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Planet Terror
In rural Texas, go-go dancer Cherry Darling runs into her mysterious ex-boyfriend El Wray at the Bone Shack, a restaurant owned by brothers J.T. and Sheriff Hague. Meanwhile, the demented Lt. Muldoon and his men make a transaction with chemical engineer Abby for mass quantities of DC2, a deadly biochemical agent. When Muldoon learns that Abby has an extra supply, he attempts to take Abby hostage, causing him to release the gas into the air, mutating most of the town's residents into deformed zombie -like creatures. The infected townspeople are treated at a local hospital by Dr. William Block and his bisexual anesthesiologist wife, Dakota, who is abused by him.
Random attacks begin along the highway, causing El Wray and Cherry to crash. In the aftermath, several zombies tear off Cherry's right leg. At the hospital is Tammy, the former lover of Dakota, who Block recognizes. Upon realizing Dakota was about to leave him for Tammy, he stabs Dakota's hands with her anesthetic syringe needles repeatedly, rendering them useless, before locking her in a supply closet.
El Wray is detained by Sheriff Hague based on past encounters between the two. As the patients mutate, El Wray leaves the station and arrives at the hospital, attaching a wooden table leg to Cherry's stump. As El Wray and Cherry fight their way out of the hospital, Dakota manages to escape in her car. Meanwhile, Block becomes infected along with others, while Cherry and El Wray take refuge at the Bone Shack.
Dakota retrieves her son Tony and takes him to her estranged father, Texas Ranger Earl McGraw. Tony accidentally shoots himself while waiting in the car. (Following a "missing reel" segment) Dakota, Earl, Cherry's former boss Skip, and Tony's crazed babysitter twins arrive at the Bone Shack. With Hague badly injured, the group decides to flee to the Mexican border, before being stopped by a large mass of zombies. Muldoon's men arrive, killing the zombies before arresting the group. Abby tells them that the soldiers are stealing the gas supply because they are infected and constant inhalation of the gas delays mutation. They also learn that some of the population is immune, hinting at the possibility of a cure.
As Cherry and Dakota are taken away by two soldiers, the others defeat the guards. J.T. sustains a gunshot wound in the process while the group searches for Muldoon. When he is found by El Wray and Abby, Muldoon explains that he killed Osama bin Laden before he and his men were infected and were ordered to protect the area before being killed by Abby and El Wray. Meanwhile, Cherry is held at gunpoint and forced to dance by a soldier who threatens to rape her. Eventually, she breaks her wooden leg across his face and stabs him in the eye. Dakota, after realizing that her hands have regained feeling, uses her syringe launcher to subdue another soldier. El Wray and Abby arrive to rescue Cherry and Dakota; El Wray replaces Cherry's broken wooden leg with an assault rifle and grenade launcher.
J.T. decides to stay behind to detonate explosives to eliminate the remaining zombies while the others flee. The survivors make plans to escape by stealing helicopters after fighting through a large group of zombies, but Abby gets his head blown apart by a ballistic missile in the process. An infected Block attacks Dakota but is shot dead by Earl. While saving Cherry from a zombie, El Wray is fatally wounded. Cherry, now sporting a minigun leg, leads survivors to the Caribbean beach at Tulum, where they start a peaceful new society during a worldwide zombie outbreak. It is also revealed that Cherry has given birth to her and El Wray's daughter.
In a post-credits scene, Tony is sitting on the beach at the survivor's "base" playing with his turtle, scorpion, and tarantula.