes a captured Smoker's jet ski to chase down the Smokers' base of operations, the remains of the Exxon Valdez, where they manage to manufacture fuel, ammunition and cigarettes. Deacon's advisors struggle to decipher the tattoo. To keep his followers' minds off their dwindling resources, he bluffs that he has decoded the map on Enola's back and orders them back to their stations to row. The Mariner infiltrates the "'Dez" and confronts the Deacon, threatening to ignite the oil reserves in the hold unless Enola is returned. The Deacon calls the Mariner's bluff, knowing that it would destroy the ship, but to his shock, the Mariner drops a flare into the oil reservoir. The ship is engulfed in flames, and begins to sink. The Mariner rescues Enola, escaping via a rope from Gregor's balloon with Helen and the Atoll Enforcer aboard. The Deacon fires on the balloon, shaking Enola into the ocean. As the Deacon and some of his men converge on her, the Mariner makes an impromptu bungee jump from the balloon to grab Enola before the Deacon and his men collide on their jet-skis, inducing an explosion that kills the trio. Gregor later identifies Enola's tattoo as coordinates with reversed directions. Following the map, the balloon party discover Dryland, covered with vegetation and wildlife. They also find a hut with the remains of Enola's parents. The Mariner, feeling that he does not belong on Dryland, takes an old wooden catamaran from the island and departs, as Helen and Enola bid him farewell.

While vacationing in Switzerland, pediatrician Chris Nielsen meets artist Annie Collins. They marry and have two children, Ian and Marie. Their idyllic life ends when the children die in a car crash. Four years later, Chris is also killed in a car crash. Unaware that he is dead, and confused that no one will interact with him, Chris lingers on Earth as a ghost. Chris sees Annie's attempts to cope with his loss and attempts to communicate with her, despite advice from a presence that this will cause her only more pain. When his attempts indeed cause more sorrow, he decides to move on. Chris awakens in a Heaven that he has created with his imagination; his surroundings are mountainous landscapes that resemble a painting created by his wife and are similar to a place where the two desired to spend their old age. Chris is accompanied in Heaven by Albert Lewis, his friend and mentor from his medical residency, and Leona, a stewardess whom Chris had once admired in the presence of his daughter; he later comes to recognize Leona as his daughter Marie. Meanwhile, Annie is wracked with guilt for the deaths of Chris and their children and dies by suicide. Chris, who is initially relieved that her suffering is over, grows angry when he learns that those who die by suicide go to Hell. It is not the result of a judgment made against them, but rather their own tendency to create nightmare afterlife worlds based on their pain. Chris is adamant that he will rescue Annie from Hell, despite Albert's insistence that no one has ever succeeded in doing so with someone who died by suicide. Aided by a "tracker", Chris and Albert descend into Hell. On the journey there, Chris realizes that Albert is actually Ian and parts ways with him before his search for Annie. Chris and the tracker arrive at a dark and twisted version of Chris and Annie's house. The tracker reveals himself as the real Albert and warns Chris that if he stays with Annie for more than a few minutes, he may be permanently trapped in Hell, advising that all Chris can reasonably expect is an opportunity for a final farewell to Annie. Chris enters their horrific-looking home to find Annie suffering from amnesia, unable to remember her suicide and visibly tortured by her decrepit surroundings. Unable to stir her memories, the tracker sees Chris give up his quest to save Annie from Hell. Instead of returning to Heaven, Chris chooses to join Annie forever in Hell. As he declares to Annie his intent to stay, his words parallel something that he had said to her as he left her in an institution following the children's deaths, and she regains her memories while Chris is making her nightmare his. Annie ascends to Heaven, taking Chris with her. Chris and Annie are reunited with their children in Heaven, and all appearances are restored. Chris proposes reincarnation so that he and Annie can experience life together again. Chris and Annie meet again as young children in a situation that parallels their first meeting. In an alternate ending found on the DVD, their children explain that because Annie died by suicide, she must return to Earth and complete her next life naturally. Chris offers to go with her, and the two meet again as children.

