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Snakes on a Plane
After witnessing crime lord Eddie Kim brutally murder prosecutor Daniel Hayes in a secluded forest in Hawaii, Sean Jones is escorted by FBI agents Neville Flynn and John Sanders on a Boeing 747-400 to testify in a trial against Kim in Los Angeles. Kim arranges for a time-release crate full of venomous snakes to be placed in the cargo hold in an attempt to bring down the plane before it reaches Los Angeles International Airport (LAX). To ensure the snakes indiscriminately attack everybody without the need for provocation, he has one of his henchmen disguised as an airport ground employee spray the passengers' leis with a special pheromone which makes the snakes highly aggressive.
The crate opens midway through the flight and the snakes make their way through the cabin, with a viper attacking an electric panel in the process, thus shutting down the power. A cat in the cargo bay, a couple having sex in a bathroom, and a man using another bathroom are the first ones to be killed. The plane's captain, Sam McKeon, investigates the power outage and fixes an electrical short, but is killed by the viper that caused it. Co-pilot Rick, unaware of the snakes, believes Sam has suffered a heart attack and continues toward LAX. Some snakes attack Rick, and while fending them off, he accidentally releases the oxygen masks throughout the plane, causing most of the snakes to drop into the cabin with them. Numerous passengers, including Agent Sanders, are killed when the snakes invade the cabin.
The surviving passengers, who have made their way to the front of the plane, put up blockades of luggage in a desperate attempt to stop the snakes. Rick is attacked and the plane starts to descend, causing a food trolley to crash through the luggage blockade. The passengers flee to the upstairs first-class cabin before blocking the stairwell with an inflatable life raft. Flynn and flight attendant Claire regain control of the plane while Rick retakes the controls and has Flynn go into the cargo hold to restore the air conditioning/ventilation system. Flynn contacts FBI special agent Hank Harris on the ground, who gets in touch with ophiologist Dr. Steven Price, Customs' main source for animal smuggling cases.
Based on pictures of the reptiles emailed to him via Mercedes's mobile phone, Price believes that Kraitler Mullet, a snake dealer based in the Los Angeles outskirts known for illegally importing exotic and highly dangerous snakes, is responsible. After a shootout, the agents subject Kraitler to tactical interrogation after the latter is injured by a snakebite; with Harris withholding the antivenom, the injured Kraitler finally reveals that Kim hired him to obtain the snakes and exposes more of Kim's schemes of smuggling them on board the flight. Price medicates Kraitler and commands his supplies of antivenom for the victims on the plane based on the list given to him while Harris orders Kim arrested and tried on multiple counts of murder and attempted murder, with the death penalty as an option.
Harris contacts Flynn, telling him that antivenom will be ready for the passengers when they land. However, Flynn discovers that the cockpit is filled with snakes and Rick is dead. After a brief discussion, Troy, a bodyguard for rapper Three G's, agrees to land the plane based on his experience playing a flight simulator. After everyone gets prepared, Flynn shoots out two windows with his pistol, causing the plane to depressurize. The snakes are blown out of the cockpit and the lower floor of the plane. Despite his lack of real-world experience, Troy makes an emergency landing and the plane makes it to the terminal. The passengers exit the plane and antivenom is given to those who need it.
Just as Flynn and Sean are about to disembark, a remaining snake jumps out and bites Sean in the chest. Flynn draws his gun and shoots the snake, and paramedics rush to a traumatized Sean, who remains unharmed due to a ballistic vest he wore throughout the ordeal after his rescue from Kim's henchmen. As a token of gratitude, Sean later takes Flynn to Bali and teaches him how to surf.