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Nobel Prizes have been awarded to over 900 individuals, of whom at least 20% were Jews although the Jewish population comprises less than 0.2% of the world's population. Various theories have been proposed to explain this phenomenon, which has received considerable attention. Israeli academics Dr. Elay Ben-Gal and Professor Yeshayahu Leibowitz, curious about the phenomenon, started to form an encyclopedia of Jewish Nobel laureates and interview as many as possible about their life and work.

Jews have been recipients of all six awards. The first Jewish recipient, Adolf von Baeyer, was awarded the prize in Chemistry in 1905. As of 2019, the most recent Jewish recipient was economics laureate Michael Kremer.

Jewish laureates Elie Wiesel and Imre Kertész survived the extermination camps during the Holocaust, while François Englert survived by being hidden in orphanages and children's homes. Others, such as Walter Kohn, Otto Stern, Albert Einstein, Hans Krebs and Martin Karplus had to flee Nazi Germany to avoid persecution. Still others, including Rita Levi-Montalcini, Herbert Hauptman, Robert Furchgott, Arthur Kornberg, and Jerome Karle experienced significant antisemitism in their careers.

Arthur Ashkin, a 96-year-old American Jew was, at the time of his award, the oldest person to receive a Nobel Prize.