In New York City, award-winning male model Derek Zoolander is at a low point; he is ousted as the top male fashion model by rising star Hansel McDonald, his roommates and colleagues Brint, Rufus and Meekus are killed in a "freak gasoline-fight accident". He decides to retire from modeling, ands attempts to reconnect with his southern New Jersey working-class relatives but the family rejects him. Meanwhile, fashion mogul Jacobim Mugatu and Derek's agent Maury Ballstein are charged by the fashion industry with finding a model who can be brainwashed into assassinating the new progressive-leaning Prime Minister of Malaysia, whose policies will prohibit them from retaining cheap child labor in the country. Upon seeing Derek's confusing behaviour at the awards ceremony, Mugatu hires Derek, whom he had never worked with, to star in the next runway show for his brainwashing plan. It involves Derek being conditioned to attempt the assassination when the song " Relax " by Frankie Goes to Hollywood is played. Zoolander agrees to work with Mugatu and soon faces off in a runway walk-off with Hansel only to be humiliated. Journalist Matilda Jeffries, feeling responsible for Derek's downfall as she wrote a scathing Time article about him, becomes suspicious of Mugatu's offer. She informs Derek of her concerns, but he ignores her. After receiving info through calls from former hand model J.P. Prewett, who keeps his hand preserved in a glass container, Matilda and Derek meet him in a cemetery. Prewett reveals that the fashion industry has been behind several of history's political assassinations, including Abraham Lincoln and John F. Kennedy, and the brainwashed models are soon killed after they have completed their task. Prewett revealed that he was selected to assassinate Jimmy Carter, but was able to resist as hand models had different mindsets from regular models. Mugatu's cronies attack the group, forcing Derek and Matilda to flee. They go to Hansel's home, the last place they believe Mugatu will think to look. Derek, Hansel and Matilda bond, the two male models resolving their differences while partaking of Hansel's collection of narcotics and participating in an orgy with Matilda and others. Derek and Hansel break into Maury's office to find evidence of the assassination plot, but they cannot operate his computer to find them. Matilda is given information on Mugatu, learning his birth name was Jacob Moogberg, a washed-up 1980s musician who switched to the fashion industry. Derek goes to the runway and Mugatu's DJ plays a remix version of "Relax". This activates Derek's mental programming, only for it to stop after Hansel breaks into the DJ booth and shuts off the turntable. After Hansel smashes the computer on the floor much to Matilda's dismay (since he took her saying the incriminating files were "in the computer" literally), a guilt-ridden Maury admits to the conspiracy. Mugatu then attempts to kill the Prime Minister himself by throwing a shuriken at him, but Derek stops it by unleashing his ultimate model look, "Magnum". In Derek's rural hometown, his father Larry watches the event on television and proudly acknowledges Derek as his son while Mugatu is arrested for his crimes and swears vengeance on Derek. A few years later, Derek, Hansel and Maury start "The Derek Zoolander Center for Kids Who Can't Read Good and Who Wanna Learn to Do Other Stuff Good Too". Derek and Matilda have a son named Derek Zoolander Jr.

At the White House, a teleporting mutant, Nightcrawler, attacks the President of the United States; he is shot and retreats. Meanwhile, Logan explores an abandoned military installation at Alkali Lake in Alberta for clues to his past, but finds nothing. Jean Grey has been having premonitions and struggles to concentrate as her powers become increasingly difficult to control. Later, Logan returns to Professor Xavier 's school for mutants, and Xavier tracks Nightcrawler using Cerebro. Xavier and Cyclops go to question the imprisoned Magneto about the attack, while Jean and Storm retrieve Nightcrawler. Military scientist Colonel William Stryker approaches the President and receives approval to investigate Xavier's mansion for their ties to mutants after the recent attack. Stryker's forces invade the school and abduct some of the students. Colossus leads the remaining students to safety while Logan, Rogue, Iceman, and Pyro escape. Stryker's assistant Yuriko Oyama captures Cyclops and Xavier. During the attack, Logan confronts Stryker, who addresses him as "Wolverine" and appears to be aware of his past. The shapeshifting mutant, Mystique, helps Magneto escape and finds Cerebro schematics. Logan, Rogue, Iceman, and Pyro visit Iceman's family in Boston. Iceman's brother calls the police after learning he's a mutant. Officers surround the house; one shoots Logan after feeling threatened. Pyro fights back against officers with his pyrokinesis before Storm, Jean, and Nightcrawler pick them up in their jet. The X-Jet is attacked by fighter jets and shot down while returning to the mansion, but Magneto saves them. He explains that Stryker built a second Cerebro to kill every mutant telepathically, using his mutant son Jason, who can control minds, to coerce Xavier. Stryker previously used Jason's powers on Nightcrawler to attack the White House to justify his excuse for invading Xavier's mansion. Magneto also tells Logan that Stryker grafted adamantium onto his bones and caused his amnesia. Jean discovers Stryker's underground base in a dam at Alkali Lake. Disguised as Logan, Mystique infiltrates Stryker's base, letting mutants in while she and Magneto head to disable Cerebro before Xavier, brainwashed, can activate it. Storm and Nightcrawler rescue students, and Jean fights a mind-controlled Cyclops; their fight frees Cyclops but damages the dam, causing it to rupture. Logan finds Stryker in an adamantium smelting lab, recalling where he got his skeleton. Logan fights and kills Yuriko, then chases Stryker to a helicopter pad and chains him to the wheel. Magneto stops Cerebro and, with Mystique impersonating Stryker to command Jason, has Xavier redirect its powers on humans. They escape in Stryker's helicopter, and Pyro, swayed to Magneto, joins them. Nightcrawler teleports Storm inside Cerebro, where she creates a snowstorm to break Jason's concentration and free Xavier. The X-Men flee the dam as water engulfs it, killing Stryker, but their X-Jet loses power and struggles to take off as floodwaters approach. Jean sneaks off, telepathically says goodbye, and holds back the water—raising the jet above it with flames erupting from her body—until she releases and the flood crashes down on her. The X-Men give Stryker's files to the President, with Xavier warning that humans and mutants must unite for peace. At the school, Xavier, Cyclops, and Logan remember Jean as Xavier begins a class. Meanwhile, a Phoenix-like shape rises from flooded Alkali Lake.

Russian terrorist group Anarchy 99 acquires the biochemical weapon "Silent Night", presumed missing since the dissolution of the Soviet Union. Undercover NSA agent Jim McGrath is assigned to recover the weapon, but is killed by Anarchy 99 at a Rammstein concert. NSA Agent Augustus Gibbons suggests sending Xander "XXX" Cage, an extreme sports professional wanted for unlawful protesting, citing his lack of ties to the United States government. Under Gibbons' supervision, Cage passes two tests, one involving stopping a fake armed robbery, and another where he and two other potential candidates are dropped into Colombia where they're thrown into an actual conflict between the Cartel and the Colombian Army. Xander was given the options to take a job or go to prison, in which Xander reluctantly accepts the contract. In Prague, Cage meets his team, which includes his supervisor, Czech agent Milan Sova. While scouting an Anarchy 99 party, Cage identifies Sova as a police officer, earning him favor with the group and catching the attention of the leader Yorgi. Cage asks Yorgi about purchasing high end sports cars, and Yorgi's girlfriend and lieutenant Yelena, gives Cage an account number. Gibbons calls Cage about changes to the plan, but is impressed when he gives them information provided by Kolya, Yorgi's star-struck younger brother. Tech-specialist Agent Toby Shavers then provides Cage with gadgets, including a revolver with special ammunition, binoculars that can see through walls and explosives disguised as bandages. As Cage attends the car deal he made with Yorgi, Sova attempts to intercede. Using the special ammunition, Cage fakes Sova's death. Having earned Yorgi's trust, Cage joins Anarchy 99. After a dance party at one of his nightclubs, Yorgi brings Cage back to a castle that serves as Anarchy 99's headquarters. Cage, while searching for the biochemical weapon, catches Yelena investigating Yorgi's secret safe. He takes her to a nearby restaurant to discuss the matter and reveals his true identity. Sova betrays Cage to Yorgi, so he sends his trusted sniper Kirill to kill him. While watching the pair, Kirill, who is in love with Yelena, warns her. As Cage and Yelena stage a fight, the NSA suddenly appears to capture him, and Yelena is taken back to Anarchy 99. Cage meets with Gibbons, who demands he return to America, as his cover is blown and special forces are planning to assault the castle. He refuses, fearing for Yelena's life and bitter that Sova blew his cover. Cage sneaks into Yorgi's castle and follows him into a secret underground laboratory. Overhearing his plan to launch "Silent Night" from the water-borne drone Ahab; he first tests the weapon on the scientists who developed it, to Cage and Yelena's horror. Cage flees the area after killing Kolya. At his hideout, Sova is waiting for him, now with Yorgi. Yelena saves Cage, revealing herself to be an abandoned undercover Russian Federal Security Service agent. Cage relays Yorgi's plans to the NSA in return for Yelena's asylum. Against orders, Shavers heavily arms Cage's car, who then parachutes from a plane on a snowboard near Anarchy 99's communication tower. The avalanche he starts destroys the tower, but he is captured by Yorgi, who already knew Yelena's true identity. As Yorgi prepares to kill them, the special forces attack. Cage and Yelena free themselves, but Yorgi launches Ahab before Cage kills him. The Czech military prepares to destroy Ahab with airstrikes, though this will release some of the biochemical agent. Cage and Yelena take his heavily modified car, to catch up to Ahab. Cage harpoons and disables the weapon moments before it goes off. Cage and Yelena are recovered, and Gibbons follows through on his promises. Sometime later, the couple is relaxing in Bora Bora when Gibbons contacts him for another mission, but Cage ignores him.

Sergeant Chris Vaughn is a former Green Beret who returns to his small hometown in Kitsap County. Looking for work, Chris finds that the local cedar mill was closed down three years earlier by its owner, Jay Hamilton, who opened a casino that now accounts for the majority of the local area's revenue. Hamilton, who was Chris' school friend, invites him to a night of fun at the casino. While checking out the VIP lounge, Chris stumbles upon his childhood friend Deni, who is now working as a stripper. He notices the craps dealer using loaded dice and demonstrates this to the patrons. When the floorman refuses to pay out, Chris instigates a fight. Although Chris beats most of the security guards, he is subdued with a cattle prod. In the basement, Hamilton's head of security, Booth, cuts Chris' torso with a utility knife and leaves him for dead. After recovering, Chris attempts to press charges, but Sheriff Stan Watkins refuses, saying the casino is untouchable. Chris learns that his nephew Pete has overdosed on meth, which was sold to his friends by the casino security guards. Furious, Chris arrives at the casino and, using a piece of lumber as a club, destroys casino property and brutally beats the security guards. Sheriff Watkins and his deputies apprehend Chris as he drives away. In the ensuing trial, Hamilton's security and staff testify against Chris. When the judge allows Chris to present his defense, he fires his appointed attorney, whom he suspects of working for Hamilton. Chris gives a civic speech about the town's former glory and promises to clean it up if acquitted. To further emphasize his plea, Chris reveals the grotesque scars on his torso. Chris is acquitted and wins the sheriff's election. Upon taking office, Chris summarily dismisses the entire police force and deputizes his friend Ray Templeton. Being a former drug addict, Ray teaches Chris about narcotics. Chris and Ray crack down on a supply spot and take Booth into custody. Despite stripping his truck into pieces in front of him, Booth reveals nothing. Chris assigns Ray to stand watch over his house in case Hamilton targets his family. Chris remains at the sheriff's office to supervise Booth. Deni visits him, brings him food, and reveals that she quit her job. The next morning, Watkins and his deputies arrive at Chris' office, blow up his truck, and fire upon the building with machine guns. Recognizing his dangerous predicament, Booth pleads for Chris to let him out of his cell. Chris uses the situation as leverage, and Booth reveals that the drug lab is in the cedar mill. Booth is killed immediately by the attackers' indiscriminate fire, but Chris kills the attackers with Deni's help. Chris' parents' house is also attacked, but Ray and Chris' father dispatch the gunmen. After ensuring their safety, Chris heads for the mill. Hamilton, calmly waiting in a control room, attempts to kill Chris with the mill equipment. Chris drags Hamilton through a trap door with him, and the two fall through a chute. Chris, whose leg is injured, tends to his injury in a nearby forest before Hamilton attacks him with an axe. Chris cripples Hamilton and arrests him. With Ray's assistance, Chris shuts down the casino and reopens the cedar mill.

The film begins in 1968 with Johnny Cash performing at Folsom State Prison. As the audience of inmates cheer him on, Cash waits backstage near a table saw, which reminds him of his early life. Two decades earlier, in 1944, 12-year-old Johnny is raised on a cotton farm in Dyess, Arkansas, with his brother Jack, his abusive father Ray, his mother Carrie, and his two sisters. One day, Jack is killed in a sawmill accident while Johnny is out fishing. Ray blames Johnny for Jack's death, saying that the Devil "took the wrong son". In 1950, Johnny enlists in the U.S. Air Force and is stationed in West Germany. While there, he purchases a guitar and finds solace in writing songs, including " Folsom Prison Blues ", which he develops in 1952. After his discharge from the military in 1954, Johnny returns to the United States and marries his girlfriend, Vivian Liberto. The couple moves to Memphis, Tennessee, where Cash works as a door-to-door salesman to support his growing family, but with little success. One day, Johnny walks past a recording studio and is inspired to form a band to play gospel music. He and his band audition for Sam Phillips, the owner of Sun Records, and Phillips signs them after they play "Folsom Prison Blues." The band tours as Johnny Cash and the Tennessee Two, along with other rising stars Elvis Presley, Carl Perkins, Roy Orbison and Jerry Lee Lewis. Johnny meets country music singer and songwriter June Carter while on tour and is immediately smitten. He tries to woo her, but she gently rebuffs his attempts. Despite this, they become friends. As Johnny grows up, he begins abusing drugs and alcohol, and over the objections of Vivian, he persuades June to go on tour with him. The tour is a success, but backstage, Vivian becomes critical of June's influence over Johnny. After one performance in Las Vegas, Johnny and June sleep together. The next morning, June notices Johnny taking pills and begins to doubt her choice to be with him. At their concert that evening, Johnny is upset by June's apparent rejection and behaves erratically, eventually passing out on stage. June is upset with Johnny's behavior and decides to dispose of his drugs. She begins to write " Ring of Fire " as a way to describe her feelings for him and the pain she feels as she watches him descend into addiction. After returning to California, Johnny travels to Mexico to purchase more drugs and is arrested. Soon after, Johnny's marriage to Vivian implodes; they divorce, and he moves to Nashville, Tennessee, in 1966. Johnny buys a large house near a lake in Hendersonville, Tennessee, in an attempt to reconcile with June. Ray and other members of the extended Carter family arrive for Thanksgiving, where Ray and Johnny get into an argument, and June's mother urges June to help Johnny. Johnny goes into detox and awakens next to June, who says they have been given a second chance. They begin a tentative relationship, but June resists Cash's marriage proposals. Later, Johnny records an album live at Folsom Prison after discovering that most of his fan mail is from prisoners. The performance is a success, and Johnny embarks on a tour with June and his band. At the end of the film, Johnny invites June to join him for a duet but stops in the middle of the song and tells her that he can't sing " Jackson " anymore unless she agrees to marry him. June accepts, and they share a passionate embrace on stage. Later, Johnny and his father reconcile their relationship while they are with their families.